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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
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Accession:GO:0010881 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of cardiac muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction.


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regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANK2 ankyrin 2 IGI
ISS
(PMID:17178715)
(PMID:21859974)
BHF-UCL PMID:17178715, PMID:21859974 NCBI chr 4:112,705,622...113,383,736
Ensembl chr 4:112,818,032...113,384,221
JBrowse link
G ASPH aspartate beta-hydroxylase TAS
ISS
(PMID:22123818)
(PMID:17400717)
BHF-UCL PMID:17400717, PMID:22123818 NCBI chr 8:61,500,556...61,714,609
Ensembl chr 8:61,500,556...61,714,640
JBrowse link
G ATP1A2 ATPase Na+/K+ transporting subunit alpha 2 TAS (PMID:23608603) BHF-UCL PMID:23608603 NCBI chr 1:160,115,759...160,143,591
Ensembl chr 1:160,115,759...160,143,591
JBrowse link
G CACNA1C calcium voltage-gated channel subunit alpha1 C TAS
ISS
(PMID:11576544) BHF-UCL
UniProtKB
PMID:11576544 GO_REF:0000024 NCBI chr12:1,969,552...2,697,950
Ensembl chr12:1,970,786...2,697,950
JBrowse link
G CALM1 calmodulin 1 IC BHF-UCL GO_REF:0000036 NCBI chr14:90,396,502...90,408,268
Ensembl chr14:90,396,502...90,408,268
JBrowse link
G CALM2 calmodulin 2 IC BHF-UCL GO_REF:0000036 NCBI chr 2:47,160,082...47,176,936
Ensembl chr 2:47,160,083...47,176,921
JBrowse link
G CALM3 calmodulin 3 IC BHF-UCL GO_REF:0000036 NCBI chr19:46,601,074...46,610,782
Ensembl chr19:46,601,074...46,610,782
JBrowse link
G CAMK2D calcium/calmodulin dependent protein kinase II delta IC
TAS
(PMID:12676813)
(PMID:17157285)
BHF-UCL
UniProtKB
PMID:12676813, PMID:17157285 NCBI chr 4:113,451,032...113,762,177
Ensembl chr 4:113,451,032...113,761,927
JBrowse link
G CASQ2 calsequestrin 2 IMP
IBA
(PMID:16601229), (PMID:16908766)
(PMID:21873635)
BHF-UCL
GO_Central
PMID:16601229, PMID:16908766, PMID:21873635 NCBI chr 1:115,700,021...115,768,714
Ensembl chr 1:115,700,021...115,768,714
Ensembl chr 1:115,700,021...115,768,714
JBrowse link
G CLIC2 chloride intracellular channel 2 IC (PMID:15147738) BHF-UCL PMID:15147738 NCBI chr  X:155,276,211...155,334,614
Ensembl chr  X:155,276,211...155,334,657
JBrowse link
G DMD dystrophin IEA
ISS
(PMID:20080623) Ensembl
BHF-UCL
PMID:20080623 GO_REF:0000107 NCBI chr  X:31,119,219...33,339,460
Ensembl chr  X:31,097,677...33,339,441
JBrowse link
G FKBP1B FKBP prolyl isomerase 1B ISS
IBA
(PMID:21873635) BHF-UCL
GO_Central
PMID:21873635 GO_REF:0000024 NCBI chr 2:24,033,205...24,067,743
Ensembl chr 2:24,049,701...24,063,681
JBrowse link
G GSTM2 glutathione S-transferase mu 2 IC (PMID:17023043)
(PMID:22406107)
BHF-UCL PMID:17023043, PMID:22406107 NCBI chr 1:109,668,057...109,683,997
Ensembl chr 1:109,668,022...109,709,551
JBrowse link
G GSTO1 glutathione S-transferase omega 1 IC (PMID:11035031) BHF-UCL PMID:11035031 NCBI chr10:104,254,173...104,267,455
Ensembl chr10:104,235,356...104,267,459
JBrowse link
G HRC histidine rich calcium binding protein TAS (PMID:17526652) BHF-UCL PMID:17526652 NCBI chr19:49,151,198...49,155,464
Ensembl chr19:49,151,198...49,155,396
JBrowse link
G PLN phospholamban IEA Ensembl GO_REF:0000107 NCBI chr 6:118,548,296...118,561,716
Ensembl chr 6:118,548,296...118,561,716
JBrowse link
G PRKACA protein kinase cAMP-activated catalytic subunit alpha TAS (PMID:23507255) BHF-UCL PMID:23507255 NCBI chr19:14,091,688...14,117,762
Ensembl chr19:14,091,688...14,118,084
JBrowse link
G RYR2 ryanodine receptor 2 IC
ISS
(PMID:19220289) BHF-UCL PMID:19220289 GO_REF:0000024 NCBI chr 1:237,042,184...237,833,988
Ensembl chr 1:237,042,184...237,833,988
JBrowse link
G SLC8A1 solute carrier family 8 member A1 TAS
ISS
(PMID:23608603) BHF-UCL PMID:23608603 GO_REF:0000024 NCBI chr 2:40,094,523...40,512,452
Ensembl chr 2:40,097,270...40,611,053
JBrowse link
G TMEM38A transmembrane protein 38A IEA Ensembl GO_REF:0000107 NCBI chr19:16,661,139...16,690,023
Ensembl chr19:16,661,139...16,690,023
JBrowse link
G TMEM38B transmembrane protein 38B IEA Ensembl GO_REF:0000107 NCBI chr 9:105,694,541...105,776,629
Ensembl chr 9:105,694,541...105,776,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18670
    regulation of biological process 12640
      regulation of localization 3090
        regulation of sequestering of calcium ion 139
          regulation of release of sequestered calcium ion into cytosol 96
            regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 30
              regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion 21
Path 2
Term Annotations click to browse term
  biological_process 18670
    biological regulation 13308
      regulation of biological quality 4611
        homeostatic process 2208
          chemical homeostasis 1392
            ion homeostasis 931
              cellular ion homeostasis 768
                cellular cation homeostasis 755
                  cellular metal ion homeostasis 672
                    cellular calcium ion homeostasis 528
                      regulation of cytosolic calcium ion concentration 415
                        positive regulation of cytosolic calcium ion concentration 372
                          calcium ion transport into cytosol 190
                            calcium ion transmembrane import into cytosol 165
                              release of sequestered calcium ion into cytosol 136
                                release of sequestered calcium ion into cytosol by endoplasmic reticulum 34
                                  release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 33
                                    regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 30
                                      regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion 21
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.