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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
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Accession:GO:0010881 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of cardiac muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction.


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regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANK2 ankyrin 2 IEA Ensembl GO_REF:0000107 NCBI chr32:32,484,196...33,143,295
Ensembl chr32:32,671,281...33,141,036
JBrowse link
G ASPH aspartate beta-hydroxylase IDA (PMID:17400717) BHF-UCL PMID:17400717 NCBI chr29:11,812,275...12,022,755
Ensembl chr29:11,814,554...12,022,680
JBrowse link
G CASQ2 calsequestrin 2 IBA
IEA
(PMID:21873635) GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr17:53,233,966...53,299,093
Ensembl chr17:53,224,438...53,299,708
JBrowse link
G DMD dystrophin IEA Ensembl GO_REF:0000107 NCBI chr  X:26,290,903...28,444,635
Ensembl chr  X:26,290,910...28,333,576
JBrowse link
G FKBP1B FKBP prolyl isomerase 1B IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr17:18,534,295...18,544,973
Ensembl chr17:18,534,741...18,544,943
JBrowse link
G PLN phospholamban IEA Ensembl GO_REF:0000107 NCBI chr 1:58,579,095...58,590,541
Ensembl chr 1:58,579,145...58,590,535
JBrowse link
G RYR2 ryanodine receptor 2 IEA Ensembl GO_REF:0000107 NCBI chr 4:2,371,868...2,908,132
Ensembl chr 4:2,373,114...2,907,875
JBrowse link
G SLC8A1 solute carrier family 8 member A1 ISO PMID:21779914 BHF-UCL PMID:21779914 RGD:8554732 NCBI chr17:32,004,207...32,381,399
Ensembl chr17:32,005,245...32,307,700
JBrowse link
G TMEM38A transmembrane protein 38A IEA Ensembl GO_REF:0000107 NCBI chr20:45,876,642...45,895,054
Ensembl chr20:45,877,524...45,894,986
JBrowse link
G TMEM38B transmembrane protein 38B IEA Ensembl GO_REF:0000107 NCBI chr11:61,511,756...61,561,987
Ensembl chr11:61,511,750...61,560,556
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16181
    regulation of biological process 10944
      regulation of localization 2875
        regulation of sequestering of calcium ion 124
          regulation of release of sequestered calcium ion into cytosol 84
            regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 23
              regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion 10
Path 2
Term Annotations click to browse term
  biological_process 16181
    biological regulation 11544
      regulation of biological quality 3995
        homeostatic process 1957
          chemical homeostasis 1246
            ion homeostasis 829
              cellular ion homeostasis 671
                cellular cation homeostasis 658
                  cellular metal ion homeostasis 592
                    cellular calcium ion homeostasis 482
                      regulation of cytosolic calcium ion concentration 382
                        positive regulation of cytosolic calcium ion concentration 334
                          calcium ion transport into cytosol 174
                            calcium ion transmembrane import into cytosol 150
                              release of sequestered calcium ion into cytosol 122
                                release of sequestered calcium ion into cytosol by endoplasmic reticulum 28
                                  release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 27
                                    regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 23
                                      regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion 10
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.