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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
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Accession:GO:0010881 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of cardiac muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction.


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regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ank2 ankyrin 2 ISO (MGI:MGI:5427070|PMID:21859974), (MGI:MGI:5430893|PMID:17178715)
(PMID:17178715)
BHF-UCL PMID:17178715, PMID:21859974 MGI:MGI:5427070, MGI:MGI:5430893 NCBI chrNW_004955457:13,624,590...13,938,427
Ensembl chrNW_004955457:13,624,413...14,076,261
JBrowse link
G Asph aspartate beta-hydroxylase ISO (PMID:17400717) BHF-UCL PMID:17400717 NCBI chrNW_004955444:17,116,060...17,320,966
Ensembl chrNW_004955444:17,121,559...17,318,295
JBrowse link
G Casq2 calsequestrin 2 ISO PMID:17569730
(PMID:16601229), (PMID:16908766)
(MGI:MGI:1202079|PMID:9525981)
(MGI:MGI:3689635|PMID:16932808)
BHF-UCL
MGI
UniProtKB
PMID:9525981, PMID:16601229, PMID:16908766, PMID:16932808, PMID:17569730 MGI:MGI:1202079, MGI:MGI:3689635, RGD:2314601 NCBI chrNW_004955435:18,941,975...18,996,027
Ensembl chrNW_004955435:18,941,936...18,996,200
JBrowse link
G Dmd dystrophin ISO (MGI:MGI:4420848|PMID:20080623) BHF-UCL PMID:20080623 MGI:MGI:4420848 NCBI chrNW_004955535:1,283,084...3,297,015
Ensembl chrNW_004955535:1,283,523...3,299,542
JBrowse link
G Fkbp1b FKBP prolyl isomerase 1B ISO (MGI:MGI:3621834|PMID:12837242) BHF-UCL PMID:12837242 MGI:MGI:3621834 NCBI chrNW_004955469:6,263,271...6,274,823
Ensembl chrNW_004955469:6,263,271...6,277,767
JBrowse link
G Pln phospholamban ISO (MGI:MGI:82999|PMID:8831698) MGI PMID:8831698 MGI:MGI:82999 NCBI chrNW_004955436:1,439,098...1,447,070
Ensembl chrNW_004955436:1,439,098...1,447,070
JBrowse link
G Ryr2 ryanodine receptor 2 ISO (MGI:MGI:3621834|PMID:12837242) BHF-UCL PMID:12837242 MGI:MGI:3621834 NCBI chrNW_004955492:2,647,597...3,275,512
Ensembl chrNW_004955492:2,648,956...3,076,509
JBrowse link
G Slc8a1 solute carrier family 8 member A1 ISO PMID:21779914 BHF-UCL PMID:21779914 RGD:8554732 NCBI chrNW_004955441:7,653,107...8,037,784
Ensembl chrNW_004955441:7,656,031...7,957,640
JBrowse link
G Tmem38a transmembrane protein 38A ISO (MGI:MGI:3715564|PMID:17611541) MGI PMID:17611541 MGI:MGI:3715564 NCBI chrNW_004955524:1,132,111...1,144,335
Ensembl chrNW_004955524:1,132,111...1,144,380
JBrowse link
G Tmem38b transmembrane protein 38B ISO (MGI:MGI:3715564|PMID:17611541) MGI PMID:17611541 MGI:MGI:3715564 NCBI chrNW_004955419:20,811,931...20,844,420
Ensembl chrNW_004955419:20,812,702...20,878,599
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11892
    regulation of biological process 8267
      regulation of localization 2578
        regulation of sequestering of calcium ion 109
          regulation of release of sequestered calcium ion into cytosol 82
            regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 23
              regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion 10
Path 2
Term Annotations click to browse term
  biological_process 11892
    biological regulation 8722
      regulation of biological quality 3365
        homeostatic process 1718
          chemical homeostasis 1052
            ion homeostasis 688
              cellular ion homeostasis 547
                cellular cation homeostasis 535
                  cellular metal ion homeostasis 487
                    cellular calcium ion homeostasis 401
                      regulation of cytosolic calcium ion concentration 308
                        positive regulation of cytosolic calcium ion concentration 270
                          calcium ion transport into cytosol 155
                            calcium ion transmembrane import into cytosol 132
                              release of sequestered calcium ion into cytosol 108
                                release of sequestered calcium ion into cytosol by endoplasmic reticulum 25
                                  release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 24
                                    regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 23
                                      regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion 10
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.