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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
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Accession:GO:0010881 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of cardiac muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction.


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regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ank2 ankyrin 2 ISO UniProtKB:Q8C8R3 (PMID:17178715)
(MGI:MGI:5427070|PMID:21859974), (MGI:MGI:5430893|PMID:17178715)
RGD PMID:17178715, PMID:21859974 MGI:MGI:5427070, MGI:MGI:5430893 NCBI chr 2:231,224,643...231,522,655
Ensembl chr 2:231,226,949...231,648,122
JBrowse link
G Asph aspartate-beta-hydroxylase ISO (PMID:17400717) RGD PMID:17400717 NCBI chr 5:22,577,680...22,799,333
Ensembl chr 5:22,577,675...22,799,349
JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 4:150,635,808...151,270,790
Ensembl chr 4:150,641,066...150,829,913
JBrowse link
G Camk2d calcium/calmodulin-dependent protein kinase II delta IC PMID:12676813 BHF-UCL PMID:12676813 RGD:10047271 NCBI chr 2:230,900,907...231,132,207
Ensembl chr 2:230,901,126...231,132,039
JBrowse link
G Casq2 calsequestrin 2 IMP
IBA
ISO
IEA
PMID:17569730
PMID:21873635
(MGI:MGI:1202079|PMID:9525981), (MGI:MGI:3689635|PMID:16932808)
(PMID:16601229), (PMID:16908766)
GO_REF:0000107
RGD
Ensembl
PMID:9525981, PMID:16601229, PMID:16908766, PMID:16932808, PMID:17569730, PMID:21873635 GO_REF:0000107, MGI:MGI:1202079, MGI:MGI:3689635, RGD:2314601, RGD:13792537 NCBI chr 2:204,512,361...204,568,643
Ensembl chr 2:204,512,302...204,568,656
JBrowse link
G Dmd dystrophin ISO (MGI:MGI:4420848|PMID:20080623) RGD PMID:20080623 MGI:MGI:4420848 NCBI chr  X:51,149,358...53,519,271
Ensembl chr  X:51,286,737...53,519,259
JBrowse link
G Fkbp1b FKBP prolyl isomerase 1B ISO
IBA
(MGI:MGI:3621834|PMID:12837242)
PMID:21873635
RGD PMID:12837242, PMID:21873635 MGI:MGI:3621834, RGD:13792537 NCBI chr 6:29,975,863...29,987,252
Ensembl chr 6:29,977,797...29,987,451
JBrowse link
G Pln phospholamban ISO MGI:MGI:2158357 (MGI:MGI:82999|PMID:8831698) RGD PMID:8831698 MGI:MGI:82999 NCBI chr20:34,633,157...34,642,904
Ensembl chr20:34,633,157...34,642,904
JBrowse link
G Ryr2 ryanodine receptor 2 ISO
IEA
UniProtKB:Q9Z2I2 (MGI:MGI:3621834|PMID:12837242)
GO_REF:0000107
RGD
Ensembl
PMID:12837242 GO_REF:0000107, MGI:MGI:3621834 NCBI chr17:65,533,998...65,955,606
Ensembl chr17:65,535,403...65,955,606
JBrowse link
G Slc8a1 solute carrier family 8 member A1 IDA PMID:21779914 BHF-UCL PMID:21779914 RGD:8554732 NCBI chr 6:4,244,076...4,564,262
Ensembl chr 6:4,258,991...4,520,604
JBrowse link
G Tmem38a transmembrane protein 38a ISO
IEA
MGI:MGI:1098718 (MGI:MGI:3715564|PMID:17611541)
GO_REF:0000107
RGD
Ensembl
PMID:17611541 GO_REF:0000107, MGI:MGI:3715564 NCBI chr16:18,960,197...18,974,942
Ensembl chr16:18,959,315...18,974,770
JBrowse link
G Tmem38b transmembrane protein 38B ISO MGI:MGI:1921416 (MGI:MGI:3715564|PMID:17611541) RGD PMID:17611541 MGI:MGI:3715564 NCBI chr 5:70,639,156...70,675,055
Ensembl chr 5:70,639,156...70,675,054
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    regulation of biological process 13075
      regulation of localization 3018
        regulation of sequestering of calcium ion 130
          regulation of release of sequestered calcium ion into cytosol 88
            regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 28
              regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion 12
Path 2
Term Annotations click to browse term
  biological_process 20027
    biological regulation 13773
      regulation of biological quality 4280
        homeostatic process 2077
          chemical homeostasis 1334
            ion homeostasis 887
              cellular ion homeostasis 730
                cellular cation homeostasis 717
                  cellular metal ion homeostasis 649
                    cellular calcium ion homeostasis 515
                      regulation of cytosolic calcium ion concentration 412
                        positive regulation of cytosolic calcium ion concentration 361
                          calcium ion transport into cytosol 176
                            calcium ion transmembrane import into cytosol 152
                              release of sequestered calcium ion into cytosol 127
                                release of sequestered calcium ion into cytosol by endoplasmic reticulum 32
                                  release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 31
                                    regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 28
                                      regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion 12
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.