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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
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Accession:GO:0010881 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of cardiac muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction.



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regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ank2 ankyrin 2 involved_in ISO UniProtKB:Q8C8R3 (PMID:17178715)
(MGI:5427070|PMID:21859974), (MGI:5430893|PMID:17178715)
RGD PMID:17178715 PMID:21859974 MGI:5427070 MGI:5430893 NCBI chr 2:215,378,028...215,954,015
Ensembl chr 2:215,379,680...215,862,923
JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648
JBrowse link
G Camk2d calcium/calmodulin-dependent protein kinase II delta involved_in IC PMID:12676813 BHF-UCL PMID:12676813 RGD:10047271 NCBI chr 2:215,023,785...215,287,351
Ensembl chr 2:215,024,004...215,286,178
JBrowse link
G Casq2 calsequestrin 2 involved_in
acts_upstream_of_or_within
ISO
IMP
IEA
IBA
(PMID:16601229), (PMID:16908766)
PMID:17569730
(MGI:3689635|PMID:16932808)
(MGI:1202079|PMID:9525981)
GO_REF:0000107
GO_REF:0000118
GO_REF:0000033
RGD
Ensembl
TreeGrafter
GO_Central
PMID:9525981 PMID:16601229 PMID:16908766 PMID:16932808 PMID:17569730 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 MGI:1202079 MGI:3689635, RGD:2314601 NCBI chr 2:189,526,003...189,582,276
Ensembl chr 2:189,525,960...189,582,267
JBrowse link
G Dmd dystrophin involved_in ISO (MGI:4420848|PMID:20080623) RGD PMID:20080623 MGI:4420848 NCBI chr  X:47,272,324...49,504,219
Ensembl chr  X:47,272,331...49,504,207
JBrowse link
G Fkbp1b FKBP prolyl isomerase 1B involved_in ISO
IEA
IBA
(MGI:3621834|PMID:12837242)
GO_REF:0000118
GO_REF:0000033
RGD
TreeGrafter
GO_Central
PMID:12837242 GO_REF:0000033 GO_REF:0000118 MGI:3621834 NCBI chr 6:27,832,128...27,850,600
Ensembl chr 6:27,838,802...27,848,653
JBrowse link
G Pln phospholamban acts_upstream_of_or_within ISO MGI:2158357 (MGI:82999|PMID:8831698) RGD PMID:8831698 MGI:82999 NCBI chr20:32,629,537...32,639,559 JBrowse link
G Ryr2 ryanodine receptor 2 involved_in IEA
ISO
GO_REF:0000107
UniProtKB:Q9Z2I2 (MGI:3621834|PMID:12837242)
Ensembl
RGD
PMID:12837242 GO_REF:0000107 MGI:3621834 NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142
JBrowse link
G Slc8a1 solute carrier family 8 member A1 involved_in IDA PMID:21779914 BHF-UCL PMID:21779914 RGD:8554732 NCBI chr 6:13,194,609...13,547,369
Ensembl chr 6:13,194,662...13,535,628
JBrowse link
G Tmem38a transmembrane protein 38a involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1098718 (MGI:3715564|PMID:17611541)
Ensembl
RGD
PMID:17611541 GO_REF:0000107 MGI:3715564 NCBI chr16:17,258,160...17,274,204
Ensembl chr16:17,258,164...17,273,415
JBrowse link
G Tmem38b transmembrane protein 38B acts_upstream_of_or_within ISO MGI:1921416 (MGI:3715564|PMID:17611541) RGD PMID:17611541 MGI:3715564 NCBI chr 5:68,460,304...68,496,026
Ensembl chr 5:68,460,304...68,496,025
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20325
    regulation of biological process 13227
      regulation of localization 2324
        regulation of sequestering of calcium ion 133
          regulation of release of sequestered calcium ion into cytosol 79
            regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 29
              regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion 11
Path 2
Term Annotations click to browse term
  biological_process 20325
    homeostatic process 1968
      chemical homeostasis 1206
        monoatomic ion homeostasis 673
          monoatomic cation homeostasis 659
            calcium ion homeostasis 368
              intracellular calcium ion homeostasis 339
                sequestering of calcium ion 135
                  regulation of sequestering of calcium ion 133
                    negative regulation of sequestering of calcium ion 131
                      release of sequestered calcium ion into cytosol 130
                        release of sequestered calcium ion into cytosol by endoplasmic reticulum 34
                          release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 33
                            regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 29
                              regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion 11
paths to the root