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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of cholesterol efflux
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Accession:GO:0010874 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle.


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regulation of cholesterol efflux term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA5 ATP binding cassette subfamily A member 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:11,018,692...11,152,916
Ensembl chr12:11,067,500...11,152,688 		JBrowse link
G ABCA8 ATP binding cassette subfamily A member 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:11,366,734...11,447,297
Ensembl chr12:11,373,238...11,447,295 		JBrowse link
G LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:6,674,045...6,680,067
Ensembl chr 9:6,672,475...6,680,053 		JBrowse link
G NAXE NAD(P)HX epimerase involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:93,493,234...93,495,912
Ensembl chr 4:93,490,537...93,496,396 		JBrowse link
G TTC39B tetratricopeptide repeat domain 39B involved_in IEA
IBA		 Ensembl
GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:207,347,345...207,490,753
Ensembl chr 1:207,347,360...207,495,965 		JBrowse link
G TTC39D tetratricopeptide repeat domain 39D involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 3:101,577,184...101,580,487 JBrowse link
negative regulation of cholesterol efflux term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA2 ATP binding cassette subfamily A member 2 acts_upstream_of
involved_in		 ISO
IEA		 (PMID:21810484) ARUK-UCL
Ensembl		 PMID:21810484 GO_REF:0000107
G APOE apolipoprotein E involved_in ISO (PMID:12042316) Alzheimers_University_of_Toronto PMID:12042316 NCBI chr 6:51,373,113...51,375,333
Ensembl chr 6:51,372,292...51,375,330 		JBrowse link
G EGF epidermal growth factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:112,235,607...112,330,062
Ensembl chr 8:112,234,386...112,330,046 		JBrowse link
G IRAK1 interleukin 1 receptor associated kinase 1 involved_in ISO (MGI:4411947|PMID:19752193) UniProt PMID:19752193 MGI:4411947 NCBI chr  X:124,717,604...124,724,855
Ensembl chr  X:124,717,612...124,724,860 		JBrowse link
G LOC110259864 group 10 secretory phospholipase A2-like involved_in ISO (MGI:5051938|PMID:20844270) BHF-UCL PMID:20844270 MGI:5051938 NCBI chr 3:7,623,326...7,641,061
Ensembl chr 3:7,623,312...7,642,002 		JBrowse link
G MIR128-1 microRNA mir-128-1 involved_in
acts_upstream_of		 ISO (PMID:26501192)
(PMID:23990020)		 BHF-UCL PMID:23990020 PMID:26501192 NCBI chr15:16,273,557...16,273,638
Ensembl chr15:16,273,551...16,273,659 		JBrowse link
G MIR128-2 microRNA mir-128-2 acts_upstream_of
involved_in		 ISO (PMID:23990020)
(PMID:26501192)		 BHF-UCL PMID:23990020 PMID:26501192 NCBI chr13:21,038,445...21,038,524
Ensembl chr13:21,038,442...21,038,525 		JBrowse link
G MIR130B microRNA mir-130b involved_in ISO (PMID:26501192) BHF-UCL PMID:26501192 NCBI chr14:50,245,041...50,245,120
Ensembl chr14:50,245,041...50,245,120 		JBrowse link
G MIR144 microRNA mir-144 involved_in ISO (PMID:23519695)
(PMID:24733347)		 BHF-UCL
ARUK-UCL		 PMID:23519695 PMID:24733347 NCBI chr12:45,088,958...45,089,033
Ensembl chr12:45,088,959...45,089,035 		JBrowse link
G MIR145 microRNA mir-145 involved_in ISO (PMID:24135019) BHF-UCL PMID:24135019 NCBI chr 2:150,580,126...150,580,211
Ensembl chr 2:150,580,126...150,580,211 		JBrowse link
G MIR148A microRNA mir-148a involved_in ISO (PMID:26437365), (PMID:26501192) BHF-UCL PMID:26437365 PMID:26501192 NCBI chr18:46,415,213...46,415,280
Ensembl chr18:46,415,202...46,415,281 		JBrowse link
G MIR19B-1 microRNA mir-19b-1 involved_in ISO (PMID:25084135)
(PMID:25765596)		 BHF-UCL PMID:25084135 PMID:25765596 NCBI chr11:60,735,238...60,735,317
Ensembl chr11:60,735,230...60,735,328 		JBrowse link
G MIR19B-2 microRNA mir-19b-2 involved_in ISO (PMID:25084135)
(PMID:25765596)		 BHF-UCL PMID:25084135 PMID:25765596 NCBI chr  X:110,113,855...110,113,934
Ensembl chr  X:110,113,855...110,113,934 		JBrowse link
G MIR206 microRNA mir-206 acts_upstream_of ISO (PMID:24603323) BHF-UCL PMID:24603323 NCBI chr 7:45,976,293...45,976,372
Ensembl chr 7:45,976,293...45,976,372 		JBrowse link
G MIR27A microRNA mir-27a involved_in ISO (PMID:24608080) ARUK-UCL PMID:24608080 NCBI chr 2:65,308,294...65,308,375
Ensembl chr 2:65,308,294...65,308,375 		JBrowse link
G MIR27B microRNA mir-27b involved_in ISO (PMID:24608080), (PMID:26520906) ARUK-UCL PMID:24608080 PMID:26520906 NCBI chr10:27,079,963...27,080,042
Ensembl chr10:27,079,954...27,080,056 		JBrowse link
G MIR9-1 microRNA mir-9-1 involved_in ISO (PMID:29584810) BHF-UCL PMID:29584810 NCBI chr 4:93,660,422...93,660,510 JBrowse link
G MIR9-2 microRNA mir-9-2 involved_in ISO (PMID:29584810) BHF-UCL PMID:29584810 NCBI chr 2:96,076,352...96,076,438 JBrowse link
G MIR9-3 microRNA mir-9-3 involved_in ISO (PMID:29584810) BHF-UCL PMID:29584810 NCBI chr 7:54,948,452...54,948,532
Ensembl chr 7:54,948,447...54,948,536 		JBrowse link
G SHH sonic hedgehog signaling molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:2,546,202...2,555,484
Ensembl chr18:2,545,994...2,555,484 		JBrowse link
G SREBF2 sterol regulatory element binding transcription factor 2 acts_upstream_of
involved_in		 ISO
IEA		 (PMID:15358760) BHF-UCL
Ensembl		 PMID:15358760 GO_REF:0000107 NCBI chr 5:6,719,484...6,784,724
Ensembl chr 5:6,719,490...6,784,671 		JBrowse link
positive regulation of cholesterol efflux term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA1 ATP binding cassette subfamily A member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:246,144,277...246,278,492
Ensembl chr 1:246,144,277...246,278,492 		JBrowse link
G ABCA12 ATP binding cassette subfamily A member 12 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23931754) Ensembl
MGI		 PMID:23931754 GO_REF:0000107 NCBI chr15:117,244,704...117,451,009
Ensembl chr15:117,244,719...117,450,863 		JBrowse link
G ABCA3 ATP binding cassette subfamily A member 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:39,689,133...39,732,466
Ensembl chr 3:39,698,895...39,732,978 		JBrowse link
G ABCA7 ATP binding cassette subfamily A member 7 involved_in ISO (MGI:5553242|PMID:18429932) Alzheimers_University_of_Toronto PMID:18429932 MGI:5553242 NCBI chr 2:77,357,161...77,375,349
Ensembl chr 2:77,357,218...77,375,180 		JBrowse link
G ABCA8 ATP binding cassette subfamily A member 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:11,366,734...11,447,297
Ensembl chr12:11,373,238...11,447,295 		JBrowse link
G ABCG1 ATP binding cassette subfamily G member 1 involved_in ISO (MGI:3047008|PMID:15210959) BHF-UCL PMID:15210959 MGI:3047008 NCBI chr13:205,561,897...205,628,428
Ensembl chr13:205,561,951...205,628,425 		JBrowse link
G ABCG4 ATP binding cassette subfamily G member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:46,364,546...46,380,545
Ensembl chr 9:46,364,936...46,380,544 		JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr13:124,633,906...124,646,237
Ensembl chr13:124,633,685...124,646,646 		JBrowse link
G APOA1 apolipoprotein A1 involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 9:44,216,481...44,218,360
Ensembl chr 9:44,216,392...44,218,713 		JBrowse link
G APOE apolipoprotein E involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:51,373,113...51,375,333
Ensembl chr 6:51,372,292...51,375,330 		JBrowse link
G CAV1 caveolin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:29,648,120...29,682,451
Ensembl chr18:29,649,992...29,682,465 		JBrowse link
G EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:37,824,450...37,948,855
Ensembl chr18:37,823,920...37,948,659 		JBrowse link
G GPS2 G protein pathway suppressor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:52,664,869...52,667,643
Ensembl chr12:52,664,875...52,667,610 		JBrowse link
G LOC110255234 liver carboxylesterase-like involved_in IEA Ensembl GO_REF:0000107
G LRP1 LDL receptor related protein 1 involved_in ISO (MGI:4358638|PMID:19718435) BHF-UCL PMID:19718435 MGI:4358638 NCBI chr 5:22,435,636...22,519,276 JBrowse link
G MIR206 microRNA mir-206 acts_upstream_of ISO (PMID:24603323) BHF-UCL PMID:24603323 NCBI chr 7:45,976,293...45,976,372
Ensembl chr 7:45,976,293...45,976,372 		JBrowse link
G NFKBIA NFKB inhibitor alpha involved_in ISO (PMID:16938301) BHF-UCL PMID:16938301 NCBI chr 7:64,508,119...64,510,754
Ensembl chr 7:64,507,822...64,511,277 		JBrowse link
G NR1H2 nuclear receptor subfamily 1 group H member 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23931754) Ensembl
MGI		 PMID:23931754 GO_REF:0000107 NCBI chr 6:55,238,536...55,245,457
Ensembl chr 6:55,239,500...55,245,456 		JBrowse link
G NR1H3 nuclear receptor subfamily 1 group H member 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:15,315,283...15,336,785
Ensembl chr 2:15,315,282...15,334,820 		JBrowse link
G PLTP phospholipid transfer protein involved_in IMP (PMID:24369175) AgBase PMID:24369175 NCBI chr17:48,089,789...48,101,604
Ensembl chr17:48,089,785...48,101,515 		JBrowse link
G PON1 paraoxonase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:74,943,646...74,974,720
Ensembl chr 9:74,926,048...74,974,723 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma acts_upstream_of
involved_in		 ISO
IMP		 (PMID:24751522)
(PMID:16530456)		 BHF-UCL
AgBase		 PMID:16530456 PMID:24751522 NCBI chr13:68,301,566...68,433,951
Ensembl chr13:68,302,322...68,433,944 		JBrowse link
G PTCH1 patched 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:26,627,165...26,703,225
Ensembl chr10:26,627,425...26,703,223 		JBrowse link
G SIRT1 sirtuin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:71,091,167...71,126,351
Ensembl chr14:71,091,167...71,123,297 		JBrowse link
G TREM2 triggering receptor expressed on myeloid cells 2 involved_in ISO (MGI:6448697|PMID:31902528) ARUK-UCL PMID:31902528 MGI:6448697 NCBI chr 7:36,465,921...36,471,509
Ensembl chr 7:36,465,324...36,471,516 		JBrowse link
G ZDHHC8 zinc finger DHHC-type palmitoyltransferase 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:51,503,074...51,517,577
Ensembl chr14:51,503,114...51,516,885 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17799
    localization 5399
      regulation of localization 2239
        regulation of lipid localization 202
          regulation of lipid transport 167
            regulation of sterol transport 71
              regulation of cholesterol transport 71
                regulation of cholesterol efflux 50
                  negative regulation of cholesterol efflux 21
                  positive regulation of cholesterol efflux 26
Path 2
Term Annotations click to browse term
  biological_process 17799
    localization 5399
      establishment of localization 4701
        transport 4392
          organic substance transport 2351
            lipid transport 457
              sterol transport 126
                cholesterol transport 122
                  regulation of cholesterol transport 71
                    regulation of cholesterol efflux 50
                      negative regulation of cholesterol efflux 21
                      positive regulation of cholesterol efflux 26
paths to the root