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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of cholesterol efflux
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Accession:GO:0010874 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle.



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regulation of cholesterol efflux term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca5 ATP binding cassette subfamily A member 5 involved_in ISS
ISO
GO_REF:0000024
(MGI:6508518|PMID:32687853)
(PMID:25125465)
UniProt
RGD
PMID:25125465 PMID:32687853 GO_REF:0000024 MGI:6508518 NCBI chr10:95,240,159...95,309,195
Ensembl chr10:95,240,154...95,308,976
JBrowse link
G Abca8 ATP binding cassette subfamily A member 8 involved_in ISO (PMID:28882873) RGD PMID:28882873 NCBI chr10:94,917,520...94,991,199
Ensembl chr10:94,917,520...94,990,988
JBrowse link
G Lamtor1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:20544018)
UniProt
RGD
PMID:20544018 GO_REF:0000024 NCBI chr 1:156,272,116...156,277,687
Ensembl chr 1:156,272,064...156,291,179
JBrowse link
G LOC100361543 RhoA activator C11orf59-like involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr  X:34,637,461...34,638,516
Ensembl chr  X:34,637,459...34,638,516
JBrowse link
G Naxe NAD(P)HX epimerase involved_in ISS
ISO
GO_REF:0000024
ZFIN:ZDB-MRPHLNO-130813-3 (PMID:23719382)
UniProt
RGD
PMID:23719382 GO_REF:0000024 NCBI chr 2:173,518,966...173,521,048
Ensembl chr 2:173,518,971...173,521,040
JBrowse link
G Ttc39b tetratricopeptide repeat domain 39B involved_in IBA
ISO
ISS
PMID:21873635
(MGI:5800596|PMID:27383786)
GO_REF:0000024
RGD
UniProt
PMID:27383786 PMID:21873635 GO_REF:0000024 MGI:5800596, RGD:13792537 NCBI chr 5:97,603,329...97,708,103
Ensembl chr 5:97,609,392...97,736,270
JBrowse link
G Ttc39d tetratricopeptide repeat domain 39D involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 6:14,802,753...14,811,516
Ensembl chr 6:14,786,089...14,811,978
JBrowse link
negative regulation of cholesterol efflux term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca2 ATP binding cassette subfamily A member 2 acts_upstream_of
involved_in
ISO
IEA
(PMID:21810484)
GO_REF:0000107
RGD
Ensembl
PMID:21810484 GO_REF:0000107 NCBI chr 3:8,244,515...8,264,545
Ensembl chr 3:8,244,639...8,264,537
JBrowse link
G Apoe apolipoprotein E involved_in ISO (PMID:12042316) RGD PMID:12042316 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G Egf epidermal growth factor involved_in ISO (MGI:4460848|PMID:20037141) RGD PMID:20037141 MGI:4460848 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 involved_in ISO (MGI:4411947|PMID:19752193) RGD PMID:19752193 MGI:4411947 NCBI chr  X:151,768,621...151,778,521
Ensembl chr  X:151,768,777...151,778,521
JBrowse link
G Mir128-1 microRNA 128-1 acts_upstream_of
involved_in
ISO (PMID:23990020)
(PMID:26501192)
RGD PMID:23990020 PMID:26501192 NCBI chr13:39,699,449...39,699,530
Ensembl chr13:39,699,449...39,699,530
JBrowse link
G Mir128-2 microRNA 128-2 acts_upstream_of
involved_in
ISO (PMID:23990020)
(PMID:26501192)
RGD PMID:23990020 PMID:26501192 NCBI chr 8:112,085,467...112,085,550
Ensembl chr 8:112,085,467...112,085,550
JBrowse link
G Mir130b microRNA 130b involved_in ISO (PMID:26501192) RGD PMID:26501192 NCBI chr11:83,880,163...83,880,244
Ensembl chr11:83,880,163...83,880,244
JBrowse link
G Mir144 microRNA 144 involved_in ISO UniProtKB:O95477 (PMID:23519695), (PMID:24733347) RGD PMID:23519695 PMID:24733347 NCBI chr10:62,961,348...62,961,430
Ensembl chr10:62,961,348...62,961,430
JBrowse link
G Mir148a microRNA 148a involved_in ISO (PMID:26437365), (PMID:26501192) RGD PMID:26437365 PMID:26501192 NCBI chr 4:80,333,762...80,333,858
Ensembl chr 4:80,333,762...80,333,858
JBrowse link
G Mir19b1 microRNA 19b-1 involved_in ISO (PMID:25084135), (PMID:25765596) RGD PMID:25084135 PMID:25765596 NCBI chr15:92,181,214...92,181,300
Ensembl chr15:92,181,214...92,181,300
JBrowse link
G Mir19b2 microRNA 19b-2 involved_in ISO (PMID:25084135), (PMID:25765596) RGD PMID:25084135 PMID:25765596 NCBI chr  X:132,422,072...132,422,167
Ensembl chr  X:132,422,072...132,422,167
JBrowse link
G Mir206 microRNA 206 acts_upstream_of ISO (PMID:24603323) RGD PMID:24603323 NCBI chr 9:23,094,249...23,094,332
Ensembl chr 9:23,094,249...23,094,332
JBrowse link
G Mir27a microRNA 27a involved_in ISO (PMID:24608080) RGD PMID:24608080 NCBI chr19:23,954,831...23,954,917
Ensembl chr19:23,954,831...23,954,917
JBrowse link
G Mir27b microRNA 27b involved_in ISO (PMID:24608080), (PMID:26520906) RGD PMID:24608080 PMID:26520906 NCBI chr17:1,813,427...1,813,523
Ensembl chr17:1,813,426...1,813,529
JBrowse link
G Mir301b microRNA 301b involved_in ISO (PMID:26501192) RGD PMID:26501192 NCBI chr11:83,879,816...83,879,893
Ensembl chr11:83,879,816...83,879,893
JBrowse link
G Mir33 microRNA 33 involved_in
acts_upstream_of
ISO (PMID:20466885), (PMID:20566875), (PMID:20855588)
(PMID:20466882)
RGD PMID:20466882 PMID:20466885 PMID:20566875 PMID:20855588 NCBI chr 7:113,713,855...113,713,923
Ensembl chr 7:113,713,855...113,713,923
JBrowse link
G Mir9-3 microRNA 9-3 involved_in ISO (PMID:29584810) RGD PMID:29584810 NCBI chr 1:133,440,049...133,440,138 JBrowse link
G Pla2g10 phospholipase A2, group X involved_in IEA
ISO
GO_REF:0000107
(MGI:5051938|PMID:20844270)
Ensembl
RGD
PMID:20844270 GO_REF:0000107 MGI:5051938 NCBI chr10:1,597,761...1,610,822
Ensembl chr10:1,597,761...1,609,000
JBrowse link
G Shh sonic hedgehog signaling molecule involved_in IEA
ISO
GO_REF:0000107
(MGI:5306540|PMID:21931618)
Ensembl
RGD
PMID:21931618 GO_REF:0000107 MGI:5306540 NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170
JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 involved_in
acts_upstream_of
IEA
ISO
GO_REF:0000107
(PMID:15358760)
Ensembl
RGD
PMID:15358760 GO_REF:0000107 NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848
JBrowse link
positive regulation of cholesterol efflux term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 involved_in ISO (MGI:3047008|PMID:15210959) RGD PMID:15210959 MGI:3047008 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
JBrowse link
G Abca12 ATP binding cassette subfamily A member 12 involved_in
acts_upstream_of_or_within
ISO (PMID:23931754)
MGI:1352463|MGI:4461044 (MGI:5510615|PMID:23931754)
RGD PMID:23931754 MGI:5510615 NCBI chr 9:72,822,661...72,995,748
Ensembl chr 9:72,823,350...72,996,049
JBrowse link
G Abca3 ATP binding cassette subfamily A member 3 involved_in ISS
ISO
GO_REF:0000024
(PMID:25817392)
UniProt
RGD
PMID:25817392 GO_REF:0000024 NCBI chr10:13,382,439...13,439,748
Ensembl chr10:13,382,540...13,439,745
JBrowse link
G Abca7 ATP binding cassette subfamily A member 7 involved_in ISS
ISO
GO_REF:0000024
(MGI:5553242|PMID:18429932)
Alzheimers_University_of_Toronto
RGD
PMID:18429932 GO_REF:0000024 MGI:5553242 NCBI chr 7:9,691,452...9,711,466
Ensembl chr 7:9,691,449...9,711,425
JBrowse link
G Abca8 ATP binding cassette subfamily A member 8 involved_in ISO (PMID:23560799) RGD PMID:23560799 NCBI chr10:94,917,520...94,991,199
Ensembl chr10:94,917,520...94,990,988
JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 involved_in ISO (MGI:3047008|PMID:15210959) RGD PMID:15210959 MGI:3047008 NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948
JBrowse link
G Abcg4 ATP binding cassette subfamily G member 4 involved_in ISO (MGI:3047008|PMID:15210959) RGD PMID:15210959 MGI:3047008 NCBI chr 8:44,611,187...44,629,818
Ensembl chr 8:44,611,187...44,626,881
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing involved_in ISS
ISO
GO_REF:0000024
(PMID:18703020)
UniProt
RGD
PMID:18703020 GO_REF:0000024 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Apoa1 apolipoprotein A1 involved_in ISO
IEA
ISS
(PMID:27472885)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:27472885 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
JBrowse link
G Apoe apolipoprotein E involved_in IEA
ISO
GO_REF:0000107
(MGI:6448697|PMID:31902528)
UniProtKB:P08226 (PMID:12042316), (PMID:12401887), (PMID:14754908)
Ensembl
RGD
PMID:12042316 PMID:12401887 PMID:14754908 PMID:31902528 GO_REF:0000107 MGI:6448697 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G Cav1 caveolin 1 involved_in ISO (PMID:24576892) RGD PMID:24576892 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
JBrowse link
G Ces1d carboxylesterase 1D involved_in ISO (PMID:16971496), (PMID:18599737), (PMID:18762277) RGD PMID:16971496 PMID:18599737 PMID:18762277 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
JBrowse link
G Eepd1 endonuclease/exonuclease/phosphatase family domain containing 1 involved_in ISO (PMID:28082258)
(MGI:6162611|PMID:28082258)
RGD PMID:28082258 MGI:6162611 NCBI chr 8:23,957,258...24,064,343
Ensembl chr 8:23,957,255...24,064,340
JBrowse link
G Gps2 G protein pathway suppressor 2 involved_in ISO (PMID:19481530) RGD PMID:19481530 NCBI chr10:54,637,360...54,640,542
Ensembl chr10:54,637,455...54,640,650
JBrowse link
G Lrp1 LDL receptor related protein 1 involved_in ISO (MGI:4358638|PMID:19718435) RGD PMID:19718435 MGI:4358638 NCBI chr 7:63,380,325...63,461,029
Ensembl chr 7:63,380,356...63,460,910
JBrowse link
G Mir206 microRNA 206 acts_upstream_of ISO (PMID:24603323) RGD PMID:24603323 NCBI chr 9:23,094,249...23,094,332
Ensembl chr 9:23,094,249...23,094,332
JBrowse link
G Nfkbia NFKB inhibitor alpha involved_in ISO (PMID:16938301) RGD PMID:16938301 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nr1h2 nuclear receptor subfamily 1, group H, member 2 involved_in
acts_upstream_of_or_within
ISO (PMID:17186944)
(MGI:3720271|PMID:17657314), (MGI:3794353|PMID:16825483)
MGI:2676312 (MGI:5510615|PMID:23931754)
RGD PMID:16825483 PMID:17186944 PMID:17657314 PMID:23931754 MGI:3720271 MGI:3794353 MGI:5510615 NCBI chr 1:95,041,967...95,047,377
Ensembl chr 1:95,041,967...95,047,377
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 involved_in IEA
ISO
ISS
GO_REF:0000107
(MGI:3794353|PMID:16825483)
(PMID:16141411), (PMID:17186944), (PMID:19481530)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:16141411 PMID:16825483 PMID:17186944 PMID:19481530 GO_REF:0000024 GO_REF:0000107 MGI:3794353 NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722
JBrowse link
G Pltp phospholipid transfer protein involved_in ISO (PMID:24369175) RGD PMID:24369175 NCBI chr 3:153,574,825...153,592,647
Ensembl chr 3:153,574,825...153,592,647
JBrowse link
G Pon1 paraoxonase 1 involved_in ISO (PMID:15721011) RGD PMID:15721011 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma acts_upstream_of
involved_in
ISO (PMID:24751522)
(PMID:16530456)
RGD PMID:16530456 PMID:24751522 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ptch1 patched 1 involved_in ISO (PMID:21931618) RGD PMID:21931618 NCBI chr17:1,542,705...1,607,730
Ensembl chr17:1,542,877...1,607,333
JBrowse link
G Sirt1 sirtuin 1 involved_in ISO (MGI:3790014|PMID:17936707) RGD PMID:17936707 MGI:3790014 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO (MGI:6448697|PMID:31902528) RGD PMID:31902528 MGI:6448697 NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170
JBrowse link
G Zdhhc8 zinc finger DHHC-type palmitoyltransferase 8 involved_in ISO (PMID:19556522) RGD PMID:19556522 NCBI chr11:82,755,110...82,769,280
Ensembl chr11:82,755,143...82,767,734
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20026
    localization 5659
      regulation of localization 2472
        regulation of lipid localization 209
          regulation of lipid transport 173
            regulation of sterol transport 79
              regulation of cholesterol transport 79
                regulation of cholesterol efflux 50
                  negative regulation of cholesterol efflux 20
                  positive regulation of cholesterol efflux 26
Path 2
Term Annotations click to browse term
  biological_process 20026
    localization 5659
      establishment of localization 4986
        transport 4821
          organic substance transport 2582
            lipid transport 472
              sterol transport 143
                cholesterol transport 128
                  regulation of cholesterol transport 79
                    regulation of cholesterol efflux 50
                      negative regulation of cholesterol efflux 20
                      positive regulation of cholesterol efflux 26
paths to the root