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ONTOLOGY REPORT - ANNOTATIONS


Term:telomere maintenance via telomere lengthening
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Accession:GO:0010833 term browser browse the term
Definition:Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and lengthening the telomeric DNA.



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telomere maintenance via telomere lengthening term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CTC1 CST telomere replication complex component 1 acts_upstream_of_or_within ISO (MGI:5426340|PMID:22531781) MGI PMID:22531781 MGI:5426340 NCBI chr17:43,410,385...43,433,784
Ensembl chr17:48,142,864...48,165,537
JBrowse link
G DCLRE1B DNA cross-link repair 1B involved_in ISO (PMID:20479256) BHF-UCL PMID:20479256 NCBI chr 1:88,643,664...88,651,962
Ensembl chr 1:123,692,915...123,701,403
JBrowse link
G RAD51 RAD51 recombinase involved_in ISO (MGI:5707585|PMID:21076401) BHF-UCL PMID:21076401 MGI:5707585 NCBI chr15:19,638,310...19,672,474
Ensembl chr15:37,891,056...37,925,207
JBrowse link
G SLX1A SLX1 homolog A, structure-specific endonuclease subunit involved_in ISO (PMID:24012755) BHF-UCL PMID:24012755
G STN1 STN1 subunit of CST complex involved_in ISO (PMID:19648609) UniProt PMID:19648609 NCBI chr10:100,456,589...100,518,010
Ensembl chr10:103,942,422...103,977,847
JBrowse link
G TERF2IP TERF2 interacting protein involved_in ISO (MGI:4440768|PMID:20339076), (MGI:4839412|PMID:20622869) UniProt PMID:20339076 PMID:20622869 MGI:4440768 MGI:4839412 NCBI chr16:56,216,920...56,226,612
Ensembl chr16:75,565,184...75,573,882
JBrowse link
G ZBTB48 zinc finger and BTB domain containing 48 involved_in ISO (PMID:28082411), (PMID:28500257) UniProt PMID:28082411 PMID:28500257 NCBI chr 1:5,341,282...5,350,590
Ensembl chr 1:6,594,372...6,603,367
JBrowse link
negative regulation of telomere maintenance via telomerase term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACD ACD shelterin complex subunit and telomerase recruitment factor involved_in ISO (PMID:15181449)
(PMID:15380063)
BHF-UCL PMID:15181449 PMID:15380063 NCBI chr16:48,001,408...48,004,620
Ensembl chr16:67,390,703...67,393,685
JBrowse link
G CTC1 CST telomere replication complex component 1 involved_in ISO (PMID:22763445) BHF-UCL PMID:22763445 NCBI chr17:43,410,385...43,433,784
Ensembl chr17:48,142,864...48,165,537
JBrowse link
G DCP2 decapping mRNA 2 involved_in ISO (PMID:26950371) BHF-UCL PMID:26950371 NCBI chr 5:108,333,091...108,377,119
Ensembl chr 5:114,144,999...114,172,480
JBrowse link
G EXOSC10 exosome component 10 involved_in ISO (PMID:26950371) BHF-UCL PMID:26950371 NCBI chr 1:9,829,922...9,865,092
Ensembl chr 1:11,050,727...11,087,241
JBrowse link
G GNL3L G protein nucleolar 3 like involved_in ISO (PMID:18082603) BHF-UCL PMID:18082603 NCBI chr  X:46,733,431...46,825,139
Ensembl chr  X:54,966,121...55,002,925
JBrowse link
G HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 involved_in ISO (PMID:23935072) BHF-UCL PMID:23935072 NCBI chr12:34,456,900...34,463,317
Ensembl chr12:35,184,943...35,188,443
JBrowse link
G HNRNPC heterogeneous nuclear ribonucleoprotein C involved_in ISO (PMID:18082603) BHF-UCL PMID:18082603 NCBI chr14:2,022,280...2,083,215 JBrowse link
G HNRNPU heterogeneous nuclear ribonucleoprotein U involved_in ISO (PMID:18082603) BHF-UCL PMID:18082603 NCBI chr 1:220,450,218...220,461,412
Ensembl chr 1:225,817,899...225,842,031
JBrowse link
G NAT10 N-acetyltransferase 10 involved_in ISO (PMID:18082603) BHF-UCL PMID:18082603 NCBI chr11:34,082,304...34,127,793
Ensembl chr11:33,960,739...34,002,069
JBrowse link
G PIF1 PIF1 5'-to-3' DNA helicase involved_in ISO (PMID:23657261) BHF-UCL PMID:23657261 NCBI chr15:43,756,605...43,766,631
Ensembl chr15:62,041,461...62,052,311
JBrowse link
G PINX1 PIN2 (TERF1) interacting telomerase inhibitor 1 involved_in ISO (PMID:21119197)
(PMID:11701125)
BHF-UCL PMID:11701125 PMID:21119197 NCBI chr 8:8,366,819...8,443,359 JBrowse link
G PML PML nuclear body scaffold involved_in ISO (PMID:19567472) UniProt PMID:19567472 NCBI chr15:52,903,874...52,955,151
Ensembl chr15:71,658,884...71,710,883
JBrowse link
G POT1 protection of telomeres 1 involved_in ISO (PMID:15181449) BHF-UCL PMID:15181449 NCBI chr 7:116,807,913...116,926,998
Ensembl chr 7:129,487,571...129,605,558
JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase involved_in ISO (PMID:21531765) BHF-UCL PMID:21531765 NCBI chr20:33,667,614...33,727,126
Ensembl chr20:34,822,271...34,839,634
JBrowse link
G STN1 STN1 subunit of CST complex involved_in ISO (PMID:22763445) BHF-UCL PMID:22763445 NCBI chr10:100,456,589...100,518,010
Ensembl chr10:103,942,422...103,977,847
JBrowse link
G TEN1 TEN1 subunit of CST complex involved_in ISO (PMID:22763445) BHF-UCL PMID:22763445 NCBI chr17:69,928,204...69,947,138 JBrowse link
G TENT4B terminal nucleotidyltransferase 4B involved_in ISO (PMID:26950371) BHF-UCL PMID:26950371 NCBI chr16:30,415,668...30,494,758
Ensembl chr16:49,299,498...49,373,665
JBrowse link
G TERF1 telomeric repeat binding factor 1 involved_in ISO (PMID:11971978) BHF-UCL PMID:11971978 NCBI chr 8:69,545,115...69,583,997 JBrowse link
G TERF2 telomeric repeat binding factor 2 involved_in ISO (PMID:17055345)
(PMID:11971978)
BHF-UCL PMID:11971978 PMID:17055345 NCBI chr16:49,729,906...49,763,002
Ensembl chr16:69,116,539...69,148,423
JBrowse link
G TINF2 TERF1 interacting nuclear factor 2 involved_in ISO (PMID:10581025)
(PMID:15133513)
BHF-UCL PMID:10581025 PMID:15133513 NCBI chr14:5,015,862...5,019,228
Ensembl chr14:23,139,445...23,142,825
JBrowse link
negative regulation of telomere maintenance via telomere lengthening term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ERCC4 ERCC excision repair 4, endonuclease catalytic subunit involved_in ISO (PMID:18812185) BHF-UCL PMID:18812185 NCBI chr16:12,848,334...12,880,480
Ensembl chr16:14,272,417...14,304,496
JBrowse link
G MCRS1 microspherule protein 1 involved_in ISO (PMID:15044100) BHF-UCL PMID:15044100 NCBI chr12:39,183,112...39,192,925
Ensembl chr12:40,073,860...40,083,655
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 involved_in ISO (MGI:5705431|PMID:26586427) BHF-UCL PMID:26586427 MGI:5705431 NCBI chr 1:201,820,355...201,867,673
Ensembl chr 1:206,812,981...206,860,356
JBrowse link
G SLX1A SLX1 homolog A, structure-specific endonuclease subunit involved_in ISO (PMID:24012755) BHF-UCL PMID:24012755
G SLX4 SLX4 structure-specific endonuclease subunit involved_in ISO (PMID:24012755) BHF-UCL PMID:24012755 NCBI chr16:2,502,334...2,532,172
Ensembl chr16:3,678,018...3,707,842
JBrowse link
G TERF2 telomeric repeat binding factor 2 involved_in ISO (PMID:24012755) BHF-UCL PMID:24012755 NCBI chr16:49,729,906...49,763,002
Ensembl chr16:69,116,539...69,148,423
JBrowse link
G TNKS tankyrase involved_in ISO (PMID:25939383) BHF-UCL PMID:25939383 NCBI chr 8:9,435,412...9,654,810 JBrowse link
G TNKS2 tankyrase 2 involved_in ISO (PMID:25939383) BHF-UCL PMID:25939383 NCBI chr10:88,547,396...88,612,973
Ensembl chr10:92,070,362...92,134,911
JBrowse link
positive regulation of telomere maintenance via telomerase term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACD ACD shelterin complex subunit and telomerase recruitment factor involved_in ISO (PMID:17237768) BHF-UCL PMID:17237768 NCBI chr16:48,001,408...48,004,620
Ensembl chr16:67,390,703...67,393,685
JBrowse link
G ATM ATM serine/threonine kinase involved_in ISO (MGI:5705431|PMID:26586427) BHF-UCL PMID:26586427 MGI:5705431 NCBI chr11:103,109,979...103,256,405
Ensembl chr11:106,584,228...106,727,041
JBrowse link
G ATR ATR serine/threonine kinase involved_in ISO (MGI:5705431|PMID:26586427) BHF-UCL PMID:26586427 MGI:5705431 NCBI chr 3:139,482,606...139,612,274
Ensembl chr 3:147,075,185...147,196,261
JBrowse link
G AURKB aurora kinase B involved_in ISO (PMID:21531765) BHF-UCL PMID:21531765 NCBI chr17:43,447,661...43,453,864
Ensembl chr17:48,180,066...48,186,129
JBrowse link
G CCT2 chaperonin containing TCP1 subunit 2 involved_in ISO (PMID:25467444) BHF-UCL PMID:25467444 NCBI chr12:67,113,221...67,128,159
Ensembl chr12:69,883,710...69,898,671
JBrowse link
G CCT3 chaperonin containing TCP1 subunit 3 involved_in ISO (PMID:25467444) BHF-UCL PMID:25467444 NCBI chr 1:131,652,058...131,679,802
Ensembl chr 1:135,481,427...135,508,983
JBrowse link
G CCT4 chaperonin containing TCP1 subunit 4 involved_in ISO (PMID:25467444) BHF-UCL PMID:25467444 NCBI chr2A:61,950,477...61,970,783
Ensembl chr2A:63,084,090...63,105,216
JBrowse link
G CCT5 chaperonin containing TCP1 subunit 5 involved_in ISO (PMID:25467444) BHF-UCL PMID:25467444 NCBI chr 5:10,565,911...10,580,808
Ensembl chr 5:10,424,157...10,440,613
JBrowse link
G CCT6A chaperonin containing TCP1 subunit 6A involved_in ISO (PMID:25467444) BHF-UCL PMID:25467444 NCBI chr 7:56,664,757...56,677,000
Ensembl chr 7:57,087,072...57,098,613
JBrowse link
G CCT7 chaperonin containing TCP1 subunit 7 involved_in ISO (PMID:25467444) BHF-UCL PMID:25467444 NCBI chr2A:73,287,026...73,305,792
Ensembl chr2A:74,775,781...74,794,515
JBrowse link
G CCT8 chaperonin containing TCP1 subunit 8 involved_in ISO (PMID:25467444) BHF-UCL PMID:25467444 NCBI chr21:15,489,698...15,507,292
Ensembl chr21:28,878,113...28,895,912
JBrowse link
G CTNNB1 catenin beta 1 acts_upstream_of ISO (MGI:5428344|PMID:22723415) BHF-UCL PMID:22723415 MGI:5428344 NCBI chr 3:41,104,940...41,145,934
Ensembl chr 3:41,373,726...41,414,030
JBrowse link
G DKC1 dyskerin pseudouridine synthase 1 acts_upstream_of_or_within ISO (MGI:3047190|PMID:15240872) MGI PMID:15240872 MGI:3047190 NCBI chr  X:144,243,493...144,257,419
Ensembl chr  X:154,084,412...154,098,475
JBrowse link
G FBXO4 F-box protein 4 involved_in ISO (PMID:16275645) BHF-UCL PMID:16275645 NCBI chr 5:68,336,673...68,474,481
Ensembl chr 5:73,500,850...73,517,051
JBrowse link
G HMBOX1 homeobox containing 1 involved_in ISO (PMID:23685356) BHF-UCL PMID:23685356 NCBI chr 8:28,173,256...28,350,591
Ensembl chr 8:25,446,264...25,547,208
JBrowse link
G HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 involved_in ISO (PMID:23935072) BHF-UCL PMID:23935072 NCBI chr12:34,456,900...34,463,317
Ensembl chr12:35,184,943...35,188,443
JBrowse link
G MAP2K7 mitogen-activated protein kinase kinase 7 involved_in ISO (PMID:21531765) BHF-UCL PMID:21531765 NCBI chr19:7,205,124...7,215,776
Ensembl chr19:8,057,598...8,066,512
JBrowse link
G MAP3K4 mitogen-activated protein kinase kinase kinase 4 involved_in ISO (PMID:21531765) BHF-UCL PMID:21531765 NCBI chr 6:158,937,424...159,062,550
Ensembl chr 6:163,948,122...164,073,264
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 involved_in ISO (PMID:21531765) BHF-UCL PMID:21531765 NCBI chr22:3,883,119...3,990,368
Ensembl chr22:20,365,487...20,450,335
JBrowse link
G MAPK15 mitogen-activated protein kinase 15 involved_in ISO (PMID:21531765) BHF-UCL PMID:21531765 NCBI chr 8:140,468,365...140,474,604
Ensembl chr 8:143,481,567...143,492,859
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 involved_in ISO (PMID:21531765) BHF-UCL PMID:21531765 Ensembl chr16:30,489,362...30,498,017 JBrowse link
G MAPKAPK5 MAPK activated protein kinase 5 involved_in ISO (PMID:21531765) BHF-UCL PMID:21531765 NCBI chr12:109,416,610...109,471,729
Ensembl chr12:112,812,769...112,863,595
JBrowse link
G NEK2 NIMA related kinase 2 involved_in ISO (PMID:21531765) BHF-UCL PMID:21531765 NCBI chr 1:187,225,947...187,243,605
Ensembl chr 1:192,092,885...192,105,737
JBrowse link
G NEK7 NIMA related kinase 7 involved_in ISO (PMID:21531765) BHF-UCL PMID:21531765 NCBI chr 1:173,752,892...173,918,258
Ensembl chr 1:178,138,925...178,228,197
JBrowse link
G PARN poly(A)-specific ribonuclease involved_in ISO (PMID:26482878), (PMID:26950371) BHF-UCL PMID:26482878 PMID:26950371 NCBI chr16:13,363,879...13,556,054
Ensembl chr16:14,787,881...14,977,786
JBrowse link
G PKIB cAMP-dependent protein kinase inhibitor beta involved_in ISO (PMID:21531765) BHF-UCL PMID:21531765 NCBI chr 6:120,373,497...120,517,119
Ensembl chr 6:124,612,910...124,640,260
JBrowse link
G PNKP polynucleotide kinase 3'-phosphatase involved_in ISO (PMID:21531765) BHF-UCL PMID:21531765 NCBI chr19:46,874,216...46,880,954
Ensembl chr19:55,790,048...55,796,762
JBrowse link
G POT1 protection of telomeres 1 involved_in ISO (PMID:17237768)
(PMID:12768206), (PMID:12781132)
BHF-UCL PMID:12768206 PMID:12781132 PMID:17237768 NCBI chr 7:116,807,913...116,926,998
Ensembl chr 7:129,487,571...129,605,558
JBrowse link
G PRKCQ protein kinase C theta involved_in ISO (PMID:21531765) BHF-UCL PMID:21531765 NCBI chr10:6,458,138...6,610,781
Ensembl chr10:6,440,316...6,593,900
JBrowse link
G TCP1 t-complex 1 involved_in ISO (PMID:25467444) BHF-UCL PMID:25467444 NCBI chr 6:157,661,409...157,672,581
Ensembl chr 6:162,673,596...162,683,985
JBrowse link
G TNKS tankyrase involved_in ISO (PMID:12782650), (PMID:18221737)
(PMID:11739745)
BHF-UCL PMID:11739745 PMID:12782650 PMID:18221737 NCBI chr 8:9,435,412...9,654,810 JBrowse link
G XRCC5 X-ray repair cross complementing 5 involved_in ISO (PMID:19188702) BHF-UCL PMID:19188702 NCBI chr2B:103,371,459...103,468,419
Ensembl chr2B:221,972,742...222,071,235
JBrowse link
positive regulation of telomere maintenance via telomere lengthening term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATM ATM serine/threonine kinase involved_in ISO (PMID:17694070), (PMID:26586427) BHF-UCL PMID:17694070 PMID:26586427 NCBI chr11:103,109,979...103,256,405
Ensembl chr11:106,584,228...106,727,041
JBrowse link
G DHX36 DEAH-box helicase 36 involved_in ISO (PMID:21149580) UniProt PMID:21149580 NCBI chr 3:151,331,468...151,382,406
Ensembl chr 3:158,885,541...158,935,871
JBrowse link
G HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 involved_in ISO PMID:23184978 BHF-UCL PMID:23184978 RGD:11567256 NCBI chr 7:26,835,881...26,846,578
Ensembl chr 7:26,439,443...26,449,985
JBrowse link
G NAF1 nuclear assembly factor 1 ribonucleoprotein involved_in ISO (PMID:27510903) BHF-UCL PMID:27510903 NCBI chr 4:155,383,245...155,425,479
Ensembl chr 4:167,157,770...167,214,065
JBrowse link
G RTEL1 regulator of telomere elongation helicase 1 involved_in ISO (PMID:23959892) BHF-UCL PMID:23959892
regulation of telomere maintenance via telomerase term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATM ATM serine/threonine kinase involved_in ISO (PMID:26586433) BHF-UCL PMID:26586433 NCBI chr11:103,109,979...103,256,405
Ensembl chr11:106,584,228...106,727,041
JBrowse link
G POT1 protection of telomeres 1 involved_in ISO (PMID:26586433) BHF-UCL PMID:26586433 NCBI chr 7:116,807,913...116,926,998
Ensembl chr 7:129,487,571...129,605,558
JBrowse link
G TERF2 telomeric repeat binding factor 2 involved_in ISO (PMID:19864690)
(PMID:23685356)
BHF-UCL PMID:19864690 PMID:23685356 NCBI chr16:49,729,906...49,763,002
Ensembl chr16:69,116,539...69,148,423
JBrowse link
regulation of telomere maintenance via telomere lengthening term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TINF2 TERF1 interacting nuclear factor 2 involved_in ISO (PMID:18669893) BHF-UCL PMID:18669893 NCBI chr14:5,015,862...5,019,228
Ensembl chr14:23,139,445...23,142,825
JBrowse link
telomere maintenance via telomerase term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DKC1 dyskerin pseudouridine synthase 1 involved_in ISO (PMID:23685356), (PMID:29695869)
(PMID:26950371)
UniProt
BHF-UCL
PMID:23685356 PMID:26950371 PMID:29695869 NCBI chr  X:144,243,493...144,257,419
Ensembl chr  X:154,084,412...154,098,475
JBrowse link
G GAR1 GAR1 ribonucleoprotein involved_in ISO (PMID:29695869) UniProt PMID:29695869 NCBI chr 4:102,311,275...102,320,579
Ensembl chr 4:112,879,223...112,887,828
JBrowse link
G HSP90AA1 heat shock protein 90 alpha family class A member 1 involved_in ISO (PMID:10197982) BHF-UCL PMID:10197982 NCBI chr14:82,700,881...82,707,020
Ensembl chr14:102,519,699...102,576,723
JBrowse link
G HSP90AB1 heat shock protein 90 alpha family class B member 1 involved_in ISO (PMID:10197982) BHF-UCL PMID:10197982 NCBI chr 6:43,842,796...43,849,637
Ensembl chr 6:45,125,773...45,133,872
JBrowse link
G NHP2 NHP2 ribonucleoprotein involved_in ISO (PMID:29695869) UniProt PMID:29695869 NCBI chr 5:173,308,560...173,313,046
Ensembl chr 5:180,566,008...180,570,502
JBrowse link
G NOP10 NOP10 ribonucleoprotein involved_in ISO (PMID:29695869) UniProt PMID:29695869 NCBI chr15:12,850,708...12,852,171
Ensembl chr15:31,684,833...31,686,305
JBrowse link
G PARP4 poly(ADP-ribose) polymerase family member 4 NOT|acts_upstream_of_or_within ISO (MGI:3045914|PMID:15169895) MGI PMID:15169895 MGI:3045914 NCBI chr13:5,734,322...5,827,323
Ensembl chr13:24,029,405...24,113,075
JBrowse link
G PINX1 PIN2 (TERF1) interacting telomerase inhibitor 1 acts_upstream_of_or_within ISO (PMID:11701125) MGI PMID:11701125 NCBI chr 8:8,366,819...8,443,359 JBrowse link
G POT1 protection of telomeres 1 involved_in ISO (PMID:12768206) UniProt PMID:12768206 NCBI chr 7:116,807,913...116,926,998
Ensembl chr 7:129,487,571...129,605,558
JBrowse link
G PTGES3 prostaglandin E synthase 3 involved_in ISO (PMID:10197982), (PMID:19740745)
(MGI:5819359|PMID:10197982)
(PMID:19740745)
BHF-UCL PMID:10197982 PMID:19740745 MGI:5819359 NCBI chr12:32,221,908...32,247,228
Ensembl chr12:32,476,835...32,503,181
JBrowse link
G RAD50 RAD50 double strand break repair protein involved_in ISO (PMID:9705271) UniProt PMID:9705271 NCBI chr 5:127,972,630...128,059,911 JBrowse link
G TEP1 telomerase associated protein 1 NOT|acts_upstream_of_or_within ISO (MGI:3045914|PMID:15169895) MGI PMID:15169895 MGI:3045914 NCBI chr14:1,240,370...1,285,787
Ensembl chr14:19,293,452...19,332,960
JBrowse link
G TERF1 telomeric repeat binding factor 1 involved_in ISO (PMID:9034193)
(PMID:23685356)
UniProt
BHF-UCL
PMID:9034193 PMID:23685356 NCBI chr 8:69,545,115...69,583,997 JBrowse link
G TERT telomerase reverse transcriptase involved_in ISO (PMID:9454332)
(PMID:16043710), (PMID:17940095), (PMID:19701182), (PMID:21531765), (PMID:29695869), (PMID:9443919)
BHF-UCL
UniProt
PMID:9443919 PMID:9454332 PMID:16043710 PMID:17940095 PMID:19701182 More... NCBI chr 5:1,542,217...1,586,775
Ensembl chr 5:1,300,960...1,338,872
JBrowse link
G WRAP53 WD repeat containing antisense to TP53 involved_in ISO (PMID:23685356)
(PMID:23685356), (PMID:29695869), (PMID:29804836)
BHF-UCL
UniProt
PMID:23685356 PMID:29695869 PMID:29804836 NCBI chr17:7,715,897...7,735,873
Ensembl chr17:7,707,221...7,723,394
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12659
    metabolic process 7935
      cellular metabolic process 7257
        cellular macromolecule metabolic process 5568
          DNA metabolic process 682
            telomere maintenance 116
              telomere maintenance via telomere lengthening 74
                negative regulation of telomere maintenance via telomere lengthening + 27
                positive regulation of telomere maintenance via telomere lengthening + 36
                regulation of telomere maintenance via telomere lengthening + 59
                telomere maintenance via telomerase + 60
Path 2
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  biological_process 12659
    metabolic process 7935
      cellular metabolic process 7257
        cellular nitrogen compound metabolic process 4263
          nucleobase-containing compound metabolic process 3724
            nucleic acid metabolic process 3409
              DNA metabolic process 682
                telomere maintenance 116
                  telomere maintenance via telomere lengthening 74
                    negative regulation of telomere maintenance via telomere lengthening + 27
                    positive regulation of telomere maintenance via telomere lengthening + 36
                    regulation of telomere maintenance via telomere lengthening + 59
                    telomere maintenance via telomerase + 60
paths to the root