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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of myotube differentiation
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Accession:GO:0010830 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.


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regulation of myotube differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dmpk DM1 protein kinase involved_in ISO (MGI:3806406|PMID:18729234) RGD PMID:18729234 MGI:3806406 NCBI chr 1:78,730,255...78,740,585
Ensembl chr 1:78,730,275...78,740,593 		JBrowse link
G Fbxo22 F-box protein 22 acts_upstream_of_or_within ISO (PMID:19319192) RGD PMID:19319192 NCBI chr 8:55,579,906...55,595,981
Ensembl chr 8:55,579,891...55,596,148 		JBrowse link
G Hdac5 histone deacetylase 5 involved_in ISO (MGI:3712602|PMID:17468767) RGD PMID:17468767 MGI:3712602 NCBI chr10:87,152,978...87,187,921
Ensembl chr10:87,152,978...87,188,235 		JBrowse link
G Rbm24 RNA binding motif protein 24 involved_in ISO (MGI:4999688|PMID:20977548) RGD PMID:20977548 MGI:4999688 NCBI chr17:18,275,681...18,288,231
Ensembl chr17:18,275,688...18,288,102 		JBrowse link
G Rbm38 RNA binding motif protein 38 involved_in ISO (MGI:4438547|PMID:19817877) RGD PMID:19817877 MGI:4438547 NCBI chr 3:161,801,577...161,814,381
Ensembl chr 3:161,801,577...161,814,381 		JBrowse link
G Sik1 salt-inducible kinase 1 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(MGI:3712602|PMID:17468767)		 UniProt
Ensembl
RGD		 PMID:17468767 GO_REF:0000024 GO_REF:0000107 MGI:3712602 NCBI chr20:9,949,407...9,959,036
Ensembl chr20:9,947,396...9,958,991 		JBrowse link
negative regulation of myotube differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ankrd2 ankyrin repeat domain 2 acts_upstream_of_or_within ISO (PMID:18302940), (PMID:23824195) RGD PMID:18302940 PMID:23824195 NCBI chr 1:240,847,111...240,856,563
Ensembl chr 1:240,847,072...240,856,566 		JBrowse link
G Bdnf brain-derived neurotrophic factor involved_in IMP PMID:16723531 BHF-UCL PMID:16723531 RGD:1580249 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Bhlha15 basic helix-loop-helix family, member a15 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5607242|PMID:17612490)		 UniProt
RGD		 PMID:17612490 GO_REF:0000024 MGI:5607242 NCBI chr12:10,420,465...10,424,641
Ensembl chr12:10,420,467...10,424,713 		JBrowse link
G Bhlhe41 basic helix-loop-helix family, member e41 involved_in ISO
IEA		 (MGI:5297791|PMID:12657651)
GO_REF:0000107		 RGD
Ensembl		 PMID:12657651 GO_REF:0000107 MGI:5297791 NCBI chr 4:178,834,264...178,838,618
Ensembl chr 4:178,834,271...178,838,468 		JBrowse link
G Ccn3 cellular communication network factor 3 involved_in ISS
ISO		 GO_REF:0000024
(PMID:12050162)		 UniProt
RGD		 PMID:12050162 GO_REF:0000024 NCBI chr 7:86,094,000...86,101,022
Ensembl chr 7:86,094,000...86,101,019 		JBrowse link
G Csf1r colony stimulating factor 1 receptor IMP RGD PMID:7737360 RGD:151665771 NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415 		JBrowse link
G Daxx death-domain associated protein IDA RGD PMID:19308989 RGD:9587764 NCBI chr20:4,970,090...4,976,145
Ensembl chr20:4,970,092...4,975,843 		JBrowse link
G Hdac1 histone deacetylase 1 NOT|involved_in ISO (PMID:10983972) RGD PMID:10983972 NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111 		JBrowse link
G Hdac3 histone deacetylase 3 NOT|involved_in ISO (PMID:10983972) RGD PMID:10983972 NCBI chr18:29,770,637...29,789,850
Ensembl chr18:29,770,636...29,793,856 		JBrowse link
G Hdac4 histone deacetylase 4 involved_in ISO (PMID:10983972) RGD PMID:10983972 NCBI chr 9:92,503,467...92,750,164
Ensembl chr 9:92,507,611...92,750,164 		JBrowse link
G Hdac5 histone deacetylase 5 involved_in ISO (PMID:10983972), (PMID:11081517) RGD PMID:10983972 PMID:11081517 NCBI chr10:87,152,978...87,187,921
Ensembl chr10:87,152,978...87,188,235 		JBrowse link
G Myocd myocardin involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:3849559 (PMID:17940050)		 Ensembl
RGD		 PMID:17940050 GO_REF:0000107 NCBI chr10:49,833,219...49,928,806
Ensembl chr10:49,836,641...49,927,627 		JBrowse link
G Nkx2-5 NK2 homeobox 5 involved_in ISO
IEA		 (PMID:15653675)
GO_REF:0000107		 RGD
Ensembl		 PMID:15653675 GO_REF:0000107 NCBI chr10:16,340,428...16,347,004
Ensembl chr10:16,344,159...16,346,934 		JBrowse link
G Notch1 notch receptor 1 involved_in ISO (MGI:5319604|PMID:18299578) RGD PMID:18299578 MGI:5319604 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531 		JBrowse link
G Plpp7 phospholipid phosphatase 7 (inactive) acts_upstream_of_or_within ISO MGI:1928394 (PMID:19704009) RGD PMID:19704009 NCBI chr 3:15,384,461...15,398,820
Ensembl chr 3:15,384,492...15,398,883 		JBrowse link
G Rpl3l ribosomal protein L3-like involved_in ISO (MGI:6838892|PMID:26684695) RGD PMID:26684695 MGI:6838892 NCBI chr10:13,753,914...13,764,458
Ensembl chr10:13,753,886...13,764,457 		JBrowse link
G Tmem119 transmembrane protein 119 involved_in ISO (MGI:6294241|PMID:22579779) RGD PMID:22579779 MGI:6294241 NCBI chr12:42,828,621...42,835,678
Ensembl chr12:42,828,418...42,835,689 		JBrowse link
G Trim72 tripartite motif containing 72 acts_upstream_of_or_within ISO (PMID:23965929) RGD PMID:23965929 NCBI chr 1:182,613,753...182,621,613
Ensembl chr 1:182,613,712...182,621,606 		JBrowse link
G Xbp1 X-box binding protein 1 involved_in ISO (MGI:5607242|PMID:17612490) RGD PMID:17612490 MGI:5607242 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693 		JBrowse link
positive regulation of myotube differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp11a ATPase phospholipid transporting 11A involved_in ISO (PMID:29799007)
(MGI:6161090|PMID:29799007)		 RGD PMID:29799007 MGI:6161090 NCBI chr16:76,657,752...76,767,640
Ensembl chr16:76,657,752...76,767,640 		JBrowse link
G Cav3 caveolin 3 acts_upstream_of_or_within ISO MGI:2180558 (PMID:14517320) RGD PMID:14517320 NCBI chr 4:145,582,168...145,598,142
Ensembl chr 4:145,582,060...145,598,137 		JBrowse link
G Csrp3 cysteine and glycine rich protein 3 acts_upstream_of_or_within IGI
IDA		 PMID:9234731 MGI PMID:9234731 PMID:9234731 RGD:10047266, RGD:10047266 NCBI chr 1:98,528,067...98,546,647
Ensembl chr 1:98,528,068...98,546,653 		JBrowse link
G Maml1 mastermind-like transcriptional coactivator 1 involved_in ISO UniProtKB:Q6T264 (PMID:16510869)
UniProtKB:Q92585 (MGI:3619288|PMID:16510869)		 RGD PMID:16510869 MGI:3619288 NCBI chr10:34,588,639...34,623,024
Ensembl chr10:34,588,646...34,623,338 		JBrowse link
G Mamstr MEF2 activating motif and SAP domain containing transcriptional regulator acts_upstream_of_or_within ISO MGI:97275 (PMID:16818234) RGD PMID:16818234 NCBI chr 1:96,109,715...96,116,295
Ensembl chr 1:96,110,343...96,115,744 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 involved_in IEA
ISO
ISS		 GO_REF:0000107
(MGI:5526919|PMID:22847234)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:22847234 GO_REF:0000024 GO_REF:0000107 MGI:5526919 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mmp14 matrix metallopeptidase 14 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5013661|PMID:21572390)		 UniProt
RGD		 PMID:21572390 GO_REF:0000024 MGI:5013661 NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864 		JBrowse link
G Mtor mechanistic target of rapamycin kinase involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2445183 (PMID:19704009)		 Ensembl
RGD		 PMID:19704009 GO_REF:0000107 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Myog myogenin involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(MGI:5526919|PMID:22847234)		 UniProt
Ensembl
RGD		 PMID:22847234 GO_REF:0000024 GO_REF:0000107 MGI:5526919 NCBI chr13:45,745,455...45,748,044
Ensembl chr13:45,745,436...45,748,039 		JBrowse link
G Neu2 neuraminidase 2 IMP RGD PMID:8630046 RGD:2316563 NCBI chr 9:88,218,494...88,267,356
Ensembl chr 9:88,249,135...88,267,355 		JBrowse link
G Piezo1 piezo-type mechanosensitive ion channel component 1 involved_in ISO
ISS
IEA		 (PMID:29799007)
(MGI:6161090|PMID:29799007)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:29799007 GO_REF:0000024 GO_REF:0000107 MGI:6161090 NCBI chr19:50,544,580...50,606,812
Ensembl chr19:50,544,582...50,606,501 		JBrowse link
G Rbm24 RNA binding motif protein 24 involved_in ISO
IBA		 (PMID:26844700)
GO_REF:0000033		 RGD
GO_Central		 PMID:26844700 GO_REF:0000033 NCBI chr17:18,275,681...18,288,231
Ensembl chr17:18,275,688...18,288,102 		JBrowse link
G Smyd1 SET and MYND domain containing 1 involved_in ISO (PMID:19783823) RGD PMID:19783823 NCBI chr 4:103,195,330...103,252,989
Ensembl chr 4:103,200,322...103,311,766 		JBrowse link
positive regulation of skeletal muscle fiber development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actn3 actinin alpha 3 involved_in ISO (MGI:3778600|PMID:18178581) RGD PMID:18178581 MGI:3778600 NCBI chr 1:202,159,081...202,175,012
Ensembl chr 1:202,159,082...202,175,012 		JBrowse link
G Bcl2 BCL2, apoptosis regulator involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1857134 (PMID:11146504)		 Ensembl
RGD		 PMID:11146504 GO_REF:0000107 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Lmod3 leiomodin 3 involved_in ISO (PMID:25250574) RGD PMID:25250574 NCBI chr 4:129,843,964...129,858,684
Ensembl chr 4:129,843,970...129,858,244 		JBrowse link
G Myf5 myogenic factor 5 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:42,802,946...42,806,177
Ensembl chr 7:42,802,946...42,806,177 		JBrowse link
G Myf6 myogenic factor 6 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:42,813,008...42,814,852
Ensembl chr 7:42,812,792...42,814,852 		JBrowse link
G Myod1 myogenic differentiation 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:96,884,864...96,887,574
Ensembl chr 1:96,884,948...96,887,554 		JBrowse link
G Myog myogenin involved_in ISS
IBA
IEA
ISO		 GO_REF:0000024
GO_REF:0000033
GO_REF:0000107
(MGI:62381|PMID:8393145)		 UniProt
GO_Central
Ensembl
RGD		 PMID:8393145 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 MGI:62381 NCBI chr13:45,745,455...45,748,044
Ensembl chr13:45,745,436...45,748,039 		JBrowse link
G Shox2 SHOX homeobox 2 involved_in ISO
IEA		 (MGI:4946446|PMID:21156168)
GO_REF:0000107		 RGD
Ensembl		 PMID:21156168 GO_REF:0000107 MGI:4946446 NCBI chr 2:151,217,049...151,227,180
Ensembl chr 2:151,217,552...151,227,143 		JBrowse link
positive regulation of skeletal muscle fiber differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rbm24 RNA binding motif protein 24 involved_in ISO (MGI:6148527|PMID:25313962) RGD PMID:25313962 MGI:6148527 NCBI chr17:18,275,681...18,288,231
Ensembl chr17:18,275,688...18,288,102 		JBrowse link
positive regulation of tongue muscle cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 involved_in ISO (MGI:3809313|PMID:18816858) RGD PMID:18816858 MGI:3809313 NCBI chr 4:117,041,808...117,058,628
Ensembl chr 4:117,041,808...117,058,628 		JBrowse link
G Tbx1 T-box transcription factor 1 involved_in ISS
ISO		 GO_REF:0000024
(MGI:3809313|PMID:18816858)		 UniProt
RGD		 PMID:18816858 GO_REF:0000024 MGI:3809313 NCBI chr11:82,409,275...82,419,058
Ensembl chr11:82,409,275...82,418,380 		JBrowse link
regulation of skeletal muscle fiber development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fbxo22 F-box protein 22 involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
(PMID:19319192)		 GO_Central
RGD		 PMID:19319192 GO_REF:0000033 NCBI chr 8:55,579,906...55,595,981
Ensembl chr 8:55,579,891...55,596,148 		JBrowse link
G Hdac4 histone deacetylase 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1333784|MGI:1931221 (PMID:17786239)		 Ensembl
RGD		 PMID:17786239 GO_REF:0000107 NCBI chr 9:92,503,467...92,750,164
Ensembl chr 9:92,507,611...92,750,164 		JBrowse link
G Hdac5 histone deacetylase 5 acts_upstream_of_or_within ISO MGI:1931221|MGI:3036234 (PMID:17786239) RGD PMID:17786239 NCBI chr10:87,152,978...87,187,921
Ensembl chr10:87,152,978...87,188,235 		JBrowse link
G Hdac9 histone deacetylase 9 acts_upstream_of_or_within ISO MGI:1333784|MGI:3036284 (PMID:17786239) RGD PMID:17786239 NCBI chr 6:50,762,074...51,624,311
Ensembl chr 6:50,763,590...51,625,333 		JBrowse link
G Naca nascent polypeptide associated complex subunit alpha involved_in ISO (MGI:4867362|PMID:21071677) RGD PMID:21071677 MGI:4867362 NCBI chr 7:468,862...481,992
Ensembl chr 7:469,723...481,992 		JBrowse link
regulation of skeletal muscle fiber differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hdac4 histone deacetylase 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1333784|MGI:1931221 (PMID:17786239)		 Ensembl
RGD		 PMID:17786239 GO_REF:0000107 NCBI chr 9:92,503,467...92,750,164
Ensembl chr 9:92,507,611...92,750,164 		JBrowse link
G Hdac5 histone deacetylase 5 acts_upstream_of_or_within ISO MGI:1931221|MGI:3036234 (PMID:17786239) RGD PMID:17786239 NCBI chr10:87,152,978...87,187,921
Ensembl chr10:87,152,978...87,188,235 		JBrowse link
G Hdac9 histone deacetylase 9 acts_upstream_of_or_within ISO MGI:1333784|MGI:3036284 (PMID:17786239) RGD PMID:17786239 NCBI chr 6:50,762,074...51,624,311
Ensembl chr 6:50,763,590...51,625,333 		JBrowse link
G Nln neurolysin involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:4125183 (PMID:24719333)		 Ensembl
RGD		 PMID:24719333 GO_REF:0000107 NCBI chr 2:35,133,634...35,232,927
Ensembl chr 2:35,134,145...35,232,914 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20115
    regulation of biological process 13126
      regulation of cellular process 12523
        regulation of cell differentiation 1786
          regulation of muscle cell differentiation 179
            regulation of striated muscle cell differentiation 115
              regulation of myotube differentiation 48
                negative regulation of myotube differentiation + 19
                positive regulation of myotube differentiation + 15
                regulation of skeletal muscle fiber development + 13
                regulation of skeletal muscle fiber differentiation + 7
Path 2
Term Annotations click to browse term
  biological_process 20115
    cellular process 18525
      cellular developmental process 4729
        cell differentiation 4728
          muscle cell differentiation 484
            striated muscle cell differentiation 363
              myotube differentiation 146
                regulation of myotube differentiation 48
                  negative regulation of myotube differentiation + 19
                  positive regulation of myotube differentiation + 15
                  regulation of skeletal muscle fiber development + 13
                  regulation of skeletal muscle fiber differentiation + 7
paths to the root