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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of myotube differentiation
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Accession:GO:0010830 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.



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regulation of myotube differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dmpk DM1 protein kinase involved_in ISO (MGI:3806406|PMID:18729234) RGD PMID:18729234 MGI:3806406 NCBI chr 1:78,730,255...78,740,585
Ensembl chr 1:78,730,275...78,740,593
JBrowse link
G Fbxo22 F-box protein 22 acts_upstream_of_or_within ISO (MGI:3840749|PMID:19319192) RGD PMID:19319192 MGI:3840749 NCBI chr 8:55,579,906...55,595,981
Ensembl chr 8:55,579,891...55,596,148
JBrowse link
G Hdac5 histone deacetylase 5 involved_in ISO (MGI:3712602|PMID:17468767) RGD PMID:17468767 MGI:3712602 NCBI chr10:87,152,978...87,187,921
Ensembl chr10:87,152,978...87,188,235
JBrowse link
G Rbm24 RNA binding motif protein 24 involved_in ISO (MGI:4999688|PMID:20977548) RGD PMID:20977548 MGI:4999688 NCBI chr17:18,275,681...18,288,231
Ensembl chr17:18,275,688...18,288,102
JBrowse link
G Rbm38 RNA binding motif protein 38 involved_in ISO (MGI:4438547|PMID:19817877) RGD PMID:19817877 MGI:4438547 NCBI chr 3:161,801,550...161,814,381
Ensembl chr 3:161,801,577...161,814,381
JBrowse link
G Sik1 salt-inducible kinase 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:3712602|PMID:17468767)
UniProt
RGD
PMID:17468767 GO_REF:0000024 MGI:3712602 NCBI chr20:9,949,407...9,959,036
Ensembl chr20:9,947,396...9,958,991
JBrowse link
negative regulation of myotube differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ankrd2 ankyrin repeat domain 2 acts_upstream_of_or_within ISO (MGI:3796961|PMID:18302940), (MGI:5527051|PMID:23824195) RGD PMID:18302940 PMID:23824195 MGI:3796961 MGI:5527051 NCBI chr 1:240,847,111...240,856,563
Ensembl chr 1:240,847,072...240,856,566
JBrowse link
G Bdnf brain-derived neurotrophic factor involved_in IMP PMID:16723531 BHF-UCL PMID:16723531 RGD:1580249 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Bhlha15 basic helix-loop-helix family, member a15 involved_in ISS
ISO
GO_REF:0000024
(MGI:5607242|PMID:17612490)
UniProt
RGD
PMID:17612490 GO_REF:0000024 MGI:5607242 NCBI chr12:10,420,465...10,424,641
Ensembl chr12:10,420,467...10,424,713
JBrowse link
G Bhlhe41 basic helix-loop-helix family, member e41 involved_in ISO (MGI:5297791|PMID:12657651) RGD PMID:12657651 MGI:5297791 NCBI chr 4:178,833,085...178,838,685
Ensembl chr 4:178,834,271...178,838,468
JBrowse link
G Ccn3 cellular communication network factor 3 involved_in ISS
ISO
GO_REF:0000024
(PMID:12050162)
UniProt
RGD
PMID:12050162 GO_REF:0000024 NCBI chr 7:86,094,000...86,101,022
Ensembl chr 7:86,094,000...86,101,019
JBrowse link
G Csf1r colony stimulating factor 1 receptor IMP RGD PMID:7737360 RGD:151665771 NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415
JBrowse link
G Daxx death-domain associated protein IDA RGD PMID:19308989 RGD:9587764 NCBI chr20:4,970,090...4,976,145
Ensembl chr20:4,970,092...4,975,843
JBrowse link
G Hdac1 histone deacetylase 1 NOT|involved_in ISO (PMID:10983972) RGD PMID:10983972 NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111
JBrowse link
G Hdac3 histone deacetylase 3 NOT|involved_in ISO (PMID:10983972) RGD PMID:10983972 NCBI chr18:29,770,637...29,789,850
Ensembl chr18:29,770,636...29,793,856
JBrowse link
G Hdac4 histone deacetylase 4 involved_in ISO (PMID:10983972) RGD PMID:10983972 NCBI chr 9:92,503,467...92,750,164
Ensembl chr 9:92,507,611...92,750,164
JBrowse link
G Hdac5 histone deacetylase 5 involved_in ISO (PMID:10983972), (PMID:11081517) RGD PMID:10983972 PMID:11081517 NCBI chr10:87,152,978...87,187,921
Ensembl chr10:87,152,978...87,188,235
JBrowse link
G Myocd myocardin involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:3849559 (MGI:3849299|PMID:17940050)
Ensembl
RGD
PMID:17940050 GO_REF:0000107 MGI:3849299 NCBI chr10:49,833,219...49,928,806
Ensembl chr10:49,836,641...49,927,627
JBrowse link
G Nkx2-5 NK2 homeobox 5 involved_in ISO
IEA
(PMID:15653675)
GO_REF:0000107
RGD
Ensembl
PMID:15653675 GO_REF:0000107 NCBI chr10:16,340,428...16,347,004
Ensembl chr10:16,344,159...16,346,934
JBrowse link
G Notch1 notch receptor 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:5319604|PMID:18299578)
UniProt
RGD
PMID:18299578 GO_REF:0000024 MGI:5319604 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
JBrowse link
G Plpp7 phospholipid phosphatase 7 (inactive) acts_upstream_of_or_within ISO MGI:1928394 (MGI:4366685|PMID:19704009) RGD PMID:19704009 MGI:4366685 NCBI chr 3:15,384,461...15,398,820
Ensembl chr 3:15,384,492...15,398,883
JBrowse link
G Tmem119 transmembrane protein 119 involved_in ISO (MGI:6294241|PMID:22579779) RGD PMID:22579779 MGI:6294241 NCBI chr12:42,828,621...42,835,678
Ensembl chr12:42,828,418...42,835,689
JBrowse link
G Trim72 tripartite motif containing 72 acts_upstream_of_or_within ISO (MGI:5602876|PMID:23965929) RGD PMID:23965929 MGI:5602876 NCBI chr 1:182,613,753...182,621,613
Ensembl chr 1:182,613,712...182,621,606
JBrowse link
G Xbp1 X-box binding protein 1 involved_in ISO (MGI:5607242|PMID:17612490) RGD PMID:17612490 MGI:5607242 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
JBrowse link
positive regulation of myotube differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp11a ATPase phospholipid transporting 11A involved_in ISO (PMID:29799007)
(MGI:6161090|PMID:29799007)
RGD PMID:29799007 MGI:6161090 NCBI chr16:76,657,752...76,767,640
Ensembl chr16:76,657,752...76,767,640
JBrowse link
G Cav3 caveolin 3 acts_upstream_of_or_within ISO MGI:2180558 (MGI:3761450|PMID:14517320) RGD PMID:14517320 MGI:3761450 NCBI chr 4:145,582,168...145,598,142
Ensembl chr 4:145,582,060...145,598,137
JBrowse link
G Csrp3 cysteine and glycine rich protein 3 acts_upstream_of_or_within IGI
IDA
PMID:9234731 MGI PMID:9234731 PMID:9234731 RGD:10047266, RGD:10047266 NCBI chr 1:98,528,067...98,546,647
Ensembl chr 1:98,528,068...98,546,653
JBrowse link
G Maml1 mastermind-like transcriptional coactivator 1 involved_in ISO UniProtKB:Q6T264 (PMID:16510869)
UniProtKB:Q92585 (MGI:3619288|PMID:16510869)
RGD PMID:16510869 MGI:3619288 NCBI chr10:34,588,639...34,624,298
Ensembl chr10:34,588,646...34,623,338
JBrowse link
G Mamstr MEF2 activating motif and SAP domain containing transcriptional regulator acts_upstream_of_or_within ISO MGI:97275 (MGI:3653312|PMID:16818234) RGD PMID:16818234 MGI:3653312 NCBI chr 1:96,109,715...96,116,295
Ensembl chr 1:96,110,343...96,115,744
JBrowse link
G Mapk14 mitogen activated protein kinase 14 involved_in IEA
ISO
ISS
GO_REF:0000107
(MGI:5526919|PMID:22847234)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:22847234 GO_REF:0000024 GO_REF:0000107 MGI:5526919 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Mmp14 matrix metallopeptidase 14 involved_in ISS
ISO
GO_REF:0000024
(MGI:5013661|PMID:21572390)
UniProt
RGD
PMID:21572390 GO_REF:0000024 MGI:5013661 NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864
JBrowse link
G Mtor mechanistic target of rapamycin kinase acts_upstream_of_or_within ISO MGI:2445183 (MGI:4366685|PMID:19704009) RGD PMID:19704009 MGI:4366685 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Myog myogenin involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(MGI:5526919|PMID:22847234)
UniProt
Ensembl
RGD
PMID:22847234 GO_REF:0000024 GO_REF:0000107 MGI:5526919 NCBI chr13:45,745,455...45,748,044
Ensembl chr13:45,745,436...45,748,039
JBrowse link
G Neu2 neuraminidase 2 IMP RGD PMID:8630046 RGD:2316563 NCBI chr 9:88,218,494...88,267,356
Ensembl chr 9:88,249,135...88,267,355
JBrowse link
G Piezo1 piezo-type mechanosensitive ion channel component 1 involved_in ISO
ISS
IEA
(PMID:29799007)
(MGI:6161090|PMID:29799007)
GO_REF:0000024
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:29799007 GO_REF:0000024 GO_REF:0000107 MGI:6161090 NCBI chr19:50,544,580...50,606,812
Ensembl chr19:50,544,582...50,606,501
JBrowse link
G Rbm24 RNA binding motif protein 24 involved_in ISO
IBA
(PMID:26844700)
PMID:21873635
RGD PMID:26844700 PMID:21873635 RGD:13792537 NCBI chr17:18,275,681...18,288,231
Ensembl chr17:18,275,688...18,288,102
JBrowse link
G Smyd1 SET and MYND domain containing 1 involved_in ISO (PMID:19783823) RGD PMID:19783823 NCBI chr 4:103,195,330...103,252,989
Ensembl chr 4:103,200,322...103,311,766
JBrowse link
G Thra thyroid hormone receptor alpha acts_upstream_of_or_within ISO (MGI:3619869|PMID:16322094) RGD PMID:16322094 MGI:3619869 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
JBrowse link
positive regulation of skeletal muscle fiber development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actn3 actinin alpha 3 involved_in ISO (MGI:3778600|PMID:18178581) RGD PMID:18178581 MGI:3778600 NCBI chr 1:202,159,081...202,175,012
Ensembl chr 1:202,159,082...202,175,012
JBrowse link
G Bcl2 BCL2, apoptosis regulator acts_upstream_of_or_within ISO MGI:1857134 (MGI:1928555|PMID:11146504) RGD PMID:11146504 MGI:1928555 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Lmod3 leiomodin 3 involved_in ISO (PMID:25250574) RGD PMID:25250574 NCBI chr 4:129,843,964...129,858,684
Ensembl chr 4:129,843,970...129,858,244
JBrowse link
G Myf5 myogenic factor 5 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:42,802,946...42,806,177
Ensembl chr 7:42,802,946...42,806,177
JBrowse link
G Myf6 myogenic factor 6 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:42,813,008...42,814,852
Ensembl chr 7:42,812,792...42,814,852
JBrowse link
G Myod1 myogenic differentiation 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:96,884,864...96,887,574
Ensembl chr 1:96,884,948...96,887,554
JBrowse link
G Myog myogenin involved_in IBA
IEA
ISO
ISS
PMID:21873635
GO_REF:0000107
(MGI:62381|PMID:8393145)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:8393145 PMID:21873635 GO_REF:0000024 GO_REF:0000107 MGI:62381, RGD:13792537 NCBI chr13:45,745,455...45,748,044
Ensembl chr13:45,745,436...45,748,039
JBrowse link
G Shox2 short stature homeobox 2 involved_in ISO
IEA
(MGI:4946446|PMID:21156168)
GO_REF:0000107
RGD
Ensembl
PMID:21156168 GO_REF:0000107 MGI:4946446 NCBI chr 2:151,217,049...151,227,180
Ensembl chr 2:151,217,552...151,227,143
JBrowse link
positive regulation of skeletal muscle fiber differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rbm24 RNA binding motif protein 24 involved_in ISO (MGI:6148527|PMID:25313962) RGD PMID:25313962 MGI:6148527 NCBI chr17:18,275,681...18,288,231
Ensembl chr17:18,275,688...18,288,102
JBrowse link
positive regulation of tongue muscle cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 involved_in ISO (MGI:3809313|PMID:18816858) RGD PMID:18816858 MGI:3809313 NCBI chr 4:117,041,808...117,058,628
Ensembl chr 4:117,041,808...117,058,628
JBrowse link
G Tbx1 T-box transcription factor 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:3809313|PMID:18816858)
UniProt
RGD
PMID:18816858 GO_REF:0000024 MGI:3809313 NCBI chr11:82,409,275...82,419,058
Ensembl chr11:82,409,275...82,418,380
JBrowse link
regulation of skeletal muscle fiber development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fbxo22 F-box protein 22 acts_upstream_of_or_within ISO (MGI:3840749|PMID:19319192) RGD PMID:19319192 MGI:3840749 NCBI chr 8:55,579,906...55,595,981
Ensembl chr 8:55,579,891...55,596,148
JBrowse link
G Hdac4 histone deacetylase 4 acts_upstream_of_or_within ISO MGI:1333784|MGI:1931221 (MGI:3763703|PMID:17786239) RGD PMID:17786239 MGI:3763703 NCBI chr 9:92,503,467...92,750,164
Ensembl chr 9:92,507,611...92,750,164
JBrowse link
G Hdac5 histone deacetylase 5 acts_upstream_of_or_within ISO MGI:1931221|MGI:3036234 (MGI:3763703|PMID:17786239) RGD PMID:17786239 MGI:3763703 NCBI chr10:87,152,978...87,187,921
Ensembl chr10:87,152,978...87,188,235
JBrowse link
G Hdac9 histone deacetylase 9 acts_upstream_of_or_within ISO MGI:1333784|MGI:3036284 (MGI:3763703|PMID:17786239) RGD PMID:17786239 MGI:3763703 NCBI chr 6:50,762,074...51,624,311
Ensembl chr 6:50,763,590...51,625,333
JBrowse link
G Naca nascent polypeptide associated complex subunit alpha involved_in ISO (MGI:4867362|PMID:21071677) RGD PMID:21071677 MGI:4867362 NCBI chr 7:468,862...481,992
Ensembl chr 7:469,723...481,992
JBrowse link
regulation of skeletal muscle fiber differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hdac4 histone deacetylase 4 acts_upstream_of_or_within
involved_in
ISO
IEA
MGI:1333784|MGI:1931221 (MGI:3763703|PMID:17786239)
GO_REF:0000107
RGD
Ensembl
PMID:17786239 GO_REF:0000107 MGI:3763703 NCBI chr 9:92,503,467...92,750,164
Ensembl chr 9:92,507,611...92,750,164
JBrowse link
G Hdac5 histone deacetylase 5 acts_upstream_of_or_within ISO MGI:1931221|MGI:3036234 (MGI:3763703|PMID:17786239) RGD PMID:17786239 MGI:3763703 NCBI chr10:87,152,978...87,187,921
Ensembl chr10:87,152,978...87,188,235
JBrowse link
G Hdac9 histone deacetylase 9 acts_upstream_of_or_within ISO MGI:1333784|MGI:3036284 (MGI:3763703|PMID:17786239) RGD PMID:17786239 MGI:3763703 NCBI chr 6:50,762,074...51,624,311
Ensembl chr 6:50,763,590...51,625,333
JBrowse link
G Nln neurolysin involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:4125183 (MGI:5588076|PMID:24719333)
Ensembl
RGD
PMID:24719333 GO_REF:0000107 MGI:5588076 NCBI chr 2:35,133,634...35,232,927
Ensembl chr 2:35,134,145...35,232,914
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18734
    regulation of biological process 12594
      regulation of cellular process 11909
        regulation of cell differentiation 1771
          regulation of muscle cell differentiation 174
            regulation of striated muscle cell differentiation 115
              regulation of myotube differentiation 48
                negative regulation of myotube differentiation + 18
                positive regulation of myotube differentiation + 16
                regulation of skeletal muscle fiber development + 13
                regulation of skeletal muscle fiber differentiation + 7
Path 2
Term Annotations click to browse term
  biological_process 18734
    cellular process 17431
      cellular developmental process 4533
        cell differentiation 4510
          muscle cell differentiation 466
            striated muscle cell differentiation 347
              myotube differentiation 144
                regulation of myotube differentiation 48
                  negative regulation of myotube differentiation + 18
                  positive regulation of myotube differentiation + 16
                  regulation of skeletal muscle fiber development + 13
                  regulation of skeletal muscle fiber differentiation + 7
paths to the root