regulation of hormone levels - Ontology Report

(PMID:17767905)

PMID:17767905

GO_REF:0000107

NCBI chr 6:42,031,003...42,051,770
Ensembl chr 6:42,030,984...42,049,050

CACNA1A

calcium voltage-gated channel subunit alpha1 A

acts_upstream_of_or_within

(PMID:8229069), (PMID:8957685)

PMID:8229069 PMID:8957685

MGI:85368

NCBI chr 6:11,883,353...12,307,023

SIN3A

SIN3 transcription regulator family member A

NCBI chr26:7,971,208...8,060,888
Ensembl chr26:7,975,484...8,058,278

SLC39A14

solute carrier family 39 member 14

acts_upstream_of

(MGI:4950776|PMID:21445361)
(PMID:21445361)

PMID:21445361

MGI:4950776

NCBI chr 8:20,446,756...20,502,585

SOX8

SRY-box transcription factor 8

involved_in
acts_upstream_of_or_within

(PMID:19286648)

PMID:19286648

GO_REF:0000107

NCBI chr 5:877,988...883,278
Ensembl chr 5:878,217...881,662

9-cis-retinoic acid biosynthetic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ALDH1A1

aldehyde dehydrogenase 1 family member A1

acts_upstream_of_or_within

(PMID:11876656)

PMID:11876656

NCBI chr12:83,949,529...84,092,452
Ensembl chr12:83,949,399...84,009,003

ALDH1A2

aldehyde dehydrogenase 1 family member A2

acts_upstream_of_or_within

(PMID:11876656)

PMID:11876656

NCBI chr26:25,439,159...25,557,199
Ensembl chr26:25,439,360...25,557,202

ALDH8A1

aldehyde dehydrogenase 8 family member A1

involved_in
acts_upstream_of_or_within

(PMID:11876656)

PMID:11876656

GO_REF:0000107

NCBI chr13:38,489,459...38,521,983
Ensembl chr13:38,490,181...38,522,087

cytochrome P450 family 1 subfamily A member 1

9-cis- and all-trans-retinoic acid synthesized from 9-cis- and all-trans-retinal

PMID:8765131

RGD:2306683

NCBI chr26:8,753,236...8,759,378
Ensembl chr26:8,753,327...8,759,384

DHRS9

dehydrogenase/reductase 9

involved_in

GO_REF:0000107

NCBI chr10:54,611,792...54,641,037
Ensembl chr10:54,614,559...54,641,877

9-cis-retinoic acid metabolic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ALDH1A1

aldehyde dehydrogenase 1 family member A1

NCBI chr12:83,949,529...84,092,452
Ensembl chr12:83,949,399...84,009,003

aldosterone biosynthetic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

CACNA1H

calcium voltage-gated channel subunit alpha1 H

involved_in

GO_REF:0000107

NCBI chr 5:1,039,709...1,106,212
Ensembl chr 5:1,078,973...1,106,507

CYP11B1

cytochrome P450 family 11 subfamily B member 1

involved_in

PMID:11832364

GO_REF:0000118 RGD:727991

NCBI chr 8:137,125,409...137,132,267

CYP11B1

cytochrome P450 family 11 subfamily B member 1

involved_in

GO_REF:0000118

Ensembl chr 8:137,126,690...137,167,911

CYP11B2

cytochrome P450 family 11 subfamily B member 2

involved_in

GO_REF:0000118

NCBI chr 8:137,160,919...137,168,332
Ensembl chr 8:137,162,325...137,168,350

aldosterone metabolic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

EDNRB

endothelin receptor type B

involved_in

GO_REF:0000107

NCBI chr 3:56,969,493...56,993,719
Ensembl chr 3:56,969,101...56,992,731

SCNN1B

sodium channel epithelial 1 subunit beta

involved_in
acts_upstream_of_or_within

(PMID:28567665)

PMID:28567665

GO_REF:0000107

NCBI chr 5:21,021,181...21,107,746
Ensembl chr 5:21,022,133...21,107,824

aldosterone secretion

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

AGT

angiotensinogen

acts_upstream_of_or_within
involved_in

(PMID:9557921)
(PMID:22550170)

PMID:9557921 PMID:22550170

NCBI chr25:67,964,840...67,977,006
Ensembl chr25:67,962,401...67,973,324

WNK4

WNK lysine deficient protein kinase 4

involved_in

(PMID:22550170)

PMID:22550170

NCBI chr16:63,494,090...63,512,068

androgen biosynthetic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

CYP17A1

cytochrome P450 family 17 subfamily A member 1

involved_in

GO_REF:0000107

NCBI chr 9:95,870,098...95,877,345
Ensembl chr 9:95,866,908...95,877,180

HSD17B2

hydroxysteroid 17-beta dehydrogenase 2

androstenedione

NCBI chr 5:67,464,986...67,529,079
Ensembl chr 5:67,464,334...67,529,182

HSD17B3

hydroxysteroid 17-beta dehydrogenase 3

involved_in

GO_REF:0000107

NCBI chr12:106,831,807...106,885,543
Ensembl chr12:106,832,034...106,886,385

HSD3B2

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2

involved_in

GO_REF:0000107

NCBI chr20:14,351,189...14,359,146
Ensembl chr20:14,351,458...14,359,290

MED1

mediator complex subunit 1

involved_in

GO_REF:0000107

NCBI chr16:66,719,393...66,764,902
Ensembl chr16:66,719,423...66,762,896

SCARB1

scavenger receptor class B member 1

NCBI chr11:120,134,485...120,223,512
Ensembl chr11:120,134,874...120,216,904

SRD5A1

steroid 5 alpha-reductase 1

acts_upstream_of_or_within
involved_in

PMID:12606426 PMID:15249131

dihydrotestosterone
(PMID:15249131)

RGD
MGI
UniProt

GO_REF:0000117 RGD:4891962

NCBI chr 4:6,312,770...6,348,449
Ensembl chr 4:6,312,757...6,350,550

SRD5A2

steroid 5 alpha-reductase 2

acts_upstream_of_or_within
involved_in

PMID:12606426 PMID:15249131

dihydrotestosterone
(PMID:15249131)

RGD
MGI
UniProt

GO_REF:0000117 RGD:4891962

NCBI chr14:75,915,495...75,971,280
Ensembl chr14:75,917,260...75,970,365

androgen catabolic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

cytochrome P450 family 19 subfamily A member 1

involved_in

GO_REF:0000107

NCBI chr26:32,074,260...32,164,926
Ensembl chr26:32,132,425...32,164,277

HSD17B11

hydroxysteroid 17-beta dehydrogenase 11

involved_in

GO_REF:0000107

NCBI chr 7:35,715,493...35,777,245
Ensembl chr 7:35,714,925...35,777,229

SPP1

secreted phosphoprotein 1

involved_in

(PMID:26482249)

CAFA

PMID:26482249

NCBI chr 7:36,337,165...36,344,927
Ensembl chr 7:36,338,386...36,344,407

SRD5A1

steroid 5 alpha-reductase 1

NCBI chr 4:6,312,770...6,348,449
Ensembl chr 4:6,312,757...6,350,550

androgen metabolic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

adrenomedullin

NCBI chr 1:54,518,359...54,520,683
Ensembl chr 1:54,518,358...54,520,686

AKR1D1

aldo-keto reductase family 1 member D1

involved_in

GO_REF:0000107 GO_REF:0000118

NCBI chr21:106,705,197...106,822,194
Ensembl chr21:106,780,339...106,822,696

CHST10

carbohydrate sulfotransferase 10

involved_in

GO_REF:0000107

NCBI chr14:4,114,495...4,139,741
Ensembl chr14:4,114,464...4,131,524

cytochrome P450 family 19 subfamily A member 1

acts_upstream_of_or_within
involved_in

PMID:11356695 PMID:19492405

(PMID:11356695)

RGD
MGI
Ensembl

GO_REF:0000107 RGD:4890392

NCBI chr26:32,074,260...32,164,926
Ensembl chr26:32,132,425...32,164,277

DHRS9

dehydrogenase/reductase 9

involved_in

GO_REF:0000107

NCBI chr10:54,611,792...54,641,037
Ensembl chr10:54,614,559...54,641,877

ESR1

estrogen receptor 1

acts_upstream_of_or_within

(PMID:18755802)

PMID:18755802

NCBI chr13:79,153,418...79,554,552
Ensembl chr13:79,270,265...79,554,549

HSD17B10

hydroxysteroid 17-beta dehydrogenase 10

involved_in

GO_REF:0000118

NCBI chr X:49,568,206...49,571,356
Ensembl chr X:49,567,267...49,571,292

HSD17B2

hydroxysteroid 17-beta dehydrogenase 2

involved_in

GO_REF:0000107

NCBI chr 5:67,464,986...67,529,079
Ensembl chr 5:67,464,334...67,529,182

HSD17B4

hydroxysteroid 17-beta dehydrogenase 4

involved_in

GO_REF:0000107

NCBI chr23:22,674,059...22,761,270
Ensembl chr23:22,674,072...22,762,056

HSD17B7

hydroxysteroid 17-beta dehydrogenase 7

involved_in

(PMID:12732193)
(MGI:2662631|PMID:12732193)

PMID:12732193

MGI:2662631

NCBI chr20:1,271,259...1,289,232
Ensembl chr20:1,273,052...1,288,930

HSD17B8

hydroxysteroid 17-beta dehydrogenase 8

involved_in
acts_upstream_of_or_within

(PMID:9712896)

PMID:9712896

GO_REF:0000107

NCBI chr17:38,868,307...38,870,564
Ensembl chr17:38,868,685...38,870,459

INHBA

inhibin subunit beta A

acts_upstream_of_or_within
involved_in

(PMID:32274496), (PMID:32954300)

PMID:32274496 PMID:32954300

GO_REF:0000107

NCBI chr21:16,936,054...16,951,430
Ensembl chr21:16,936,175...16,946,880

NR3C1

nuclear receptor subfamily 3 group C member 1

dihydrotestosterone

NCBI chr23:45,904,926...46,031,804
Ensembl chr23:45,904,873...46,031,125

PLEKHA1

pleckstrin homology domain containing A1

involved_in
acts_upstream_of_or_within

(PMID:19056881)

GO_REF:0000107

NCBI chr 9:115,110,316...115,168,113
Ensembl chr 9:115,128,942...115,165,576

PPARGC1A

PPARG coactivator 1 alpha

nandrolone

NCBI chr27:25,882,385...26,563,530
Ensembl chr27:26,465,499...26,564,582

SGPL1

sphingosine-1-phosphate lyase 1

involved_in
acts_upstream_of_or_within

(PMID:19056881)

GO_REF:0000107

NCBI chr 9:60,425,703...60,487,196
Ensembl chr 9:60,424,305...60,487,146

SHH

sonic hedgehog signaling molecule

involved_in
acts_upstream_of_or_within

(PMID:15013801)

PMID:15013801

GO_REF:0000107

NCBI chr21:123,929,937...123,942,451
Ensembl chr21:123,932,900...123,942,395

SRD5A1

steroid 5 alpha-reductase 1

NCBI chr 4:6,312,770...6,348,449
Ensembl chr 4:6,312,757...6,350,550

SRD5A2

steroid 5 alpha-reductase 2

involved_in

PMID:1944596 PMID:20954080

(PMID:1944596)

RGD
UniProt

RGD:4891498

NCBI chr14:75,915,495...75,971,280
Ensembl chr14:75,917,260...75,970,365

TIPARP

TCDD inducible poly(ADP-ribose) polymerase

involved_in
acts_upstream_of_or_within

(PMID:19056881)

GO_REF:0000107

NCBI chr15:34,041,208...34,073,428
Ensembl chr15:34,039,657...34,073,319

angiotensin maturation

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ACE

angiotensin I converting enzyme

involved_in

GO_REF:0000107

Ensembl chr16:57,700,977...57,806,815

ATP6AP2

ATPase H+ transporting accessory protein 2

involved_in

GO_REF:0000107

NCBI chr X:37,742,550...37,769,022
Ensembl chr X:37,742,545...37,769,062

REN

renin

involved_in
acts_upstream_of_or_within

PMID:10617578 PMID:21321306

(PMID:10617578)

RGD
TreeGrafter
MGI
Ensembl

GO_REF:0000107 GO_REF:0000118 RGD:5132599

NCBI chr25:25,159,816...25,193,620
Ensembl chr25:25,183,037...25,193,420

brassinosteroid biosynthetic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

DHCR7

7-dehydrocholesterol reductase

involved_in

GO_REF:0000118

NCBI chr 1:3,243,263...3,257,332
Ensembl chr 1:3,243,313...3,257,487

C21-steroid hormone biosynthetic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

CYP11A1

cytochrome P450 family 11 subfamily A member 1

involved_in
acts_upstream_of_or_within

PMID:7527351 PMID:19665544

pregnenolone
(PMID:7527351)

RGD
TreeGrafter
MGI
Ensembl

GO_REF:0000107 GO_REF:0000118 RGD:4891164

NCBI chr26:9,122,008...9,151,844

CYP11B1

cytochrome P450 family 11 subfamily B member 1

involved_in

PMID:2256920 PMID:11832364

(PMID:2256920)

BHF-UCL
RGD

RGD:727991

NCBI chr 8:137,125,409...137,132,267

CYP24A1

cytochrome P450 family 24 subfamily A member 1

involved_in

GO_REF:0000118

NCBI chr 2:9,868,794...9,889,510
Ensembl chr 2:9,868,678...9,885,884

CYP27A1

cytochrome P450 family 27 subfamily A member 1

involved_in

GO_REF:0000118

NCBI chr10:104,682,437...104,723,781
Ensembl chr10:104,682,673...104,726,687

CYP27B1

cytochrome P450 family 27 subfamily B member 1

involved_in

GO_REF:0000118

NCBI chr11:53,675,704...53,681,372
Ensembl chr11:53,675,226...53,680,443

CYP27C1

cytochrome P450 family 27 subfamily C member 1

involved_in

GO_REF:0000118

Ensembl chr10:3,016,992...3,034,072

C21-steroid hormone metabolic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

AKR1D1

aldo-keto reductase family 1 member D1

involved_in

GO_REF:0000107

NCBI chr21:106,705,197...106,822,194
Ensembl chr21:106,780,339...106,822,696

CYP11A1

cytochrome P450 family 11 subfamily A member 1

involved_in

GO_REF:0000041

NCBI chr26:9,122,008...9,151,844

cytochrome P450 family 19 subfamily A member 1

7-dehydropregnenolone

PMID:19190754

RGD:4889515

NCBI chr26:32,074,260...32,164,926
Ensembl chr26:32,132,425...32,164,277

CYP2D6

cytochrome P450 family 2 subfamily D member 6

NCBI chr19:24,667,207...24,672,580
Ensembl chr19:24,667,282...24,671,513

HSD17B10

hydroxysteroid 17-beta dehydrogenase 10

involved_in

(PMID:12917011)

PMID:12917011

NCBI chr X:49,568,206...49,571,356
Ensembl chr X:49,567,267...49,571,292

calcitonin catabolic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

endothelin converting enzyme 1

involved_in

(PMID:18039931)

PMID:18039931

NCBI chr20:111,212,567...111,342,755
Ensembl chr20:111,212,594...111,342,821

corticosterone secretion

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

KCNQ1

potassium voltage-gated channel subfamily Q member 1

involved_in

GO_REF:0000107

NCBI chr 1:2,261,448...2,661,840
Ensembl chr 1:2,261,845...2,661,863

SELENOM

selenoprotein M

acts_upstream_of_or_within

(PMID:23880772)

PMID:23880772

NCBI chr19:13,996,307...13,999,083

corticotropin secretion

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

AQP1

aquaporin 1 (Colton blood group)

involved_in
acts_upstream_of_or_within

(PMID:18511498)

PMID:18511498

GO_REF:0000107

NCBI chr21:27,456,553...27,473,196
Ensembl chr21:27,456,259...27,470,728

LOC103243260

corticotropin-releasing factor receptor 1

involved_in

(MGI:1267130|PMID:9655498)

PMID:9655498

MGI:1267130

NCBI chr16:60,070,156...60,120,857
Ensembl chr16:60,070,066...60,120,712

cortisol secretion

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

POMC

proopiomelanocortin

involved_in

(PMID:15201064)

PMID:15201064

NCBI chr14:82,491,296...82,499,289
Ensembl chr14:82,494,323...82,499,447

endothelin maturation

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

endothelin converting enzyme 1

involved_in

(PMID:7805846)

PMID:7805846

NCBI chr20:111,212,567...111,342,755
Ensembl chr20:111,212,594...111,342,821

enkephalin processing

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

carboxypeptidase E

NCBI chr 7:111,747,265...111,867,548
Ensembl chr 7:111,747,172...111,868,754

proprotein convertase subtilisin/kexin type 2

involved_in

(MGI:3773775|PMID:8262946)
(PMID:8262946)

PMID:8262946

MGI:3773775

NCBI chr 2:46,293,983...46,548,902
Ensembl chr 2:46,294,005...46,549,609

epidermal growth factor receptor ligand maturation

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ADAM10

ADAM metallopeptidase domain 10

involved_in

GO_REF:0000107

NCBI chr26:24,768,827...24,921,169
Ensembl chr26:24,768,915...24,919,009

MEP1A

meprin A subunit alpha

involved_in

GO_REF:0000107

NCBI chr17:25,439,415...25,479,092
Ensembl chr17:25,439,442...25,473,681

estrogen biosynthetic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

cytochrome P450 family 19 subfamily A member 1

estrone

NCBI chr26:32,074,260...32,164,926
Ensembl chr26:32,132,425...32,164,277

HSD17B1

hydroxysteroid 17-beta dehydrogenase 1

involved_in

RGD
TreeGrafter
UniProt
InterPro
Ensembl

estradiol

PMID:8612487

GO_REF:0000002 GO_REF:0000041 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 RGD:728619

NCBI chr16:63,730,303...63,733,974
Ensembl chr16:63,728,777...63,732,411

HSD17B2

hydroxysteroid 17-beta dehydrogenase 2

involved_in

estrone

PMID:8612487

GO_REF:0000107 RGD:728619

NCBI chr 5:67,464,986...67,529,079
Ensembl chr 5:67,464,334...67,529,182

HSD17B7

hydroxysteroid 17-beta dehydrogenase 7

involved_in

PMID:9658408
(PMID:12732193)
(MGI:1267145|PMID:9658408), (MGI:2662631|PMID:12732193)

PMID:9658408 PMID:12732193

MGI:1267145 MGI:2662631 RGD:30309934

NCBI chr20:1,271,259...1,289,232
Ensembl chr20:1,273,052...1,288,930

HSD17B8

hydroxysteroid 17-beta dehydrogenase 8

involved_in

GO_REF:0000107 GO_REF:0000118

NCBI chr17:38,868,307...38,870,564
Ensembl chr17:38,868,685...38,870,459

STAR

steroidogenic acute regulatory protein

estradiol; positive regulation

PMID:16579833

RGD:1600078

NCBI chr 8:36,164,891...36,174,424
Ensembl chr 8:36,167,694...36,174,583

estrogen catabolic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

SULT1E1

sulfotransferase family 1E member 1

involved_in

GO_REF:0000107

NCBI chr 7:18,313,510...18,330,768
Ensembl chr 7:18,313,238...18,330,741

estrogen metabolic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

CDH11

cadherin 11

acts_upstream_of_or_within

(PMID:19056881)

NCBI chr 5:50,652,628...50,825,640
Ensembl chr 5:50,649,627...50,775,440

CHST10

carbohydrate sulfotransferase 10

involved_in

GO_REF:0000107

NCBI chr14:4,114,495...4,139,741
Ensembl chr14:4,114,464...4,131,524

COMT

catechol-O-methyltransferase

NCBI chr19:5,775,829...5,803,260
Ensembl chr19:5,773,225...5,785,422

cytochrome P450 family 1 subfamily A member 1

involved_in

GO_REF:0000107

NCBI chr26:8,753,236...8,759,378
Ensembl chr26:8,753,327...8,759,384

CYP1A2

cytochrome P450 family 1 subfamily A member 2

involved_in

(PMID:11555828), (PMID:12865317)

PMID:11555828 PMID:12865317

NCBI chr26:8,727,996...8,733,254

CYP1B1

cytochrome P450 family 1 subfamily B member 1

involved_in

PMID:16893557 PMID:23821647

GO_REF:0000107 RGD:1599718 RGD:7829732

NCBI chr14:69,318,713...69,327,277
Ensembl chr14:69,319,495...69,324,157

CYP2C8

cytochrome P450 family 2 subfamily C member 8

involved_in

(PMID:12865317), (PMID:14559847)

PMID:12865317 PMID:14559847

NCBI chr 9:88,154,131...88,183,915
Ensembl chr 9:88,154,134...88,183,458

CYP2C9

cytochrome P450 family 2 subfamily C member 9

involved_in

(PMID:12865317)

PMID:12865317

NCBI chr 9:88,082,124...88,125,390

CYP2C9

cytochrome P450 family 2 subfamily C member 9

involved_in

GO_REF:0000107

Ensembl chr 9:87,938,712...88,125,658

CYP2D6

cytochrome P450 family 2 subfamily D member 6

involved_in

(PMID:12865317)

PMID:12865317

NCBI chr19:24,667,207...24,672,580
Ensembl chr19:24,667,282...24,671,513

CYP3A5

cytochrome P450 family 3 subfamily A member 5

involved_in

GO_REF:0000107

NCBI chr28:13,473,649...13,517,905
Ensembl chr28:13,491,483...13,519,507

HSD17B10

hydroxysteroid 17-beta dehydrogenase 10

involved_in

GO_REF:0000118

NCBI chr X:49,568,206...49,571,356
Ensembl chr X:49,567,267...49,571,292

HSD17B4

hydroxysteroid 17-beta dehydrogenase 4

involved_in

GO_REF:0000107

NCBI chr23:22,674,059...22,761,270
Ensembl chr23:22,674,072...22,762,056

HSD17B8

hydroxysteroid 17-beta dehydrogenase 8

involved_in
acts_upstream_of_or_within

(PMID:9712896)

PMID:9712896

GO_REF:0000107

NCBI chr17:38,868,307...38,870,564
Ensembl chr17:38,868,685...38,870,459

LOC103235587

UDP-glucuronosyltransferase 2B33

involved_in

GO_REF:0000118

NCBI chr 7:166,021...174,294

LOC103235588

UDP-glucuronosyltransferase 2B18

involved_in

GO_REF:0000118

NCBI chr 7:315,569...343,837

LOC103235590

UDP-glucuronosyltransferase 2B20

involved_in

GO_REF:0000118

NCBI chr 7:395,170...427,953
Ensembl chr 7:402,452...428,292

LOC103235720

UDP-glucuronosyltransferase 2B30

involved_in

GO_REF:0000118

NCBI chr 7:17,972,157...17,991,978
Ensembl chr 7:17,971,037...17,987,897

LOC103246766

cytochrome P450 3A8

involved_in

(PMID:11555828), (PMID:12865317), (PMID:14559847)

PMID:11555828 PMID:12865317 PMID:14559847

NCBI chr28:13,297,566...13,330,023

PDGFRA

platelet derived growth factor receptor alpha

acts_upstream_of_or_within

(PMID:19056881)

NCBI chr 7:14,243,291...14,307,373
Ensembl chr 7:14,241,070...14,307,422

PLEKHA1

pleckstrin homology domain containing A1

involved_in
acts_upstream_of_or_within

(PMID:19056881)

GO_REF:0000107

NCBI chr 9:115,110,316...115,168,113
Ensembl chr 9:115,128,942...115,165,576

SGPL1

sphingosine-1-phosphate lyase 1

involved_in
acts_upstream_of_or_within

(PMID:19056881)

GO_REF:0000107

NCBI chr 9:60,425,703...60,487,196
Ensembl chr 9:60,424,305...60,487,146

SULT1E1

sulfotransferase family 1E member 1

involved_in
acts_upstream_of_or_within

(PMID:15685171)

PMID:15685171

GO_REF:0000107

NCBI chr 7:18,313,510...18,330,768
Ensembl chr 7:18,313,238...18,330,741

TIPARP

TCDD inducible poly(ADP-ribose) polymerase

involved_in
acts_upstream_of_or_within

(PMID:19056881)

GO_REF:0000107

NCBI chr15:34,041,208...34,073,428
Ensembl chr15:34,039,657...34,073,319

follicle-stimulating hormone secretion

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

CGA

glycoprotein hormones, alpha polypeptide

acts_upstream_of_or_within

(PMID:12114718)

PMID:12114718

NCBI chr13:11,560,543...11,578,070
Ensembl chr13:11,560,222...11,578,093

TBX3

T-box transcription factor 3

involved_in

(PMID:12116211)

PMID:12116211

NCBI chr11:109,952,100...109,966,328
Ensembl chr11:109,952,054...109,965,065

ghrelin secretion

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

free fatty acid receptor 4

involved_in

GO_REF:0000107

NCBI chr 9:86,805,262...86,829,271
Ensembl chr 9:86,805,848...86,829,446

GHSR

growth hormone secretagogue receptor

NCBI chr15:17,008,185...17,013,504
Ensembl chr15:17,009,369...17,012,618

glucagon secretion

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

IL6

interleukin 6

involved_in

(MGI:3807360|PMID:18719127)
(PMID:18719127)

PMID:18719127

MGI:3807360

NCBI chr21:35,577,513...35,582,385
Ensembl chr21:35,577,939...35,582,237

gonadotropin secretion

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

NIBAN2

niban apoptosis regulator 2

involved_in

GO_REF:0000107

NCBI chr12:10,556,661...10,621,281
Ensembl chr12:10,556,650...10,621,589

growth hormone secretion

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

CACNA1C

calcium voltage-gated channel subunit alpha1 C

acts_upstream_of_or_within

(PMID:1385406)

PMID:1385406

NCBI chr11:2,107,722...2,753,970
Ensembl chr11:2,508,705...2,752,991

CDK16

cyclin dependent kinase 16

involved_in

(MGI:5447616|PMID:16461345)

PMID:16461345

MGI:5447616

NCBI chr X:44,405,672...44,416,478
Ensembl chr X:44,410,598...44,416,818

growth hormone releasing hormone

acts_upstream_of_or_within
involved_in

PMID:2857452 PMID:9348175 PMID:15070777 PMID:15985453

(PMID:2857452)
(PMID:9348175)
(PMID:15985453)
(PMID:15070777)

MGI
TreeGrafter

GO_REF:0000118

NCBI chr 2:26,482,734...26,493,761
Ensembl chr 2:26,487,973...26,493,499

growth hormone releasing hormone receptor

acts_upstream_of

(PMID:3008329)

PMID:3008329

NCBI chr21:27,402,765...27,417,536
Ensembl chr21:27,404,886...27,417,521

GHSR

growth hormone secretagogue receptor

acts_upstream_of_or_within

(PMID:15070777)

PMID:15070777

NCBI chr15:17,008,185...17,013,504
Ensembl chr15:17,009,369...17,012,618

RAB1A

RAB1A, member RAS oncogene family

involved_in

(PMID:22939626)

PMID:22939626

NCBI chr14:41,890,055...41,932,180

histamine secretion by mast cell

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

BTK

Bruton tyrosine kinase

NCBI chr X:89,690,569...89,727,420

LOC103224223

adenosine receptor A3

acts_upstream_of_or_within

(PMID:12817016)

PMID:12817016

NCBI chr20:22,043,367...22,127,103
Ensembl chr20:22,106,190...22,123,629

LYN

LYN proto-oncogene, Src family tyrosine kinase

NCBI chr 8:51,919,656...52,057,376
Ensembl chr 8:51,919,808...52,057,959

RAB44

RAB44, member RAS oncogene family

acts_upstream_of_or_within

(PMID:32238914)

PMID:32238914

NCBI chr17:35,399,866...35,435,599

SLC18A2

solute carrier family 18 member A2

involved_in

GO_REF:0000107

NCBI chr 9:110,039,783...110,078,822
Ensembl chr 9:110,040,391...110,076,647

SNAP23

synaptosome associated protein 23

involved_in

GO_REF:0000107

NCBI chr26:40,443,478...40,485,211
Ensembl chr26:40,442,615...40,482,346

YWHAZ

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta

NCBI chr 8:95,786,197...95,821,270
Ensembl chr 8:95,788,305...95,819,197

histamine secretion mediated by IgE immunoglobulin

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

RAB44

RAB44, member RAS oncogene family

acts_upstream_of_or_within

(PMID:32238914)

PMID:32238914

NCBI chr17:35,399,866...35,435,599

hormone biosynthetic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

CACNA1A

calcium voltage-gated channel subunit alpha1 A

acts_upstream_of

(PMID:11182254)

PMID:11182254

NCBI chr 6:11,883,353...12,307,023

CHST8

carbohydrate sulfotransferase 8

involved_in

GO_REF:0000107

NCBI chr 6:28,657,639...28,808,906
Ensembl chr 6:28,722,901...28,808,904

CYP11A1

cytochrome P450 family 11 subfamily A member 1

involved_in

GO_REF:0000117

NCBI chr26:9,122,008...9,151,844

CYP17A1

cytochrome P450 family 17 subfamily A member 1

involved_in

GO_REF:0000107 GO_REF:0000118

NCBI chr 9:95,870,098...95,877,345
Ensembl chr 9:95,866,908...95,877,180

cytochrome P450 family 1 subfamily A member 1

involved_in

GO_REF:0000118

NCBI chr26:8,753,236...8,759,378
Ensembl chr26:8,753,327...8,759,384

CYP1B1

cytochrome P450 family 1 subfamily B member 1

involved_in

GO_REF:0000118

NCBI chr14:69,318,713...69,327,277
Ensembl chr14:69,319,495...69,324,157

CYP1D1

cytochrome P450 family 1 subfamily D member 1

involved_in

GO_REF:0000118

Ensembl chr12:84,092,071...84,105,822

CYP21A2

cytochrome P450 family 21 subfamily A member 2

involved_in

GO_REF:0000118

NCBI chr17:39,987,608...39,990,936
Ensembl chr17:39,988,116...40,016,448

DUOX1

dual oxidase 1

involved_in

GO_REF:0000043

NCBI chr26:38,038,093...38,073,993
Ensembl chr26:38,038,771...38,072,023

DUOX2

dual oxidase 2

involved_in

GO_REF:0000043

NCBI chr26:38,090,053...38,110,781
Ensembl chr26:38,090,648...38,109,636

FDX1

ferredoxin 1

involved_in

GO_REF:0000107

NCBI chr 1:101,777,499...101,813,753
Ensembl chr 1:101,777,678...101,816,379

HFE

homeostatic iron regulator

acts_upstream_of_or_within

(PMID:15914561)

PMID:15914561

NCBI chr17:46,159,770...46,168,831
Ensembl chr17:46,156,685...46,164,649

thyroglobulin

involved_in

GO_REF:0000043

NCBI chr 8:127,293,797...127,567,218
Ensembl chr 8:127,293,834...127,567,771

TPO

thyroid peroxidase

involved_in

GO_REF:0000043

NCBI chr14:106,148,214...106,255,442
Ensembl chr14:106,146,946...106,255,298

hormone catabolic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ACE

angiotensin I converting enzyme

involved_in

GO_REF:0000107

Ensembl chr16:57,700,977...57,806,815

CPA4

carboxypeptidase A4

involved_in

GO_REF:0000107

NCBI chr21:98,924,054...98,979,674
Ensembl chr21:98,924,100...98,955,260

endothelin converting enzyme 1

involved_in

(PMID:7864876)

PMID:7864876

NCBI chr20:111,212,567...111,342,755
Ensembl chr20:111,212,594...111,342,821

IDE

insulin degrading enzyme

involved_in

RGD
TreeGrafter
Ensembl

PMID:15494400

GO_REF:0000107 GO_REF:0000118 RGD:1626705

NCBI chr 9:85,722,728...85,843,247
Ensembl chr 9:85,721,886...85,843,117

MME

membrane metalloendopeptidase

involved_in

GO_REF:0000107

NCBI chr15:35,577,460...35,681,730
Ensembl chr15:35,580,714...35,633,914

hormone metabolic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ACE

angiotensin I converting enzyme

involved_in

GO_REF:0000107

Ensembl chr16:57,700,977...57,806,815

AGT

angiotensinogen

acts_upstream_of_or_within

(PMID:12660889)

PMID:12660889

NCBI chr25:67,964,840...67,977,006
Ensembl chr25:67,962,401...67,973,324

BBS1

Bardet-Biedl syndrome 1

involved_in
acts_upstream_of_or_within

(PMID:18032602)

PMID:18032602

GO_REF:0000107

NCBI chr 1:7,737,887...7,765,022
Ensembl chr 1:7,737,578...7,764,732

CRHBP

corticotropin releasing hormone binding protein

acts_upstream_of_or_within

PMID:7556876 PMID:15530648

(PMID:7556876)

RGD
MGI

RGD:1358528

NCBI chr 4:71,203,335...71,223,179
Ensembl chr 4:71,205,932...71,223,172

CYP17A1

cytochrome P450 family 17 subfamily A member 1

involved_in

GO_REF:0000117

NCBI chr 9:95,870,098...95,877,345
Ensembl chr 9:95,866,908...95,877,180

cytochrome P450 family 1 subfamily A member 1

involved_in

GO_REF:0000117

NCBI chr26:8,753,236...8,759,378
Ensembl chr26:8,753,327...8,759,384

CYP1B1

cytochrome P450 family 1 subfamily B member 1

involved_in

GO_REF:0000117

NCBI chr14:69,318,713...69,327,277
Ensembl chr14:69,319,495...69,324,157

CYP21A2

cytochrome P450 family 21 subfamily A member 2

involved_in

GO_REF:0000117

NCBI chr17:39,987,608...39,990,936
Ensembl chr17:39,988,116...40,016,448

DDO

D-aspartate oxidase

involved_in
acts_upstream_of_or_within

(PMID:16525061)

PMID:16525061

GO_REF:0000107

NCBI chr13:63,484,726...63,510,181

DUOX2

dual oxidase 2

involved_in
acts_upstream_of_or_within

(PMID:17440044)

PMID:17440044

GO_REF:0000107

NCBI chr26:38,090,053...38,110,781
Ensembl chr26:38,090,648...38,109,636

ENPP1

ectonucleotide pyrophosphatase/phosphodiesterase 1

involved_in

(PMID:25368121)
(PMID:31730234)

PMID:25368121 PMID:31730234

NCBI chr13:41,670,416...41,755,549

FOXA1

forkhead box A1

involved_in
acts_upstream_of_or_within

(PMID:10049364)

PMID:10049364

GO_REF:0000107

NCBI chr24:14,397,759...14,403,078
Ensembl chr24:14,396,702...14,403,094

GHR

growth hormone receptor

involved_in

GO_REF:0000107

NCBI chr 4:41,171,038...41,464,474
Ensembl chr 4:41,285,712...41,464,666

growth hormone releasing hormone receptor

acts_upstream_of_or_within

(PMID:1270792)

PMID:1270792

NCBI chr21:27,402,765...27,417,536
Ensembl chr21:27,404,886...27,417,521

HTT

huntingtin

acts_upstream_of_or_within

(PMID:10078572)
(PMID:10739639)

PMID:10078572 PMID:10739639

NCBI chr27:45,493,467...45,657,690
Ensembl chr27:45,497,352...45,657,621

LEP

leptin

acts_upstream_of_or_within

(PMID:16513828)

PMID:16513828

NCBI chr21:97,056,913...97,071,161
Ensembl chr21:97,057,529...97,071,220

NAGLU

N-acetyl-alpha-glucosaminidase

involved_in
acts_upstream_of_or_within

(PMID:29624734)

PMID:29624734

GO_REF:0000107

NCBI chr16:63,735,411...63,744,365

NR5A1

nuclear receptor subfamily 5 group A member 1

acts_upstream_of_or_within

(PMID:21820362)

PMID:21820362

NCBI chr12:13,640,453...13,666,748
Ensembl chr12:13,640,473...13,666,863

PAPSS2

3'-phosphoadenosine 5'-phosphosulfate synthase 2

involved_in

GO_REF:0000107

NCBI chr 9:81,102,477...81,191,951
Ensembl chr 9:81,102,520...81,190,230

PRLHR

prolactin releasing hormone receptor

acts_upstream_of_or_within

(PMID:14742914)

PMID:14742914

NCBI chr 9:111,399,821...111,402,946

protein tyrosine phosphatase non-receptor type 11

involved_in
acts_upstream_of_or_within

(PMID:15520383)

GO_REF:0000107

NCBI chr11:107,658,495...107,754,457
Ensembl chr11:107,658,453...107,752,637

SAFB

scaffold attachment factor B

acts_upstream_of_or_within

(PMID:15798188)

PMID:15798188

NCBI chr 6:5,281,171...5,326,049
Ensembl chr 6:5,281,232...5,328,511

SELENOM

selenoprotein M

acts_upstream_of_or_within

(PMID:23880772)

PMID:23880772

NCBI chr19:13,996,307...13,999,083

Wnt family member 4

involved_in
acts_upstream_of_or_within

(PMID:12399432)

PMID:12399432

GO_REF:0000107

NCBI chr20:110,517,391...110,543,802
Ensembl chr20:110,517,564...110,541,203

hormone secretion

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

CREB1

cAMP responsive element binding protein 1

acts_upstream_of

(PMID:16141355)

PMID:16141355

NCBI chr10:93,316,774...93,395,187
Ensembl chr10:93,316,840...93,388,832

free fatty acid receptor 4

involved_in
acts_upstream_of_or_within

(PMID:15619630)

Ensembl
TreeGrafter
MGI

PMID:15619630

GO_REF:0000107 GO_REF:0000118

NCBI chr 9:86,805,262...86,829,271
Ensembl chr 9:86,805,848...86,829,446

growth hormone releasing hormone

acts_upstream_of

(PMID:15985453), (PMID:16246898)

PMID:15985453 PMID:16246898

NCBI chr 2:26,482,734...26,493,761
Ensembl chr 2:26,487,973...26,493,499

growth hormone releasing hormone receptor

acts_upstream_of

(PMID:7679139)

PMID:7679139

NCBI chr21:27,402,765...27,417,536
Ensembl chr21:27,404,886...27,417,521

GLP1R

glucagon like peptide 1 receptor

involved_in
acts_upstream_of_or_within_positive_effect

PMID:8828468 PMID:23542788

PMID:8828468
(PMID:23542788)

UniProt
MGI

RGD:8554483

NCBI chr17:33,053,442...33,092,806
Ensembl chr17:33,054,574...33,091,422

LTBP4

latent transforming growth factor beta binding protein 4

involved_in
acts_upstream_of_or_within

(PMID:12208849)

PMID:12208849

GO_REF:0000107

NCBI chr 6:35,056,287...35,090,544
Ensembl chr 6:35,061,225...35,090,542

RAPGEF4

Rap guanine nucleotide exchange factor 4

involved_in
acts_upstream_of_or_within_positive_effect

(PMID:23542788)

PMID:23542788

GO_REF:0000107

NCBI chr10:58,233,503...58,549,337
Ensembl chr10:58,233,654...58,549,331

STX1A

syntaxin 1A

involved_in

GO_REF:0000107

NCBI chr28:9,347,495...9,367,948
Ensembl chr28:9,347,532...9,368,585

VAMP2

vesicle associated membrane protein 2

involved_in

(MGI:6294198|PMID:24356748)
(PMID:24356748)

PMID:24356748

MGI:6294198

NCBI chr16:7,539,098...7,542,466

hormone transport

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ABCB1

ATP binding cassette subfamily B member 1

dexamethasone

NCBI chr21:61,211,044...61,430,691
Ensembl chr21:61,322,748...61,529,274

SLC16A2

solute carrier family 16 member 2

NCBI chr X:64,023,846...64,123,428
Ensembl chr X:64,023,327...64,125,422

insulin processing

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

CPE

carboxypeptidase E

involved_in
acts_upstream_of_or_within

PMID:2822027 PMID:7663508 PMID:9348219 PMID:12829804

(PMID:9348219)
(PMID:7663508)

MGI
RGD

RGD:1626225 RGD:405650689

NCBI chr 7:111,747,265...111,867,548
Ensembl chr 7:111,747,172...111,868,754

ERO1B

endoplasmic reticulum oxidoreductase 1 beta

acts_upstream_of_or_within
involved_in

(PMID:20308425)

PMID:20308425

NCBI chr25:73,378,209...73,445,280
Ensembl chr25:73,381,153...73,445,251

INS

insulin

involved_in

(PMID:20424817)

PMID:20424817

NCBI chr 1:1,965,128...1,969,090

P4HB

prolyl 4-hydroxylase subunit beta

involved_in

GO_REF:0000107

NCBI chr16:73,718,743...73,733,488
Ensembl chr16:73,718,656...73,733,892

PCSK1

proprotein convertase subtilisin/kexin type 1

involved_in

(PMID:12136131)

PMID:12136131

NCBI chr 4:90,246,413...90,289,148
Ensembl chr 4:90,248,598...90,289,089

proprotein convertase subtilisin/kexin type 2

involved_in

PMID:7626024 PMID:9452465

(PMID:7626024)
(PMID:9452465)

BHF-UCL
MGI

NCBI chr 2:46,293,983...46,548,902
Ensembl chr 2:46,294,005...46,549,609

SLC30A8

solute carrier family 30 member 8

involved_in

GO_REF:0000107

NCBI chr 8:111,588,517...111,819,908
Ensembl chr 8:111,769,181...111,815,885

YIPF5

Yip1 domain family member 5

involved_in

GO_REF:0000107

NCBI chr23:46,765,326...46,777,245
Ensembl chr23:46,766,484...46,777,244

insulin secretion

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ACVR1C

activin A receptor type 1C

involved_in
acts_upstream_of

(PMID:18480258)

PMID:18480258

GO_REF:0000107

NCBI chr10:42,935,085...43,030,581
Ensembl chr10:42,942,284...42,994,488

ACVR2B

activin A receptor type 2B

acts_upstream_of_or_within

(PMID:17849440)

PMID:17849440

NCBI chr15:923,222...962,438

ACVR2B

activin A receptor type 2B

involved_in

GO_REF:0000107

Ensembl chr15:933,070...939,419

ADCYAP1

adenylate cyclase activating polypeptide 1

involved_in

(MGI:5525944|PMID:23913443)
(PMID:23913443)

PMID:23913443

MGI:5525944

NCBI chr18:60,259,479...60,267,302

ANXA1

annexin A1

involved_in

PMID:12459455

GO_REF:0000118 RGD:628365

NCBI chr12:84,207,818...84,226,438
Ensembl chr12:84,207,820...84,226,562

ANXA7

annexin A7

acts_upstream_of

(PMID:20440069)

PMID:20440069

NCBI chr 9:57,863,482...57,900,972
Ensembl chr 9:57,863,546...57,900,324

CACNA1C

calcium voltage-gated channel subunit alpha1 C

acts_upstream_of_or_within

(PMID:12881419)

PMID:12881419

NCBI chr11:2,107,722...2,753,970
Ensembl chr11:2,508,705...2,752,991

CCKAR

cholecystokinin A receptor

NCBI chr27:23,855,766...23,866,104
Ensembl chr27:23,856,705...23,865,367

CPLX1

complexin 1

involved_in

GO_REF:0000107

NCBI chr27:47,959,109...48,002,338
Ensembl chr27:47,959,091...48,002,527

CPLX3

complexin 3

involved_in

GO_REF:0000107

NCBI chr26:8,640,661...8,649,510
Ensembl chr26:8,641,551...8,645,155

CYB5R4

cytochrome b5 reductase 4

involved_in
acts_upstream_of_or_within

(PMID:15247412)

PMID:15247412

GO_REF:0000107

NCBI chr13:8,524,358...8,632,837
Ensembl chr13:8,524,400...8,632,288

DGAT1

diacylglycerol O-acyltransferase 1

NCBI chr 8:138,531,113...138,541,721
Ensembl chr 8:138,531,384...138,541,637

FAM3B

FAM3 metabolism regulating signaling molecule B

involved_in

GO_REF:0000118

NCBI chr 2:85,211,126...85,277,034
Ensembl chr 2:85,223,553...85,277,839

FFAR1

free fatty acid receptor 1

involved_in
acts_upstream_of_or_within

(PMID:17395749)

PMID:17395749

GO_REF:0000107

NCBI chr 6:30,289,268...30,290,838
Ensembl chr 6:30,289,285...30,290,187

FKBP1B

FKBP prolyl isomerase 1B

involved_in
acts_upstream_of_or_within

(PMID:18466757)

PMID:18466757

GO_REF:0000107

NCBI chr14:83,606,511...83,620,289
Ensembl chr14:83,606,454...83,620,205

GLP1R

glucagon like peptide 1 receptor

involved_in

PMID:10362617

NCBI chr17:33,053,442...33,092,806
Ensembl chr17:33,054,574...33,091,422

GPR119

G protein-coupled receptor 119

acts_upstream_of_or_within

(PMID:15607732)

PMID:15607732

NCBI chr X:105,641,691...105,646,692
Ensembl chr X:105,644,002...105,645,009

GPR68

G protein-coupled receptor 68

involved_in
acts_upstream_of

(PMID:22733973)

PMID:22733973

GO_REF:0000107

NCBI chr24:68,998,721...69,027,237
Ensembl chr24:68,998,805...68,999,902

HMGA1

high mobility group AT-hook 1

acts_upstream_of_or_within

(PMID:15924147)

PMID:15924147

NCBI chr17:37,848,110...37,857,835
Ensembl chr17:37,849,412...37,853,880

HNF1A

HNF1 homeobox A

involved_in
acts_upstream_of_or_within

PMID:9566924 PMID:9593777 PMID:9733737 PMID:15142986

(PMID:9566924), (PMID:9733737)
(PMID:15142986), (PMID:9593777)

InterPro
MGI

GO_REF:0000002

NCBI chr11:116,334,935...116,358,582
Ensembl chr11:116,335,675...116,357,751

HNF1B

HNF1 homeobox B

involved_in
acts_upstream_of_or_within

(PMID:15142986)

Ensembl
MGI
InterPro

PMID:15142986

GO_REF:0000002 GO_REF:0000107

NCBI chr16:30,033,486...30,097,106
Ensembl chr16:30,036,766...30,097,088

HTT

huntingtin

acts_upstream_of_or_within

(PMID:10078572)

PMID:10078572

NCBI chr27:45,493,467...45,657,690
Ensembl chr27:45,497,352...45,657,621

IL1RN

interleukin 1 receptor antagonist

acts_upstream_of_or_within

(PMID:12975454)

PMID:12975454

NCBI chr14:16,136,667...16,152,451
Ensembl chr14:16,146,333...16,151,326

ILDR2

immunoglobulin like domain containing receptor 2

involved_in
acts_upstream_of_or_within

(PMID:18654634)

PMID:18654634

GO_REF:0000107

NCBI chr25:62,058,441...62,120,031
Ensembl chr25:62,075,658...62,113,853

insulin receptor substrate 1

NOT|acts_upstream_of_or_within

(PMID:9062343)

PMID:9062343

NCBI chr10:112,748,283...112,812,368

LEP

leptin

acts_upstream_of_or_within

(PMID:16141392)

PMID:16141392

NCBI chr21:97,056,913...97,071,161
Ensembl chr21:97,057,529...97,071,220

MAFA

MAF bZIP transcription factor A

involved_in
acts_upstream_of

Ensembl
TreeGrafter
BHF-UCL

(PMID:17941991)

PMID:17941991

GO_REF:0000107 GO_REF:0000118

NCBI chr 8:137,647,459...137,650,169
Ensembl chr 8:137,648,746...137,649,804

MC4R

melanocortin 4 receptor

involved_in
acts_upstream_of_or_within

(PMID:16141392)

PMID:16141392

GO_REF:0000107

NCBI chr18:19,380,054...19,386,412
Ensembl chr18:19,380,849...19,381,847

MYO5A

myosin VA

acts_upstream_of_or_within

(PMID:15788565)

PMID:15788565

NCBI chr26:30,865,947...31,085,184

NEUROD1

neuronal differentiation 1

involved_in
acts_upstream_of

(PMID:17941991)

Ensembl
BHF-UCL

PMID:17941991

GO_REF:0000107

NCBI chr10:67,203,714...67,208,644
Ensembl chr10:67,205,141...67,206,211

NNAT

neuronatin

acts_upstream_of

(PMID:15793245)

PMID:15793245

NCBI chr 2:26,229,765...26,232,249
Ensembl chr 2:26,230,696...26,232,127

PARK7

Parkinsonism associated deglycase

involved_in

GO_REF:0000107

NCBI chr20:123,776,084...123,808,031
Ensembl chr20:123,776,297...123,798,434

PCLO

piccolo presynaptic cytomatrix protein

acts_upstream_of_or_within

(PMID:12401793)

PMID:12401793

NCBI chr21:65,729,762...66,129,806

PCLO

piccolo presynaptic cytomatrix protein

involved_in

GO_REF:0000107

Ensembl chr21:65,924,701...66,133,404

PDX1

pancreatic and duodenal homeobox 1

acts_upstream_of

(PMID:17941991)

PMID:17941991

NCBI chr 3:7,038,088...7,046,593
Ensembl chr 3:7,041,466...7,045,976

PRKCE

protein kinase C epsilon

involved_in
acts_upstream_of

(PMID:12837755)

PMID:12837755

GO_REF:0000107

NCBI chr14:61,022,903...61,570,390
Ensembl chr14:61,026,017...61,242,343

PTPRN

protein tyrosine phosphatase receptor type N

involved_in

(PMID:24843546)

GO_Central

PMID:24843546

NCBI chr10:105,196,508...105,216,665
Ensembl chr10:105,196,505...105,216,525

RAB3A

RAB3A, member RAS oncogene family

involved_in

GO_REF:0000107

NCBI chr 6:16,671,388...16,678,780
Ensembl chr 6:16,670,431...16,678,644

RAPGEF4

Rap guanine nucleotide exchange factor 4

involved_in
acts_upstream_of_or_within

(PMID:11598134), (PMID:12401793)

PMID:11598134 PMID:12401793

GO_REF:0000107

NCBI chr10:58,233,503...58,549,337
Ensembl chr10:58,233,654...58,549,331

RIMS2

regulating synaptic membrane exocytosis 2

involved_in
acts_upstream_of_or_within

(PMID:11598134)

PMID:11598134

NCBI chr 8:98,354,271...99,097,457
Ensembl chr 8:98,354,131...99,097,577

SERP1

stress associated endoplasmic reticulum protein 1

acts_upstream_of

(PMID:16415102)

PMID:16415102

NCBI chr15:40,146,868...40,150,873
Ensembl chr15:40,146,977...40,149,022

SLC18A2

solute carrier family 18 member A2

NCBI chr 9:110,039,783...110,078,822
Ensembl chr 9:110,040,391...110,076,647

SLC30A8

solute carrier family 30 member 8

involved_in

RGD
TreeGrafter
Ensembl

PMID:19479076

GO_REF:0000107 GO_REF:0000118 RGD:2315022

NCBI chr 8:111,588,517...111,819,908
Ensembl chr 8:111,769,181...111,815,885

SMAD2

SMAD family member 2

acts_upstream_of_or_within

(PMID:17849440)

PMID:17849440

NCBI chr18:33,017,138...33,105,320
Ensembl chr18:33,017,492...33,104,606

SNX19

sorting nexin 19

involved_in
acts_upstream_of_or_within

(PMID:24843546)

PMID:24843546

GO_REF:0000107

NCBI chr 1:121,927,660...121,968,101
Ensembl chr 1:121,930,165...121,968,075

SREBF1

sterol regulatory element binding transcription factor 1

involved_in
acts_upstream_of

(PMID:16890542)

GO_REF:0000107

NCBI chr16:16,847,603...16,874,239
Ensembl chr16:16,845,491...16,859,554

STX1A

syntaxin 1A

involved_in

GO_REF:0000107

NCBI chr28:9,347,495...9,367,948
Ensembl chr28:9,347,532...9,368,585

STXBP3

syntaxin binding protein 3

involved_in
acts_upstream_of_or_within

(PMID:19188424)

PMID:19188424

GO_REF:0000107

NCBI chr20:24,779,510...24,840,668
Ensembl chr20:24,779,271...24,840,643

SYTL4

synaptotagmin like 4

involved_in
acts_upstream_of

(PMID:16890542)

GO_REF:0000107

NCBI chr X:88,985,495...89,041,256
Ensembl chr X:88,987,016...89,041,194

VGF

VGF nerve growth factor inducible

involved_in
acts_upstream_of_or_within

(PMID:16141392)

PMID:16141392

GO_REF:0000107

NCBI chr28:12,016,216...12,021,151
Ensembl chr28:12,018,800...12,020,647

insulin secretion involved in cellular response to glucose stimulus

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ATG7

autophagy related 7

acts_upstream_of

(PMID:24105478)

PMID:24105478

NCBI chr22:47,187,305...47,571,309
Ensembl chr22:47,325,614...47,571,070

CCDC186

coiled-coil domain containing 186

acts_upstream_of_or_within

(PMID:27293546)

PMID:27293546

NCBI chr 9:106,995,610...107,048,884
Ensembl chr 9:106,998,396...107,048,533

CLTRN

collectrin, amino acid transport regulator

acts_upstream_of_positive_effect

(PMID:16330323)

GO_Central

PMID:16330323

NCBI chr X:14,103,046...14,154,936
Ensembl chr X:14,102,497...14,154,123

carboxypeptidase E

NCBI chr 7:111,747,265...111,867,548
Ensembl chr 7:111,747,172...111,868,754

FKBP1B

FKBP prolyl isomerase 1B

involved_in
acts_upstream_of

(PMID:19805579)

PMID:19805579

GO_REF:0000107

NCBI chr14:83,606,511...83,620,289
Ensembl chr14:83,606,454...83,620,205

HIF1A

hypoxia inducible factor 1 subunit alpha

involved_in
acts_upstream_of

(PMID:20440072)

PMID:20440072

GO_REF:0000107

NCBI chr24:38,873,830...38,927,657
Ensembl chr24:38,873,861...38,928,288

LOC103221203

RNA-binding protein 4

acts_upstream_of_or_within

(PMID:23129807)

PMID:23129807

NCBI chr 1:7,604,440...7,638,536

PTPRN

protein tyrosine phosphatase receptor type N

involved_in

GO_REF:0000118

NCBI chr10:105,196,508...105,216,665
Ensembl chr10:105,196,505...105,216,525

PTPRN2

protein tyrosine phosphatase receptor type N2

involved_in

(MGI:5141326|PMID:21732083)

PMID:21732083

MGI:5141326

NCBI chr21:125,655,787...126,622,503

RAB11B

RAB11B, member RAS oncogene family

involved_in

GO_REF:0000107

NCBI chr 6:7,743,130...7,757,237
Ensembl chr 6:7,743,361...7,757,305

RAB11FIP2

RAB11 family interacting protein 2

involved_in

GO_REF:0000107

NCBI chr 9:110,805,236...110,846,691
Ensembl chr 9:110,805,022...110,846,830

RAB11FIP5

RAB11 family interacting protein 5

involved_in

(MGI:4352608|PMID:19335615)

PMID:19335615

MGI:4352608

NCBI chr14:34,057,650...34,093,851
Ensembl chr14:34,057,878...34,091,692

RAF1

Raf-1 proto-oncogene, serine/threonine kinase

acts_upstream_of_or_within

(PMID:21817126)

PMID:21817126

NCBI chr22:48,560,270...48,643,537
Ensembl chr22:48,561,161...48,618,020

SELENOT

selenoprotein T

acts_upstream_of_or_within

(PMID:23913443)

PMID:23913443

NCBI chr15:40,062,259...40,094,676

islet amyloid polypeptide processing

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

proprotein convertase subtilisin/kexin type 2

involved_in

PMID:15983213

NCBI chr 2:46,293,983...46,548,902
Ensembl chr 2:46,294,005...46,549,609

luteinizing hormone secretion

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

CGA

glycoprotein hormones, alpha polypeptide

acts_upstream_of_or_within

(PMID:12114718)

PMID:12114718

NCBI chr13:11,560,543...11,578,070
Ensembl chr13:11,560,222...11,578,093

FOXD1

forkhead box D1

involved_in

(MGI:5484943|PMID:23284914)

PMID:23284914

MGI:5484943

NCBI chr 4:67,790,423...67,796,901

TBX3

T-box transcription factor 3

involved_in

(PMID:12116211)

PMID:12116211

NCBI chr11:109,952,100...109,966,328
Ensembl chr11:109,952,054...109,965,065

TMF1

TATA element modulatory factor 1

involved_in
acts_upstream_of_or_within

(PMID:23000399)

PMID:23000399

GO_REF:0000107

NCBI chr22:30,048,269...30,078,600
Ensembl chr22:30,045,685...30,078,414

melatonin biosynthetic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

AANAT

aralkylamine N-acetyltransferase

involved_in

Ensembl
TreeGrafter
UniProt

GO_REF:0000043 GO_REF:0000107 GO_REF:0000118

NCBI chr16:45,206,233...45,215,761
Ensembl chr16:45,206,377...45,207,591

ASMTL

acetylserotonin O-methyltransferase like

involved_in

UniProt
TreeGrafter

GO_REF:0000043 GO_REF:0000118

LOC103232876

acetylserotonin O-methyltransferase

acts_upstream_of_or_within
involved_in

PMID:3941912 PMID:8930356 PMID:12198599 PMID:20308563 PMID:22775292

(PMID:20308563)
(PMID:3941912)
(PMID:22775292)

RGD
MGI
UniProt

RGD:1299464 RGD:1359073

NCBI chr X:1,838...12,924

melatonin metabolic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

cytochrome P450 family 19 subfamily A member 1

NCBI chr26:32,074,260...32,164,926
Ensembl chr26:32,132,425...32,164,277

mineralocorticoid metabolic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

HSD11B1

hydroxysteroid 11-beta dehydrogenase 1

NCBI chr25:19,720,096...19,772,806
Ensembl chr25:19,719,848...19,750,200

negative regulation of adiponectin secretion

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

IL1B

interleukin 1 beta

involved_in

(MGI:3828398|PMID:16865359)
(PMID:16865359)

PMID:16865359

MGI:3828398

NCBI chr14:15,844,628...15,852,652
Ensembl chr14:15,844,672...15,850,729

RAB11FIP1

RAB11 family interacting protein 1

involved_in

(PMID:24040321)

PMID:24040321

NCBI chr 8:35,900,452...35,934,116
Ensembl chr 8:35,900,516...35,934,034

RAB11FIP3

RAB11 family interacting protein 3

involved_in

GO_REF:0000107

NCBI chr 5:358,951...445,150

RAB11FIP5

RAB11 family interacting protein 5

involved_in

(PMID:24040321)

PMID:24040321

NCBI chr14:34,057,650...34,093,851
Ensembl chr14:34,057,878...34,091,692

negative regulation of aldosterone biosynthetic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

BMP2

bone morphogenetic protein 2

involved_in

GO_REF:0000107

NCBI chr 2:31,349,394...31,361,227
Ensembl chr 2:31,348,808...31,360,901

BMP5

bone morphogenetic protein 5

involved_in

GO_REF:0000107

NCBI chr17:15,696,379...15,819,454
Ensembl chr17:15,696,580...15,819,564

DKK3

dickkopf WNT signaling pathway inhibitor 3

involved_in

GO_REF:0000107

NCBI chr 1:52,823,415...52,868,804
Ensembl chr 1:52,824,176...52,868,885

REST

RE1 silencing transcription factor

involved_in

GO_REF:0000107

NCBI chr 7:11,749,312...11,776,103
Ensembl chr 7:11,749,168...11,773,340

negative regulation of androgen biosynthetic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Wnt family member 4

involved_in

GO_REF:0000107

NCBI chr20:110,517,391...110,543,802
Ensembl chr20:110,517,564...110,541,203

negative regulation of calcidiol 1-monooxygenase activity

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

CYP27B1

cytochrome P450 family 27 subfamily B member 1

involved_in

GO_REF:0000107

NCBI chr11:53,675,704...53,681,372
Ensembl chr11:53,675,226...53,680,443

GFI1

growth factor independent 1 transcriptional repressor

involved_in

GO_REF:0000107

NCBI chr20:40,771,238...40,786,008
Ensembl chr20:40,776,816...40,783,717

NFKB1

nuclear factor kappa B subunit 1

involved_in

GO_REF:0000107

NCBI chr 7:50,589,494...50,711,472
Ensembl chr 7:50,589,856...50,711,498

negative regulation of corticosterone secretion

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

neuregulin 1

NCBI chr 8:29,745,984...30,862,140
Ensembl chr 8:30,635,803...30,856,487

translocator protein

NCBI chr19:25,678,602...25,690,556
Ensembl chr19:25,686,981...25,690,768

negative regulation of corticotropin secretion

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

CRHBP

corticotropin releasing hormone binding protein

involved_in

GO_REF:0000118

NCBI chr 4:71,203,335...71,223,179
Ensembl chr 4:71,205,932...71,223,172

negative regulation of cortisol biosynthetic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

BMP2

bone morphogenetic protein 2

involved_in

GO_REF:0000107

NCBI chr 2:31,349,394...31,361,227
Ensembl chr 2:31,348,808...31,360,901

BMP5

bone morphogenetic protein 5

involved_in

GO_REF:0000107

NCBI chr17:15,696,379...15,819,454
Ensembl chr17:15,696,580...15,819,564

DKK3

dickkopf WNT signaling pathway inhibitor 3

involved_in

GO_REF:0000107

NCBI chr 1:52,823,415...52,868,804
Ensembl chr 1:52,824,176...52,868,885

REST

RE1 silencing transcription factor

involved_in

GO_REF:0000107

NCBI chr 7:11,749,312...11,776,103
Ensembl chr 7:11,749,168...11,773,340

negative regulation of cortisol secretion

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

protein tyrosine phosphatase non-receptor type 11

involved_in
acts_upstream_of_or_within

(PMID:15520383)

GO_REF:0000107

NCBI chr11:107,658,495...107,754,457
Ensembl chr11:107,658,453...107,752,637

negative regulation of estrogen biosynthetic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

PRL

prolactin

involved_in

(PMID:24530842)

PMID:24530842

NCBI chr17:49,922,750...49,938,084
Ensembl chr17:49,928,321...49,938,631

negative regulation of follicle-stimulating hormone secretion

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

CRHR2

corticotropin releasing hormone receptor 2

NCBI chr21:27,703,637...27,738,873
Ensembl chr21:27,708,113...27,739,116

INHA

inhibin subunit alpha

immature male rats
female rats during diestrus-1

PMID:2500324 PMID:8015360

RGD:2290442 RGD:2290444

NCBI chr10:105,467,575...105,471,388
Ensembl chr10:105,467,963...105,471,688

inhibin subunit beta B

involved_in

(PMID:3122219)

PMID:3122219

NCBI chr10:9,943,015...9,948,721

inhibin subunit beta B

involved_in

GO_REF:0000107

Ensembl chr10:9,943,014...9,948,675

urocortin 2

NCBI chr22:9,962,339...9,964,553

negative regulation of glucagon secretion

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

CART prepropeptide

NCBI chr 4:66,058,755...66,060,635
Ensembl chr 4:66,058,769...66,061,112

corticotropin releasing hormone

involved_in

PMID:12606499

GO_REF:0000118 RGD:704397

NCBI chr 8:62,052,155...62,056,424
Ensembl chr 8:62,052,592...62,053,182

LEP

leptin

involved_in

(MGI:4889014|PMID:21234744)

PMID:21234744

MGI:4889014

NCBI chr21:97,056,913...97,071,161
Ensembl chr21:97,057,529...97,071,220

nucleobindin 2

NCBI chr 1:47,634,425...47,690,723
Ensembl chr 1:47,634,531...47,689,011

negative regulation of glucocorticoid biosynthetic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ATP1A1

ATPase Na+/K+ transporting subunit alpha 1

involved_in
acts_upstream_of_or_within

(PMID:17234593)

PMID:17234593

GO_REF:0000107

NCBI chr20:17,319,440...17,351,054
Ensembl chr20:17,315,117...17,351,054

negative regulation of glucocorticoid secretion

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

CRY1

cryptochrome circadian regulator 1

involved_in

GO_REF:0000107

NCBI chr11:102,200,822...102,306,165
Ensembl chr11:102,204,224...102,306,182

CRY2

cryptochrome circadian regulator 2

involved_in

GO_REF:0000107

NCBI chr 1:19,459,734...19,498,807
Ensembl chr 1:19,472,231...19,498,790

negative regulation of gonadotropin secretion

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

GJA1

gap junction protein alpha 1

involved_in

GO_REF:0000107

NCBI chr13:52,397,291...52,410,341
Ensembl chr13:52,396,109...52,410,339

NPVF

neuropeptide VF precursor

involved_in

GO_REF:0000118

NCBI chr21:33,118,553...33,123,057

negative regulation of growth hormone secretion

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

KALRN

kalirin RhoGEF kinase

involved_in
acts_upstream_of_or_within

(PMID:23116210)

PMID:23116210

GO_REF:0000107

NCBI chr22:56,106,677...56,820,004
Ensembl chr22:56,151,819...56,754,538

MADD

MAP kinase activating death domain

NCBI chr 1:17,987,573...18,041,317
Ensembl chr 1:17,986,860...18,042,266

protein tyrosine phosphatase non-receptor type 11

involved_in
acts_upstream_of_or_within

(PMID:15520383)

GO_REF:0000107

NCBI chr11:107,658,495...107,754,457
Ensembl chr11:107,658,453...107,752,637

sirtuin 1

NCBI chr 9:63,463,059...63,497,893
Ensembl chr 9:63,462,389...63,497,867

SSTR1

somatostatin receptor 1

involved_in

(PMID:16543371)

PMID:16543371

NCBI chr24:15,000,190...15,006,757
Ensembl chr24:15,003,116...15,004,291

SSTR2

somatostatin receptor 2

involved_in

(PMID:16543371)

PMID:16543371

NCBI chr16:48,462,472...48,470,586
Ensembl chr16:48,464,342...48,465,451

SSTR3

somatostatin receptor 3

involved_in

(PMID:16543371)

PMID:16543371

NCBI chr19:19,908,562...19,916,787
Ensembl chr19:19,910,898...19,912,154

negative regulation of hormone biosynthetic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

CACNA1A

calcium voltage-gated channel subunit alpha1 A

acts_upstream_of_or_within

(PMID:11182254)

PMID:11182254

NCBI chr 6:11,883,353...12,307,023

negative regulation of hormone secretion

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ADIPOQ

adiponectin, C1Q and collagen domain containing

NCBI chr15:81,128,427...81,142,779
Ensembl chr15:81,129,795...81,147,391

ADORA1

adenosine A1 receptor

gastrin

NCBI chr25:26,180,898...26,221,424
Ensembl chr25:26,182,446...26,220,776

endothelin 1

NCBI chr17:59,854,186...59,861,319
Ensembl chr17:59,853,699...59,861,198

endothelin 2

NCBI chr20:91,425,979...91,432,609
Ensembl chr20:91,426,747...91,431,973

endothelin 3

NCBI chr 2:4,814,447...4,839,950
Ensembl chr 2:4,814,140...4,839,626

FGF23

fibroblast growth factor 23

involved_in

PMID:17992255

NCBI chr11:4,398,318...4,408,415
Ensembl chr11:4,398,675...4,407,209

IL11

interleukin 11

acts_upstream_of_or_within
involved_in

(PMID:7867561)

GO_REF:0000107

NCBI chr 6:47,967,245...47,972,557
Ensembl chr 6:47,967,680...47,971,316

IL6

interleukin 6

acts_upstream_of_or_within

(PMID:7867561)

NCBI chr21:35,577,513...35,582,385
Ensembl chr21:35,577,939...35,582,237

LIF

LIF interleukin 6 family cytokine

acts_upstream_of_or_within
involved_in

(PMID:7867561)

GO_REF:0000107

NCBI chr19:13,121,261...13,127,663
Ensembl chr19:13,121,297...13,127,679

NMB

neuromedin B

thyrotropin (TSH); anterior pituitary gland of euthyroid and hyperthyroid rats

PMID:1557409

RGD:1642347

NCBI chr29:3,703,390...3,706,463

NPY1R

neuropeptide Y receptor Y1

NCBI chr 7:109,774,700...109,794,543
Ensembl chr 7:109,774,918...109,776,905

OSM

oncostatin M

acts_upstream_of_or_within

(PMID:7867561)

NCBI chr19:13,142,652...13,147,548
Ensembl chr19:13,144,442...13,147,494

protein tyrosine phosphatase non-receptor type 11

involved_in
acts_upstream_of_or_within

(PMID:15520383)

GO_REF:0000107

NCBI chr11:107,658,495...107,754,457
Ensembl chr11:107,658,453...107,752,637

urocortin

ghrelin

NCBI chr14:80,303,210...80,304,910
Ensembl chr14:80,304,416...80,304,790

negative regulation of insulin secretion

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ABCC8

ATP binding cassette subfamily C member 8

involved_in

PMID:15163199

GO_REF:0000107 RGD:1598646

NCBI chr 1:47,494,861...47,578,818
Ensembl chr 1:47,494,959...47,578,882

ACVR1C

activin A receptor type 1C

involved_in
acts_upstream_of_or_within

(PMID:18480258)

PMID:18480258

GO_REF:0000107

NCBI chr10:42,935,085...43,030,581
Ensembl chr10:42,942,284...42,994,488

ADRA2A

adrenoceptor alpha 2A

involved_in

PMID:1898674 PMID:10952463 PMID:17992256

(PMID:10952463)
(PMID:17992256), (PMID:1898674)
(PMID:1898674)

BHF-UCL
MGI

NCBI chr 9:104,015,577...104,019,364
Ensembl chr 9:104,016,580...104,017,932

BMP8A

bone morphogenetic protein 8a

involved_in

(PMID:22579288)

PMID:22579288

NCBI chr20:93,102,468...93,133,875

CCN3

cellular communication network factor 3

involved_in

(MGI:5517610|PMID:23705021)

PMID:23705021

MGI:5517610

NCBI chr 8:113,989,862...113,998,187
Ensembl chr 8:113,990,152...113,998,261

CHGA

chromogranin A

involved_in

GO_REF:0000118

NCBI chr24:70,663,040...70,675,827
Ensembl chr24:70,663,298...70,677,116

dopamine receptor D2

NCBI chr 1:104,774,632...104,843,417
Ensembl chr 1:104,774,180...104,842,736

F2RL1

F2R like trypsin receptor 1

involved_in

GO_REF:0000107

NCBI chr 4:71,095,446...71,109,832
Ensembl chr 4:71,095,500...71,110,005

FAM3D

FAM3 metabolism regulating signaling molecule D

involved_in

(PMID:12160727)

PMID:12160727

NCBI chr22:19,929,632...19,964,541
Ensembl chr22:19,929,635...19,963,201

FBN1

fibrillin 1

involved_in

(MGI:6442875|PMID:30997682)

PMID:30997682

MGI:6442875

NCBI chr26:34,637,916...34,877,499
Ensembl chr26:34,638,838...34,879,217

FFAR2

free fatty acid receptor 2

involved_in

(PMID:25581519)
(PMID:26075576)

PMID:25581519 PMID:26075576

NCBI chr 6:30,375,607...30,379,479
Ensembl chr 6:30,377,427...30,378,419

FFAR3

free fatty acid receptor 3

involved_in

GO_REF:0000107

NCBI chr 6:30,296,020...30,306,671

FOXO1

forkhead box O1

involved_in

(MGI:2388494|PMID:12219087), (MGI:6101624|PMID:27457971)

PMID:12219087 PMID:27457971

MGI:2388494 MGI:6101624

NCBI chr 3:18,916,849...19,027,776
Ensembl chr 3:18,920,651...19,027,707

ghrelin and obestatin prepropeptide

acts_upstream_of_or_within
involved_in

PMID:17130496
(PMID:17130496)

PMID:17130496

GO_REF:0000107 RGD:8553721

NCBI chr22:46,326,458...46,332,906
Ensembl chr22:46,325,913...46,330,962

GHSR

growth hormone secretagogue receptor

acts_upstream_of_or_within

PMID:17130496

NCBI chr15:17,008,185...17,013,504
Ensembl chr15:17,009,369...17,012,618

GNAO1

G protein subunit alpha o1

involved_in

(PMID:20622165)

PMID:20622165

NCBI chr 5:42,105,295...42,272,573
Ensembl chr 5:42,105,334...42,273,059

GNAZ

G protein subunit alpha z

involved_in

GO_REF:0000107

NCBI chr19:2,758,097...2,812,306
Ensembl chr19:2,757,819...2,788,076

HADH

hydroxyacyl-CoA dehydrogenase

NCBI chr 7:55,919,499...55,965,074
Ensembl chr 7:55,919,623...55,964,857

HDAC1

histone deacetylase 1

NCBI chr20:100,529,782...100,575,953
Ensembl chr20:100,530,369...100,558,556

inhibin subunit beta B

acts_upstream_of_or_within

(PMID:18480258)

PMID:18480258

NCBI chr10:9,943,015...9,948,721

inhibin subunit beta B

involved_in

GO_REF:0000107

Ensembl chr10:9,943,014...9,948,675

insulin receptor substrate 1

involved_in

(PMID:15572028)
PMID:12435589

PMID:12435589 PMID:15572028

RGD:729325

NCBI chr10:112,748,283...112,812,368

KCNB1

potassium voltage-gated channel subfamily B member 1

involved_in

(MGI:3770494|PMID:17767909)
(PMID:17767909)

PMID:17767909

MGI:3770494

NCBI chr 2:14,510,176...14,623,054
Ensembl chr 2:14,510,464...14,619,023

KCNJ11

potassium inwardly rectifying channel subfamily J member 11

involved_in

GO_REF:0000107

NCBI chr 1:47,582,519...47,586,466
Ensembl chr 1:47,583,629...47,584,801

KCNQ1

potassium voltage-gated channel subfamily Q member 1

NCBI chr 1:2,261,448...2,661,840
Ensembl chr 1:2,261,845...2,661,863

MIDN

midnolin

acts_upstream_of_or_within

PMID:24187134

NCBI chr 6:1,017,141...1,027,577
Ensembl chr 6:1,018,290...1,027,618

MTNR1A

melatonin receptor 1A

NCBI chr 7:132,423,619...132,445,881
Ensembl chr 7:132,424,052...132,444,860

MTNR1B

melatonin receptor 1B

NCBI chr 1:84,222,150...84,238,850
Ensembl chr 1:84,223,147...84,235,463

NOS1

nitric oxide synthase 1

NCBI chr11:112,642,374...112,673,882

NPFF

neuropeptide FF-amide peptide precursor

NCBI chr11:49,607,352...49,608,304
Ensembl chr11:49,607,443...49,608,139

phosphodiesterase 8B

NCBI chr 4:71,425,722...71,668,747
Ensembl chr 4:71,456,017...71,668,437

PFKL

phosphofructokinase, liver type

acts_upstream_of_or_within

(PMID:9287040)

PMID:9287040

NCBI chr 2:88,035,409...88,063,376
Ensembl chr 2:88,035,347...88,063,442

PPP3CA

protein phosphatase 3 catalytic subunit alpha

involved_in

PMID:19965390

NCBI chr 7:49,149,044...49,478,796
Ensembl chr 7:49,148,933...49,321,013

PRKN

parkin RBR E3 ubiquitin protein ligase

acts_upstream_of_or_within

(PMID:24187134)

PMID:24187134

NCBI chr13:88,856,056...90,329,379

PSMD9

proteasome 26S subunit, non-ATPase 9

involved_in

PMID:16099819

NCBI chr11:117,246,171...117,275,766
Ensembl chr11:117,246,186...117,275,757

PTGER3

prostaglandin E receptor 3

NCBI chr20:62,093,830...62,293,360
Ensembl chr20:62,095,458...62,174,959

protein tyrosine phosphatase non-receptor type 11

involved_in
acts_upstream_of_or_within

(PMID:15520383)

GO_REF:0000107

NCBI chr11:107,658,495...107,754,457
Ensembl chr11:107,658,453...107,752,637

REST

RE1 silencing transcription factor

involved_in

GO_REF:0000107

NCBI chr 7:11,749,312...11,776,103
Ensembl chr 7:11,749,168...11,773,340

RPTOR

regulatory associated protein of MTOR complex 1

involved_in

(MGI:5619445|PMID:23092880)
(PMID:23092880)

PMID:23092880

MGI:5619445

NCBI chr16:72,513,593...72,916,950
Ensembl chr16:72,513,619...72,918,416

SFRP1

secreted frizzled related protein 1

involved_in

GO_REF:0000107

NCBI chr 8:39,243,775...39,289,050
Ensembl chr 8:39,243,780...39,288,984

SIRT4

sirtuin 4

involved_in
acts_upstream_of_or_within

(PMID:16959573)

PMID:16959573

GO_REF:0000107

NCBI chr11:115,640,976...115,659,074
Ensembl chr11:115,640,555...115,658,687

SREBF1

sterol regulatory element binding transcription factor 1

involved_in
acts_upstream_of_or_within

(PMID:16890542)

GO_REF:0000107

NCBI chr16:16,847,603...16,874,239
Ensembl chr16:16,845,491...16,859,554

STXBP5L

syntaxin binding protein 5L

acts_upstream_of_or_within

(PMID:21998599)

PMID:21998599

NCBI chr22:59,460,278...59,938,228
Ensembl chr22:59,465,870...59,938,129

SYTL4

synaptotagmin like 4

involved_in
acts_upstream_of_or_within

(PMID:16890542)

GO_REF:0000107

NCBI chr X:88,985,495...89,041,256
Ensembl chr X:88,987,016...89,041,194

urotensin 2

NCBI chr20:123,903,137...123,910,180

VSNL1

visinin like 1

involved_in
acts_upstream_of_or_within

(PMID:16731532)

PMID:16731532

GO_REF:0000107

NCBI chr14:90,012,733...90,127,994
Ensembl chr14:90,010,913...90,126,934

negative regulation of insulin secretion involved in cellular response to glucose stimulus

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ADRA2A

adrenoceptor alpha 2A

involved_in

(PMID:19965390)

NCBI chr 9:104,015,577...104,019,364
Ensembl chr 9:104,016,580...104,017,932

CRHR2

corticotropin releasing hormone receptor 2

NCBI chr21:27,703,637...27,738,873
Ensembl chr21:27,708,113...27,739,116

ENY2

ENY2 transcription and export complex 2 subunit

NCBI chr 8:104,044,671...104,054,272
Ensembl chr 8:104,044,634...104,056,953

FKBP1B

FKBP prolyl isomerase 1B

involved_in
acts_upstream_of_or_within

(PMID:19805579)

PMID:19805579

GO_REF:0000107

NCBI chr14:83,606,511...83,620,289
Ensembl chr14:83,606,454...83,620,205

HMGCR

3-hydroxy-3-methylglutaryl-CoA reductase

NCBI chr 4:69,664,784...69,690,343
Ensembl chr 4:69,665,417...69,688,686

jagunal homolog 1

NCBI chr22:45,917,319...45,921,082
Ensembl chr22:45,917,444...45,920,250

KLF7

KLF transcription factor 7

involved_in

GO_REF:0000107

NCBI chr10:92,854,234...92,943,908
Ensembl chr10:92,859,000...92,944,062

MAP4K4

mitogen-activated protein kinase kinase kinase kinase 4

NCBI chr14:5,391,416...5,579,163
Ensembl chr14:5,391,449...5,583,916

NDUFAF2

NADH:ubiquinone oxidoreductase complex assembly factor 2

involved_in
acts_upstream_of_or_within

(PMID:22587331)

PMID:22587331

GO_REF:0000107

NCBI chr 4:57,128,382...57,326,926
Ensembl chr 4:57,128,385...57,326,966

phosphodiesterase 1C

NCBI chr21:26,094,604...26,712,127
Ensembl chr21:26,501,264...26,598,053

phosphodiesterase 3B

NCBI chr 1:50,050,168...50,254,797
Ensembl chr 1:50,047,477...50,254,807

phosphodiesterase 4C

NCBI chr 6:16,684,622...16,707,412

phosphodiesterase 8B

NCBI chr 4:71,425,722...71,668,747
Ensembl chr 4:71,456,017...71,668,437

PIM3

Pim-3 proto-oncogene, serine/threonine kinase

involved_in

(MGI:5294526|PMID:21099329)

PMID:21099329

MGI:5294526

NCBI chr19:32,466,432...32,470,001
Ensembl chr19:32,466,771...32,470,006

PTPMT1

protein tyrosine phosphatase mitochondrial 1

NCBI chr 1:17,747,371...17,754,358
Ensembl chr 1:17,747,380...17,754,161

TBC1D1

TBC1 domain family member 1

NCBI chr27:12,158,582...12,398,414
Ensembl chr27:12,156,227...12,386,980

uncoupling protein 2

NCBI chr 1:65,238,311...65,246,841
Ensembl chr 1:65,235,775...65,246,450

negative regulation of luteinizing hormone secretion

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

corticotropin releasing hormone

NCBI chr 8:62,052,155...62,056,424
Ensembl chr 8:62,052,592...62,053,182

CRHR2

corticotropin releasing hormone receptor 2

NCBI chr21:27,703,637...27,738,873
Ensembl chr21:27,708,113...27,739,116

OPRK1

opioid receptor kappa 1

NCBI chr 8:49,337,308...49,364,724
Ensembl chr 8:49,341,427...49,362,947

opioid receptor mu 1

NCBI chr13:81,568,295...81,650,005
Ensembl chr13:81,568,732...81,625,088

TACR2

tachykinin receptor 2

NCBI chr 9:61,902,565...61,915,402
Ensembl chr 9:61,903,477...61,914,558

urocortin 2

NCBI chr22:9,962,339...9,964,553

negative regulation of peptide hormone secretion

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

PPARG

peroxisome proliferator activated receptor gamma

involved_in

(MGI:5486574|PMID:11387233)
(PMID:11387233)

PMID:11387233

MGI:5486574

NCBI chr22:48,262,743...48,407,415
Ensembl chr22:48,275,600...48,407,418

negative regulation of progesterone biosynthetic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

PRL

prolactin

involved_in

(PMID:24530842)

PMID:24530842

NCBI chr17:49,922,750...49,938,084
Ensembl chr17:49,928,321...49,938,631

negative regulation of progesterone secretion

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

TP53

tumor protein p53

involved_in

(PMID:18703674)

PMID:18703674

NCBI chr16:7,047,686...7,065,567
Ensembl chr16:7,045,146...7,066,223

negative regulation of prolactin secretion

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

annexin A5

NCBI chr 7:68,940,365...68,970,324
Ensembl chr 7:68,940,304...68,970,811

negative regulation of retinoic acid biosynthetic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

PRMT3

protein arginine methyltransferase 3

involved_in

GO_REF:0000107

NCBI chr 1:44,486,165...44,621,002
Ensembl chr 1:44,485,880...44,620,936

negative regulation of somatostatin secretion

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

free fatty acid receptor 4

involved_in

GO_REF:0000107

NCBI chr 9:86,805,262...86,829,271
Ensembl chr 9:86,805,848...86,829,446

GAL

galanin and GMAP prepropeptide

involved_in

(PMID:8837218)

PMID:8837218

NCBI chr 1:5,849,947...5,857,355
Ensembl chr 1:5,849,952...5,857,072

insulin receptor substrate 1

involved_in

PMID:12435589

NCBI chr10:112,748,283...112,812,368

NPY

neuropeptide Y

involved_in

(PMID:8837218)

PMID:8837218

NCBI chr21:34,068,533...34,076,205
Ensembl chr21:34,068,530...34,075,127

negative regulation of steroid hormone biosynthetic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

PDE8B

phosphodiesterase 8B

involved_in
acts_upstream_of_or_within

(PMID:21187369)

PMID:21187369

GO_REF:0000107

NCBI chr 4:71,425,722...71,668,747
Ensembl chr 4:71,456,017...71,668,437

negative regulation of testosterone secretion

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

IGFBP3

insulin like growth factor binding protein 3

NCBI chr21:12,905,309...12,914,199
Ensembl chr21:12,905,280...12,914,205

parathyroid hormone secretion

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

GATA3

GATA binding protein 3

acts_upstream_of_or_within

(PMID:20484821)

PMID:20484821

NCBI chr 9:8,101,404...8,122,762
Ensembl chr 9:8,101,432...8,123,064

TRPV6

transient receptor potential cation channel subfamily V member 6

involved_in
acts_upstream_of_or_within

(PMID:17129178)

PMID:17129178

GO_REF:0000107

NCBI chr21:111,750,821...111,766,274
Ensembl chr21:111,750,945...111,765,450

patched ligand maturation

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

DISP1

dispatched RND transporter family member 1

acts_upstream_of_or_within

(PMID:12421714)

PMID:12421714

NCBI chr25:6,559,866...6,759,092
Ensembl chr25:6,559,862...6,575,625

peptide hormone processing

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

CORIN

corin, serine peptidase

involved_in

InterPro

GO_REF:0000002

NCBI chr27:2,407,451...2,662,855
Ensembl chr27:2,408,219...2,662,279

endothelin converting enzyme 1

involved_in

GO_REF:0000118

NCBI chr20:111,212,567...111,342,755
Ensembl chr20:111,212,594...111,342,821

ECE2

endothelin converting enzyme 2

involved_in

GO_REF:0000107

NCBI chr15:5,131,038...5,148,829
Ensembl chr15:5,130,385...5,148,811

FURIN

furin, paired basic amino acid cleaving enzyme

involved_in

GO_REF:0000118

NCBI chr29:8,980,367...8,992,257
Ensembl chr29:8,979,720...8,988,235

PCSK1

proprotein convertase subtilisin/kexin type 1

involved_in

pituitary adenylate cyclase-activating polypetide

PMID:10087454 PMID:16497799

GO_REF:0000118 RGD:1601276 RGD:2308913

NCBI chr 4:90,246,413...90,289,148
Ensembl chr 4:90,248,598...90,289,089

PCSK1N

proprotein convertase subtilisin/kexin type 1 inhibitor

acts_upstream_of_or_within

(PMID:10632593)

PMID:10632593

NCBI chr X:45,957,760...45,962,588
Ensembl chr X:45,957,715...45,962,601

proprotein convertase subtilisin/kexin type 2

involved_in
acts_upstream_of_or_within

PMID:12859669 PMID:16497799

(PMID:12859669)

RGD
TreeGrafter
MGI

GO_REF:0000118 RGD:1601276

NCBI chr 2:46,293,983...46,548,902
Ensembl chr 2:46,294,005...46,549,609

PCSK4

proprotein convertase subtilisin/kexin type 4

involved_in

GO_REF:0000118

NCBI chr 6:1,253,729...1,264,114
Ensembl chr 6:1,254,276...1,263,847

PCSK5

proprotein convertase subtilisin/kexin type 5

involved_in

GO_REF:0000118

NCBI chr12:86,907,173...87,367,935
Ensembl chr12:87,042,557...87,367,033

PCSK6

proprotein convertase subtilisin/kexin type 6

involved_in

PMID:8070361

GO_REF:0000118 RGD:729476

NCBI chr29:19,758,198...19,949,875
Ensembl chr29:19,754,625...19,949,382

SCG5

secretogranin V

involved_in

(MGI:1332331|PMID:10089884)
(PMID:10089884)

PMID:10089884

MGI:1332331

NCBI chr26:50,182,966...50,243,284
Ensembl chr26:50,189,473...50,243,282

peptide hormone secretion

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

CPE

carboxypeptidase E

acts_upstream_of_or_within

(PMID:16219686)

PMID:16219686

NCBI chr 7:111,747,265...111,867,548
Ensembl chr 7:111,747,172...111,868,754

EDN1

endothelin 1

involved_in

(PMID:10770212)

PMID:10770212

NCBI chr17:59,854,186...59,861,319
Ensembl chr17:59,853,699...59,861,198

EDN3

endothelin 3

involved_in

GO_REF:0000107

NCBI chr 2:4,814,447...4,839,950
Ensembl chr 2:4,814,140...4,839,626

EXOC3L1

exocyst complex component 3 like 1

involved_in

GO_REF:0000107

NCBI chr 5:60,266,216...60,272,393
Ensembl chr 5:60,266,583...60,272,378

HTT

huntingtin

acts_upstream_of_or_within

(PMID:10078572)
(PMID:12223581)

PMID:10078572 PMID:12223581

NCBI chr27:45,493,467...45,657,690
Ensembl chr27:45,497,352...45,657,621

ILDR1

immunoglobulin like domain containing receptor 1

acts_upstream_of

(PMID:23863714)

PMID:23863714

NCBI chr22:58,833,754...58,870,547
Ensembl chr22:58,834,293...58,870,303

SMPD3

sphingomyelin phosphodiesterase 3

involved_in
acts_upstream_of_or_within

(PMID:15764706)

PMID:15764706

GO_REF:0000107

NCBI chr 5:58,965,965...59,057,823
Ensembl chr 5:59,029,093...59,059,577

positive regulation of adiponectin secretion

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

C1QTNF3

C1q and TNF related 3

involved_in

GO_REF:0000107

NCBI chr 4:33,257,167...33,281,430
Ensembl chr 4:33,256,717...33,281,161

PPARG

peroxisome proliferator activated receptor gamma

acts_upstream_of_or_within

PMID:29695452

NCBI chr22:48,262,743...48,407,415
Ensembl chr22:48,275,600...48,407,418

positive regulation of aldosterone biosynthetic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

BMP6

bone morphogenetic protein 6

involved_in

(PMID:16527843)

PMID:16527843

NCBI chr17:64,279,243...64,436,356
Ensembl chr17:64,280,609...64,435,382

DAB2

DAB adaptor protein 2

NCBI chr 4:38,171,320...38,224,275
Ensembl chr 4:38,173,026...38,224,231

Wnt family member 4

involved_in

GO_REF:0000107

NCBI chr20:110,517,391...110,543,802
Ensembl chr20:110,517,564...110,541,203

positive regulation of aldosterone secretion

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

BMP6

bone morphogenetic protein 6

NCBI chr17:64,279,243...64,436,356
Ensembl chr17:64,280,609...64,435,382

C1QTNF1

C1q and TNF related 1

involved_in

GO_REF:0000107

NCBI chr16:70,993,035...71,018,240
Ensembl chr16:70,992,936...71,018,327

DAB2

DAB adaptor protein 2

NCBI chr 4:38,171,320...38,224,275
Ensembl chr 4:38,173,026...38,224,231

positive regulation of androgen secretion

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

NKX3-1

NK3 homeobox 1

involved_in

(PMID:19886863)

PMID:19886863

NCBI chr 8:21,792,069...21,797,258
Ensembl chr 8:21,791,422...21,796,319

positive regulation of calcitonin secretion

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

PTGER3

prostaglandin E receptor 3

NCBI chr20:62,093,830...62,293,360
Ensembl chr20:62,095,458...62,174,959

PTGER4

prostaglandin E receptor 4

NCBI chr 4:39,440,697...39,453,983
Ensembl chr 4:39,440,276...39,454,004

positive regulation of corticosterone secretion

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

corticotropin releasing hormone

PMID:12606499 PMID:20663987

RGD:5508201 RGD:704397

NCBI chr 8:62,052,155...62,056,424
Ensembl chr 8:62,052,592...62,053,182

ECRG4

ECRG4 augurin precursor

involved_in

(PMID:20233222)

PMID:20233222

NCBI chr14:9,686,930...9,698,708
Ensembl chr14:9,687,043...9,699,049

TAC1

tachykinin precursor 1

NCBI chr21:51,339,085...51,347,561
Ensembl chr21:51,339,095...51,347,550

positive regulation of corticotropin secretion

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

apelin

NCBI chr X:104,885,639...104,896,371
Ensembl chr X:104,888,996...104,895,014

corticotropin releasing hormone

involved_in

PMID:7477349 PMID:20663987

GO_REF:0000107 RGD:5508201 RGD:70047

NCBI chr 8:62,052,155...62,056,424
Ensembl chr 8:62,052,592...62,053,182

ECRG4

ECRG4 augurin precursor

involved_in

(PMID:20233222)

PMID:20233222

NCBI chr14:9,686,930...9,698,708
Ensembl chr14:9,687,043...9,699,049

ghrelin and obestatin prepropeptide

involved_in

GO_REF:0000107

NCBI chr22:46,326,458...46,332,906
Ensembl chr22:46,325,913...46,330,962

LIF

LIF interleukin 6 family cytokine

NCBI chr19:13,121,261...13,127,663
Ensembl chr19:13,121,297...13,127,679

PEX5L

peroxisomal biogenesis factor 5 like

NCBI chr15:9,373,826...9,613,276

RAB8B

RAB8B, member RAS oncogene family

NCBI chr26:20,275,555...20,354,298
Ensembl chr26:20,275,258...20,354,202

UCN

urocortin

involved_in

PMID:7477349

GO_REF:0000107 RGD:70047

NCBI chr14:80,303,210...80,304,910
Ensembl chr14:80,304,416...80,304,790

positive regulation of corticotropin-releasing hormone secretion

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

apelin

NCBI chr X:104,885,639...104,896,371
Ensembl chr X:104,888,996...104,895,014

ECRG4

ECRG4 augurin precursor

involved_in

(PMID:20233222)

PMID:20233222

NCBI chr14:9,686,930...9,698,708
Ensembl chr14:9,687,043...9,699,049

TNFSF11

TNF superfamily member 11

involved_in

GO_REF:0000107

NCBI chr 3:20,717,884...20,761,520
Ensembl chr 3:20,727,592...20,760,408

positive regulation of cortisol biosynthetic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Wnt family member 4

involved_in

GO_REF:0000107

NCBI chr20:110,517,391...110,543,802
Ensembl chr20:110,517,564...110,541,203

positive regulation of cortisol secretion

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

corticotropin releasing hormone

involved_in

GO_REF:0000107 GO_REF:0000118

NCBI chr 8:62,052,155...62,056,424
Ensembl chr 8:62,052,592...62,053,182

GAL

galanin and GMAP prepropeptide

involved_in

GO_REF:0000107

NCBI chr 1:5,849,947...5,857,355
Ensembl chr 1:5,849,952...5,857,072

GALR1

galanin receptor 1

involved_in

(PMID:17982695)

PMID:17982695

NCBI chr18:2,719,736...2,739,018

ghrelin and obestatin prepropeptide

involved_in

GO_REF:0000107

NCBI chr22:46,326,458...46,332,906
Ensembl chr22:46,325,913...46,330,962

positive regulation of estradiol secretion

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

cytochrome P450 family 19 subfamily A member 1

involved_in

GO_REF:0000107

NCBI chr26:32,074,260...32,164,926
Ensembl chr26:32,132,425...32,164,277

IL6

interleukin 6

involved_in

(PMID:24139936)

PMID:24139936

NCBI chr21:35,577,513...35,582,385
Ensembl chr21:35,577,939...35,582,237

mitofusin 2

NCBI chr20:119,787,700...119,818,455
Ensembl chr20:119,787,370...119,816,693

SPP1

secreted phosphoprotein 1

involved_in

(PMID:26482249)

CAFA

PMID:26482249

NCBI chr 7:36,337,165...36,344,927
Ensembl chr 7:36,338,386...36,344,407

TNF

tumor necrosis factor

involved_in

(PMID:24139936)

PMID:24139936

positive regulation of follicle-stimulating hormone secretion

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ACVR2A

activin A receptor type 2A

NCBI chr10:33,223,902...33,311,257
Ensembl chr10:33,224,099...33,307,720

FOXL2

forkhead box L2

acts_upstream_of_or_within

(PMID:24739304)

PMID:24739304

NCBI chr15:51,595,806...51,598,124
Ensembl chr15:51,596,218...51,597,348

inhibin subunit beta B

involved_in

(PMID:3122219)

PMID:3122219

NCBI chr10:9,943,015...9,948,721

inhibin subunit beta B

involved_in

GO_REF:0000107

Ensembl chr10:9,943,014...9,948,675

leptin

NCBI chr21:97,056,913...97,071,161
Ensembl chr21:97,057,529...97,071,220

SMAD4

SMAD family member 4

involved_in
acts_upstream_of_or_within

(PMID:24739304)

PMID:24739304

GO_REF:0000107

NCBI chr18:29,894,157...29,951,445
Ensembl chr18:29,897,621...29,934,478

positive regulation of glucagon secretion

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

AIMP1

aminoacyl tRNA synthetase complex interacting multifunctional protein 1

involved_in

(MGI:3689764|PMID:17001013)

PMID:17001013

MGI:3689764

NCBI chr 7:54,308,865...54,340,947

free fatty acid receptor 4

involved_in

GO_REF:0000107

NCBI chr 9:86,805,262...86,829,271
Ensembl chr 9:86,805,848...86,829,446

insulin receptor substrate 1

involved_in

PMID:12435589

NCBI chr10:112,748,283...112,812,368

positive regulation of growth hormone secretion

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ADCYAP1

adenylate cyclase activating polypeptide 1

NCBI chr18:60,259,479...60,267,302

ARHGEF7

Rho guanine nucleotide exchange factor 7

acts_upstream_of_or_within

(PMID:21828338)

PMID:21828338

NCBI chr 3:89,287,663...89,467,846
Ensembl chr 3:89,287,863...89,468,511

DRD2

dopamine receptor D2

involved_in
acts_upstream_of_or_within

(PMID:11897683)

PMID:11897683

GO_REF:0000107

NCBI chr 1:104,774,632...104,843,417
Ensembl chr 1:104,774,180...104,842,736

GABBR1

gamma-aminobutyric acid type B receptor subunit 1

NCBI chr17:42,985,816...43,017,278
Ensembl chr17:42,986,513...43,014,577

growth hormone releasing hormone

acts_upstream_of_or_within
involved_in

PMID:3008329 PMID:6130528 PMID:10579333

(PMID:3008329)

MGI
TreeGrafter
RGD

GO_REF:0000118 RGD:1624957 RGD:5687318

NCBI chr 2:26,482,734...26,493,761
Ensembl chr 2:26,487,973...26,493,499

growth hormone releasing hormone receptor

acts_upstream_of_or_within

PMID:978118 PMID:3008329 PMID:6303755 PMID:23825127

(PMID:3008329), (PMID:6303755), (PMID:978118)

RGD
MGI

RGD:10401239

NCBI chr21:27,402,765...27,417,536
Ensembl chr21:27,404,886...27,417,521

ghrelin and obestatin prepropeptide

involved_in

GO_REF:0000107 GO_REF:0000118

NCBI chr22:46,326,458...46,332,906
Ensembl chr22:46,325,913...46,330,962

intersectin 1

NCBI chr 2:58,298,529...58,543,297
Ensembl chr 2:58,301,399...58,543,281

KISS1

KiSS-1 metastasis suppressor

NCBI chr25:25,151,642...25,159,723

O-GlcNAcase

NCBI chr 9:94,812,126...94,847,118

SELENOT

selenoprotein T

involved_in

PMID:18198219

NCBI chr15:40,062,259...40,094,676

SERP1

stress associated endoplasmic reticulum protein 1

acts_upstream_of_or_within

(PMID:16415102)

PMID:16415102

NCBI chr15:40,146,868...40,150,873
Ensembl chr15:40,146,977...40,149,022

positive regulation of histamine secretion by mast cell

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

NPPA

natriuretic peptide A

involved_in

PMID:9663691

NCBI chr20:119,942,412...119,946,211
Ensembl chr20:119,944,532...119,945,917

PLA2G3

phospholipase A2 group III

involved_in

GO_REF:0000107

NCBI chr19:14,025,373...14,033,214
Ensembl chr19:14,025,742...14,030,643

SNX4

sorting nexin 4

involved_in

(PMID:18253931)

PMID:18253931

NCBI chr22:55,311,896...55,389,174
Ensembl chr22:55,311,933...55,389,349

VAMP7

vesicle associated membrane protein 7

involved_in

(PMID:18253931)

PMID:18253931

NCBI chr X:129,937,026...129,984,071
Ensembl chr X:129,937,046...129,984,119

VAMP8

vesicle associated membrane protein 8

involved_in

(PMID:18253931)

PMID:18253931

NCBI chr14:21,575,057...21,580,054
Ensembl chr14:21,575,161...21,579,820

positive regulation of hormone biosynthetic process

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ARNT

aryl hydrocarbon receptor nuclear translocator

involved_in

GO_REF:0000107

EGR1

early growth response 1

involved_in

GO_REF:0000107

NCBI chr23:41,139,636...41,143,598
Ensembl chr23:41,140,065...41,142,374

HIF1A

hypoxia inducible factor 1 subunit alpha

involved_in

GO_REF:0000107

NCBI chr24:38,873,830...38,927,657
Ensembl chr24:38,873,861...38,928,288

LHCGR

luteinizing hormone/choriogonadotropin receptor

progesterone

NCBI chr14:58,413,334...58,479,124
Ensembl chr14:58,413,993...58,477,987

positive regulation of hormone secretion

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

CNTF

ciliary neurotrophic factor

Fgf2 release from spinal cord astrocytes

PMID:11771938

RGD:1626172

NCBI chr 1:14,724,562...14,730,698
Ensembl chr 1:14,728,383...14,730,150

CREB1

cAMP responsive element binding protein 1

acts_upstream_of_or_within

(PMID:16141355)

PMID:16141355

NCBI chr10:93,316,774...93,395,187
Ensembl chr10:93,316,840...93,388,832

EDN1

endothelin 1

involved_in

(PMID:10770212)

PMID:10770212

NCBI chr17:59,854,186...59,861,319
Ensembl chr17:59,853,699...59,861,198

endothelin 2

NCBI chr20:91,425,979...91,432,609
Ensembl chr20:91,426,747...91,431,973

EDN3

endothelin 3

involved_in

GO_REF:0000107

NCBI chr 2:4,814,447...4,839,950
Ensembl chr 2:4,814,140...4,839,626

growth hormone releasing hormone

acts_upstream_of_or_within

(PMID:15985453), (PMID:16246898)
(PMID:9348175)

PMID:9348175 PMID:15985453 PMID:16246898

NCBI chr 2:26,482,734...26,493,761
Ensembl chr 2:26,487,973...26,493,499

growth hormone releasing hormone receptor

acts_upstream_of_or_within

(PMID:7679139)

PMID:7679139

NCBI chr21:27,402,765...27,417,536
Ensembl chr21:27,404,886...27,417,521

KISS1 receptor

NCBI chr 6:666,386...670,833
Ensembl chr 6:667,210...670,563

NELL2

neural EGFL like 2

involved_in

PMID:18547942

NCBI chr11:40,701,718...41,057,489
Ensembl chr11:40,701,723...41,057,349

NMB

neuromedin B

involved_in

thyrotropin (TSH); pituitary gland of hyperthyroid rats with or without addition of thyroxin (T4)

PMID:8136736

GO_REF:0000118 RGD:1642348

NCBI chr29:3,703,390...3,706,463

neuromedin U

NCBI chr 7:12,931,176...12,967,294
Ensembl chr 7:12,932,226...12,962,741

P2RY1

purinergic receptor P2Y1

NCBI chr15:37,822,474...37,827,245

protein tyrosine phosphatase non-receptor type 11

involved_in
acts_upstream_of_or_within

(PMID:15520383)

GO_REF:0000107

NCBI chr11:107,658,495...107,754,457
Ensembl chr11:107,658,453...107,752,637

SNAP25

synaptosome associated protein 25

NCBI chr 2:27,857,093...27,944,487
Ensembl chr 2:27,858,319...27,944,496

SOX11

SRY-box transcription factor 11

involved_in

(MGI:5285123|PMID:21527504)

PMID:21527504

MGI:5285123

NCBI chr14:101,982,551...101,991,305
Ensembl chr14:101,989,895...101,991,220

TACR1

tachykinin receptor 1

NCBI chr14:32,080,319...32,236,556
Ensembl chr14:32,083,615...32,233,596

positive regulation of insulin secretion

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

AACS

acetoacetyl-CoA synthetase

involved_in

PMID:17724028

GO_REF:0000118 RGD:2301019

NCBI chr11:120,422,138...120,502,200
Ensembl chr11:120,422,232...120,502,271

ABAT

4-aminobutyrate aminotransferase

NCBI chr 5:8,274,310...8,380,973
Ensembl chr 5:8,315,952...8,379,549

ACSL4

acyl-CoA synthetase long chain family member 4

involved_in

PMID:23766516

NCBI chr X:97,488,414...97,575,251

ADCY8

adenylate cyclase 8

involved_in

GO_REF:0000107

NCBI chr 8:125,269,396...125,535,806
Ensembl chr 8:125,269,736...125,533,015

ANXA7

annexin A7

acts_upstream_of_or_within_positive_effect

(PMID:10570150)

PMID:10570150

NCBI chr 9:57,863,482...57,900,972
Ensembl chr 9:57,863,546...57,900,324

BAD

BCL2 associated agonist of cell death

involved_in

(MGI:3778846|PMID:18223655)

PMID:18223655

MGI:3778846

NCBI chr 1:9,949,717...9,964,433
Ensembl chr 1:9,949,762...9,964,432

BLK

BLK proto-oncogene, Src family tyrosine kinase

involved_in

(PMID:19667185)

PMID:19667185

NCBI chr 8:7,547,200...7,618,645
Ensembl chr 8:7,547,299...7,569,188

CACNA1C

calcium voltage-gated channel subunit alpha1 C

NCBI chr11:2,107,722...2,753,970
Ensembl chr11:2,508,705...2,752,991

CAPN10

calpain 10

involved_in

GO_REF:0000107

NCBI chr10:126,613,722...126,626,388

CASK

calcium/calmodulin dependent serine protein kinase

NCBI chr X:38,704,623...39,121,309

CASR

calcium sensing receptor

NCBI chr22:58,579,640...58,612,142
Ensembl chr22:58,578,396...58,604,756

CD38 molecule

NCBI chr27:34,375,859...34,449,131
Ensembl chr27:34,376,271...34,449,425

CHRM3

cholinergic receptor muscarinic 3

involved_in

(PMID:20440069)
(PMID:16753580)

PMID:16753580 PMID:20440069

NCBI chr25:76,772,212...77,009,433
Ensembl chr25:77,001,477...77,003,249

DOC2B

double C2 domain beta

involved_in

(MGI:4457249|PMID:17548353)
(PMID:17548353)

PMID:17548353

MGI:4457249

NCBI chr16:17,890...51,080
Ensembl chr16:19,294...49,309

F2RL2

coagulation factor II thrombin receptor like 2

involved_in

GO_REF:0000107

NCBI chr 4:70,887,979...70,895,419
Ensembl chr 4:70,886,113...70,895,113

FFAR1

free fatty acid receptor 1

involved_in

RGD
TreeGrafter
Ensembl

PMID:16081037

GO_REF:0000107 GO_REF:0000118 RGD:2315053

NCBI chr 6:30,289,268...30,290,838
Ensembl chr 6:30,289,285...30,290,187

FFAR2

free fatty acid receptor 2

involved_in

(PMID:26075576)

PMID:26075576

NCBI chr 6:30,375,607...30,379,479
Ensembl chr 6:30,377,427...30,378,419

GCK

glucokinase

acts_upstream_of_or_within
involved_in

PMID:7556622 PMID:17028192 PMID:17360975

(PMID:7556622)
in response to glucose stimulation

RGD
MGI
Ensembl

GO_REF:0000107 RGD:1581879 RGD:2301916

NCBI chr21:14,475,723...14,523,086
Ensembl chr21:14,507,902...14,523,850

ghrelin and obestatin prepropeptide

involved_in

GO_REF:0000104

NCBI chr22:46,326,458...46,332,906
Ensembl chr22:46,325,913...46,330,962

GIP

gastric inhibitory polypeptide

involved_in

PMID:8958204

GO_REF:0000107 RGD:2312537

NCBI chr16:69,367,030...69,377,563
Ensembl chr16:69,367,207...69,377,155

GIPR

gastric inhibitory polypeptide receptor

involved_in

PMID:11014226 PMID:15111503 PMID:23099862

(PMID:23099862)
(PMID:15111503)

RGD
MGI

RGD:2312607

NCBI chr 6:39,108,319...39,122,973
Ensembl chr 6:39,110,387...39,122,874

GJA1

gap junction protein alpha 1

NCBI chr13:52,397,291...52,410,341
Ensembl chr13:52,396,109...52,410,339

GLP1R

glucagon like peptide 1 receptor

NCBI chr17:33,053,442...33,092,806
Ensembl chr17:33,054,574...33,091,422

glutaredoxin

NCBI chr 4:89,687,354...89,696,236
Ensembl chr 4:89,685,984...89,696,231

GLUD1

glutamate dehydrogenase 1

involved_in
acts_upstream_of_or_within

(PMID:16959573)

PMID:16959573

GO_REF:0000107

NCBI chr 9:44,653,044...44,690,142
Ensembl chr 9:44,653,289...44,688,954

GLUL

glutamate-ammonia ligase

ornithine alpha-ketoglutarate-induced secretion

PMID:12575909

RGD:2301557

NCBI chr25:46,988,853...46,998,112
Ensembl chr25:46,989,205...47,000,555

GNA11

G protein subunit alpha 11

involved_in

(PMID:26075576)
(PMID:20440069)

PMID:20440069 PMID:26075576

NCBI chr 6:2,858,880...2,887,694
Ensembl chr 6:2,858,937...2,887,704

GNAQ

G protein subunit alpha q

involved_in

(PMID:26075576)
(PMID:20440069)

PMID:20440069 PMID:26075576

NCBI chr12:88,666,375...88,988,989
Ensembl chr12:88,670,424...88,871,154

GPER1

G protein-coupled estrogen receptor 1

involved_in

GO_REF:0000107

NCBI chr28:20,491,874...20,497,966
Ensembl chr28:20,492,188...20,493,315

GPR68

G protein-coupled receptor 68

involved_in
acts_upstream_of_or_within

(PMID:22733973)

PMID:22733973

GO_REF:0000107

NCBI chr24:68,998,721...69,027,237
Ensembl chr24:68,998,805...68,999,902

HNF1 homeobox A

NCBI chr11:116,334,935...116,358,582
Ensembl chr11:116,335,675...116,357,751

IRS2

insulin receptor substrate 2

involved_in

(MGI:4456946|PMID:15572028)

PMID:15572028

MGI:4456946

NCBI chr 3:88,045,439...88,076,468

ISL1

ISL LIM homeobox 1

involved_in

PMID:11978636 PMID:19619559 PMID:29678908

(PMID:19619559)

RGD
BHF-UCL

RGD:243065231 RGD:729103

NCBI chr 4:47,665,861...47,678,631
Ensembl chr 4:47,666,536...47,677,552

ITPR1

inositol 1,4,5-trisphosphate receptor type 1

involved_in

GO_REF:0000107

NCBI chr22:40,574,569...40,925,857
Ensembl chr22:40,574,374...40,926,842

JAK2

Janus kinase 2

in response to human growth hormone

PMID:16597920

RGD:1641815

NCBI chr12:74,421,243...74,566,766
Ensembl chr12:74,421,016...74,566,710

LOC103232074

cAMP-dependent protein kinase type I-alpha regulatory subunit-like

involved_in

GO_REF:0000107

NCBI chr X:53,803,106...53,806,474

LOC103236354

prothrombin

involved_in

GO_REF:0000107

NCBI chr 1:18,589,658...18,627,459
Ensembl chr 1:18,620,215...18,627,511
Ensembl chr 1:18,620,215...18,627,511

LOC103243509

neuroendocrine secretory protein 55

involved_in

(PMID:17971513)
(PMID:33196462)
(PMID:34091063)

PMID:17971513 PMID:33196462 PMID:34091063

NCBI chr 2:5,233,893...5,303,433
Ensembl chr 2:5,233,874...5,249,192

LRRC8A

leucine rich repeat containing 8 VRAC subunit A

involved_in

GO_REF:0000107

NCBI chr12:9,237,706...9,272,637
Ensembl chr12:9,234,738...9,272,565

MCU

mitochondrial calcium uniporter

involved_in

(PMID:22829870)

PMID:22829870

NCBI chr 9:58,383,650...58,594,542
Ensembl chr 9:58,383,235...58,571,480

MYRIP

myosin VIIA and Rab interacting protein

involved_in

PMID:17827149

NCBI chr22:1,369,820...1,765,121
Ensembl chr22:1,370,001...1,765,311

NK6 homeobox 1

NCBI chr 7:32,846,436...32,851,526
Ensembl chr 7:32,846,528...32,851,447

NLGN2

neuroligin 2

involved_in

PMID:18755801 PMID:22528485

GO_REF:0000107 RGD:2314456 RGD:9743981

NCBI chr16:6,781,510...6,796,304
Ensembl chr16:6,784,642...6,794,419

NNAT

neuronatin

acts_upstream_of_or_within
involved_in

(PMID:15793245)

MGI
TreeGrafter

PMID:15793245

GO_REF:0000118

NCBI chr 2:26,229,765...26,232,249
Ensembl chr 2:26,230,696...26,232,127

NR0B2

nuclear receptor subfamily 0 group B member 2

NCBI chr20:105,850,328...105,853,076
Ensembl chr20:105,850,598...105,853,060

O-GlcNAcase

NCBI chr 9:94,812,126...94,847,118

ORAI1

ORAI calcium release-activated calcium modulator 1

involved_in

GO_REF:0000107

NCBI chr11:116,997,375...117,012,115
Ensembl chr11:116,997,636...117,011,737

PCK2

phosphoenolpyruvate carboxykinase 2, mitochondrial

NCBI chr24:1,077,206...1,087,306
Ensembl chr24:1,077,447...1,087,607

PDX1

pancreatic and duodenal homeobox 1

involved_in

PMID:12219087 PMID:18439098

(MGI:2388494|PMID:12219087)

RGD
UniProt

MGI:2388494 RGD:2306975

NCBI chr 3:7,038,088...7,046,593
Ensembl chr 3:7,041,466...7,045,976

PFKFB2

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2

NCBI chr25:22,277,692...22,306,057
Ensembl chr25:22,286,305...22,305,490

PFKM

phosphofructokinase, muscle

acts_upstream_of_or_within

(PMID:17595219)

PMID:17595219

NCBI chr11:44,332,857...44,378,273
Ensembl chr11:44,334,605...44,377,877

PLCB1

phospholipase C beta 1

involved_in

(PMID:26075576)
(PMID:10570150)
(PMID:31268747)

PMID:10570150 PMID:26075576 PMID:31268747

NCBI chr 2:29,242,601...29,994,238
Ensembl chr 2:29,242,425...29,496,793

PRKACA

protein kinase cAMP-activated catalytic subunit alpha

involved_in

(PMID:9075801)
(PMID:23349500), (PMID:25475437)

PMID:9075801 PMID:23349500 PMID:25475437

NCBI chr 6:12,743,752...12,759,155

PRKAR1A

protein kinase cAMP-dependent type I regulatory subunit alpha

involved_in

GO_REF:0000107

NCBI chr16:53,021,666...53,042,594
Ensembl chr16:53,023,963...53,042,493

PRKCB

protein kinase C beta

involved_in

(PMID:27226533)

PMID:27226533

NCBI chr 5:21,558,608...21,940,536
Ensembl chr 5:21,558,441...21,943,864

PRKCE

protein kinase C epsilon

involved_in
acts_upstream_of_or_within

(PMID:12837755)

PMID:12837755

GO_REF:0000107

NCBI chr14:61,022,903...61,570,390
Ensembl chr14:61,026,017...61,242,343

PSMD9

proteasome 26S subunit, non-ATPase 9

involved_in

PMID:10567574

NCBI chr11:117,246,171...117,275,766
Ensembl chr11:117,246,186...117,275,757

PTBP1

polypyrimidine tract binding protein 1

NCBI chr 6:546,010...560,086
Ensembl chr 6:545,964...562,630

RAPGEF4

Rap guanine nucleotide exchange factor 4

involved_in

GO_REF:0000107

NCBI chr10:58,233,503...58,549,337
Ensembl chr10:58,233,654...58,549,331

RBP4

retinol binding protein 4

involved_in

GO_REF:0000107

NCBI chr 9:86,831,042...86,840,668
Ensembl chr 9:86,830,957...86,840,250

RPH3AL

rabphilin 3A like (without C2 domains)

involved_in

(MGI:3044444|PMID:15159548)
(PMID:15159548)

PMID:15159548

MGI:3044444

NCBI chr16:80,050...194,489

RPH3AL

rabphilin 3A like (without C2 domains)

involved_in

GO_REF:0000107

Ensembl chr16:80,668...171,573

SERP1

stress associated endoplasmic reticulum protein 1

acts_upstream_of_or_within

(PMID:16415102)

PMID:16415102

NCBI chr15:40,146,868...40,150,873
Ensembl chr15:40,146,977...40,149,022

sirtuin 3

NCBI chr 1:25,740...49,471
Ensembl chr 1:26,927...48,944

SIRT6

sirtuin 6

involved_in

(MGI:6101624|PMID:27457971)
(PMID:27457971)

PMID:27457971

MGI:6101624

NCBI chr 6:3,924,230...3,932,583
Ensembl chr 6:3,924,230...3,932,590

SLC30A8

solute carrier family 30 member 8

involved_in

PMID:19479076

NCBI chr 8:111,588,517...111,819,908
Ensembl chr 8:111,769,181...111,815,885

SNAP25

synaptosome associated protein 25

NCBI chr 2:27,857,093...27,944,487
Ensembl chr 2:27,858,319...27,944,496

STIM1

stromal interaction molecule 1

involved_in

(PMID:30131394), (PMID:31664108)
(PMID:31664108)
(PMID:18452988)

PMID:18452988 PMID:30131394 PMID:31664108

NCBI chr 1:62,651,472...62,865,992
Ensembl chr 1:62,651,290...62,865,986

TARDBP

TAR DNA binding protein

NCBI chr20:120,753,764...120,765,259

TCF7L2

transcription factor 7 like 2

involved_in

(PMID:19386626)
(MGI:4412432|PMID:19168596)

PMID:19168596 PMID:19386626

MGI:4412432

NCBI chr 9:105,828,834...106,047,810

TM7SF3

transmembrane 7 superfamily member 3

involved_in

GO_REF:0000107

NCBI chr11:26,723,505...26,764,951
Ensembl chr11:26,723,834...26,764,877

TRH

thyrotropin releasing hormone

involved_in

PMID:16118471

GO_REF:0000118 RGD:1600419

NCBI chr22:51,075,814...51,079,852
Ensembl chr22:51,076,157...51,078,236

TRPM2

transient receptor potential cation channel subfamily M member 2

NCBI chr 2:88,082,391...88,170,340
Ensembl chr 2:88,087,448...88,170,344

urocortin 3

NCBI chr 9:5,491,134...5,500,663
Ensembl chr 9:5,498,945...5,499,430

positive regulation of insulin secretion involved in cellular response to glucose stimulus

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ABCC8

ATP binding cassette subfamily C member 8

involved_in

GO_REF:0000107

NCBI chr 1:47,494,861...47,578,818
Ensembl chr 1:47,494,959...47,578,882

ABCG1

ATP binding cassette subfamily G member 1

NCBI chr 2:86,098,818...86,176,101
Ensembl chr 2:86,099,414...86,179,949

ADCY8

adenylate cyclase 8

involved_in

GO_REF:0000107

NCBI chr 8:125,269,396...125,535,806
Ensembl chr 8:125,269,736...125,533,015

ANO1

anoctamin 1

involved_in

GO_REF:0000107

NCBI chr 1:4,373,256...4,581,914
Ensembl chr 1:4,373,252...4,490,557

ARRB1

arrestin beta 1

involved_in

(MGI:4453294|PMID:19915011)
(PMID:19915011)

PMID:19915011

MGI:4453294

NCBI chr 1:66,489,358...66,580,167
Ensembl chr 1:66,490,102...66,580,154

ATG7

autophagy related 7

acts_upstream_of_or_within

(PMID:24105478)

PMID:24105478

NCBI chr22:47,187,305...47,571,309
Ensembl chr22:47,325,614...47,571,070

BAD

BCL2 associated agonist of cell death

involved_in

(MGI:3778846|PMID:18223655)

PMID:18223655

MGI:3778846

NCBI chr 1:9,949,717...9,964,433
Ensembl chr 1:9,949,762...9,964,432

BAIAP3

BAI1 associated protein 3

involved_in

GO_REF:0000107

NCBI chr 5:1,222,994...1,237,823
Ensembl chr 5:1,227,910...1,236,898

C1QTNF12

C1q and TNF related 12

involved_in
acts_upstream_of_or_within

(PMID:22275362)

PMID:22275362

GO_REF:0000107

NCBI chr20:130,195,746...130,204,338
Ensembl chr20:130,198,005...130,202,441

C2CD2L

C2CD2 like

involved_in
acts_upstream_of_or_within

(PMID:24012759)

Ensembl
TreeGrafter
MGI

PMID:24012759

GO_REF:0000107 GO_REF:0000118

NCBI chr 1:110,475,073...110,490,431
Ensembl chr 1:110,480,738...110,491,508

CACNA1D

calcium voltage-gated channel subunit alpha1 D

NCBI chr22:14,868,459...15,195,002
Ensembl chr22:15,027,565...15,197,101

CAMK2N1

calcium/calmodulin dependent protein kinase II inhibitor 1

NCBI chr20:112,064,718...112,068,505
Ensembl chr20:112,065,581...112,067,256

CFTR

CF transmembrane conductance regulator

involved_in

(MGI:5640937|PMID:24885604)
(PMID:24885604)

PMID:24885604

MGI:5640937

NCBI chr21:86,154,313...86,332,436

corticotropin releasing hormone

NCBI chr 8:62,052,155...62,056,424
Ensembl chr 8:62,052,592...62,053,182

DYNLL1

dynein light chain LC8-type 1

NCBI chr11:115,851,020...115,855,526
Ensembl chr11:115,851,381...115,851,647

FTO

FTO alpha-ketoglutarate dependent dioxygenase

NCBI chr 5:39,487,304...39,900,238
Ensembl chr 5:39,487,418...39,725,747

GCG

glucagon

involved_in

(MGI:4453294|PMID:19915011)

PMID:19915011

MGI:4453294

NCBI chr10:47,550,097...47,560,610

GCG

glucagon

involved_in

GO_REF:0000107 GO_REF:0000118

Ensembl chr10:47,549,860...47,559,642

ghrelin and obestatin prepropeptide

NCBI chr22:46,326,458...46,332,906
Ensembl chr22:46,325,913...46,330,962

GPLD1

glycosylphosphatidylinositol specific phospholipase D1

involved_in

(MGI:5448527|PMID:20153004)

PMID:20153004

MGI:5448527

NCBI chr17:47,748,183...47,809,459
Ensembl chr17:47,765,699...47,804,378

GPR27

G protein-coupled receptor 27

involved_in
acts_upstream_of_or_within

(PMID:22253604)

PMID:22253604

GO_REF:0000107

NCBI chr22:32,708,228...32,709,820
Ensembl chr22:32,708,599...32,709,729

GPR68

G protein-coupled receptor 68

involved_in
acts_upstream_of_or_within

(PMID:22733973)

PMID:22733973

GO_REF:0000107

NCBI chr24:68,998,721...69,027,237
Ensembl chr24:68,998,805...68,999,902

HCFC1

host cell factor C1

involved_in

PMID:24250814

NCBI chr X:128,371,518...128,395,920
Ensembl chr X:128,371,517...128,394,861

HIF1A

hypoxia inducible factor 1 subunit alpha

involved_in
acts_upstream_of_or_within

(PMID:20440072)

PMID:20440072

GO_REF:0000107

NCBI chr24:38,873,830...38,927,657
Ensembl chr24:38,873,861...38,928,288

KIF5B

kinesin family member 5B

NCBI chr 9:31,321,615...31,369,549
Ensembl chr 9:31,320,549...31,369,519

leptin receptor

NCBI chr20:67,454,205...67,567,524
Ensembl chr20:67,454,334...67,524,229

LOC103221700

HLA class II histocompatibility antigen, DR beta 3 chain

involved_in

GO_REF:0000107

NCBI chr17:39,471,058...39,484,265

LOC103247148

HLA class II histocompatibility antigen, DRB1 beta chain

involved_in

GO_REF:0000107

NCBI chr17:39,556,020...39,564,488

LOC119618083

HLA class II histocompatibility antigen, DRB1 beta chain-like

involved_in

GO_REF:0000107

LRP1

LDL receptor related protein 1

NCBI chr11:53,039,147...53,125,041
Ensembl chr11:53,039,364...53,125,776

MPC2

mitochondrial pyruvate carrier 2

acts_upstream_of_or_within

(PMID:24910426)

PMID:24910426

NCBI chr25:61,109,742...61,128,675

myosin heavy chain 9

NCBI chr19:18,985,709...19,093,304
Ensembl chr19:18,986,598...19,052,671

NAD kinase

NCBI chr20:129,770,575...129,800,914
Ensembl chr20:129,769,822...129,803,817

NCOA6

nuclear receptor coactivator 6

NCBI chr 2:39,013,364...39,129,723
Ensembl chr 2:39,013,232...39,129,658

NR1H4

nuclear receptor subfamily 1 group H member 4

involved_in