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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of cell-substrate adhesion
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Accession:GO:0010812 term browser browse the term
Definition:Any process that decreases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules.



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negative regulation of cell-substrate adhesion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Angpt2 angiopoietin 2 acts_upstream_of_or_within ISO (MGI:1315113|PMID:9846489) RGD PMID:9846489 MGI:1315113 NCBI chr16:71,088,364...71,138,805
Ensembl chr16:71,088,364...71,138,804
JBrowse link
G Col1a1 collagen type I alpha 1 chain acts_upstream_of_or_within ISO (MGI:3697032|PMID:17018525) RGD PMID:17018525 MGI:3697032 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Coro2b coronin 2B acts_upstream_of_or_within ISO (PMID:29162887) RGD PMID:29162887 NCBI chr 8:62,906,861...63,017,295
Ensembl chr 8:62,906,867...63,017,302
JBrowse link
G Dmtn dematin actin binding protein involved_in ISO (MGI:3803395|PMID:18505823) RGD PMID:18505823 MGI:3803395 NCBI chr15:45,677,974...45,705,601
Ensembl chr15:45,677,977...45,705,601
JBrowse link
G Fzd4 frizzled class receptor 4 involved_in ISO (PMID:18156211)
(MGI:3772546|PMID:18156211)
RGD PMID:18156211 MGI:3772546 NCBI chr 1:143,280,065...143,288,799
Ensembl chr 1:143,280,065...143,285,724
JBrowse link
G Fzd7 frizzled class receptor 7 involved_in ISO (PMID:18156211)
(MGI:3772546|PMID:18156211)
RGD PMID:18156211 MGI:3772546 NCBI chr 9:60,931,433...60,934,252
Ensembl chr 9:60,930,875...60,935,781
JBrowse link
G Gcnt2 glucosaminyl (N-acetyl) transferase 2 (I blood group) involved_in ISO (PMID:21750175) RGD PMID:21750175 NCBI chr17:23,796,859...23,901,625
Ensembl chr17:23,796,859...23,901,611
JBrowse link
G Lgals1 galectin 1 IDA RGD PMID:1955484 RGD:2316546 NCBI chr 7:110,485,239...110,488,345
Ensembl chr 7:110,481,392...110,488,345
JBrowse link
G Lrp1 LDL receptor related protein 1 IMP RGD PMID:20197276 RGD:13800550 NCBI chr 7:63,380,325...63,461,029
Ensembl chr 7:63,380,356...63,460,910
JBrowse link
G Men1 menin 1 IMP RGD PMID:15054094 RGD:1304318 NCBI chr 1:203,638,905...203,644,871
Ensembl chr 1:203,639,000...203,644,871
JBrowse link
G Notch1 notch receptor 1 involved_in ISO (PMID:16501043) RGD PMID:16501043 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
JBrowse link
G Plg plasminogen involved_in ISO (PMID:14699093) RGD PMID:14699093 NCBI chr 1:48,325,186...48,367,643
Ensembl chr 1:48,325,185...48,367,786
JBrowse link
G Ptprz1 protein tyrosine phosphatase, receptor type Z1 IDA RGD PMID:12821372 RGD:9589826 NCBI chr 4:51,397,316...51,595,220
Ensembl chr 4:51,397,601...51,595,218
JBrowse link
G Rhoa ras homolog family member A involved_in ISO (MGI:5927441|PMID:18981818) RGD PMID:18981818 MGI:5927441 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
JBrowse link
G Spock1 sparc/osteonectin, cwcv and kazal like domains proteoglycan 1 involved_in ISO (PMID:12853036) RGD PMID:12853036 NCBI chr17:6,741,504...7,221,685
Ensembl chr17:6,742,273...7,224,935
JBrowse link
G Wnt1 Wnt family member 1 involved_in ISO (PMID:16501043) RGD PMID:16501043 NCBI chr 7:129,938,604...129,942,651
Ensembl chr 7:129,938,604...129,942,651
JBrowse link
negative regulation of cell-matrix adhesion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acer2 alkaline ceramidase 2 involved_in ISO (PMID:18945876) RGD PMID:18945876 NCBI chr 5:101,391,830...101,442,615
Ensembl chr 5:101,391,885...101,442,614
JBrowse link
G Adam15 ADAM metallopeptidase domain 15 involved_in ISO (PMID:22505472) RGD PMID:22505472 NCBI chr 2:174,754,631...174,765,136
Ensembl chr 2:174,754,633...174,765,113
JBrowse link
G Ajap1 adherens junctions associated protein 1 involved_in IEA
ISO
GO_REF:0000107
(PMID:16410724)
Ensembl
RGD
PMID:16410724 GO_REF:0000107 NCBI chr 5:163,907,846...164,021,004
Ensembl chr 5:163,907,847...164,020,317
JBrowse link
G Bcl6 BCL6, transcription repressor acts_upstream_of_or_within ISO MGI:2158438 (MGI:3576987|PMID:15860730) RGD PMID:15860730 MGI:3576987 NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389
JBrowse link
G Cask calcium/calmodulin dependent serine protein kinase involved_in ISO (PMID:18664494) RGD PMID:18664494 NCBI chr  X:8,899,500...9,243,014
Ensembl chr  X:8,899,833...9,238,694
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A involved_in ISO (PMID:10205165) RGD PMID:10205165 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 IDA RGD PMID:12837632 RGD:1299196 NCBI chr 7:86,202,345...86,325,050
Ensembl chr 7:86,202,350...86,324,827
JBrowse link
G Hoxa7 homeobox A7 involved_in ISO (PMID:14704364) RGD PMID:14704364 NCBI chr 4:81,315,730...81,317,629
Ensembl chr 4:81,314,625...81,317,659
JBrowse link
G Jag1 jagged canonical Notch ligand 1 involved_in ISO
IEA
(PMID:11549580)
GO_REF:0000107
RGD
Ensembl
PMID:11549580 GO_REF:0000107 NCBI chr 3:124,406,794...124,442,220
Ensembl chr 3:124,406,794...124,442,209
JBrowse link
G Muc4 mucin 4, cell surface associated IDA RGD PMID:9407114 RGD:2303753 NCBI chr11:68,008,245...68,053,229 JBrowse link
G Myoc myocilin involved_in IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:17984096)
Ensembl
UniProt
RGD
PMID:17984096 GO_REF:0000024 GO_REF:0000107 NCBI chr13:74,976,730...74,987,128
Ensembl chr13:74,976,730...74,987,127
JBrowse link
G Nexmif neurite extension and migration factor involved_in IMP
IBA
PMID:21873635 RGD
GO_Central
PMID:24071057 PMID:21873635 RGD:13442493, RGD:13792537 NCBI chr  X:69,088,076...69,219,253
Ensembl chr  X:69,088,076...69,112,930
JBrowse link
G Nf1 neurofibromin 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1339753|MGI:97583 (MGI:3689489|PMID:17053831)
Ensembl
RGD
PMID:17053831 GO_REF:0000107 MGI:3689489 NCBI chr10:64,306,027...64,539,112
Ensembl chr10:64,306,301...64,536,658
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:97306 (MGI:3689489|PMID:17053831)
Ensembl
RGD
PMID:17053831 GO_REF:0000107 MGI:3689489 NCBI chr 2:32,878,942...32,963,611
Ensembl chr 2:32,882,032...32,963,631
JBrowse link
G Plet1 placenta expressed transcript 1 involved_in IBA
ISO
ISS
PMID:21873635
(MGI:4453442|PMID:20130590)
GO_REF:0000024
RGD
UniProt
PMID:20130590 PMID:21873635 GO_REF:0000024 MGI:4453442, RGD:13792537 NCBI chr 8:50,842,210...50,854,015
Ensembl chr 8:50,841,854...50,853,659
JBrowse link
G Postn periostin IDA RGD PMID:15381649 RGD:10040999 NCBI chr 2:138,527,714...138,559,098
Ensembl chr 2:138,527,696...138,559,099
JBrowse link
G Rasa1 RAS p21 protein activator 1 involved_in ISO
ISS
IEA
(PMID:8344248)
GO_REF:0000024
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:8344248 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:15,857,704...15,940,757
Ensembl chr 2:15,857,980...15,940,854
JBrowse link
G Sema3e semaphorin 3E involved_in ISO (MGI:4819325|PMID:20385769) RGD PMID:20385769 MGI:4819325 NCBI chr 4:20,297,534...20,555,287
Ensembl chr 4:20,299,718...20,555,229
JBrowse link
G Thbs1 thrombospondin 1 involved_in
acts_upstream_of_or_within
ISO (PMID:17416590)
(PMID:16150726)
RGD PMID:16150726 PMID:17416590 NCBI chr 3:105,056,286...105,071,445
Ensembl chr 3:105,056,292...105,071,440
JBrowse link
negative regulation of endothelial cell-matrix adhesion via fibronectin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mmp12 matrix metallopeptidase 12 involved_in ISO
IEA
(PMID:29101312)
GO_REF:0000107
RGD
Ensembl
PMID:29101312 GO_REF:0000107 NCBI chr 8:4,581,785...4,591,687
Ensembl chr 8:4,581,785...4,599,611
JBrowse link
negative regulation of focal adhesion assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvrl1 activin A receptor like type 1 involved_in ISO (PMID:12453878) RGD PMID:12453878 NCBI chr 7:132,239,200...132,256,592
Ensembl chr 7:132,239,729...132,256,591
JBrowse link
G Apod apolipoprotein D involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:21705670)
UniProt
Ensembl
RGD
PMID:21705670 GO_REF:0000024 GO_REF:0000107 NCBI chr11:69,431,261...69,452,306
Ensembl chr11:69,431,260...69,452,305
JBrowse link
G Arhgap6 Rho GTPase activating protein 6 involved_in ISO (PMID:10699171) RGD PMID:10699171 NCBI chr  X:24,953,464...25,490,003
Ensembl chr  X:24,953,464...25,488,663
JBrowse link
G Bcas3 BCAS3, microtubule associated cell migration factor involved_in ISO (MGI:5582152|PMID:22300583) RGD PMID:22300583 MGI:5582152 NCBI chr10:70,213,710...70,673,080
Ensembl chr10:70,214,098...70,673,080
JBrowse link
G Clasp2 cytoplasmic linker associated protein 2 involved_in ISO (PMID:24859005) RGD PMID:24859005 NCBI chr 8:113,677,345...113,859,957
Ensembl chr 8:113,677,284...113,858,731
JBrowse link
G Coro1c coronin 1C involved_in ISO (PMID:19913511) RGD PMID:19913511 NCBI chr12:42,712,960...42,785,179
Ensembl chr12:42,712,991...42,785,179
JBrowse link
G Dlc1 DLC1 Rho GTPase activating protein involved_in IEA
ISO
GO_REF:0000107
(PMID:19158340)
Ensembl
RGD
PMID:19158340 GO_REF:0000107 NCBI chr16:55,246,716...55,671,441
Ensembl chr16:55,291,584...55,671,439
JBrowse link
G Dmtn dematin actin binding protein involved_in ISO (MGI:3803395|PMID:18505823) RGD PMID:18505823 MGI:3803395 NCBI chr15:45,677,974...45,705,601
Ensembl chr15:45,677,977...45,705,601
JBrowse link
G Dusp22 dual specificity phosphatase 22 involved_in ISO (PMID:20018849) RGD PMID:20018849 NCBI chr17:33,780,980...33,831,540
Ensembl chr17:33,780,981...33,831,321
JBrowse link
G Fam107a family with sequence similarity 107, member A involved_in ISO
IEA
ISS
(PMID:20543869)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:20543869 GO_REF:0000024 GO_REF:0000107 NCBI chr15:16,608,362...16,630,398
Ensembl chr15:16,607,205...16,630,396
JBrowse link
G Itgb1bp1 integrin subunit beta 1 binding protein 1 involved_in ISO (PMID:12473654)
(MGI:5486544|PMID:18227284)
RGD PMID:12473654 PMID:18227284 MGI:5486544 NCBI chr 6:40,820,693...40,836,074
Ensembl chr 6:40,821,339...40,836,037
JBrowse link
G Lrp1 LDL receptor related protein 1 IMP RGD PMID:20197276 RGD:13800550 NCBI chr 7:63,380,325...63,461,029
Ensembl chr 7:63,380,356...63,460,910
JBrowse link
G Mmp14 matrix metallopeptidase 14 IDA RGD PMID:15044209 RGD:1582604 NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864
JBrowse link
G Phldb2 pleckstrin homology-like domain, family B, member 2 involved_in ISO (PMID:24859005) RGD PMID:24859005 NCBI chr11:54,859,173...55,078,212
Ensembl chr11:54,859,135...55,078,467
JBrowse link
G Pten phosphatase and tensin homolog involved_in ISO (PMID:9616126) RGD PMID:9616126 NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Rcc2 regulator of chromosome condensation 2 involved_in ISO (MGI:5551375|PMID:19738201) RGD PMID:19738201 MGI:5551375 NCBI chr 5:152,994,406...153,017,223
Ensembl chr 5:152,993,665...153,017,205
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase involved_in IMP PMID:21440892 BHF-UCL PMID:21440892 RGD:7248703 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
negative regulation of smooth muscle cell-matrix adhesion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apod apolipoprotein D involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:21705670)
UniProt
Ensembl
RGD
PMID:21705670 GO_REF:0000024 GO_REF:0000107 NCBI chr11:69,431,261...69,452,306
Ensembl chr11:69,431,260...69,452,305
JBrowse link
G Serpine1 serpin family E member 1 involved_in IEA
ISO
GO_REF:0000107
(PMID:8837777)
Ensembl
RGD
PMID:8837777 GO_REF:0000107 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
negative regulation of substrate adhesion-dependent cell spreading term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actn4 actinin alpha 4 involved_in ISO (PMID:25918384) RGD PMID:25918384 NCBI chr 1:84,182,783...84,251,867
Ensembl chr 1:84,182,788...84,251,847
JBrowse link
G Ap1ar adaptor-related protein complex 1 associated regulatory protein acts_upstream_of_or_within ISO MGI:5439984 (MGI:5429457|PMID:22689987)
(PMID:22689987)
RGD PMID:22689987 MGI:5429457 NCBI chr 2:216,276,631...216,309,020
Ensembl chr 2:216,276,631...216,309,013
JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member IMP RGD PMID:15817476 RGD:7488898 NCBI chr19:39,679,218...39,713,952
Ensembl chr19:39,679,204...39,713,907
JBrowse link
G Coro1c coronin 1C involved_in ISO (PMID:19913511) RGD PMID:19913511 NCBI chr12:42,712,960...42,785,179
Ensembl chr12:42,712,991...42,785,179
JBrowse link
G Dmtn dematin actin binding protein involved_in ISO (MGI:3803395|PMID:18505823) RGD PMID:18505823 MGI:3803395 NCBI chr15:45,677,974...45,705,601
Ensembl chr15:45,677,977...45,705,601
JBrowse link
G Efna5 ephrin A5 acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:23242526)
GO_REF:0000107
RGD
Ensembl
PMID:23242526 GO_REF:0000107 NCBI chr 9:102,316,753...102,595,480
Ensembl chr 9:102,320,295...102,597,413
JBrowse link
G Fbln1 fibulin 1 involved_in ISO (PMID:11792823) RGD PMID:11792823 NCBI chr 7:116,310,582...116,390,075
Ensembl chr 7:116,310,582...116,390,075
JBrowse link
G Gbp1 guanylate binding protein 1 involved_in ISO (PMID:24337748) RGD PMID:24337748 NCBI chr 2:231,398,136...231,432,773
Ensembl chr 2:231,517,398...231,529,600
JBrowse link
G Itgb1bp1 integrin subunit beta 1 binding protein 1 involved_in ISO (PMID:11807099)
(MGI:5486544|PMID:18227284)
RGD PMID:11807099 PMID:18227284 MGI:5486544 NCBI chr 6:40,820,693...40,836,074
Ensembl chr 6:40,821,339...40,836,037
JBrowse link
G Kank1 KN motif and ankyrin repeat domains 1 involved_in ISO (PMID:19171758) RGD PMID:19171758 NCBI chr 1:222,877,962...223,074,514
Ensembl chr 1:222,877,622...223,074,514
JBrowse link
G Meltf melanotransferrin involved_in ISO (PMID:16713448) RGD PMID:16713448 NCBI chr11:68,884,446...68,906,300
Ensembl chr11:68,884,446...68,906,300
JBrowse link
G Postn periostin IDA RGD PMID:15381649 RGD:10040999 NCBI chr 2:138,527,714...138,559,098
Ensembl chr 2:138,527,696...138,559,099
JBrowse link
G Rcc2 regulator of chromosome condensation 2 involved_in ISO (MGI:5551375|PMID:19738201) RGD PMID:19738201 MGI:5551375 NCBI chr 5:152,994,406...153,017,223
Ensembl chr 5:152,993,665...153,017,205
JBrowse link
G Spry4 sprouty RTK signaling antagonist 4 involved_in ISO (PMID:15584898) RGD PMID:15584898 NCBI chr18:30,436,513...30,451,426
Ensembl chr18:30,436,443...30,453,004
JBrowse link
G Tacstd2 tumor-associated calcium signal transducer 2 involved_in ISS
ISO
IEA
GO_REF:0000024
(MGI:5315060|PMID:22194864)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:22194864 GO_REF:0000024 GO_REF:0000107 MGI:5315060 NCBI chr 4:96,707,950...96,709,650
Ensembl chr 4:96,707,951...96,709,650
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19390
    cellular process 18252
      cell adhesion 1404
        negative regulation of cell adhesion 307
          negative regulation of cell-substrate adhesion 62
            negative regulation of cell adhesion involved in single-species biofilm formation 0
            negative regulation of cell-matrix adhesion + 38
            negative regulation of substrate adhesion-dependent cell spreading 15
            negative regulation of substrate-dependent cell migration, cell attachment to substrate 0
Path 2
Term Annotations click to browse term
  biological_process 19390
    biological regulation 13476
      regulation of biological process 12735
        regulation of cellular process 12196
          regulation of cell adhesion 782
            negative regulation of cell adhesion 307
              negative regulation of cell-substrate adhesion 62
                negative regulation of cell adhesion involved in single-species biofilm formation 0
                negative regulation of cell-matrix adhesion + 38
                negative regulation of substrate adhesion-dependent cell spreading 15
                negative regulation of substrate-dependent cell migration, cell attachment to substrate 0
paths to the root