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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of macrophage derived foam cell differentiation
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Accession:GO:0010743 term browser browse the term
Definition:Any process that modulates the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions.



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negative regulation of macrophage derived foam cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca5 ATP binding cassette subfamily A member 5 involved_in IEA
ISO
GO_REF:0000107
(MGI:4454250|PMID:20382126)
Ensembl
RGD
PMID:20382126 GO_REF:0000107 MGI:4454250 NCBI chr10:95,240,159...95,309,195
Ensembl chr10:95,240,154...95,308,976
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing involved_in ISO
ISS
(PMID:11222466)
GO_REF:0000024
RGD
UniProt
PMID:11222466 GO_REF:0000024 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Crp C-reactive protein involved_in ISO (PMID:18322245) RGD PMID:18322245 NCBI chr13:85,131,635...85,175,179
Ensembl chr13:85,124,977...85,175,178
JBrowse link
G Itgav integrin subunit alpha V involved_in ISO (PMID:15215180) RGD PMID:15215180 NCBI chr 3:68,838,524...68,926,653
Ensembl chr 3:68,838,189...68,926,639
JBrowse link
G Itgb3 integrin subunit beta 3 involved_in ISO (PMID:15215180) RGD PMID:15215180 NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679
JBrowse link
G Nfkbia NFKB inhibitor alpha involved_in ISO (PMID:16938301) RGD PMID:16938301 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha involved_in ISO (PMID:19114110) RGD PMID:19114110 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma involved_in ISO (PMID:19114110) RGD PMID:19114110 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
positive regulation of macrophage derived foam cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox15b arachidonate 15-lipoxygenase, type B involved_in ISO
IEA
(PMID:22912809)
GO_REF:0000107
RGD
Ensembl
PMID:22912809 GO_REF:0000107 NCBI chr10:53,892,496...53,901,812
Ensembl chr10:53,892,466...53,901,812
JBrowse link
G Apob apolipoprotein B involved_in ISO (PMID:17244792), (PMID:18322245), (PMID:19114110) RGD PMID:17244792 PMID:18322245 PMID:19114110 NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497
JBrowse link
G Cd36 CD36 molecule involved_in ISO
IEA
(PMID:10772654)
GO_REF:0000107
(MGI:2447499|PMID:12376530), (MGI:3836139|PMID:10772654)
RGD
Ensembl
PMID:10772654 PMID:12376530 GO_REF:0000107 MGI:2447499 MGI:3836139 NCBI chr 4:17,317,343...17,410,084 JBrowse link
G Csf1 colony stimulating factor 1 involved_in ISO
IEA
(PMID:17244792)
GO_REF:0000107
RGD
Ensembl
PMID:17244792 GO_REF:0000107 NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704
JBrowse link
G Csf2 colony stimulating factor 2 involved_in ISO (PMID:19032770) RGD PMID:19032770 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Il18 interleukin 18 involved_in IEA
ISO
GO_REF:0000107
(MGI:3608083|PMID:12829194)
Ensembl
RGD
PMID:12829194 GO_REF:0000107 MGI:3608083 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Lpl lipoprotein lipase involved_in ISO UniProtKB:P35951 (MGI:1888585|PMID:10858435) RGD PMID:10858435 MGI:1888585 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 involved_in ISO
IEA
(PMID:18262097)
GO_REF:0000107
RGD
Ensembl
PMID:18262097 GO_REF:0000107 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Msr1 macrophage scavenger receptor 1 involved_in ISO UniProtKB:Q08857 (MGI:2447499|PMID:12376530) RGD PMID:12376530 MGI:2447499 NCBI chr16:52,717,775...52,802,890
Ensembl chr16:52,717,732...52,799,676
JBrowse link
G Pf4 platelet factor 4 involved_in ISO (PMID:17244792) RGD PMID:17244792 NCBI chr14:17,298,438...17,299,148
Ensembl chr14:17,298,308...17,299,365
JBrowse link
G Pla2g3 phospholipase A2, group III involved_in ISO (PMID:18801741) RGD PMID:18801741 NCBI chr14:78,367,625...78,373,913
Ensembl chr14:78,368,105...78,373,913
JBrowse link
G Pla2g5 phospholipase A2, group V involved_in ISS
ISO
GO_REF:0000024
(MGI:6393145|PMID:14962950)
UniProt
RGD
PMID:14962950 GO_REF:0000024 MGI:6393145 NCBI chr 5:151,041,339...151,109,433
Ensembl chr 5:151,041,340...151,062,658
JBrowse link
G Prkch protein kinase C, eta involved_in ISS
ISO
GO_REF:0000024
(MGI:5306557|PMID:20558593)
UniProt
RGD
PMID:20558593 GO_REF:0000024 MGI:5306557 NCBI chr 6:92,292,000...92,490,663
Ensembl chr 6:92,292,000...92,490,654
JBrowse link
G RGD1565355 similar to fatty acid translocase/CD36 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 4:17,424,749...17,465,808
Ensembl chr 4:17,354,466...17,513,903
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19497
    developmental process 6889
      regulation of developmental process 2704
        regulation of cell differentiation 1719
          regulation of macrophage derived foam cell differentiation 22
            negative regulation of macrophage derived foam cell differentiation 8
            positive regulation of macrophage derived foam cell differentiation 14
Path 2
Term Annotations click to browse term
  biological_process 19497
    developmental process 6889
      cellular developmental process 4543
        cell differentiation 4448
          foam cell differentiation 27
            macrophage derived foam cell differentiation 26
              regulation of macrophage derived foam cell differentiation 22
                negative regulation of macrophage derived foam cell differentiation 8
                positive regulation of macrophage derived foam cell differentiation 14
paths to the root