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ONTOLOGY REPORT - ANNOTATIONS


Term:macrophage derived foam cell differentiation
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Accession:GO:0010742 term browser browse the term
Definition:The process in which a monocyte acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions.



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macrophage derived foam cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Selenok selenoprotein K acts_upstream_of_or_within ISO MGI:4941878 (PMID:23444136) RGD PMID:23444136 NCBI chr16:5,152,066...5,160,648 JBrowse link
G Soat1 sterol O-acyltransferase 1 involved_in IEA
ISO
GO_REF:0000107
(PMID:15353128), (PMID:8407899)
Ensembl
RGD
PMID:8407899 PMID:15353128 GO_REF:0000107 NCBI chr13:68,552,274...68,597,529 JBrowse link
G Wnt5a Wnt family member 5A involved_in ISO
IEA
(PMID:31512787)
GO_REF:0000107
RGD
Ensembl
PMID:31512787 GO_REF:0000107 NCBI chr16:3,702,300...3,724,860 JBrowse link
negative regulation of macrophage derived foam cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca5 ATP binding cassette subfamily A member 5 involved_in ISO (PMID:20382126) RGD PMID:20382126 NCBI chr10:95,739,610...95,808,633 JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing involved_in ISO
ISS
(PMID:11222466)
GO_REF:0000024
RGD
UniProt
PMID:11222466 GO_REF:0000024 NCBI chr11:91,226,524...91,240,244 JBrowse link
G Crp C-reactive protein involved_in ISO (PMID:18322245) RGD PMID:18322245 NCBI chr13:87,694,062...87,695,978 JBrowse link
G Itgav integrin subunit alpha V involved_in ISO (PMID:15215180) RGD PMID:15215180 NCBI chr 3:89,245,382...89,333,512 JBrowse link
G Itgb3 integrin subunit beta 3 involved_in ISO
IEA
(PMID:15215180)
GO_REF:0000107
RGD
Ensembl
PMID:15215180 GO_REF:0000107 NCBI chr10:90,009,927...90,067,787 JBrowse link
G Mir130b microRNA 130b involved_in ISO (PMID:31512787) RGD PMID:31512787 NCBI chr11:83,880,163...83,880,244 JBrowse link
G Nfkbia NFKB inhibitor alpha involved_in ISO (PMID:16938301) RGD PMID:16938301 NCBI chr 6:78,593,844...78,597,307 JBrowse link
G Ppara peroxisome proliferator activated receptor alpha involved_in ISO (PMID:12700342), (PMID:19114110) RGD PMID:12700342 PMID:19114110 NCBI chr 7:118,712,261...118,780,723 JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma involved_in ISO (PMID:12700342), (PMID:19114110) RGD PMID:12700342 PMID:19114110 NCBI chr 4:150,095,743...150,221,104 JBrowse link
positive regulation of macrophage derived foam cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen involved_in ISO
IEA
(PMID:18971559)
GO_REF:0000107
RGD
Ensembl
PMID:18971559 GO_REF:0000107 NCBI chr19:69,426,540...69,447,017 JBrowse link
G Agtr1a angiotensin II receptor, type 1a involved_in ISO (PMID:18971559) RGD PMID:18971559 NCBI chr17:34,383,397...34,435,523 JBrowse link
G Alox15b arachidonate 15-lipoxygenase, type B involved_in ISO
IEA
(PMID:22912809)
GO_REF:0000107
RGD
Ensembl
PMID:22912809 GO_REF:0000107 NCBI chr10:53,892,496...53,901,812 JBrowse link
G Apob apolipoprotein B involved_in ISO
IEA
(PMID:17244792), (PMID:18322245), (PMID:19114110)
GO_REF:0000107
RGD
Ensembl
PMID:17244792 PMID:18322245 PMID:19114110 GO_REF:0000107 NCBI chr 6:36,563,704...36,603,300 JBrowse link
G Cd36 CD36 molecule involved_in ISO
IEA
(PMID:10772654)
GO_REF:0000107
(PMID:10772654), (PMID:12376530)
RGD
Ensembl
PMID:10772654 PMID:12376530 GO_REF:0000107 NCBI chr 4:18,209,088...18,302,142 JBrowse link
G Csf1 colony stimulating factor 1 involved_in ISO
IEA
(PMID:17244792)
GO_REF:0000107
RGD
Ensembl
PMID:17244792 GO_REF:0000107 NCBI chr 2:198,065,400...198,084,774 JBrowse link
G Csf2 colony stimulating factor 2 involved_in ISO (PMID:19032770) RGD PMID:19032770 NCBI chr10:38,887,692...38,889,673 JBrowse link
G Il18 interleukin 18 involved_in IEA
ISO
GO_REF:0000107
(PMID:12829194)
Ensembl
RGD
PMID:12829194 GO_REF:0000107 NCBI chr 8:59,802,072...59,829,275 JBrowse link
G Il1b interleukin 1 beta involved_in ISO (PMID:19032770) RGD PMID:19032770 NCBI chr 3:137,030,200...137,036,581 JBrowse link
G Lpl lipoprotein lipase involved_in IEA
ISO
GO_REF:0000107
(PMID:12573449)
UniProtKB:P35951 (PMID:10858435)
Ensembl
RGD
PMID:10858435 PMID:12573449 GO_REF:0000107 NCBI chr16:25,596,205...25,621,928 JBrowse link
G Mapk9 mitogen-activated protein kinase 9 involved_in ISO
IEA
(PMID:18262097)
GO_REF:0000107
RGD
Ensembl
PMID:18262097 GO_REF:0000107 NCBI chr10:34,670,750...34,711,972 JBrowse link
G Mir185 microRNA 185 involved_in ISO (PMID:26523989) RGD PMID:26523989 NCBI chr11:82,664,716...82,664,795 JBrowse link
G Msr1 macrophage scavenger receptor 1 involved_in ISO UniProtKB:Q08857 (PMID:12376530) RGD PMID:12376530 NCBI chr16:52,717,775...52,803,602 JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 involved_in IEA
ISO
GO_REF:0000107
UniProtKB:P25963 (PMID:16938301)
Ensembl
RGD
PMID:16938301 GO_REF:0000107 NCBI chr 2:226,689,745...226,805,897 JBrowse link
G Pf4 platelet factor 4 involved_in ISO (PMID:17244792) RGD PMID:17244792 NCBI chr14:17,582,477...17,583,392 JBrowse link
G Pla2g3 phospholipase A2, group III involved_in ISO (PMID:18801741) RGD PMID:18801741 NCBI chr14:82,589,908...82,597,542 JBrowse link
G Pla2g5 phospholipase A2, group V involved_in ISS
ISO
GO_REF:0000024
(PMID:14962950)
UniProt
RGD
PMID:14962950 GO_REF:0000024 NCBI chr 5:156,324,628...156,393,065 JBrowse link
G Prkch protein kinase C, eta involved_in ISS
ISO
GO_REF:0000024
(PMID:20558593)
UniProt
RGD
PMID:20558593 GO_REF:0000024 NCBI chr 6:98,027,830...98,226,486 JBrowse link
G Tnf tumor necrosis factor involved_in IEA
ISO
GO_REF:0000107
(PMID:19032770)
Ensembl
RGD
PMID:19032770 GO_REF:0000107 NCBI chr20:3,626,685...3,629,303 JBrowse link

Term paths to the root
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Term Annotations click to browse term
  biological_process 20534
    developmental process 7107
      cellular developmental process 4811
        cell differentiation 4810
          foam cell differentiation 32
            macrophage derived foam cell differentiation 31
              negative regulation of macrophage derived foam cell differentiation 9
              positive regulation of macrophage derived foam cell differentiation 19
              regulation of macrophage derived foam cell differentiation + 28
paths to the root