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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of epithelial to mesenchymal transition
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Accession:GO:0010719 term browser browse the term
Definition:Any process that decreases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.



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negative regulation of epithelial to mesenchymal transition term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipor1 adiponectin receptor 1 involved_in ISO (PMID:23776679) RGD PMID:23776679 NCBI chr13:45,859,461...45,879,248
Ensembl chr13:45,859,533...45,879,241
JBrowse link
G Dab2ip DAB2 interacting protein involved_in ISO
IEA
ISS
(PMID:20080667), (PMID:20154697)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:20080667 PMID:20154697 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:18,915,290...19,086,282
Ensembl chr 3:18,915,290...19,086,280
JBrowse link
G Dact3 dishevelled-binding antagonist of beta-catenin 3 acts_upstream_of_or_within ISO MGI:5515616 (MGI:5503293|PMID:23580654) RGD PMID:23580654 MGI:5503293 NCBI chr 1:77,546,900...77,558,631
Ensembl chr 1:77,546,900...77,558,630
JBrowse link
G Efna1 ephrin A1 involved_in ISO (MGI:4847981|PMID:20960543) RGD PMID:20960543 MGI:4847981 NCBI chr 2:174,681,676...174,690,306
Ensembl chr 2:174,681,682...174,690,866
JBrowse link
G Epha4 Eph receptor A4 involved_in ISO
IEA
(PMID:29093007)
GO_REF:0000107
RGD
Ensembl
PMID:29093007 GO_REF:0000107 NCBI chr 9:78,815,460...78,958,139
Ensembl chr 9:78,815,460...78,958,139
JBrowse link
G Foxa1 forkhead box A1 involved_in IEA
ISO
GO_REF:0000107
(PMID:20160041)
Ensembl
RGD
PMID:20160041 GO_REF:0000107 NCBI chr 6:75,099,907...75,136,534
Ensembl chr 6:75,103,503...75,136,188
JBrowse link
G Foxa2 forkhead box A2 involved_in IEA
ISO
GO_REF:0000107
(PMID:20160041)
Ensembl
RGD
PMID:20160041 GO_REF:0000107 NCBI chr 3:135,470,123...135,474,326
Ensembl chr 3:135,470,131...135,474,326
JBrowse link
G Gata3 GATA binding protein 3 acts_upstream_of ISO (PMID:26451614) RGD PMID:26451614 NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391
JBrowse link
G Hpn hepsin involved_in ISS
IEA
IBA
ISO
GO_REF:0000024
GO_REF:0000107
PMID:21873635
(PMID:19843851)
UniProt
Ensembl
RGD
PMID:19843851 PMID:21873635 GO_REF:0000024 GO_REF:0000107, RGD:13792537 NCBI chr 1:86,337,085...86,352,785
Ensembl chr 1:86,337,087...86,352,811
JBrowse link
G Il17rd interleukin 17 receptor D involved_in ISO (MGI:6414689|PMID:25576668) RGD PMID:25576668 MGI:6414689 NCBI chr16:2,228,467...2,295,126
Ensembl chr16:2,228,287...2,292,556
JBrowse link
G Ldlrad4 low density lipoprotein receptor class A domain containing 4 involved_in ISO (PMID:24627487) RGD PMID:24627487 NCBI chr18:61,519,253...61,848,403
Ensembl chr18:61,521,428...61,843,238
JBrowse link
G Mad2l2 mitotic arrest deficient 2 like 2 involved_in ISO (PMID:19443654) RGD PMID:19443654 NCBI chr 5:158,563,545...158,576,698
Ensembl chr 5:158,563,567...158,576,693
JBrowse link
G Mark1 microtubule affinity regulating kinase 1 involved_in ISO (PMID:31281935) RGD PMID:31281935 NCBI chr13:96,450,189...96,555,304
Ensembl chr13:96,451,487...96,555,173
JBrowse link
G Nkx2-1 NK2 homeobox 1 involved_in IEA
ISO
GO_REF:0000107
(PMID:19293183)
Ensembl
RGD
PMID:19293183 GO_REF:0000107 NCBI chr 6:73,996,601...74,001,483
Ensembl chr 6:73,996,601...73,999,791
JBrowse link
G Ovol2 ovo-like zinc finger 2 involved_in ISO (MGI:5574425|PMID:24735879), (MGI:6284898|PMID:28455959) RGD PMID:24735879 PMID:28455959 MGI:5574425 MGI:6284898 NCBI chr 3:131,677,388...131,707,844
Ensembl chr 3:131,677,391...131,708,359
JBrowse link
G Ppp2ca protein phosphatase 2 catalytic subunit alpha involved_in ISO (PMID:20080667) RGD PMID:20080667 NCBI chr10:36,358,110...36,377,864
Ensembl chr10:36,358,101...36,377,862
JBrowse link
G Pten phosphatase and tensin homolog involved_in ISO (PMID:27919618) RGD PMID:27919618 NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Sdhaf2 succinate dehydrogenase complex assembly factor 2 acts_upstream_of_or_within ISO (MGI:5529200|PMID:23983127)
(PMID:23983127)
RGD PMID:23983127 MGI:5529200 NCBI chr 1:207,139,070...207,167,830
Ensembl chr 1:207,139,112...207,168,616
JBrowse link
G Sfrp1 secreted frizzled-related protein 1 involved_in ISO
IEA
(PMID:19095296)
GO_REF:0000107
RGD
Ensembl
PMID:19095296 GO_REF:0000107 NCBI chr16:68,575,763...68,613,905
Ensembl chr16:68,575,763...68,614,286
JBrowse link
G Sfrp2 secreted frizzled-related protein 2 involved_in ISO (PMID:19095296) RGD PMID:19095296 NCBI chr 2:169,089,517...169,097,064
Ensembl chr 2:169,089,517...169,097,063
JBrowse link
G Spred1 sprouty-related, EVH1 domain containing 1 involved_in ISO (MGI:6414689|PMID:25576668) RGD PMID:25576668 MGI:6414689 NCBI chr 3:103,983,120...104,050,321
Ensembl chr 3:103,983,072...104,049,718
JBrowse link
G Spred2 sprouty-related, EVH1 domain containing 2 involved_in ISS
ISO
GO_REF:0000024
(MGI:6414689|PMID:25576668)
UniProt
RGD
PMID:25576668 GO_REF:0000024 MGI:6414689 NCBI chr14:94,226,312...94,248,162
Ensembl chr14:94,148,837...94,249,162
JBrowse link
G Spred3 sprouty-related, EVH1 domain containing 3 involved_in ISO (MGI:6414689|PMID:25576668) RGD PMID:25576668 MGI:6414689 NCBI chr 1:84,458,779...84,470,425
Ensembl chr 1:84,459,314...84,470,249
JBrowse link
G Spry1 sprouty RTK signaling antagonist 1 involved_in ISO (MGI:6414689|PMID:25576668) RGD PMID:25576668 MGI:6414689 NCBI chr 2:120,557,276...120,561,918
Ensembl chr 2:120,556,706...120,566,189
JBrowse link
G Spry2 sprouty RTK signaling antagonist 2 involved_in ISO (MGI:6414689|PMID:25576668) RGD PMID:25576668 MGI:6414689 NCBI chr15:82,692,312...82,697,408
Ensembl chr15:82,692,143...82,698,009
JBrowse link
G Tgfbr3 transforming growth factor beta receptor 3 acts_upstream_of_or_within ISO (MGI:3762085|PMID:17823118) RGD PMID:17823118 MGI:3762085 NCBI chr14:2,489,397...2,665,383
Ensembl chr14:2,489,397...2,663,341
JBrowse link
G Trim62 tripartite motif-containing 62 acts_upstream_of_or_within ISO MGI:5538538 (MGI:5585203|PMID:24890125) RGD PMID:24890125 MGI:5585203 NCBI chr 5:141,230,830...141,260,629 JBrowse link
G Tsc2 TSC complex subunit 2 IMP RGD PMID:20813961 RGD:11568680 NCBI chr10:13,621,135...13,655,773
Ensembl chr10:13,621,136...13,655,951
JBrowse link
G Usf3 upstream transcription factor family member 3 involved_in ISO (PMID:28011713) RGD PMID:28011713 NCBI chr11:56,470,738...56,529,736
Ensembl chr11:56,476,122...56,529,884
JBrowse link
G Vasn vasorin involved_in ISO (PMID:21170088) RGD PMID:21170088 NCBI chr10:10,917,750...10,928,259
Ensembl chr10:10,917,605...10,928,357
JBrowse link
G Vegfa vascular endothelial growth factor A involved_in ISO (MGI:5502250|PMID:23863481) RGD PMID:23863481 MGI:5502250 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Znf750 zinc finger protein 750 involved_in ISO (PMID:32042337) RGD PMID:32042337 NCBI chr10:106,772,162...106,781,186
Ensembl chr10:106,772,669...106,781,200
JBrowse link
negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nog noggin involved_in IEA
ISO
GO_REF:0000107
(MGI:3783944|PMID:17218603)
Ensembl
RGD
PMID:17218603 GO_REF:0000107 MGI:3783944 NCBI chr10:74,128,712...74,130,339
Ensembl chr10:74,128,712...74,130,339
JBrowse link
G Tgfb2 transforming growth factor, beta 2 involved_in ISO (MGI:3830400|PMID:19161227) RGD PMID:19161227 MGI:3830400 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
JBrowse link
negative regulation of neural crest formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fuz fuzzy planar cell polarity protein involved_in ISS
ISO
GO_REF:0000024
(MGI:5498583|PMID:23806618)
UniProt
RGD
PMID:23806618 GO_REF:0000024 MGI:5498583 NCBI chr 1:95,379,542...95,384,532
Ensembl chr 1:95,379,587...95,384,530
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19497
    multicellular organismal process 8976
      negative regulation of multicellular organismal process 1145
        negative regulation of epithelial to mesenchymal transition 35
          negative regulation of cardiac epithelial to mesenchymal transition + 2
          negative regulation of neural crest formation + 1
Path 2
Term Annotations click to browse term
  biological_process 19497
    developmental process 6889
      anatomical structure development 6306
        multicellular organism development 5727
          system development 5373
            animal organ development 4130
              mesenchyme development 301
                mesenchymal cell differentiation 242
                  epithelial to mesenchymal transition 158
                    regulation of epithelial to mesenchymal transition 97
                      negative regulation of epithelial to mesenchymal transition 35
                        negative regulation of cardiac epithelial to mesenchymal transition + 2
                        negative regulation of neural crest formation + 1
paths to the root