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ONTOLOGY REPORT - ANNOTATIONS

Term:positive regulation of epithelial to mesenchymal transition
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Accession:GO:0010718 term browser browse the term
Definition:Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.

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positive regulation of epithelial to mesenchymal transition term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor IMP RGD PMID:21743278 RGD:7243870 NCBI chr20:4,363,152...4,366,079
Ensembl chr20:4,363,152...4,366,079 		JBrowse link
G Alx1 ALX homeobox 1 involved_in ISO
ISS		 (PMID:23288509)
GO_REF:0000024		 RGD
UniProt		 PMID:23288509 GO_REF:0000024 NCBI chr 7:44,751,865...44,771,458
Ensembl chr 7:44,751,873...44,771,458 		JBrowse link
G Axin2 axin 2 involved_in ISO
IEA		 (PMID:17072303)
GO_REF:0000107		 RGD
Ensembl		 PMID:17072303 GO_REF:0000107 NCBI chr10:97,212,483...97,238,824
Ensembl chr10:97,212,432...97,239,642 		JBrowse link
G Bambi BMP and activin membrane-bound inhibitor involved_in ISO (PMID:19328798) RGD PMID:19328798 NCBI chr17:56,905,419...56,909,675
Ensembl chr17:56,905,112...56,909,992 		JBrowse link
G Bcl9l BCL9 like involved_in ISO (PMID:19328798) RGD PMID:19328798 NCBI chr 8:48,805,684...48,835,794
Ensembl chr 8:48,805,684...48,834,312 		JBrowse link
G Bmp2 bone morphogenetic protein 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:20890042)
MGI:3583785 (MGI:3611958|PMID:16314491)
GO_REF:0000107		 RGD
Ensembl		 PMID:16314491 PMID:20890042 GO_REF:0000107 MGI:3611958 NCBI chr 3:126,335,963...126,346,771
Ensembl chr 3:126,335,863...126,346,318 		JBrowse link
G Bmp4 bone morphogenetic protein 4 involved_in IEA
ISO		 GO_REF:0000107
UniProtKB:P23359 (MGI:5502250|PMID:23863481)		 Ensembl
RGD		 PMID:23863481 GO_REF:0000107 MGI:5502250 NCBI chr15:20,776,060...20,791,013
Ensembl chr15:20,776,054...20,822,740 		JBrowse link
G Bmp7 bone morphogenetic protein 7 involved_in ISO UniProtKB:P21275 (MGI:5502250|PMID:23863481) RGD PMID:23863481 MGI:5502250 NCBI chr 3:170,879,972...170,955,820
Ensembl chr 3:170,879,973...170,955,399 		JBrowse link
G Col1a1 collagen type I alpha 1 chain involved_in ISO (PMID:20018240) RGD PMID:20018240 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789 		JBrowse link
G Crb2 crumbs cell polarity complex component 2 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5296388|PMID:22072575), (MGI:5823085|PMID:27870829)		 UniProt
RGD		 PMID:22072575 PMID:27870829 GO_REF:0000024 MGI:5296388 MGI:5823085 NCBI chr 3:22,037,812...22,061,247
Ensembl chr 3:22,038,357...22,058,871 		JBrowse link
G Ctnnb1 catenin beta 1 involved_in ISO UniProtKB:Q9NX18 (PMID:23983127) RGD PMID:23983127 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372 		JBrowse link
G Dab2 DAB adaptor protein 2 involved_in IEA
ISO		 GO_REF:0000107
(MGI:5442513|PMID:15734730)		 Ensembl
RGD		 PMID:15734730 GO_REF:0000107 MGI:5442513 NCBI chr 2:55,747,353...55,768,848
Ensembl chr 2:55,747,318...55,768,270 		JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit involved_in ISO (PMID:20154697) RGD PMID:20154697 NCBI chr 4:77,284,404...77,347,011
Ensembl chr 4:77,284,404...77,347,011 		JBrowse link
G Fermt2 FERM domain containing kindlin 2 involved_in ISO
IEA		 (PMID:24226523)
GO_REF:0000107		 RGD
Ensembl		 PMID:24226523 GO_REF:0000107 NCBI chr15:19,807,806...19,876,557
Ensembl chr15:19,807,808...19,876,408 		JBrowse link
G Foxc1 forkhead box C1 involved_in ISO (PMID:22991501) RGD PMID:22991501 NCBI chr17:33,947,501...33,951,484
Ensembl chr17:33,947,506...33,951,484 		JBrowse link
G Gcnt2 glucosaminyl (N-acetyl) transferase 2 (I blood group) involved_in ISO (PMID:21750175)
(MGI:5545971|PMID:21750175)		 RGD PMID:21750175 MGI:5545971 NCBI chr17:21,634,546...21,677,477
Ensembl chr17:21,634,551...21,739,408 		JBrowse link
G Glipr2 GLI pathogenesis-related 2 involved_in ISO (PMID:23516513) RGD PMID:23516513 NCBI chr 5:59,415,415...59,446,732
Ensembl chr 5:59,416,076...59,446,647 		JBrowse link
G Hdac2 histone deacetylase 2 IMP RGD PMID:19553350 RGD:9590229 NCBI chr20:43,084,870...43,108,198
Ensembl chr20:43,084,870...43,108,198 		JBrowse link
G Il1b interleukin 1 beta involved_in IEA
ISO		 GO_REF:0000107
(PMID:25204733)		 Ensembl
RGD		 PMID:25204733 GO_REF:0000107 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il6 interleukin 6 involved_in ISO (PMID:25916550) RGD PMID:25916550 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Isl1 ISL LIM homeobox 1 involved_in IMP PMID:23270756 BHF-UCL PMID:23270756, PMID:23270756 RGD:13210526, RGD:13210526 NCBI chr 2:48,488,911...48,501,217
Ensembl chr 2:48,487,736...48,501,436 		JBrowse link
G Lef1 lymphoid enhancer binding factor 1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:20018240)		 Ensembl
RGD		 PMID:20018240 GO_REF:0000107 NCBI chr 2:236,232,115...236,345,061
Ensembl chr 2:236,233,239...236,345,056 		JBrowse link
G Loxl2 lysyl oxidase-like 2 involved_in IEA
ISO
ISS		 GO_REF:0000107
(PMID:24239292)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:24239292 GO_REF:0000024 GO_REF:0000107 NCBI chr15:51,276,022...51,365,238
Ensembl chr15:51,303,909...51,365,234 		JBrowse link
G Mdk midkine involved_in ISS
ISO		 GO_REF:0000024
(PMID:18469519)		 UniProt
RGD		 PMID:18469519 GO_REF:0000024 NCBI chr 3:80,841,003...80,843,895
Ensembl chr 3:80,841,005...80,842,916 		JBrowse link
G Mtor mechanistic target of rapamycin kinase involved_in ISO (PMID:27919618) RGD PMID:27919618 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967 		JBrowse link
G Myocd myocardin involved_in IMP PMID:23270756 BHF-UCL PMID:23270756, PMID:23270756 RGD:13210526, RGD:13210526 NCBI chr10:51,682,053...51,781,458
Ensembl chr10:51,683,540...51,778,986 		JBrowse link
G Notch1 notch receptor 1 involved_in ISO (MGI:4837019|PMID:20890042) RGD PMID:20890042 MGI:4837019 NCBI chr 3:3,905,562...3,951,015
Ensembl chr 3:3,905,453...3,951,025 		JBrowse link
G Olfm1 olfactomedin 1 involved_in ISS GO_REF:0000024 AgBase GO_REF:0000024 NCBI chr 3:6,761,031...6,798,739
Ensembl chr 3:6,773,813...6,798,737 		JBrowse link
G Pdpn podoplanin involved_in ISS
IBA
ISO		 GO_REF:0000024
PMID:21873635
(PMID:17046996), (PMID:21376833)		 UniProt
RGD		 PMID:17046996 PMID:21376833, PMID:21873635, PMID:21873635 GO_REF:0000024, RGD:13792537, RGD:13792537 NCBI chr 5:161,947,137...161,981,441
Ensembl chr 5:161,947,137...161,981,441 		JBrowse link
G Rgcc regulator of cell cycle involved_in ISO (PMID:19158077), (PMID:21307346) RGD PMID:19158077 PMID:21307346 NCBI chr15:61,551,861...61,564,695
Ensembl chr15:61,551,861...61,564,695 		JBrowse link
G Sdcbp syndecan binding protein involved_in ISO
ISS		 (PMID:25893292)
GO_REF:0000024		 RGD
UniProt		 PMID:25893292 GO_REF:0000024 NCBI chr 5:19,471,664...19,498,499
Ensembl chr 5:19,471,664...19,498,485 		JBrowse link
G Serpinb3 serpin family B member 3 involved_in ISO (PMID:20527027) RGD PMID:20527027 NCBI chr13:27,186,701...27,193,211
Ensembl chr13:27,187,130...27,192,592 		JBrowse link
G Smad2 SMAD family member 2 involved_in ISO (MGI:2683382|PMID:14691138) RGD PMID:14691138 MGI:2683382 NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078 		JBrowse link
G Smad3 SMAD family member 3 involved_in ISO (PMID:18505915), (PMID:21307346) RGD PMID:18505915 PMID:21307346 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349 		JBrowse link
G Smad4 SMAD family member 4 involved_in IEA
ISO		 GO_REF:0000107
(MGI:2683382|PMID:14691138)		 Ensembl
RGD		 PMID:14691138 GO_REF:0000107 MGI:2683382 NCBI chr18:69,626,682...69,657,373
Ensembl chr18:69,627,757...69,671,199 		JBrowse link
G Snai1 snail family transcriptional repressor 1 involved_in ISO (PMID:20018240), (PMID:23288509)
(MGI:4837019|PMID:20890042), (MGI:5548026|PMID:24239292)		 RGD PMID:20018240 PMID:20890042 PMID:23288509 PMID:24239292 MGI:4837019 MGI:5548026 NCBI chr 3:164,274,710...164,279,199
Ensembl chr 3:164,274,710...164,279,378 		JBrowse link
G Tbx20 T-box transcription factor 20 involved_in IEA
ISO		 GO_REF:0000107
(MGI:5299248|PMID:21983003)		 Ensembl
RGD		 PMID:21983003 GO_REF:0000107 MGI:5299248 NCBI chr 8:25,849,394...25,904,570
Ensembl chr 8:25,850,962...25,904,570 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 acts_upstream_of_or_within
involved_in		 ISS
ISO		 GO_REF:0000024
(MGI:3821807|PMID:18794329)
(PMID:17999987), (PMID:18505915)		 UniProt
RGD		 PMID:17999987 PMID:18505915 PMID:18794329 GO_REF:0000024 MGI:3821807 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199 		JBrowse link
G Tgfb1i1 transforming growth factor beta 1 induced transcript 1 involved_in ISO (PMID:18762808) RGD PMID:18762808 NCBI chr 1:199,664,039...199,670,970
Ensembl chr 1:199,664,173...199,670,961 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 involved_in ISS
ISO		 GO_REF:0000024
(PMID:17999987), (PMID:18505915)		 AgBase
RGD
UniProt		 PMID:17999987 PMID:18505915 GO_REF:0000024 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030 		JBrowse link
G Tgfb3 transforming growth factor, beta 3 involved_in ISS
ISO		 GO_REF:0000024
(MGI:2683382|PMID:14691138)
(PMID:18505915), (PMID:18718461)		 AgBase
RGD		 PMID:14691138 PMID:18505915 PMID:18718461 GO_REF:0000024 MGI:2683382 NCBI chr 6:109,913,757...109,936,217
Ensembl chr 6:109,913,757...109,935,533 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 involved_in ISO UniProtKB:P10600 (MGI:3820811|PMID:18718461) RGD PMID:18718461 MGI:3820811 NCBI chr 5:63,056,071...63,119,635
Ensembl chr 5:63,050,758...63,119,635 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 involved_in ISO (PMID:26459119) RGD PMID:26459119 NCBI chr 8:124,310,288...124,399,345
Ensembl chr 8:124,312,754...124,399,494 		JBrowse link
G Twist1 twist family bHLH transcription factor 1 involved_in ISO (PMID:18297062)
(MGI:4838344|PMID:20804746), (MGI:5284765|PMID:18297062), (MGI:5284780|PMID:17332324)		 RGD PMID:17332324 PMID:18297062 PMID:20804746 MGI:4838344 MGI:5284765 MGI:5284780 NCBI chr 6:53,401,241...53,403,235
Ensembl chr 6:53,401,109...53,403,214 		JBrowse link
G Wwtr1 WW domain containing transcription regulator 1 involved_in ISO (PMID:18227151) RGD PMID:18227151 NCBI chr 2:147,577,149...147,693,033
Ensembl chr 2:147,577,089...147,693,082 		JBrowse link
G Zfp703 zinc finger protein 703 involved_in ISO (MGI:4940410|PMID:21317240) RGD PMID:21317240 MGI:4940410 NCBI chr16:69,237,857...69,242,028
Ensembl chr16:69,237,857...69,242,028 		JBrowse link
canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctnnb1 catenin beta 1 involved_in ISO
ISS		 (PMID:17072303)
GO_REF:0000024		 RGD
UniProt		 PMID:17072303 GO_REF:0000024 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372 		JBrowse link
G Tcf7l2 transcription factor 7 like 2 involved_in ISO (PMID:17072303) RGD PMID:17072303 NCBI chr 1:276,686,911...276,730,517
Ensembl chr 1:276,659,542...276,730,514
Ensembl chr 1:276,659,542...276,730,514 		JBrowse link
positive regulation of cardiac epithelial to mesenchymal transition term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Jag1 jagged canonical Notch ligand 1 involved_in IGI PMID:20951801 BHF-UCL PMID:20951801, PMID:20951801 RGD:13601997, RGD:13601997 NCBI chr 3:130,079,361...130,114,781
Ensembl chr 3:130,079,361...130,114,770 		JBrowse link
G Notch1 notch receptor 1 involved_in IGI PMID:20951801 BHF-UCL PMID:20951801, PMID:20951801 RGD:13601997, RGD:13601997 NCBI chr 3:3,905,562...3,951,015
Ensembl chr 3:3,905,453...3,951,025 		JBrowse link
positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Twist1 twist family bHLH transcription factor 1 involved_in ISO (MGI:4838344|PMID:20804746) RGD PMID:20804746 MGI:4838344 NCBI chr 6:53,401,241...53,403,235
Ensembl chr 6:53,401,109...53,403,214 		JBrowse link
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr1 activin A receptor type 1 involved_in IEA
ISO		 GO_REF:0000107
(MGI:3610266|PMID:16140292)		 Ensembl
RGD		 PMID:16140292 GO_REF:0000107 MGI:3610266 NCBI chr 3:44,432,476...44,539,680
Ensembl chr 3:44,432,471...44,522,930 		JBrowse link
G Eng endoglin involved_in ISO (MGI:4368063|PMID:19703439) RGD PMID:19703439 MGI:4368063 NCBI chr 3:11,679,530...11,717,486
Ensembl chr 3:11,679,530...11,717,485 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 involved_in ISO (MGI:3830400|PMID:19161227) RGD PMID:19161227 MGI:3830400 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 involved_in ISO (MGI:3820811|PMID:18718461) RGD PMID:18718461 MGI:3820811 NCBI chr 5:63,056,071...63,119,635
Ensembl chr 5:63,050,758...63,119,635 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 involved_in ISO (MGI:3801267|PMID:17050629) RGD PMID:17050629 MGI:3801267 NCBI chr 8:124,310,288...124,399,345
Ensembl chr 8:124,312,754...124,399,494 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20082
    multicellular organismal process 9081
      positive regulation of multicellular organismal process 1662
        positive regulation of epithelial to mesenchymal transition 50
          canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition 2
          positive regulation of cardiac epithelial to mesenchymal transition + 8
          positive regulation of mesodermal to mesenchymal transition involved in gastrulation 0
          positive regulation of neural crest formation + 0
Path 2
Term Annotations click to browse term
  biological_process 20082
    developmental process 6853
      anatomical structure development 6313
        multicellular organism development 5789
          system development 5317
            animal organ development 4068
              mesenchyme development 298
                mesenchymal cell differentiation 238
                  epithelial to mesenchymal transition 156
                    regulation of epithelial to mesenchymal transition 98
                      positive regulation of epithelial to mesenchymal transition 50
                        canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition 2
                        positive regulation of cardiac epithelial to mesenchymal transition + 8
                        positive regulation of mesodermal to mesenchymal transition involved in gastrulation 0
                        positive regulation of neural crest formation + 0
paths to the root