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ONTOLOGY REPORT - ANNOTATIONS

Term:positive regulation of epithelial to mesenchymal transition
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Accession:GO:0010718 term browser browse the term
Definition:Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.


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positive regulation of epithelial to mesenchymal transition term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam8 ADAM metallopeptidase domain 8 involved_in IEA
ISO		 GO_REF:0000107
(MGI:7444872|PMID:34615811)		 Ensembl
RGD		 PMID:34615811 GO_REF:0000107 MGI:7444872 NCBI chr 1:194,776,559...194,789,330
Ensembl chr 1:194,770,060...194,788,801 		JBrowse link
G Ager advanced glycosylation end product-specific receptor IMP RGD PMID:21743278 RGD:7243870 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G Agt angiotensinogen involved_in ISS
ISO		 GO_REF:0000024
(MGI:7444872|PMID:34615811)		 UniProt
RGD		 PMID:34615811 GO_REF:0000024 MGI:7444872 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Alx1 ALX homeobox 1 involved_in ISO
ISS		 (PMID:23288509)
GO_REF:0000024		 RGD
UniProt		 PMID:23288509 GO_REF:0000024 NCBI chr 7:38,157,626...38,177,220
Ensembl chr 7:38,147,117...38,177,220 		JBrowse link
G Axin2 axin 2 involved_in ISO
IEA		 (PMID:17072303)
GO_REF:0000107		 RGD
Ensembl		 PMID:17072303 GO_REF:0000107 NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231 		JBrowse link
G Bambi BMP and activin membrane-bound inhibitor involved_in ISO (PMID:19328798) RGD PMID:19328798 NCBI chr17:54,121,251...54,125,816
Ensembl chr17:54,121,255...54,126,060 		JBrowse link
G Bcl9l BCL9 like involved_in ISO (PMID:19328798) RGD PMID:19328798 NCBI chr 8:44,811,977...44,840,611
Ensembl chr 8:44,811,977...44,840,611 		JBrowse link
G Bmp2 bone morphogenetic protein 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:20890042)
MGI:3583785 (MGI:3611958|PMID:16314491)		 Ensembl
RGD		 PMID:16314491 PMID:20890042 GO_REF:0000107 MGI:3611958 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397 		JBrowse link
G Bmp4 bone morphogenetic protein 4 involved_in IEA
ISO		 GO_REF:0000107
UniProtKB:P23359 (MGI:5502250|PMID:23863481)		 Ensembl
RGD		 PMID:23863481 GO_REF:0000107 MGI:5502250 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306 		JBrowse link
G Bmp7 bone morphogenetic protein 7 involved_in ISO UniProtKB:P21275 (MGI:5502250|PMID:23863481) RGD PMID:23863481 MGI:5502250 NCBI chr 3:161,639,915...161,716,938
Ensembl chr 3:161,516,462...161,716,788 		JBrowse link
G Col1a1 collagen type I alpha 1 chain involved_in ISO (PMID:20018240) RGD PMID:20018240 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Crb2 crumbs cell polarity complex component 2 involved_in ISO
ISS		 (MGI:5296388|PMID:22072575), (MGI:5823085|PMID:27870829)
GO_REF:0000024		 RGD
CAFA		 PMID:22072575 PMID:27870829 GO_REF:0000024 MGI:5296388 MGI:5823085 NCBI chr 3:21,542,138...21,564,876
Ensembl chr 3:21,542,221...21,563,294 		JBrowse link
G Ctnnb1 catenin beta 1 acts_upstream_of_or_within ISO UniProtKB:Q9NX18 (PMID:23983127) RGD PMID:23983127 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Dab2 DAB adaptor protein 2 involved_in IEA
ISO		 GO_REF:0000107
(PMID:15734730)
(MGI:5442513|PMID:15734730)		 Ensembl
RGD		 PMID:15734730 GO_REF:0000107 MGI:5442513 NCBI chr 2:55,514,692...55,567,476
Ensembl chr 2:55,514,700...55,567,476 		JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit involved_in ISO (PMID:20154697) RGD PMID:20154697 NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362 		JBrowse link
G Fermt2 FERM domain containing kindlin 2 involved_in ISO (PMID:24226523) RGD PMID:24226523 NCBI chr15:18,682,927...18,751,959
Ensembl chr15:18,682,927...18,751,811 		JBrowse link
G Foxc1 forkhead box C1 involved_in ISO (PMID:22991501) RGD PMID:22991501 NCBI chr17:32,631,379...32,635,361
Ensembl chr17:32,633,142...32,634,803 		JBrowse link
G Gcnt2 glucosaminyl (N-acetyl) transferase 2 involved_in ISO (PMID:21750175)
(MGI:5545971|PMID:21750175)		 RGD PMID:21750175 MGI:5545971 NCBI chr17:23,796,859...23,901,625
NCBI chr17:23,866,602...23,868,691
Ensembl chr17:23,796,859...23,901,611 		JBrowse link
G Glipr2 GLI pathogenesis-related 2 involved_in ISO (PMID:23516513) RGD PMID:23516513 NCBI chr 5:58,170,417...58,200,947
Ensembl chr 5:58,170,425...58,202,272 		JBrowse link
G Hdac2 histone deacetylase 2 IMP RGD PMID:19553350 RGD:9590229 NCBI chr20:40,548,250...40,571,609
Ensembl chr20:40,548,250...40,571,609 		JBrowse link
G Il1b interleukin 1 beta involved_in ISO (PMID:25204733) RGD PMID:25204733 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 involved_in ISO (PMID:25916550) RGD PMID:25916550 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Isl1 ISL LIM homeobox 1 involved_in IMP PMID:23270756 BHF-UCL
RGD		 PMID:23270756 PMID:23270756 RGD:13210526, RGD:13210526 NCBI chr 2:48,079,412...48,090,704
Ensembl chr 2:48,080,522...48,095,584 		JBrowse link
G Lef1 lymphoid enhancer binding factor 1 involved_in ISO (PMID:20018240) RGD PMID:20018240 NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794 		JBrowse link
G Loxl2 lysyl oxidase-like 2 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:24239292)		 UniProt
Ensembl
RGD		 PMID:24239292 GO_REF:0000024 GO_REF:0000107 NCBI chr15:44,683,449...44,773,067
Ensembl chr15:44,683,880...44,773,067 		JBrowse link
G Lrg1 leucine-rich alpha-2-glycoprotein 1 involved_in ISO (PMID:32887674) RGD PMID:32887674 NCBI chr 9:947,516...949,773
Ensembl chr 9:947,516...949,813 		JBrowse link
G Mad2l2 mitotic arrest deficient 2 like 2 IMP TGFb1 RGD PMID:27488450 RGD:152995505 NCBI chr 5:158,563,545...158,576,698
Ensembl chr 5:158,563,567...158,576,693 		JBrowse link
G Mdk midkine involved_in ISO
ISS		 (PMID:18469519)
GO_REF:0000024		 RGD
UniProt		 PMID:18469519 GO_REF:0000024 NCBI chr 3:77,901,156...77,903,997
Ensembl chr 3:77,901,158...77,903,130 		JBrowse link
G Mir21 microRNA 21 involved_in ISO (PMID:24887517) RGD PMID:24887517 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
G Mir221 microRNA 221 involved_in ISO RNAcentral:URS00002C6949_9606 (PMID:21673316) RGD PMID:21673316 NCBI chr  X:3,429,465...3,429,573
Ensembl chr  X:3,429,465...3,429,573 		JBrowse link
G Mir222 microRNA 222 involved_in ISO RNAcentral:URS0000170CF4_9606 (PMID:21673316) RGD PMID:21673316 NCBI chr  X:3,428,904...3,429,006
Ensembl chr  X:3,428,904...3,429,006 		JBrowse link
G Mtor mechanistic target of rapamycin kinase involved_in ISO (PMID:27919618) RGD PMID:27919618 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Myocd myocardin involved_in IMP PMID:23270756 BHF-UCL PMID:23270756 RGD:13210526 NCBI chr10:49,833,219...49,928,806
Ensembl chr10:49,836,641...49,927,627 		JBrowse link
G Notch1 notch receptor 1 involved_in ISO (MGI:4837019|PMID:20890042) RGD PMID:20890042 MGI:4837019 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531 		JBrowse link
G Olfm1 olfactomedin 1 involved_in ISS GO_REF:0000024 AgBase GO_REF:0000024 NCBI chr 3:11,520,522...11,558,240
Ensembl chr 3:11,520,729...11,558,239 		JBrowse link
G Pdpn podoplanin involved_in ISS
IBA
ISO		 GO_REF:0000024
PMID:21873635
(PMID:17046996), (PMID:21376833)		 UniProt
RGD		 PMID:17046996 PMID:21376833 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 5:155,601,691...155,635,656
Ensembl chr 5:155,601,691...155,635,656 		JBrowse link
G Ptk2 protein tyrosine kinase 2 involved_in ISO RNAcentral:URS000060A1F4_9606 (PMID:26944318) RGD PMID:26944318 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783 		JBrowse link
G Rgcc regulator of cell cycle involved_in ISO (PMID:19158077), (PMID:21307346) RGD PMID:19158077 PMID:21307346 NCBI chr15:54,662,483...54,675,320
Ensembl chr15:54,662,483...54,681,141 		JBrowse link
G Sdcbp syndecan binding protein involved_in ISO
ISS		 (PMID:25893292)
GO_REF:0000024		 RGD
UniProt		 PMID:25893292 GO_REF:0000024 NCBI chr 5:19,473,499...19,517,188
Ensembl chr 5:19,489,961...19,527,572 		JBrowse link
G Serpinb3 serpin family B member 3 involved_in ISO (PMID:20527027) RGD PMID:20527027 NCBI chr13:23,274,120...23,280,082
Ensembl chr13:23,274,484...23,313,682 		JBrowse link
G Smad2 SMAD family member 2 involved_in ISO (MGI:2683382|PMID:14691138) RGD PMID:14691138 MGI:2683382 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323 		JBrowse link
G Smad3 SMAD family member 3 involved_in ISO (PMID:18505915), (PMID:21307346) RGD PMID:18505915 PMID:21307346 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
G Smad4 SMAD family member 4 involved_in IEA
ISO		 GO_REF:0000107
(MGI:2683382|PMID:14691138)		 Ensembl
RGD		 PMID:14691138 GO_REF:0000107 MGI:2683382 NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438 		JBrowse link
G Snai1 snail family transcriptional repressor 1 involved_in ISO (PMID:20018240), (PMID:23288509)
(MGI:4837019|PMID:20890042), (MGI:5548026|PMID:24239292)		 RGD PMID:20018240 PMID:20890042 PMID:23288509 PMID:24239292 MGI:4837019 MGI:5548026 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969 		JBrowse link
G Tbx20 T-box transcription factor 20 involved_in ISO (MGI:5299248|PMID:21983003) RGD PMID:21983003 MGI:5299248 NCBI chr 8:23,200,104...23,258,218
Ensembl chr 8:23,204,507...23,258,175 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 involved_in
acts_upstream_of_or_within		 ISO
ISS		 (PMID:17999987), (PMID:18505915)
(MGI:3821807|PMID:18794329)
GO_REF:0000024		 RGD
UniProt		 PMID:17999987 PMID:18505915 PMID:18794329 GO_REF:0000024 MGI:3821807 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tgfb1i1 transforming growth factor beta 1 induced transcript 1 involved_in ISO (PMID:18762808) RGD PMID:18762808 NCBI chr 1:182,828,553...182,835,465
Ensembl chr 1:182,828,544...182,837,080 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 involved_in ISS
ISO		 GO_REF:0000024
(PMID:17999987), (PMID:18505915)		 AgBase
RGD		 PMID:17999987 PMID:18505915 GO_REF:0000024 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405 		JBrowse link
G Tgfb3 transforming growth factor, beta 3 involved_in ISS
ISO		 GO_REF:0000024
(MGI:2683382|PMID:14691138)
(PMID:18505915), (PMID:18718461)		 AgBase
RGD		 PMID:14691138 PMID:18505915 PMID:18718461 GO_REF:0000024 MGI:2683382 NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 involved_in ISO UniProtKB:P10600 (MGI:3820811|PMID:18718461) RGD PMID:18718461 MGI:3820811 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 involved_in ISO (PMID:26459119) RGD PMID:26459119 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228 		JBrowse link
G Twist1 twist family bHLH transcription factor 1 involved_in ISO (PMID:18297062)
(MGI:4838344|PMID:20804746), (MGI:5284765|PMID:18297062), (MGI:5284780|PMID:17332324)		 RGD PMID:17332324 PMID:18297062 PMID:20804746 MGI:4838344 MGI:5284765 MGI:5284780 NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653 		JBrowse link
G Wwtr1 WW domain containing transcription regulator 1 involved_in ISO (PMID:18227151) RGD PMID:18227151 NCBI chr 2:141,651,159...141,766,919
Ensembl chr 2:141,648,108...141,766,968 		JBrowse link
G Zfp703 zinc finger protein 703 involved_in ISO (MGI:4940410|PMID:21317240) RGD PMID:21317240 MGI:4940410 NCBI chr16:65,076,507...65,080,677
Ensembl chr16:65,076,507...65,080,677 		JBrowse link
canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctnnb1 catenin beta 1 involved_in ISO
IEA
ISS		 (PMID:17072303)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:17072303 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Tcf7l2 transcription factor 7 like 2 involved_in ISO (PMID:17072303) RGD PMID:17072303 NCBI chr 1:254,785,956...254,978,967
Ensembl chr 1:254,786,091...254,978,967 		JBrowse link
positive regulation of cardiac epithelial to mesenchymal transition term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Emp2 epithelial membrane protein 2 involved_in ISS
ISO		 GO_REF:0000024
(MGI:6443292|PMID:30773261)		 UniProt
RGD		 PMID:30773261 GO_REF:0000024 MGI:6443292 NCBI chr10:5,360,073...5,394,734
Ensembl chr10:5,360,073...5,394,733 		JBrowse link
G Jag1 jagged canonical Notch ligand 1 involved_in IGI PMID:20951801 BHF-UCL PMID:20951801 RGD:13601997 NCBI chr 3:124,406,794...124,442,220
Ensembl chr 3:124,406,794...124,442,209 		JBrowse link
G Notch1 notch receptor 1 involved_in IGI PMID:20951801 BHF-UCL PMID:20951801 RGD:13601997 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 involved_in ISO (MGI:5300829|PMID:22186728) RGD PMID:22186728 MGI:5300829 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405 		JBrowse link
positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Twist1 twist family bHLH transcription factor 1 involved_in ISO (MGI:4838344|PMID:20804746) RGD PMID:20804746 MGI:4838344 NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653 		JBrowse link
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr1 activin A receptor type 1 involved_in ISO (MGI:3610266|PMID:16140292) RGD PMID:16140292 MGI:3610266 NCBI chr 3:42,978,558...43,097,892
Ensembl chr 3:42,978,561...43,098,241 		JBrowse link
G Eng endoglin involved_in ISO (MGI:4368063|PMID:19703439) RGD PMID:19703439 MGI:4368063 NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 involved_in ISO (MGI:3830400|PMID:19161227) RGD PMID:19161227 MGI:3830400 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 involved_in ISO (MGI:3820811|PMID:18718461) RGD PMID:18718461 MGI:3820811 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 involved_in ISO (MGI:3801267|PMID:17050629) RGD PMID:17050629 MGI:3801267 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19738
    multicellular organismal process 9179
      positive regulation of multicellular organismal process 1869
        positive regulation of epithelial to mesenchymal transition 59
          canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition 2
          positive regulation of cardiac epithelial to mesenchymal transition + 9
          positive regulation of mesodermal to mesenchymal transition involved in gastrulation 0
          positive regulation of neural crest formation + 0
Path 2
Term Annotations click to browse term
  biological_process 19738
    developmental process 6867
      anatomical structure development 6387
        tissue development 2241
          mesenchyme development 328
            mesenchymal cell differentiation 263
              epithelial to mesenchymal transition 175
                regulation of epithelial to mesenchymal transition 112
                  positive regulation of epithelial to mesenchymal transition 59
                    canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition 2
                    positive regulation of cardiac epithelial to mesenchymal transition + 9
                    positive regulation of mesodermal to mesenchymal transition involved in gastrulation 0
                    positive regulation of neural crest formation + 0
paths to the root