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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of lamellipodium assembly
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Accession:GO:0010591 term browser browse the term
Definition:Any process that modulates the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell.
Synonyms:related_synonym: regulation of lamellipodium biogenesis


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regulation of lamellipodium assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdc42 cell division cycle 42 involved_in ISO (PMID:8625410) CAFA PMID:8625410 NCBI chrNW_004936474:7,556,765...7,598,687 JBrowse link
G Dmtn dematin actin binding protein involved_in ISO (PMID:10565303) UniProt PMID:10565303 NCBI chrNW_004936555:5,884,746...5,911,171 JBrowse link
G Epha2 EPH receptor A2 involved_in ISO (PMID:19573808) UniProt PMID:19573808 NCBI chrNW_004936474:3,648,395...3,673,856 JBrowse link
G Fer FER tyrosine kinase involved_in ISO (PMID:19738202) UniProt PMID:19738202 NCBI chrNW_004936531:3,512,976...3,898,885 JBrowse link
G Rac1 Rac family small GTPase 1 involved_in ISO (PMID:8625410) CAFA PMID:8625410 NCBI chrNW_004936750:107,689...122,679 JBrowse link
G Was WASP actin nucleation promoting factor involved_in ISO (PMID:8625410) CAFA PMID:8625410 NCBI chrNW_004936721:634,685...641,248 JBrowse link
negative regulation of lamellipodium assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abi3 ABI family member 3 involved_in ISO (MGI:6508508|PMID:26428302) ARUK-UCL PMID:26428302 MGI:6508508 NCBI chrNW_004936490:12,280,717...12,290,602 JBrowse link
G Cfl1 cofilin 1 ISO RGD PMID:24093776 RGD:11570550 NCBI chrNW_004936599:3,678,724...3,682,314 JBrowse link
G Hrg histidine rich glycoprotein involved_in ISO (PMID:16489009) UniProt PMID:16489009 NCBI chrNW_004936578:3,285,986...3,295,876 JBrowse link
G Plxnb3 plexin B3 involved_in ISO PMID:20696765 UniProt PMID:20696765 RGD:8554409 NCBI chrNW_004936809:645,569...659,850 JBrowse link
G Slit2 slit guidance ligand 2 involved_in ISO (PMID:16439689) UniProt PMID:16439689 NCBI chrNW_004936477:8,111,212...8,448,567 JBrowse link
positive regulation of lamellipodium assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abi2 abl interactor 2 involved_in ISO (PMID:21107423) ARUK-UCL PMID:21107423 NCBI chrNW_004936631:30,109...101,748 JBrowse link
G Actr2 actin related protein 2 involved_in ISO (PMID:29058690) UniProt PMID:29058690 NCBI chrNW_004936491:9,980,228...10,021,417 JBrowse link
G Actr3 actin related protein 3 involved_in ISO (PMID:29058690) RGD
UniProt
PMID:18256280 PMID:29058690 RGD:2306202 NCBI chrNW_004936469:55,639,345...55,699,330 JBrowse link
G Akirin1 akirin 1 involved_in ISO (MGI:3850794|PMID:19406121) UniProt PMID:19406121 MGI:3850794 NCBI chrNW_004936474:20,975,401...20,992,184 JBrowse link
G Aqp1 aquaporin 1 (Colton blood group) ISO RGD PMID:19539607 RGD:2316079 NCBI chrNW_004936478:7,146,997...7,160,369 JBrowse link
G Arpc2 actin related protein 2/3 complex subunit 2 involved_in ISO (PMID:18560548) RGD
UniProt
PMID:15252126 PMID:18560548 RGD:2306210 NCBI chrNW_004936569:758,358...786,995 JBrowse link
G Atp7a ATPase copper transporting alpha ISO RGD PMID:20671235 RGD:11341707 NCBI chrNW_004936683:2,874,022...2,936,214 JBrowse link
G Auts2 activator of transcription and developmental regulator AUTS2 involved_in ISO (MGI:5908783|PMID:25533347) UniProt PMID:25533347 MGI:5908783 NCBI chrNW_004936543:5,146,961...6,187,634 JBrowse link
G Avil advillin involved_in ISO (PMID:29058690) UniProt PMID:29058690 NCBI chrNW_004936646:1,930,447...1,952,069 JBrowse link
G Brk1 BRICK1 subunit of SCAR/WAVE actin nucleating complex involved_in ISO (PMID:21107423)
(PMID:18560548)
ARUK-UCL
UniProt
PMID:18560548 PMID:21107423 NCBI chrNW_004936602:3,147,773...3,155,739 JBrowse link
G Carmil2 capping protein regulator and myosin 1 linker 2 involved_in ISO (PMID:26466680) UniProt PMID:26466680 NCBI chrNW_004936475:18,036,233...18,049,144 JBrowse link
G Cdc42 cell division cycle 42 involved_in ISO (PMID:8625410) CAFA PMID:8625410 NCBI chrNW_004936474:7,556,765...7,598,687 JBrowse link
G Cfl1 cofilin 1 ISO RGD PMID:15252126 RGD:2306210 NCBI chrNW_004936599:3,678,724...3,682,314 JBrowse link
G Clrn1 clarin 1 acts_upstream_of_or_within ISO (PMID:19423712) MGI PMID:19423712 NCBI chrNW_004936758:1,250,831...1,286,016 JBrowse link
G Cyfip1 cytoplasmic FMR1 interacting protein 1 involved_in ISO (PMID:21107423) ARUK-UCL PMID:21107423 NCBI chrNW_004936471:38,264,455...38,331,995 JBrowse link
G Dnm2 dynamin 2 ISO RGD PMID:14617821 RGD:9685179 NCBI chrNW_004936659:957,408...1,046,393 JBrowse link
G Frmd7 FERM domain containing 7 acts_upstream_of_or_within ISO (MGI:5546532|PMID:23967341) MGI PMID:23967341 MGI:5546532 NCBI chrNW_004936691:2,664,968...2,756,300 JBrowse link
G Fscn1 fascin actin-bundling protein 1 involved_in ISO (PMID:9571235) UniProt PMID:9571235 NCBI chrNW_004936765:609,894...619,417 JBrowse link
G Hdac4 histone deacetylase 4 ISO RGD PMID:24166750 RGD:9681442 NCBI chrNW_004936745:1,730,743...1,942,071 JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 ISO RGD PMID:15302889 RGD:2316937 NCBI chrNW_004936835:316,767...321,999 JBrowse link
G Mstn myostatin involved_in ISO (MGI:3850794|PMID:19406121) UniProt PMID:19406121 MGI:3850794 NCBI chrNW_004936506:7,988,879...7,996,260 JBrowse link
G Mtor mechanistic target of rapamycin kinase acts_upstream_of_or_within ISO (MGI:3510095|PMID:15467718) MGI PMID:15467718 MGI:3510095 NCBI chrNW_004936474:158,376...282,310 JBrowse link
G Nckap1 NCK associated protein 1 involved_in ISO (PMID:21107423)
(MGI:5897521|PMID:27927633)
(PMID:18560548)
ARUK-UCL
BHF-UCL
UniProt
PMID:18560548 PMID:21107423 PMID:27927633 MGI:5897521 NCBI chrNW_004936509:11,525,764...11,624,833 JBrowse link
G Ocln occludin involved_in ISO (PMID:20152177) ARUK-UCL PMID:20152177 NCBI chrNW_004936480:99,516...152,834 JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 involved_in ISO (MGI:6450670|PMID:11038173) BHF-UCL PMID:11038173 MGI:6450670 NCBI chrNW_004936480:1,188,408...1,273,210 JBrowse link
G Plce1 phospholipase C epsilon 1 involved_in ISO (PMID:29058690) UniProt PMID:29058690 NCBI chrNW_004936601:817,151...1,105,824 JBrowse link
G Rac1 Rac family small GTPase 1 acts_upstream_of_or_within
involved_in
ISO (PMID:15467718)
(PMID:19625648), (PMID:8625410)
RGD
MGI
UniProt
PMID:8625410 PMID:12105187 PMID:15467718 PMID:19625648 RGD:1299247 NCBI chrNW_004936750:107,689...122,679 JBrowse link
G Rac2 Rac family small GTPase 2 involved_in ISO (PMID:19625648)
(MGI:4355276|PMID:19625648)
UniProt PMID:19625648 MGI:4355276 NCBI chrNW_004936492:3,726,375...3,737,961 JBrowse link
G Wasf2 WASP family member 2 involved_in ISO (PMID:18560548), (PMID:21107423) UniProt PMID:18560548 PMID:21107423 NCBI chrNW_004936474:11,711,582...11,736,154 JBrowse link
G Wnt1 Wnt family member 1 involved_in ISO (PMID:19756656) BHF-UCL PMID:19756656 NCBI chrNW_004936512:6,781,001...6,785,358 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12300
    cellular process 11489
      regulation of cellular process 8135
        regulation of cellular component biogenesis 951
          regulation of cell projection assembly 219
            regulation of plasma membrane bounded cell projection assembly 216
              regulation of lamellipodium assembly 38
                negative regulation of lamellipodium assembly 5
                positive regulation of lamellipodium assembly 30
Path 2
Term Annotations click to browse term
  biological_process 12300
    cellular process 11489
      cellular component organization or biogenesis 4986
        cellular component organization 4903
          cell projection organization 1547
            plasma membrane bounded cell projection organization 1531
              lamellipodium organization 91
                lamellipodium assembly 71
                  regulation of lamellipodium assembly 38
                    negative regulation of lamellipodium assembly 5
                    positive regulation of lamellipodium assembly 30
paths to the root