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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of double-strand break repair via homologous recombination
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Accession:GO:0010569 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of the error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences.


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regulation of double-strand break repair via homologous recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CHEK1 checkpoint kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:52,759,224...52,790,878
Ensembl chr 9:52,753,528...52,790,700 		JBrowse link
G FIGNL1 fidgetin like 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:136,484,217...136,488,262
Ensembl chr 9:136,484,216...136,488,250 		JBrowse link
G KDM1A lysine demethylase 1A acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:24217620) MGI
Ensembl		 PMID:24217620 GO_REF:0000107 NCBI chr 6:80,903,407...80,971,875
Ensembl chr 6:80,903,424...80,971,873 		JBrowse link
G PPP4C protein phosphatase 4 catalytic subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:18,262,817...18,271,588
Ensembl chr 3:18,262,823...18,271,586 		JBrowse link
G PPP4R2 protein phosphatase 4 regulatory subunit 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:54,324,978...54,378,277
Ensembl chr13:54,324,998...54,378,276 		JBrowse link
G RAD51 RAD51 recombinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:130,592,414...130,640,326
Ensembl chr 1:130,586,665...130,640,136 		JBrowse link
G RAD51AP1 RAD51 associated protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:65,872,277...65,897,210
Ensembl chr 5:65,872,539...65,897,212 		JBrowse link
G RPA2 replication protein A2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:85,032,604...85,045,899
Ensembl chr 6:85,031,582...85,045,915 		JBrowse link
G RTEL1 regulator of telomere elongation helicase 1 involved_in IEA UniProt
TreeGrafter
Ensembl		 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 NCBI chr17:62,611,844...62,636,628
Ensembl chr17:62,611,909...62,634,690 		JBrowse link
G SETD2 SET domain containing 2, histone lysine methyltransferase involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:29,884,708...29,996,285
Ensembl chr13:29,884,719...29,996,359 		JBrowse link
G SHLD2 shieldin complex subunit 2 involved_in IBA
IEA		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr14:88,005,599...88,121,155
Ensembl chr14:88,005,611...88,121,352 		JBrowse link
G SIRT6 sirtuin 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:74,568,539...74,577,774
Ensembl chr 2:74,568,493...74,577,772 		JBrowse link
G SPIDR scaffold protein involved in DNA repair involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:79,874,937...80,190,744
Ensembl chr 4:79,874,831...80,190,655 		JBrowse link
G TERF2IP TERF2 interacting protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:12,047,409...12,057,451
Ensembl chr 6:12,014,243...12,057,448 		JBrowse link
G TEX15 testis expressed 15, meiosis and synapsis associated involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18283110) InterPro
MGI
TreeGrafter		 PMID:18283110 GO_REF:0000002 GO_REF:0000118 NCBI chr15:54,210,139...54,277,609 JBrowse link
G TRAPPC13 trafficking protein particle complex subunit 13 involved_in IEA InterPro GO_REF:0000002 NCBI chr16:44,146,574...44,186,346
Ensembl chr16:44,156,163...44,184,662 		JBrowse link
G USP51 ubiquitin specific peptidase 51 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:48,047,658...48,051,941
Ensembl chr  X:48,048,223...48,050,355 		JBrowse link
G ZNF365 zinc finger protein 365 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr14:65,861,398...65,888,341
Ensembl chr14:65,861,564...65,888,335 		JBrowse link
negative regulation of double-strand break repair via homologous recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:270,761,641...270,906,708
Ensembl chr 1:270,761,668...270,906,708 		JBrowse link
G C1QBP complement C1q binding protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:51,548,361...51,553,076
Ensembl chr12:51,548,415...51,555,689 		JBrowse link
G CGAS cyclic GMP-AMP synthase involved_in ISS
IBA
IEA		 UniProt
GO_Central
TreeGrafter		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000118 NCBI chr 1:92,483,253...92,500,376
Ensembl chr 1:92,483,327...92,504,307 		JBrowse link
G CSNK2A1 casein kinase 2 alpha 1 involved_in ISO (PMID:28512243) UniProt PMID:28512243 NCBI chr17:34,692,960...34,748,067 JBrowse link
G FANCB FA complementation group B involved_in
acts_upstream_of_or_within		 IBA
ISO
IEA		 (PMID:25520194) GO_Central
MGI
TreeGrafter		 PMID:25520194 GO_REF:0000033 GO_REF:0000118 NCBI chr  X:11,386,360...11,408,958
Ensembl chr  X:11,384,912...11,409,057 		JBrowse link
G FBH1 F-box DNA helicase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:65,060,714...65,108,975
Ensembl chr10:65,060,312...65,108,379 		JBrowse link
G HELB DNA helicase B involved_in IEA
IBA		 Ensembl
TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 5:30,645,378...30,696,488
Ensembl chr 5:30,645,656...30,697,232 		JBrowse link
G KAT5 lysine acetyltransferase 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:6,560,544...6,572,461
Ensembl chr 2:6,560,513...6,572,466 		JBrowse link
G KLHL15 kelch like family member 15 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:20,088,208...20,130,452
Ensembl chr  X:20,091,904...20,129,561 		JBrowse link
G KMT5A lysine methyltransferase 5A involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:29,523,102...29,543,522
Ensembl chr14:29,523,105...29,543,493 		JBrowse link
G MAD2L2 mitotic arrest deficient 2 like 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:71,773,680...71,779,192
Ensembl chr 6:71,773,682...71,779,183 		JBrowse link
G MAGEF1 MAGE family member F1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:122,600,984...122,602,700
Ensembl chr13:122,598,928...122,602,646 		JBrowse link
G PARPBP PARP1 binding protein involved_in IEA InterPro
TreeGrafter
Ensembl		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr 5:82,018,857...82,091,946
Ensembl chr 5:82,019,216...82,091,376 		JBrowse link
G PLK1 polo like kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:22,537,814...22,550,901
Ensembl chr 3:22,537,831...22,552,380 		JBrowse link
G POLQ DNA polymerase theta involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:138,962,634...139,108,499
Ensembl chr13:138,978,609...139,108,500 		JBrowse link
G RADX RPA1 related single stranded DNA binding protein, X-linked involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:87,025,603...87,103,503
Ensembl chr  X:87,025,603...87,103,501 		JBrowse link
G RECQL5 RecQ like helicase 5 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:25520194) Ensembl
MGI		 PMID:25520194 GO_REF:0000107 NCBI chr12:5,732,336...5,770,136
Ensembl chr12:5,732,348...5,770,133 		JBrowse link
G RIF1 replication timing regulatory factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:769,518...832,036
Ensembl chr15:774,191...832,010 		JBrowse link
G RMI2 RecQ mediated genome instability 2 involved_in IEA
IBA		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr 3:31,807,717...31,814,869
Ensembl chr 3:31,808,015...31,814,843 		JBrowse link
G SENP3 SUMO specific peptidase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:52,857,463...52,867,583
Ensembl chr12:52,765,187...52,867,576 		JBrowse link
G SHLD1 shieldin complex subunit 1 involved_in IEA
IBA		 Ensembl
GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr17:14,610,723...14,706,082
Ensembl chr17:14,610,817...14,707,872 		JBrowse link
G SHLD2 shieldin complex subunit 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:88,005,599...88,121,155
Ensembl chr14:88,005,611...88,121,352 		JBrowse link
G SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:103,809,732...103,986,057
Ensembl chr 6:103,808,066...103,965,335 		JBrowse link
G TP53BP1 tumor protein p53 binding protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:127,958,500...128,032,370
Ensembl chr 1:127,959,213...128,028,712 		JBrowse link
G TRAPPC13 trafficking protein particle complex subunit 13 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr16:44,146,574...44,186,346
Ensembl chr16:44,156,163...44,184,662 		JBrowse link
G UBQLN4 ubiquilin 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:93,976,386...93,994,830
Ensembl chr 4:93,976,451...93,994,828 		JBrowse link
positive regulation of double-strand break repair via homologous recombination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACTB actin beta involved_in ISO (PMID:27153538) ComplexPortal PMID:27153538 NCBI chr 3:4,084,275...4,090,383
Ensembl chr 3:4,082,216...4,090,356 		JBrowse link
G ACTL6A actin like 6A involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:117,598,415...117,627,311
Ensembl chr13:117,598,496...117,628,488 		JBrowse link
G ACTR2 actin related protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:76,691,275...76,729,269
Ensembl chr 3:76,691,280...76,729,252 		JBrowse link
G ARID2 AT-rich interaction domain 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:76,637,385...76,800,155
Ensembl chr 5:76,636,967...76,797,043 		JBrowse link
G BLM BLM RecQ like helicase acts_upstream_of_or_within ISO (PMID:25520194) MGI PMID:25520194 NCBI chr 7:53,317,515...53,412,649
Ensembl chr 7:53,317,540...53,412,645 		JBrowse link
G BRD8 bromodomain containing 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:140,182,195...140,202,247
Ensembl chr 2:140,168,636...140,202,247 		JBrowse link
G CREBBP CREB binding protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:38,388,366...38,530,243
Ensembl chr 3:38,388,547...38,530,224 		JBrowse link
G DMAP1 DNA methyltransferase 1 associated protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:167,083,053...167,091,654
Ensembl chr 6:167,082,849...167,091,630 		JBrowse link
G EP400 E1A binding protein p400 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:23,286,938...23,396,316
Ensembl chr14:23,289,244...23,396,656 		JBrowse link
G EPC1 enhancer of polycomb homolog 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:42,835,280...42,946,859
Ensembl chr10:42,836,047...42,946,857 		JBrowse link
G EPC2 enhancer of polycomb homolog 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:3,417,446...3,526,223
Ensembl chr15:3,417,063...3,526,171 		JBrowse link
G ERCC6 ERCC excision repair 6, chromatin remodeling factor involved_in ISO (PMID:25820262) UniProt PMID:25820262 NCBI chr14:89,998,125...90,075,911
Ensembl chr14:90,002,024...90,075,898 		JBrowse link
G FANCB FA complementation group B involved_in
acts_upstream_of_or_within		 IBA
ISO
IEA		 (PMID:25520194) GO_Central
MGI
TreeGrafter		 PMID:25520194 GO_REF:0000033 GO_REF:0000118 NCBI chr  X:11,386,360...11,408,958
Ensembl chr  X:11,384,912...11,409,057 		JBrowse link
G FUS FUS RNA binding protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:17,314,936...17,326,663
Ensembl chr 3:17,314,332...17,326,637 		JBrowse link
G HDGFL2 HDGF like 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:74,331,891...74,357,037
Ensembl chr 2:74,332,106...74,357,040 		JBrowse link
G HELQ helicase, POLQ like involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:135,026,117...135,061,051
Ensembl chr 8:135,026,315...135,061,043 		JBrowse link
G ING3 inhibitor of growth family member 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:25,946,529...25,976,528
Ensembl chr18:25,948,097...25,976,499 		JBrowse link
G KAT5 lysine acetyltransferase 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:6,560,544...6,572,461
Ensembl chr 2:6,560,513...6,572,466 		JBrowse link
G KHDC3L KH domain containing 3 like, subcortical maternal complex member involved_in ISO (PMID:31609975)
(MGI:6716962|PMID:25936915)		 UniProt PMID:25936915 PMID:31609975 MGI:6716962 NCBI chr 1:52,996,706...52,999,074 JBrowse link
G MBTD1 mbt domain containing 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:27,450,809...27,526,412
Ensembl chr12:27,450,806...27,526,194 		JBrowse link
G MEAF6 MYST/Esa1 associated factor 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:93,559,259...93,589,030
Ensembl chr 6:93,559,101...93,589,001 		JBrowse link
G MORF4L1 mortality factor 4 like 1 involved_in ISO (PMID:27153538) ComplexPortal PMID:27153538 NCBI chr 7:48,050,050...48,075,799
Ensembl chr 7:48,050,045...48,075,795 		JBrowse link
G MORF4L2 mortality factor 4 like 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:84,553,770...84,566,304
Ensembl chr  X:84,553,774...84,569,030 		JBrowse link
G MRGBP MRG domain binding protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:62,058,401...62,062,962
Ensembl chr17:62,058,424...62,062,960 		JBrowse link
G MRNIP MRN complex interacting protein involved_in ISO (PMID:27568553) UniProt PMID:27568553 NCBI chr 2:78,730,611...78,753,152 JBrowse link
G OOEP oocyte expressed protein involved_in ISO (MGI:6272426|PMID:29955025) UniProt PMID:29955025 MGI:6272426 NCBI chr 1:53,006,898...53,007,877
Ensembl chr 1:53,006,761...53,007,877 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:14,203,157...14,241,164
Ensembl chr10:14,203,160...14,241,196 		JBrowse link
G PELI1 pellino E3 ubiquitin protein ligase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:77,740,460...77,796,911
Ensembl chr 3:77,713,489...77,796,914 		JBrowse link
G PIAS4 protein inhibitor of activated STAT 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:74,702,915...74,729,792
Ensembl chr 2:74,702,945...74,729,775 		JBrowse link
G PRMT1 protein arginine methyltransferase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:54,718,845...54,730,411
Ensembl chr 6:54,714,157...54,732,574 		JBrowse link
G RAD51AP1 RAD51 associated protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:65,872,277...65,897,210
Ensembl chr 5:65,872,539...65,897,212 		JBrowse link
G RNF126 ring finger protein 126 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:77,673,302...77,683,312
Ensembl chr 2:77,673,353...77,683,311 		JBrowse link
G RNF8 ring finger protein 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:32,931,786...32,969,536
Ensembl chr 7:32,931,786...32,970,585 		JBrowse link
G RUVBL1 RuvB like AAA ATPase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:72,196,219...72,246,514
Ensembl chr13:72,200,511...72,248,582 		JBrowse link
G RUVBL2 RuvB like AAA ATPase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:54,250,494...54,263,492
Ensembl chr 6:54,250,515...54,266,893 		JBrowse link
G SKP2 S-phase kinase associated protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:21,463,270...21,500,925
Ensembl chr16:21,463,012...21,509,310 		JBrowse link
G TIMELESS timeless circadian regulator involved_in IEA Ensembl GO_REF:0000107 Ensembl chr 5:21,763,014...21,787,521 JBrowse link
G TRRAP transformation/transcription domain associated protein involved_in ISO (PMID:27153538) ComplexPortal PMID:27153538 NCBI chr 3:5,903,205...6,029,343
Ensembl chr 3:5,909,022...6,029,333 		JBrowse link
G VPS72 vacuolar protein sorting 72 homolog involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:98,062,261...98,074,074
Ensembl chr 4:98,062,256...98,074,059 		JBrowse link
G WAS WASP actin nucleation promoting factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:42,774,597...42,793,055
Ensembl chr  X:42,774,588...42,793,055 		JBrowse link
G WDR48 WD repeat domain 48 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:23,735,566...23,786,312
Ensembl chr13:23,735,567...23,786,308 		JBrowse link
G WRAP53 WD repeat containing antisense to TP53 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:52,954,674...52,968,371
Ensembl chr12:52,954,669...52,968,364 		JBrowse link
G YEATS4 YEATS domain containing 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:33,626,816...33,649,633
Ensembl chr 5:33,626,818...33,649,627 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17813
    cellular process 16883
      regulation of cellular process 12025
        regulation of cellular response to stress 503
          regulation of DNA repair 180
            regulation of double-strand break repair 123
              regulation of double-strand break repair via homologous recombination 82
                negative regulation of double-strand break repair via homologous recombination + 26
                positive regulation of double-strand break repair via homologous recombination 43
                regulation of double-strand break repair via break-induced replication + 0
Path 2
Term Annotations click to browse term
  biological_process 17813
    metabolic process 10347
      cellular metabolic process 9044
        cellular aromatic compound metabolic process 5337
          nucleobase-containing compound metabolic process 5112
            nucleic acid metabolic process 4615
              DNA metabolic process 931
                DNA repair 523
                  recombinational repair 183
                    double-strand break repair via homologous recombination 180
                      regulation of double-strand break repair via homologous recombination 82
                        negative regulation of double-strand break repair via homologous recombination + 26
                        positive regulation of double-strand break repair via homologous recombination 43
                        regulation of double-strand break repair via break-induced replication + 0
paths to the root