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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of platelet activation
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Accession:GO:0010543 term browser browse the term
Definition:Any process that modulates the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue.

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regulation of platelet activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fcer1g Fc fragment of IgE receptor Ig involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936903:514,278...517,975
Ensembl chrNW_004936903:514,761...517,948 		JBrowse link
G Fundc2 FUN14 domain containing 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936927:304,162...318,271
Ensembl chrNW_004936927:304,197...318,271 		JBrowse link
G Hrg histidine rich glycoprotein involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936578:3,285,986...3,295,876
Ensembl chrNW_004936578:3,285,986...3,295,876 		JBrowse link
G LOC101955911 FUN14 domain-containing protein 2-like involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936664:3,188,124...3,189,114 JBrowse link
G LOC101971998 guanine nucleotide-binding protein G(q) subunit alpha involved_in ISO (MGI:1096702|PMID:9296496) UniProt PMID:9296496 MGI:1096702 NCBI chrNW_004936503:13,098,517...13,276,106
Ensembl chrNW_004936503:13,099,558...13,276,152 		JBrowse link
G Syk spleen associated tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936780:1,553,605...1,601,036
Ensembl chrNW_004936780:1,553,605...1,598,158 		JBrowse link
G Tec tec protein tyrosine kinase involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936482:14,248,277...14,341,329
Ensembl chrNW_004936482:14,248,233...14,341,402 		JBrowse link
negative regulation of platelet activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoe apolipoprotein E involved_in ISO (PMID:8995232) BHF-UCL PMID:8995232 NCBI chrNW_004936706:1,512,438...1,516,805 JBrowse link
G C1qtnf1 C1q and TNF related 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936594:3,338,863...3,358,137
Ensembl chrNW_004936594:3,338,774...3,358,985 		JBrowse link
G Gp5 glycoprotein V platelet acts_upstream_of_or_within ISO (PMID:10557321), (PMID:11435305) MGI PMID:10557321 PMID:11435305 NCBI chrNW_004936711:403,876...405,570 JBrowse link
G Pdgfa platelet derived growth factor subunit A involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936754:808,894...828,554
Ensembl chrNW_004936754:808,213...828,613 		JBrowse link
G Pdgfb platelet derived growth factor subunit B involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936492:2,353,840...2,368,573
Ensembl chrNW_004936492:2,353,841...2,368,573 		JBrowse link
G Pdgfra platelet derived growth factor receptor alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936482:16,804,129...16,853,539
Ensembl chrNW_004936482:16,807,569...16,853,587 		JBrowse link
G Serpine2 serpin family E member 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19855083) Ensembl
MGI		 PMID:19855083 GO_REF:0000107 NCBI chrNW_004936569:5,642,328...5,668,278
Ensembl chrNW_004936569:5,642,264...5,668,323 		JBrowse link
negative regulation of platelet aggregation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adamts18 ADAM metallopeptidase with thrombospondin type 1 motif 18 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19218546) Ensembl
MGI		 PMID:19218546 GO_REF:0000107 NCBI chrNW_004936475:25,698,117...25,831,291
Ensembl chrNW_004936475:25,699,840...25,831,284 		JBrowse link
G C1qtnf1 C1q and TNF related 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936594:3,338,863...3,358,137
Ensembl chrNW_004936594:3,338,774...3,358,985 		JBrowse link
G Cd9 CD9 molecule involved_in ISO (PMID:18541721) UniProt PMID:18541721 NCBI chrNW_004936709:1,497,504...1,530,114 JBrowse link
G LOC101954488 CEA cell adhesion molecule 1 involved_in ISO (MGI:3835235|PMID:19008452) UniProt PMID:19008452 MGI:3835235 NCBI chrNW_004936706:37,480...53,306 JBrowse link
G LOC101963440 polyunsaturated fatty acid lipoxygenase ALOX12 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936595:269,085...282,445
Ensembl chrNW_004936595:270,271...282,660 		JBrowse link
G Prkcd protein kinase C delta involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936473:3,892,625...3,923,467
Ensembl chrNW_004936473:3,892,366...3,923,515 		JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936787:330,390...1,491,994
Ensembl chrNW_004936787:332,342...1,491,285 		JBrowse link
G Serpine2 serpin family E member 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936569:5,642,328...5,668,278
Ensembl chrNW_004936569:5,642,264...5,668,323 		JBrowse link
G Sh2b3 SH2B adaptor protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936558:4,103,898...4,126,883
Ensembl chrNW_004936558:4,104,534...4,123,869 		JBrowse link
G Tmx1 thioredoxin related transmembrane protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936495:14,432,971...14,447,380
Ensembl chrNW_004936495:14,431,137...14,447,476 		JBrowse link
G Ubash3b ubiquitin associated and SH3 domain containing B involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20585042) Ensembl
MGI		 PMID:20585042 GO_REF:0000107 NCBI chrNW_004936542:7,225,387...7,370,163
Ensembl chrNW_004936542:7,225,977...7,373,381 		JBrowse link
positive regulation of platelet activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gp1ba glycoprotein Ib platelet subunit alpha involved_in ISO (PMID:1939645) ComplexPortal PMID:1939645 NCBI chrNW_004936677:2,774,076...2,779,660 JBrowse link
G Gp1bb glycoprotein Ib platelet subunit beta involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936619:3,627,649...3,629,129
Ensembl chrNW_004936619:3,627,999...3,628,859 		JBrowse link
G Gp5 glycoprotein V platelet involved_in ISO (PMID:1939645) ComplexPortal PMID:1939645 NCBI chrNW_004936711:403,876...405,570 JBrowse link
G Gp9 glycoprotein IX platelet involved_in ISO (PMID:1939645) ComplexPortal PMID:1939645 NCBI chrNW_004936798:170,654...171,625 JBrowse link
G Jak2 Janus kinase 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:31145836) ARUK-UCL
Ensembl		 PMID:31145836 GO_REF:0000107 NCBI chrNW_004936503:111,722...243,627
Ensembl chrNW_004936503:110,963...241,867 		JBrowse link
G Pdpn podoplanin ISO RGD PMID:16979138 RGD:2292241 NCBI chrNW_004936474:1,751,159...1,779,011
Ensembl chrNW_004936474:1,750,944...1,781,156 		JBrowse link
G Pear1 platelet endothelial aggregation receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936580:6,030,426...6,052,330
Ensembl chrNW_004936580:6,040,482...6,051,239 		JBrowse link
G Pla2g4a phospholipase A2 group IVA involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936481:3,559,377...3,689,797
Ensembl chrNW_004936481:3,559,358...3,689,833 		JBrowse link
G Plek pleckstrin involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936491:12,762,421...12,818,249
Ensembl chrNW_004936491:12,762,328...12,818,306 		JBrowse link
G Ptprj protein tyrosine phosphatase receptor type J involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936562:1,161,764...1,234,800
Ensembl chrNW_004936562:1,165,304...1,211,817 		JBrowse link
G Selp selectin P involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936481:17,076,660...17,112,501
Ensembl chrNW_004936481:17,076,536...17,107,963 		JBrowse link
G Svep1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936559:2,556,207...2,726,670
Ensembl chrNW_004936559:2,556,207...2,726,635 		JBrowse link
G Tlr4 toll like receptor 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936487:6,519,140...6,532,018
Ensembl chrNW_004936487:6,518,441...6,533,095 		JBrowse link
positive regulation of platelet aggregation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Emilin2 elastin microfibril interfacer 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936672:1,607,914...1,661,531
Ensembl chrNW_004936672:1,609,193...1,661,528 		JBrowse link
G F11r F11 receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936903:317,975...338,892
Ensembl chrNW_004936903:315,716...338,932 		JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A ISO RGD PMID:18358471 RGD:401938603 NCBI chrNW_004936565:335,238...394,683
Ensembl chrNW_004936565:334,393...394,715 		JBrowse link
G Il6 interleukin 6 acts_upstream_of ISO (PMID:31145836) ARUK-UCL PMID:31145836 NCBI chrNW_004936549:7,015,595...7,016,246 JBrowse link
G Il6r interleukin 6 receptor acts_upstream_of ISO (PMID:31145836) ARUK-UCL PMID:31145836 NCBI chrNW_004936580:4,055,438...4,081,876
Ensembl chrNW_004936580:4,057,771...4,081,885 		JBrowse link
G Jak2 Janus kinase 2 involved_in
acts_upstream_of		 IEA
ISO		 (PMID:31145836) Ensembl
ARUK-UCL		 PMID:31145836 GO_REF:0000107 NCBI chrNW_004936503:111,722...243,627
Ensembl chrNW_004936503:110,963...241,867 		JBrowse link
G LOC101959956 cathepsin G-like involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936722:34,410...37,097
Ensembl chrNW_004936722:34,392...37,097 		JBrowse link
G Mfsd2b MFSD2 lysolipid transporter B, sphingolipid involved_in ISO (MGI:6713713|PMID:33863882) UniProt PMID:33863882 MGI:6713713 NCBI chrNW_004936493:7,952,623...7,959,803
Ensembl chrNW_004936493:7,951,294...7,963,317 		JBrowse link
G Mmrn1 multimerin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936685:2,236,072...2,291,636
Ensembl chrNW_004936685:2,251,978...2,291,261 		JBrowse link
G Pdpn podoplanin involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936474:1,751,159...1,779,011
Ensembl chrNW_004936474:1,750,944...1,781,156 		JBrowse link
regulation of platelet aggregation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lyn LYN proto-oncogene, Src family tyrosine kinase involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936496:2,578,598...2,698,165
Ensembl chrNW_004936496:2,637,958...2,700,055 		JBrowse link
G Prkca protein kinase C alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936541:6,231,604...6,488,201
Ensembl chrNW_004936541:6,233,110...6,488,052 		JBrowse link
G Prkcq protein kinase C theta involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936484:8,048,239...8,166,058
Ensembl chrNW_004936484:8,048,132...8,167,636 		JBrowse link
G Syk spleen associated tyrosine kinase involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936780:1,553,605...1,601,036
Ensembl chrNW_004936780:1,553,605...1,598,158 		JBrowse link
G Vps33b VPS33B late endosome and lysosome associated involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936483:16,007,448...16,031,353
Ensembl chrNW_004936483:16,007,465...16,032,392 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15969
    cellular process 15075
      cell activation 1063
        platelet activation 112
          regulation of platelet activation 47
            negative regulation of platelet activation + 16
            positive regulation of platelet activation 13
            regulation of platelet aggregation + 26
Path 2
Term Annotations click to browse term
  biological_process 15969
    biological regulation 11154
      regulation of biological quality 2991
        regulation of body fluid levels 352
          hemostasis 182
            blood coagulation 178
              platelet activation 112
                regulation of platelet activation 47
                  negative regulation of platelet activation + 16
                  positive regulation of platelet activation 13
                  regulation of platelet aggregation + 26
paths to the root