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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of cell fate commitment
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Accession:GO:0010454 term browser browse the term
Definition:Any process that stops, prevents or reduces the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field.

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negative regulation of cell fate commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Glis1 GLIS family zinc finger 1 ISO (MGI:6294234|PMID:30544251) RGD PMID:30544251 MGI:6294234 NCBI chr 5:127,043,344...127,233,395
Ensembl chr 5:127,160,495...127,233,078 		JBrowse link
G Nanog Nanog homeobox ISO MGI:109452 (MGI:3654744|PMID:16801560) RGD PMID:16801560 MGI:3654744 NCBI chr 4:155,531,906...155,539,268
Ensembl chr 4:155,531,906...155,539,268 		JBrowse link
G Nkx6-2 NK6 homeobox 2 ISO MGI:2651850 (MGI:2150481|PMID:11567614) RGD PMID:11567614 MGI:2150481 NCBI chr 1:211,922,389...211,923,929
Ensembl chr 1:211,922,389...211,923,929 		JBrowse link
G Sostdc1 sclerostin domain containing 1 ISO MGI:3604658 (MGI:5319554|PMID:22509524) RGD PMID:22509524 MGI:5319554 NCBI chr 6:55,812,820...55,816,994
Ensembl chr 6:55,812,747...55,817,066 		JBrowse link
G Spdef SAM pointed domain containing ets transcription factor ISO MGI:4398888 (MGI:4397649|PMID:19759516) RGD PMID:19759516 MGI:4397649 NCBI chr20:7,292,823...7,308,053
Ensembl chr20:7,292,824...7,307,284 		JBrowse link
negative regulation of cell fate determination term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hes1 hes family bHLH transcription factor 1 IEA
ISO		 GO_REF:0000107
MGI:2149672 (MGI:2136156|PMID:11425898)		 Ensembl
RGD		 PMID:11425898 GO_REF:0000107, MGI:2136156 NCBI chr11:74,312,837...74,315,249
Ensembl chr11:74,312,806...74,315,248 		JBrowse link
negative regulation of cell fate specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gfi1 growth factor independent 1 transcriptional repressor ISO MGI:2449921 (MGI:3606816|PMID:16230531) RGD PMID:16230531 MGI:3606816 NCBI chr14:3,058,035...3,073,332
Ensembl chr14:3,058,993...3,068,371 		JBrowse link
negative regulation of ectodermal cell fate specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fzd7 frizzled class receptor 7 ISO (PMID:18681827) RGD PMID:18681827 NCBI chr 9:66,305,731...66,308,550
Ensembl chr 9:66,305,731...66,308,550 		JBrowse link
negative regulation of endodermal cell fate specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mesp1 mesoderm posterior bHLH transcription factor 1 ISO (MGI:4441249|PMID:18593560) RGD PMID:18593560 MGI:4441249 NCBI chr 1:141,532,390...141,533,908
Ensembl chr 1:141,532,390...141,533,908 		JBrowse link
negative regulation of heart induction by canonical Wnt signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt3a Wnt family member 3A ISO (PMID:19736317) RGD PMID:19736317 NCBI chr10:45,598,898...45,643,151
Ensembl chr10:45,598,912...45,638,035 		JBrowse link
negative regulation of mesodermal cell fate specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 ISO (PMID:20559569) RGD PMID:20559569 NCBI chr 1:248,952,896...248,956,579
Ensembl chr 1:248,895,738...248,898,607 		JBrowse link
G Mesp1 mesoderm posterior bHLH transcription factor 1 ISO (MGI:4441249|PMID:18593560) RGD PMID:18593560 MGI:4441249 NCBI chr 1:141,532,390...141,533,908
Ensembl chr 1:141,532,390...141,533,908 		JBrowse link
G Sfrp2 secreted frizzled-related protein 2 ISO MGI:98956 (MGI:3711603|PMID:17462603) RGD PMID:17462603 MGI:3711603 NCBI chr 2:182,723,732...182,731,277
Ensembl chr 2:182,723,854...182,731,764 		JBrowse link
negative regulation of retinal cone cell fate commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casz1 castor zinc finger 1 ISO MGI:3052661|MGI:4841554 (MGI:5629913|PMID:25654255) RGD PMID:25654255 MGI:5629913 NCBI chr 5:165,625,119...165,777,053
Ensembl chr 5:165,724,027...165,774,616 		JBrowse link
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Loxl3 lysyl oxidase-like 3 ISO (MGI:5825383|PMID:28065600) RGD PMID:28065600 MGI:5825383 NCBI chr 4:113,866,782...113,883,713
Ensembl chr 4:113,866,804...113,883,477 		JBrowse link
G Tbx21 T-box transcription factor 21 ISO (MGI:4868293|PMID:21151104) RGD PMID:21151104 MGI:4868293 NCBI chr10:85,032,799...85,049,331
Ensembl chr10:85,032,799...85,049,331 		JBrowse link
G Tnfsf18 TNF superfamily member 18 ISO (MGI:5551556|PMID:24107315) RGD PMID:24107315 MGI:5551556 NCBI chr13:79,378,412...79,388,687
Ensembl chr13:79,378,733...79,388,498 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    cellular process 18792
      negative regulation of cellular process 5156
        negative regulation of cell differentiation 735
          negative regulation of cell fate commitment 16
            negative regulation of T-helper 17 cell lineage commitment 3
            negative regulation of anterior neural cell fate commitment of the neural plate + 0
            negative regulation of cell fate determination + 1
            negative regulation of cell fate specification + 6
            negative regulation of establishment or maintenance of neuroblast polarity 0
            negative regulation of mating type switching 0
            negative regulation of retinal cone cell fate commitment + 1
            negative regulation of sevenless signaling pathway 0
            negative regulation of venous endothelial cell fate commitment + 0
Path 2
Term Annotations click to browse term
  biological_process 20020
    developmental process 6826
      cellular developmental process 4457
        cell differentiation 4362
          regulation of cell differentiation 1684
            negative regulation of cell differentiation 735
              negative regulation of cell fate commitment 16
                negative regulation of T-helper 17 cell lineage commitment 3
                negative regulation of anterior neural cell fate commitment of the neural plate + 0
                negative regulation of cell fate determination + 1
                negative regulation of cell fate specification + 6
                negative regulation of establishment or maintenance of neuroblast polarity 0
                negative regulation of mating type switching 0
                negative regulation of retinal cone cell fate commitment + 1
                negative regulation of sevenless signaling pathway 0
                negative regulation of venous endothelial cell fate commitment + 0
paths to the root

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