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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of cell fate commitment
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Accession:GO:0010453 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field.


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regulation of cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 involved_in ISO
ISS
IEA		 (PMID:18823971)
GO_REF:0000024
GO_REF:0000107		 RGD
CAFA
Ensembl		 PMID:18823971 GO_REF:0000024 GO_REF:0000107 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306 		JBrowse link
G Gdf3 growth differentiation factor 3 involved_in ISO (PMID:18823971) RGD PMID:18823971 NCBI chr 4:155,831,572...155,835,953
Ensembl chr 4:155,830,909...155,835,937 		JBrowse link
G Pax7 paired box 7 acts_upstream_of_or_within ISO MGI:1857831|MGI:3047633 (MGI:5440096|PMID:23070814) RGD PMID:23070814 MGI:5440096 NCBI chr 5:151,996,368...152,098,023
Ensembl chr 5:151,999,092...152,097,979 		JBrowse link
G Zfp157 zinc finger protein 157 acts_upstream_of_or_within ISO MGI:4124834 (MGI:5424261|PMID:22588720) RGD PMID:22588720 MGI:5424261 NCBI chr12:16,248,230...16,279,459
Ensembl chr12:16,248,230...16,270,698 		JBrowse link
activation of prostate induction by androgen receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:3716756 (MGI:3714080|PMID:17317769)		 Ensembl
RGD		 PMID:17317769 GO_REF:0000107 MGI:3714080 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
negative regulation of cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Glis1 GLIS family zinc finger 1 involved_in ISO (MGI:6294234|PMID:30544251) RGD PMID:30544251 MGI:6294234 NCBI chr 5:122,222,155...122,412,141
Ensembl chr 5:122,222,128...122,412,141 		JBrowse link
G Nanog Nanog homeobox acts_upstream_of_or_within ISO MGI:109452 (MGI:3654744|PMID:16801560) RGD PMID:16801560 MGI:3654744 NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116 		JBrowse link
G Nkx6-2 NK6 homeobox 2 acts_upstream_of_or_within ISO MGI:2651850 (MGI:2150481|PMID:11567614) RGD PMID:11567614 MGI:2150481 NCBI chr 1:194,380,149...194,383,533
Ensembl chr 1:194,381,975...194,383,515 		JBrowse link
G Sostdc1 sclerostin domain containing 1 acts_upstream_of_or_within ISO MGI:3604658 (MGI:5319554|PMID:22509524) RGD PMID:22509524 MGI:5319554 NCBI chr 6:53,051,336...53,055,510
Ensembl chr 6:53,051,354...53,055,579 		JBrowse link
G Spdef SAM pointed domain containing ets transcription factor acts_upstream_of_or_within ISO MGI:4398888 (MGI:4397649|PMID:19759516) RGD PMID:19759516 MGI:4397649 NCBI chr20:5,771,440...5,785,893
Ensembl chr20:5,771,441...5,785,893 		JBrowse link
negative regulation of cell fate determination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hes1 hes family bHLH transcription factor 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2149672 (MGI:2136156|PMID:11425898)		 Ensembl
RGD		 PMID:11425898 GO_REF:0000107 MGI:2136156 NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192 		JBrowse link
negative regulation of cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gfi1 growth factor independent 1 transcriptional repressor acts_upstream_of_or_within ISO MGI:2449921 (MGI:3606816|PMID:16230531) RGD PMID:16230531 MGI:3606816 NCBI chr14:2,040,576...2,056,874
Ensembl chr14:2,042,434...2,051,814 		JBrowse link
negative regulation of ectodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fzd7 frizzled class receptor 7 involved_in ISO (PMID:18681827) RGD PMID:18681827 NCBI chr 9:60,931,433...60,934,252
Ensembl chr 9:60,930,875...60,935,781 		JBrowse link
negative regulation of endodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mesp1 mesoderm posterior bHLH transcription factor 1 involved_in ISO (MGI:4441249|PMID:18593560) RGD PMID:18593560 MGI:4441249 NCBI chr 1:133,738,357...133,739,875
Ensembl chr 1:133,738,357...133,739,875 		JBrowse link
negative regulation of mesodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 involved_in ISO (PMID:20559569) RGD PMID:20559569 NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202 		JBrowse link
G Mesp1 mesoderm posterior bHLH transcription factor 1 involved_in ISO (MGI:4441249|PMID:18593560) RGD PMID:18593560 MGI:4441249 NCBI chr 1:133,738,357...133,739,875
Ensembl chr 1:133,738,357...133,739,875 		JBrowse link
G Sfrp2 secreted frizzled-related protein 2 acts_upstream_of_or_within ISO MGI:98956 (MGI:3711603|PMID:17462603) RGD PMID:17462603 MGI:3711603 NCBI chr 2:169,089,517...169,097,064
Ensembl chr 2:169,089,517...169,097,063 		JBrowse link
negative regulation of retinal cone cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casz1 castor zinc finger 1 acts_upstream_of_or_within ISO MGI:3052661|MGI:4841554 (MGI:5629913|PMID:25654255) RGD PMID:25654255 MGI:5629913 NCBI chr 5:159,243,965...159,393,935
Ensembl chr 5:159,243,995...159,393,400 		JBrowse link
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Loxl3 lysyl oxidase-like 3 involved_in ISO (MGI:5825383|PMID:28065600) RGD PMID:28065600 MGI:5825383 NCBI chr 4:115,540,640...115,556,958
Ensembl chr 4:115,540,685...115,557,466 		JBrowse link
G Tbx21 T-box transcription factor 21 involved_in ISO (MGI:4868293|PMID:21151104) RGD PMID:21151104 MGI:4868293 NCBI chr10:82,082,322...82,098,831
Ensembl chr10:82,082,322...82,098,831 		JBrowse link
G Tnfsf18 TNF superfamily member 18 involved_in ISO (MGI:5551556|PMID:24107315) RGD PMID:24107315 MGI:5551556 NCBI chr13:73,833,478...73,907,249
Ensembl chr13:73,831,252...73,843,169 		JBrowse link
positive regulation of cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nkx6-2 NK6 homeobox 2 acts_upstream_of_or_within ISO MGI:2651850 (MGI:2150481|PMID:11567614) RGD PMID:11567614 MGI:2150481 NCBI chr 1:194,380,149...194,383,533
Ensembl chr 1:194,381,975...194,383,515 		JBrowse link
G Spdef SAM pointed domain containing ets transcription factor acts_upstream_of_or_within ISO MGI:4398888 (MGI:4397649|PMID:19759516) RGD PMID:19759516 MGI:4397649 NCBI chr20:5,771,440...5,785,893
Ensembl chr20:5,771,441...5,785,893 		JBrowse link
positive regulation of cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgf2 fibroblast growth factor 2 acts_upstream_of_or_within ISO (PMID:18635606) RGD PMID:18635606 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Gfi1 growth factor independent 1 transcriptional repressor acts_upstream_of_or_within ISO MGI:2449921 (MGI:3606816|PMID:16230531) RGD PMID:16230531 MGI:3606816 NCBI chr14:2,040,576...2,056,874
Ensembl chr14:2,042,434...2,051,814 		JBrowse link
G Pax6 paired box 6 IMP RGD PMID:11880342 RGD:729590 NCBI chr 3:92,128,772...92,157,022
Ensembl chr 3:92,135,637...92,157,014 		JBrowse link
positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 involved_in ISO (MGI:3835736|PMID:18297060) RGD PMID:18297060 MGI:3835736 NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202 		JBrowse link
G Mesp1 mesoderm posterior bHLH transcription factor 1 involved_in ISO (MGI:3835736|PMID:18297060) RGD PMID:18297060 MGI:3835736 NCBI chr 1:133,738,357...133,739,875
Ensembl chr 1:133,738,357...133,739,875 		JBrowse link
G Wnt11 Wnt family member 11 involved_in ISO UniProtKB:P22725 (MGI:5424267|PMID:22569553) RGD PMID:22569553 MGI:5424267 NCBI chr 1:153,134,503...153,154,294
Ensembl chr 1:153,138,197...153,154,294 		JBrowse link
G Wnt5a Wnt family member 5A involved_in ISO
IEA		 UniProtKB:P48615 (MGI:5424267|PMID:22569553)
GO_REF:0000107		 RGD
Ensembl		 PMID:22569553 GO_REF:0000107 MGI:5424267 NCBI chr16:3,697,032...3,718,230
Ensembl chr16:3,697,032...3,718,234 		JBrowse link
positive regulation of mesodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt3a Wnt family member 3A involved_in ISO (PMID:20559569) RGD PMID:20559569 NCBI chr10:44,034,174...44,078,366
Ensembl chr10:44,034,194...44,078,324 		JBrowse link
positive regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il23a interleukin 23 subunit alpha involved_in IBA
ISO		 PMID:21873635
(MGI:3851279|PMID:19501566)		 RGD PMID:19501566 PMID:21873635 MGI:3851279, RGD:13792537 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923 		JBrowse link
regulation of cardiac cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sox17 SRY-box transcription factor 17 involved_in ISO (MGI:3703823|PMID:17360443) RGD PMID:17360443 MGI:3703823 NCBI chr 5:15,016,660...15,022,228
Ensembl chr 5:15,016,731...15,022,228 		JBrowse link
regulation of cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lmo4 LIM domain only 4 acts_upstream_of_or_within ISO MGI:3664560 (MGI:3840011|PMID:19323994) RGD PMID:19323994 MGI:3840011 NCBI chr 2:233,264,180...233,280,881
Ensembl chr 2:233,264,182...233,280,880 		JBrowse link
regulation of endodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 involved_in ISO (PMID:20559569) RGD PMID:20559569 NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202 		JBrowse link
regulation of inner ear auditory receptor cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esrp1 epithelial splicing regulatory protein 1 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5915403|PMID:29107558)		 UniProt
RGD		 PMID:29107558 GO_REF:0000024 MGI:5915403 NCBI chr 5:24,427,611...24,482,157
Ensembl chr 5:24,428,717...24,482,062 		JBrowse link
regulation of lateral mesodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmpr1a bone morphogenetic protein receptor type 1A acts_upstream_of_or_within ISO MGI:95522 (MGI:3702797|PMID:16943278) RGD PMID:16943278 MGI:3702797 NCBI chr16:9,736,390...9,829,825
Ensembl chr16:9,736,630...9,780,616 		JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 acts_upstream_of_or_within ISO MGI:1338938 (MGI:3702797|PMID:16943278) RGD PMID:16943278 MGI:3702797 NCBI chr16:66,491,930...66,547,161
Ensembl chr16:66,494,042...66,547,350 		JBrowse link
regulation of neural crest cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmpr1a bone morphogenetic protein receptor type 1A NOT|involved_in ISO (MGI:3040576|PMID:15073157) RGD PMID:15073157 MGI:3040576 NCBI chr16:9,736,390...9,829,825
Ensembl chr16:9,736,630...9,780,616 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19574
    developmental process 6911
      regulation of developmental process 2771
        regulation of cell fate commitment 31
          negative regulation of cell fate commitment + 15
          positive regulation of cell fate commitment + 7
          regulation of R7 cell fate commitment + 0
          regulation of T-helper 17 cell lineage commitment + 4
          regulation of cell fate specification + 16
          regulation of retinal cone cell fate commitment + 1
          regulation of retinal rod cell fate commitment + 0
          regulation of venous endothelial cell fate commitment + 0
Path 2
Term Annotations click to browse term
  biological_process 19574
    developmental process 6911
      cellular developmental process 4642
        cell differentiation 4641
          cell fate commitment 287
            regulation of cell fate commitment 31
              negative regulation of cell fate commitment + 15
              positive regulation of cell fate commitment + 7
              regulation of R7 cell fate commitment + 0
              regulation of T-helper 17 cell lineage commitment + 4
              regulation of cell fate specification + 16
              regulation of retinal cone cell fate commitment + 1
              regulation of retinal rod cell fate commitment + 0
              regulation of venous endothelial cell fate commitment + 0
paths to the root