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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of cell fate commitment
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Accession:GO:0010453 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field.


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regulation of cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:18823971)
Ensembl
UniProt
RGD
PMID:18823971 GO_REF:0000024, GO_REF:0000107 NCBI chr15:20,776,060...20,791,013
Ensembl chr15:20,776,054...20,822,740
JBrowse link
G Gdf3 growth differentiation factor 3 ISO (PMID:18823971) RGD PMID:18823971 NCBI chr 4:155,417,667...155,422,014
Ensembl chr 4:155,417,004...155,421,998
JBrowse link
G Pax7 paired box 7 ISO MGI:1857831|MGI:3047633 (MGI:5440096|PMID:23070814) RGD PMID:23070814 MGI:5440096 NCBI chr 5:158,211,001...158,313,510
Ensembl chr 5:158,214,616...158,313,426
JBrowse link
G Zfp157 zinc finger protein 157 ISO MGI:4124834 (MGI:5424261|PMID:22588720) RGD PMID:22588720 MGI:5424261 NCBI chr12:18,461,283...18,495,871
Ensembl chr12:18,464,781...18,487,178
JBrowse link
activation of prostate induction by androgen receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor IEA
ISO
GO_REF:0000107
MGI:3716756 (MGI:3714080|PMID:17317769)
Ensembl
RGD
PMID:17317769 GO_REF:0000107, MGI:3714080 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
maintenance of imprinting at mating-type locus term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Zfp445 zinc finger protein 445 ISO UniProtKB:Q8C6P8 (MGI:6284037|PMID:30602440) RGD PMID:30602440 MGI:6284037 NCBI chr 8:131,885,119...131,904,303
Ensembl chr 8:131,888,047...131,899,023
JBrowse link
G Zfp57 zinc finger protein 57 ISO UniProtKB:Q8R2V3 (MGI:6284037|PMID:30602440) RGD PMID:30602440 MGI:6284037 NCBI chr20:2,014,177...2,020,488
Ensembl chr20:2,014,170...2,020,537
JBrowse link
negative regulation of cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Glis1 GLIS family zinc finger 1 ISO (MGI:6294234|PMID:30544251) RGD PMID:30544251 MGI:6294234 NCBI chr 5:127,043,344...127,233,395
Ensembl chr 5:127,160,495...127,233,078
JBrowse link
G Nanog Nanog homeobox ISO MGI:109452 (MGI:3654744|PMID:16801560) RGD PMID:16801560 MGI:3654744 NCBI chr 4:155,531,906...155,539,268
Ensembl chr 4:155,531,906...155,539,268
JBrowse link
G Nkx6-2 NK6 homeobox 2 ISO MGI:2651850 (MGI:2150481|PMID:11567614) RGD PMID:11567614 MGI:2150481 NCBI chr 1:211,922,389...211,923,929
Ensembl chr 1:211,922,389...211,923,929
JBrowse link
G Sostdc1 sclerostin domain containing 1 ISO MGI:3604658 (MGI:5319554|PMID:22509524) RGD PMID:22509524 MGI:5319554 NCBI chr 6:55,812,820...55,816,994
Ensembl chr 6:55,812,747...55,817,066
JBrowse link
G Spdef SAM pointed domain containing ets transcription factor ISO MGI:4398888 (MGI:4397649|PMID:19759516) RGD PMID:19759516 MGI:4397649 NCBI chr20:7,292,823...7,308,053
Ensembl chr20:7,292,824...7,307,284
JBrowse link
negative regulation of cell fate determination term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hes1 hes family bHLH transcription factor 1 IEA
ISO
GO_REF:0000107
MGI:2149672 (MGI:2136156|PMID:11425898)
Ensembl
RGD
PMID:11425898 GO_REF:0000107, MGI:2136156 NCBI chr11:74,312,837...74,315,249
Ensembl chr11:74,312,806...74,315,248
JBrowse link
negative regulation of cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gfi1 growth factor independent 1 transcriptional repressor ISO MGI:2449921 (MGI:3606816|PMID:16230531) RGD PMID:16230531 MGI:3606816 NCBI chr14:3,058,035...3,073,332
Ensembl chr14:3,058,993...3,068,371
JBrowse link
negative regulation of ectodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fzd7 frizzled class receptor 7 ISO (PMID:18681827) RGD PMID:18681827 NCBI chr 9:66,305,731...66,308,550
Ensembl chr 9:66,305,731...66,308,550
JBrowse link
negative regulation of endodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mesp1 mesoderm posterior bHLH transcription factor 1 ISO (MGI:4441249|PMID:18593560) RGD PMID:18593560 MGI:4441249 NCBI chr 1:141,532,390...141,533,908
Ensembl chr 1:141,532,390...141,533,908
JBrowse link
negative regulation of heart induction by canonical Wnt signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt3a Wnt family member 3A ISO (PMID:19736317) RGD PMID:19736317 NCBI chr10:45,598,898...45,643,151
Ensembl chr10:45,598,912...45,638,035
JBrowse link
negative regulation of mesodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 ISO (PMID:20559569) RGD PMID:20559569 NCBI chr 1:248,952,896...248,956,579
Ensembl chr 1:248,895,738...248,898,607
JBrowse link
G Mesp1 mesoderm posterior bHLH transcription factor 1 ISO (MGI:4441249|PMID:18593560) RGD PMID:18593560 MGI:4441249 NCBI chr 1:141,532,390...141,533,908
Ensembl chr 1:141,532,390...141,533,908
JBrowse link
G Sfrp2 secreted frizzled-related protein 2 ISO MGI:98956 (MGI:3711603|PMID:17462603) RGD PMID:17462603 MGI:3711603 NCBI chr 2:182,723,732...182,731,277
Ensembl chr 2:182,723,854...182,731,764
JBrowse link
negative regulation of retinal cone cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casz1 castor zinc finger 1 ISO MGI:3052661|MGI:4841554 (MGI:5629913|PMID:25654255) RGD PMID:25654255 MGI:5629913 NCBI chr 5:165,625,119...165,777,053
Ensembl chr 5:165,724,027...165,774,616
JBrowse link
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Loxl3 lysyl oxidase-like 3 ISO (MGI:5825383|PMID:28065600) RGD PMID:28065600 MGI:5825383 NCBI chr 4:113,866,782...113,883,713
Ensembl chr 4:113,866,804...113,883,477
JBrowse link
G Tbx21 T-box transcription factor 21 ISO (MGI:4868293|PMID:21151104) RGD PMID:21151104 MGI:4868293 NCBI chr10:85,032,799...85,049,331
Ensembl chr10:85,032,799...85,049,331
JBrowse link
G Tnfsf18 TNF superfamily member 18 ISO (MGI:5551556|PMID:24107315) RGD PMID:24107315 MGI:5551556 NCBI chr13:79,378,412...79,388,687
Ensembl chr13:79,378,733...79,388,498
JBrowse link
positive regulation of cell fate commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nkx6-2 NK6 homeobox 2 ISO MGI:2651850 (MGI:2150481|PMID:11567614) RGD PMID:11567614 MGI:2150481 NCBI chr 1:211,922,389...211,923,929
Ensembl chr 1:211,922,389...211,923,929
JBrowse link
G Spdef SAM pointed domain containing ets transcription factor ISO MGI:4398888 (MGI:4397649|PMID:19759516) RGD PMID:19759516 MGI:4397649 NCBI chr20:7,292,823...7,308,053
Ensembl chr20:7,292,824...7,307,284
JBrowse link
positive regulation of cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgf2 fibroblast growth factor 2 ISO (PMID:18635606) RGD PMID:18635606 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Gfi1 growth factor independent 1 transcriptional repressor ISO MGI:2449921 (MGI:3606816|PMID:16230531) RGD PMID:16230531 MGI:3606816 NCBI chr14:3,058,035...3,073,332
Ensembl chr14:3,058,993...3,068,371
JBrowse link
G Pax6 paired box 6 IMP RGD PMID:11880342 RGD:729590 NCBI chr 3:95,700,241...95,728,682
Ensembl chr 3:95,707,386...95,728,624
JBrowse link
positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 ISO (MGI:3835736|PMID:18297060) RGD PMID:18297060 MGI:3835736 NCBI chr 1:248,952,896...248,956,579
Ensembl chr 1:248,895,738...248,898,607
JBrowse link
G Mesp1 mesoderm posterior bHLH transcription factor 1 ISO (MGI:3835736|PMID:18297060) RGD PMID:18297060 MGI:3835736 NCBI chr 1:141,532,390...141,533,908
Ensembl chr 1:141,532,390...141,533,908
JBrowse link
G Wnt11 Wnt family member 11 ISO UniProtKB:P22725 (MGI:5424267|PMID:22569553) RGD PMID:22569553 MGI:5424267 NCBI chr 1:163,794,136...163,813,756
Ensembl chr 1:163,797,660...163,813,756
JBrowse link
G Wnt5a Wnt family member 5A IEA
ISO
GO_REF:0000107
UniProtKB:P48615 (MGI:5424267|PMID:22569553)
Ensembl
RGD
PMID:22569553 GO_REF:0000107, MGI:5424267 NCBI chr16:4,469,451...4,490,271
Ensembl chr16:4,469,468...4,489,860
JBrowse link
positive regulation of mesodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt3a Wnt family member 3A ISO (PMID:20559569) RGD PMID:20559569 NCBI chr10:45,598,898...45,643,151
Ensembl chr10:45,598,912...45,638,035
JBrowse link
positive regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il23a interleukin 23 subunit alpha IBA
ISO
PMID:21873635
(MGI:3851279|PMID:19501566)
RGD PMID:19501566, PMID:21873635 MGI:3851279, RGD:13792537 NCBI chr 7:2,710,609...2,712,723
Ensembl chr 7:2,710,609...2,712,723
JBrowse link
regulation of cardiac cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sox17 SRY-box transcription factor 17 ISO (MGI:3703823|PMID:17360443) RGD PMID:17360443 MGI:3703823 NCBI chr 5:14,890,318...14,895,907
Ensembl chr 5:14,890,408...14,895,907
JBrowse link
regulation of cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lmo4 LIM domain only 4 ISO MGI:3664560 (MGI:3840011|PMID:19323994) RGD PMID:19323994 MGI:3840011 NCBI chr 2:250,218,635...250,235,435
Ensembl chr 2:250,218,641...250,241,673
JBrowse link
regulation of endodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 ISO (PMID:20559569) RGD PMID:20559569 NCBI chr 1:248,952,896...248,956,579
Ensembl chr 1:248,895,738...248,898,607
JBrowse link
regulation of heart induction by regulation of canonical Wnt signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pou5f1 POU class 5 homeobox 1 ISO (PMID:19736317) RGD PMID:19736317 NCBI chr20:3,747,231...3,751,994
Ensembl chr20:3,747,221...3,751,994
JBrowse link
regulation of inner ear auditory receptor cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esrp1 epithelial splicing regulatory protein 1 ISS
ISO
GO_REF:0000024
(MGI:5915403|PMID:29107558)
UniProt
RGD
PMID:29107558 GO_REF:0000024, MGI:5915403 NCBI chr 5:24,576,988...24,631,758
Ensembl chr 5:24,576,991...24,631,698
JBrowse link
regulation of lateral mesodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmpr1a bone morphogenetic protein receptor type 1A ISO MGI:95522 (MGI:3702797|PMID:16943278) RGD PMID:16943278 MGI:3702797 NCBI chr16:10,758,278...10,852,170
Ensembl chr16:10,758,527...10,802,512
JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 IEA
ISO
GO_REF:0000107
MGI:1338938 (MGI:3702797|PMID:16943278)
Ensembl
RGD
PMID:16943278 GO_REF:0000107, MGI:3702797 NCBI chr16:71,265,390...71,319,046
Ensembl chr16:71,266,248...71,319,449
JBrowse link
regulation of neural crest cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmpr1a bone morphogenetic protein receptor type 1A NOT ISO (MGI:3040576|PMID:15073157) RGD PMID:15073157 MGI:3040576 NCBI chr16:10,758,278...10,852,170
Ensembl chr16:10,758,527...10,802,512
JBrowse link
site-specific DNA replication termination at RTS1 barrier term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rtfdc1 replication termination factor 2 domain containing 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:170,443,895...170,473,456
Ensembl chr 3:170,443,855...170,473,456
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    developmental process 6826
      regulation of developmental process 2646
        regulation of cell fate commitment 35
          negative regulation of cell fate commitment + 16
          positive regulation of cell fate commitment + 7
          regulation of T-helper 17 cell lineage commitment + 4
          regulation of cell fate specification + 17
          regulation of mating type switching + 3
          regulation of retinal cone cell fate commitment + 1
          regulation of retinal rod cell fate commitment + 0
          regulation of venous endothelial cell fate commitment + 0
Path 2
Term Annotations click to browse term
  biological_process 20020
    developmental process 6826
      cellular developmental process 4457
        cell differentiation 4362
          cell fate commitment 282
            regulation of cell fate commitment 35
              negative regulation of cell fate commitment + 16
              positive regulation of cell fate commitment + 7
              regulation of T-helper 17 cell lineage commitment + 4
              regulation of cell fate specification + 17
              regulation of mating type switching + 3
              regulation of retinal cone cell fate commitment + 1
              regulation of retinal rod cell fate commitment + 0
              regulation of venous endothelial cell fate commitment + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.