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ONTOLOGY REPORT - ANNOTATIONS

Term:multicellular organism aging
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Accession:GO:0010259 term browser browse the term
Definition:An aging process that has as participant a whole multicellular organism. Multicellular organism aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Multicellular organisms aging includes processes like cellular senescence and organ senescence, but is more inclusive. May precede death (GO:0016265) of an organism and may succeed developmental maturation (GO:0021700).


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multicellular organism aging term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acan aggrecan IEP RGD PMID:19729050 RGD:2315752 NCBI chr 1:132,981,034...133,044,416
Ensembl chr 1:132,981,582...133,043,627 		JBrowse link
G Adra1a adrenoceptor alpha 1A involved_in ISO MGI:95766|MGI:95767|MGI:95768|MGI:95776 (MGI:6107503|PMID:26531127) RGD PMID:26531127 MGI:6107503 NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500 		JBrowse link
G Adra1b adrenoceptor alpha 1B involved_in ISO MGI:95766|MGI:95767|MGI:95768|MGI:95776 (MGI:6107503|PMID:26531127) RGD PMID:26531127 MGI:6107503 NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919 		JBrowse link
G Adra1d adrenoceptor alpha 1D involved_in ISO MGI:95766|MGI:95767|MGI:95768|MGI:95776 (MGI:6107503|PMID:26531127) RGD PMID:26531127 MGI:6107503 NCBI chr 3:118,793,356...118,809,354
Ensembl chr 3:118,793,346...118,809,354 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a involved_in ISO MGI:95766|MGI:95767|MGI:95768|MGI:95776 (MGI:6107503|PMID:26531127) RGD PMID:26531127 MGI:6107503 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Agtr1b angiotensin II receptor, type 1b involved_in ISO MGI:95766|MGI:95767|MGI:95768|MGI:95776 (MGI:6107503|PMID:26531127) RGD PMID:26531127 MGI:6107503 NCBI chr 2:102,844,969...102,920,232
Ensembl chr 2:102,844,969...102,920,232 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated involved_in ISO MGI:2183411|MGI:87983|MGI:97370 (MGI:2182493|PMID:12082181) RGD PMID:12082181 MGI:2182493 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446 		JBrowse link
G Arhgef12 Rho guanine nucleotide exchange factor 12 involved_in ISO MGI:95766|MGI:95767|MGI:95768|MGI:95776 (MGI:6107503|PMID:26531127) RGD PMID:26531127 MGI:6107503 NCBI chr 8:43,350,070...43,475,404
Ensembl chr 8:43,353,799...43,476,366 		JBrowse link
G Avpr1a arginine vasopressin receptor 1A involved_in ISO MGI:95766|MGI:95767|MGI:95768|MGI:95776 (MGI:6107503|PMID:26531127) RGD PMID:26531127 MGI:6107503 NCBI chr 7:58,114,306...58,118,230
Ensembl chr 7:58,114,284...58,122,215 		JBrowse link
G Avpr1b arginine vasopressin receptor 1B involved_in ISO MGI:95766|MGI:95767|MGI:95768|MGI:95776 (MGI:6107503|PMID:26531127) RGD PMID:26531127 MGI:6107503 NCBI chr13:43,046,960...43,057,110
Ensembl chr13:43,046,267...43,057,792 		JBrowse link
G Cisd2 CDGSH iron sulfur domain 2 involved_in ISO (MGI:3845412|PMID:19451219) RGD PMID:19451219 MGI:3845412 NCBI chr 2:223,828,937...223,853,768
Ensembl chr 2:223,828,937...223,868,946 		JBrowse link
G Comp cartilage oligomeric matrix protein involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2180787 (MGI:5824640|PMID:27498005)		 Ensembl
RGD		 PMID:27498005 GO_REF:0000107 MGI:5824640 NCBI chr16:19,047,206...19,055,584
Ensembl chr16:19,047,207...19,055,845 		JBrowse link
G Cryaa crystallin, alpha A IEP RGD PMID:19120020 RGD:13503352 NCBI chr20:9,783,605...9,787,351
Ensembl chr20:9,783,605...9,787,349 		JBrowse link
G Cryab crystallin, alpha B IEP RGD PMID:19120020 RGD:13503352 NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157 		JBrowse link
G Ctsl cathepsin L IEP kidney RGD PMID:16865413 RGD:2315581 NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548 		JBrowse link
G Dbh dopamine beta-hydroxylase IEP RGD PMID:18522866 RGD:5129682 NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248 		JBrowse link
G Ddc dopa decarboxylase IEP RGD PMID:17112516 RGD:5129108 NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208 		JBrowse link
G Edn1 endothelin 1 involved_in IEP
ISO		 arteries
(MGI:6107503|PMID:26531127)		 RGD PMID:26531127 PMID:20522806 MGI:6107503, RGD:4144863 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Ednra endothelin receptor type A involved_in ISO
IEA		 MGI:95766|MGI:95767|MGI:95768|MGI:95776 (MGI:6107503|PMID:26531127)
GO_REF:0000107		 RGD
Ensembl		 PMID:26531127 GO_REF:0000107 MGI:6107503 NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049 		JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 involved_in ISO MGI:2183411|MGI:87983|MGI:97370 (MGI:2182493|PMID:12082181) RGD PMID:12082181 MGI:2182493 NCBI chr 1:20,698,746...20,763,741
Ensembl chr 1:20,698,764...20,763,715 		JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit acts_upstream_of_or_within ISO MGI:2183944 (MGI:3696605|PMID:17183314) RGD PMID:17183314 MGI:3696605 NCBI chr 1:78,971,310...79,007,963
Ensembl chr 1:78,996,390...79,007,963 		JBrowse link
G Gna11 G protein subunit alpha 11 involved_in ISO
IEA		 MGI:95766|MGI:95767|MGI:95768|MGI:95776 (MGI:6107503|PMID:26531127)
GO_REF:0000107		 RGD
Ensembl		 PMID:26531127 GO_REF:0000107 MGI:6107503 NCBI chr 7:8,163,752...8,177,636
Ensembl chr 7:8,162,750...8,179,812 		JBrowse link
G Gna12 G protein subunit alpha 12 involved_in ISO MGI:95766|MGI:95767|MGI:95768|MGI:95776 (MGI:6107503|PMID:26531127) RGD PMID:26531127 MGI:6107503 NCBI chr12:13,805,580...13,886,255
Ensembl chr12:13,805,698...13,886,255 		JBrowse link
G Gna13 G protein subunit alpha 13 involved_in ISO MGI:95766|MGI:95767|MGI:95768|MGI:95776 (MGI:6107503|PMID:26531127) RGD PMID:26531127 MGI:6107503 NCBI chr10:94,337,939...94,370,774
Ensembl chr10:94,337,725...94,370,774 		JBrowse link
G Gnaq G protein subunit alpha q involved_in ISO
IEA		 MGI:95766|MGI:95767|MGI:95768|MGI:95776 (MGI:6107503|PMID:26531127)
GO_REF:0000107		 RGD
Ensembl		 PMID:26531127 GO_REF:0000107 MGI:6107503 NCBI chr 1:213,425,631...213,671,947
Ensembl chr 1:213,424,465...213,667,672 		JBrowse link
G Grk3 G protein-coupled receptor kinase 3 IEP RGD PMID:11171671 RGD:5685607 NCBI chr12:43,624,778...43,735,375
Ensembl chr12:43,624,897...43,731,262 		JBrowse link
G Helt helt bHLH transcription factor acts_upstream_of_or_within ISO MGI:3703237 (MGI:3702791|PMID:16968817) RGD PMID:16968817 MGI:3702791 NCBI chr16:45,991,227...45,993,045
Ensembl chr16:45,991,227...45,992,960 		JBrowse link
G Hyal2 hyaluronidase 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:3836764 (MGI:3836537|PMID:18772348)		 Ensembl
RGD		 PMID:18772348 GO_REF:0000107 MGI:3836537 NCBI chr 8:108,241,895...108,246,853
Ensembl chr 8:108,243,133...108,246,850 		JBrowse link
G Ndufs6 NADH:ubiquinone oxidoreductase subunit S6 acts_upstream_of_or_within ISO MGI:4346527 (MGI:5319010|PMID:22474353) RGD PMID:22474353 MGI:5319010 NCBI chr 2:27,201,713...27,202,126
Ensembl chr 2:27,201,713...27,202,258 		JBrowse link
G Nr5a1 nuclear receptor subfamily 5, group A, member 1 acts_upstream_of_or_within ISO MGI:5292676 (MGI:5287526|PMID:21820362) RGD PMID:21820362 MGI:5287526 NCBI chr 3:22,464,786...22,486,328
Ensembl chr 3:22,465,502...22,486,328 		JBrowse link
G Pmp22 peripheral myelin protein 22 acts_upstream_of_or_within ISO MGI:2447704 (MGI:5311965|PMID:22337502) RGD PMID:22337502 MGI:5311965 NCBI chr10:47,795,709...47,825,715
Ensembl chr10:47,795,709...47,825,714 		JBrowse link
G Rnf165 ring finger protein 165 acts_upstream_of_or_within ISO MGI:5516581 (MGI:5499270|PMID:23610558) RGD PMID:23610558 MGI:5499270 NCBI chr18:70,984,566...71,100,836
Ensembl chr18:70,989,731...71,100,836 		JBrowse link
G Sec63 SEC63 homolog, protein translocation regulator acts_upstream_of_or_within ISO MGI:5442171 (MGI:5441703|PMID:21685914) RGD PMID:21685914 MGI:5441703 NCBI chr20:46,245,101...46,314,055
Ensembl chr20:46,245,101...46,314,055 		JBrowse link
G Serp1 stress-associated endoplasmic reticulum protein 1 acts_upstream_of_or_within ISO MGI:3652355 (MGI:3629369|PMID:16705175) RGD PMID:16705175 MGI:3629369 NCBI chr 2:142,757,254...142,761,243
Ensembl chr 2:142,757,270...142,761,116 		JBrowse link
G Slc1a2 solute carrier family 1 member 2 acts_upstream_of_or_within ISO MGI:2449707 (MGI:892703|PMID:9180080) RGD PMID:9180080 MGI:892703 NCBI chr 3:89,005,129...89,126,498
Ensembl chr 3:89,005,129...89,126,498 		JBrowse link
G Terc telomerase RNA component acts_upstream_of_or_within ISO MGI:109635 (MGI:3050262|PMID:15235603) RGD PMID:15235603 MGI:3050262 NCBI chr 2:112,815,654...112,816,041 JBrowse link
G Th tyrosine hydroxylase IEP RGD PMID:17112516 RGD:5129108 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
G Tp63 tumor protein p63 acts_upstream_of_or_within ISO MGI:2385473 (MGI:3588617|PMID:16107615) RGD PMID:16107615 MGI:3588617 NCBI chr11:74,838,858...75,049,764
Ensembl chr11:74,838,859...75,049,398 		JBrowse link
G Wrn WRN RecQ like helicase involved_in
acts_upstream_of_or_within		 ISO
IBA		 (PMID:16673358)
MGI:109558 (MGI:3050262|PMID:15235603)
PMID:21873635		 RGD PMID:15235603 PMID:16673358 PMID:21873635 MGI:3050262, RGD:13792537 NCBI chr16:58,763,517...58,898,604
Ensembl chr16:58,763,504...58,895,450 		JBrowse link
determination of adult lifespan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ankle1 ankyrin repeat and LEM domain containing 1 NOT|involved_in ISO (MGI:5800654|PMID:27010503) RGD PMID:27010503 MGI:5800654 NCBI chr16:18,076,413...18,082,356
Ensembl chr16:18,076,492...18,083,729 		JBrowse link
G Atm ATM serine/threonine kinase acts_upstream_of_or_within ISO MGI:3605986|MGI:894697 (MGI:3836659|PMID:19061978) RGD PMID:19061978 MGI:3836659 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Atn1 atrophin 1 acts_upstream_of_or_within ISO MGI:4360645 (MGI:4359552|PMID:19681162) RGD PMID:19681162 MGI:4359552 NCBI chr 4:157,554,287...157,568,092
Ensembl chr 4:157,551,276...157,568,132 		JBrowse link
G Bbc3 Bcl-2 binding component 3 involved_in ISO UniProtKB:P02340 (MGI:4944151|PMID:20818388) RGD PMID:20818388 MGI:4944151 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Cfh complement factor H acts_upstream_of_or_within ISO (MGI:5883383|PMID:28057640) RGD PMID:28057640 MGI:5883383 NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838 		JBrowse link
G Cgas cyclic GMP-AMP synthase acts_upstream_of_or_within ISO MGI:1328317 (MGI:5699498|PMID:26371324) RGD PMID:26371324 MGI:5699498 NCBI chr 8:79,292,282...79,306,998
Ensembl chr 8:79,294,511...79,305,496 		JBrowse link
G Coq7 coenzyme Q7, hydroxylase involved_in
acts_upstream_of_or_within		 IBA
ISO		 PMID:21873635
MGI:2157003 (MGI:4359329|PMID:19478076)		 RGD PMID:19478076 PMID:21873635 MGI:4359329, RGD:13792537 NCBI chr 1:172,836,359...172,851,173
Ensembl chr 1:172,835,188...172,851,158 		JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 involved_in ISO MGI:1857079|MGI:3785162|MGI:6402836 (MGI:5515276|PMID:23798568), (MGI:5704242|PMID:26624227), (MGI:6101307|PMID:24770645), (MGI:6282476|PMID:28798354) RGD PMID:23798568 PMID:24770645 PMID:26624227 PMID:28798354 MGI:5515276 MGI:5704242 MGI:6101307 MGI:6282476 NCBI chr 1:20,698,746...20,763,741
Ensembl chr 1:20,698,764...20,763,715 		JBrowse link
G Ercc5 ERCC excision repair 5, endonuclease acts_upstream_of_or_within ISO MGI:3043589 (MGI:3041918|PMID:15082767) RGD PMID:15082767 MGI:3041918 NCBI chr 9:46,309,477...46,354,478
Ensembl chr 9:46,309,389...46,354,472 		JBrowse link
G Gba glucosylceramidase beta acts_upstream_of_or_within ISO (MGI:3795074|PMID:18346921) RGD PMID:18346921 MGI:3795074 NCBI chr 2:174,609,437...174,615,457
Ensembl chr 2:174,609,403...174,618,263 		JBrowse link
G Ghrhr growth hormone releasing hormone receptor acts_upstream_of_or_within ISO MGI:1856425 (MGI:2135699|PMID:11371619) RGD PMID:11371619 MGI:2135699 NCBI chr 4:84,498,159...84,532,847
Ensembl chr 4:84,500,212...84,532,776 		JBrowse link
G Hdac9 histone deacetylase 9 acts_upstream_of_or_within ISO MGI:1890508 (MGI:5139938|PMID:21746928) RGD PMID:21746928 MGI:5139938 NCBI chr 6:50,762,074...51,624,311
Ensembl chr 6:50,763,590...51,625,333 		JBrowse link
G Htt huntingtin acts_upstream_of_or_within ISO MGI:2177757|MGI:2177767|MGI:2177768 (MGI:1926691|PMID:11062468), (MGI:1929816|PMID:11152661) RGD PMID:11062468 PMID:11152661 MGI:1926691 MGI:1929816 NCBI chr14:75,845,836...75,996,094
Ensembl chr14:75,845,836...75,995,070 		JBrowse link
G Icmt isoprenylcysteine carboxyl methyltransferase acts_upstream_of_or_within ISO MGI:1890508 (MGI:5500993|PMID:23686339) RGD PMID:23686339 MGI:5500993 NCBI chr 5:162,804,368...162,811,129
Ensembl chr 5:162,804,368...162,811,128 		JBrowse link
G Ide insulin degrading enzyme involved_in ISO (PMID:18448515) RGD PMID:18448515 NCBI chr 1:235,002,984...235,102,448
Ensembl chr 1:234,995,351...235,102,440 		JBrowse link
G Inpp5d inositol polyphosphate-5-phosphatase D involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2386884 (MGI:1266928|PMID:9620849)		 Ensembl
RGD		 PMID:9620849 GO_REF:0000107 MGI:1266928 NCBI chr 9:88,287,680...88,392,748
Ensembl chr 9:88,287,677...88,392,746 		JBrowse link
G Lep leptin acts_upstream_of_or_within ISO MGI:1328317 (MGI:5829115|PMID:28069950) RGD PMID:28069950 MGI:5829115 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 involved_in ISO (PMID:19692353) RGD PMID:19692353 NCBI chr 7:122,826,712...122,987,711
Ensembl chr 7:122,826,696...122,987,703 		JBrowse link
G Msh2 mutS homolog 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1858055 (MGI:1351797|PMID:10545954)		 Ensembl
RGD		 PMID:10545954 GO_REF:0000107 MGI:1351797 NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938 		JBrowse link
G Msh6 mutS homolog 6 acts_upstream_of_or_within ISO MGI:1858014|MGI:2151803 (MGI:1100204|PMID:9390556), (MGI:1351797|PMID:10545954) RGD PMID:9390556 PMID:10545954 MGI:1100204 MGI:1351797 NCBI chr 6:6,562,631...6,579,995
Ensembl chr 6:6,562,632...6,579,956 		JBrowse link
G Pou1f1 POU class 1 homeobox 1 acts_upstream_of_or_within ISO MGI:1856024|MGI:1856025 (MGI:2135699|PMID:11371619) RGD PMID:11371619 MGI:2135699 NCBI chr11:3,316,818...3,334,804
Ensembl chr11:3,317,058...3,334,801 		JBrowse link
G Prdm2 PR/SET domain 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2388354 (MGI:2149923|PMID:11544182)		 Ensembl
RGD		 PMID:11544182 GO_REF:0000107 MGI:2149923 NCBI chr 5:155,421,066...155,531,884
Ensembl chr 5:155,422,134...155,531,825 		JBrowse link
G Rad54b RAD54 homolog B acts_upstream_of_or_within ISO MGI:107202|MGI:894697 (MGI:3836659|PMID:19061978) RGD PMID:19061978 MGI:3836659 NCBI chr 5:25,030,885...25,104,616
Ensembl chr 5:25,032,066...25,104,616 		JBrowse link
G Rad54l RAD54 like acts_upstream_of_or_within ISO MGI:107202|MGI:3605986 (MGI:3836659|PMID:19061978) RGD PMID:19061978 MGI:3836659 NCBI chr 5:129,575,431...129,605,100
Ensembl chr 5:129,575,378...129,605,070 		JBrowse link
G Suv39h1 SUV39H1 histone lysine methyltransferase acts_upstream_of_or_within ISO MGI:1890508 (MGI:5913114|PMID:23695662) RGD PMID:23695662 MGI:5913114 NCBI chr  X:141,793,695...141,795,558 JBrowse link
G Tfcp2l1 transcription factor CP2-like 1 acts_upstream_of_or_within ISO MGI:3707684 (MGI:3703120|PMID:17079272) RGD PMID:17079272 MGI:3703120 NCBI chr13:29,733,813...29,793,870
Ensembl chr13:29,733,840...29,793,870 		JBrowse link
G Tp53 tumor protein p53 involved_in ISO (MGI:4944151|PMID:20818388) RGD PMID:20818388 MGI:4944151 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Trex1 three prime repair exonuclease 1 acts_upstream_of_or_within ISO MGI:104663|MGI:2442261|MGI:3052754 (MGI:3052278|PMID:15254239), (MGI:5699498|PMID:26371324), (MGI:5829115|PMID:28069950) RGD PMID:15254239 PMID:26371324 PMID:28069950 MGI:3052278 MGI:5699498 MGI:5829115 NCBI chr 8:109,706,613...109,707,913
Ensembl chr 8:109,706,613...109,708,796 		JBrowse link
G Zmpste24 zinc metallopeptidase STE24 acts_upstream_of_or_within ISO MGI:1099440|MGI:1888594|MGI:1931221|MGI:2180033 (MGI:2178865|PMID:11923874), (MGI:3583382|PMID:15980864), (MGI:3789238|PMID:16079796), (MGI:3797328|PMID:18443001), (MGI:5139938|PMID:21746928), (MGI:5500993|PMID:23686339), (MGI:5824440|PMID:27799555), (MGI:5913114|PMID:23695662) RGD PMID:11923874 PMID:15980864 PMID:16079796 PMID:18443001 PMID:21746928 More... MGI:2178865 MGI:3583382 MGI:3789238 MGI:3797328 MGI:5139938 MGI:5500993 MGI:5824440 MGI:5913114 NCBI chr 5:134,627,218...134,660,360
Ensembl chr 5:134,627,229...134,660,110 		JBrowse link
reproductive senescence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Inhbb inhibin subunit beta B IEP RGD PMID:17636211 RGD:9743910 NCBI chr13:30,530,860...30,536,566
Ensembl chr13:30,530,860...30,537,832 		JBrowse link
G Jmjd1c jumonji domain containing 1C acts_upstream_of_or_within ISO MGI:5544070 (MGI:5529185|PMID:24006281) RGD PMID:24006281 MGI:5529185 NCBI chr20:21,332,147...21,494,220
Ensembl chr20:21,332,147...21,463,122 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19541
    multicellular organismal process 9044
      multicellular organism development 5765
        multicellular organism aging 69
          determination of adult lifespan + 29
          menopause 0
          reproductive senescence 2
Path 2
Term Annotations click to browse term
  biological_process 19541
    developmental process 6920
      anatomical structure development 6337
        multicellular organism development 5765
          multicellular organism aging 69
            determination of adult lifespan + 29
            menopause 0
            reproductive senescence 2
paths to the root