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ONTOLOGY REPORT - ANNOTATIONS

Term:multicellular organism aging
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Accession:GO:0010259 term browser browse the term
Definition:An aging process that has as participant a whole multicellular organism. Multicellular organism aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Multicellular organisms aging includes processes like cellular senescence and organ senescence, but is more inclusive. May precede death (GO:0016265) of an organism and may succeed developmental maturation (GO:0021700).

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multicellular organism aging term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acan aggrecan IEP RGD PMID:19729050 RGD:2315752 NCBI chr 1:140,762,758...140,824,441
Ensembl chr 1:140,762,758...140,824,441 		JBrowse link
G Cisd2 CDGSH iron sulfur domain 2 ISO (MGI:3845412|PMID:19451219) RGD PMID:19451219 MGI:3845412 NCBI chr 2:240,586,754...240,611,560
Ensembl chr 2:240,586,754...240,611,560 		JBrowse link
G Comp cartilage oligomeric matrix protein IEA
ISO		 GO_REF:0000107
MGI:2180787 (MGI:5824640|PMID:27498005)		 Ensembl
RGD		 PMID:27498005 GO_REF:0000107 MGI:5824640 NCBI chr16:20,798,437...20,807,070
Ensembl chr16:20,798,437...20,807,070 		JBrowse link
G Cryaa crystallin, alpha A IEP RGD PMID:19120020 RGD:13503352 NCBI chr20:10,438,444...10,442,189
Ensembl chr20:10,438,444...10,442,187 		JBrowse link
G Cryab crystallin, alpha B IEP RGD PMID:19120020 RGD:13503352 NCBI chr 8:55,178,543...55,182,546
Ensembl chr 8:55,178,289...55,182,545 		JBrowse link
G Ctsl cathepsin L IEP kidney RGD PMID:16865413 RGD:2315581 NCBI chr17:1,873,105...1,879,266
Ensembl chr17:1,872,848...1,879,279 		JBrowse link
G Dbh dopamine beta-hydroxylase IEP RGD PMID:18522866 RGD:5129682 NCBI chr 3:5,709,236...5,731,895
Ensembl chr 3:5,709,236...5,731,898 		JBrowse link
G Ddc dopa decarboxylase IEP RGD PMID:17112516 RGD:5129108 NCBI chr14:91,905,919...91,996,816
Ensembl chr14:91,905,919...91,996,774 		JBrowse link
G Edn1 endothelin 1 IEP arteries RGD PMID:20522806 RGD:4144863 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324 		JBrowse link
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit ISO MGI:2183944 (MGI:3696605|PMID:17183314) RGD PMID:17183314 MGI:3696605 NCBI chr 1:80,256,973...80,268,198
Ensembl chr 1:80,256,973...80,268,198 		JBrowse link
G Grk3 G protein-coupled receptor kinase 3 IEP RGD PMID:11171671 RGD:5685607 NCBI chr12:49,626,871...49,750,389
Ensembl chr12:49,626,871...49,746,272 		JBrowse link
G Helt helt bHLH transcription factor ISO MGI:3703237 (MGI:3702791|PMID:16968817) RGD PMID:16968817 MGI:3702791 NCBI chr16:49,185,560...49,187,293
Ensembl chr16:49,185,560...49,187,293 		JBrowse link
G Hyal2 hyaluronidase 2 IEA
ISO		 GO_REF:0000107
MGI:3836764 (MGI:3836537|PMID:18772348)		 Ensembl
RGD		 PMID:18772348 GO_REF:0000107 MGI:3836537 NCBI chr 8:116,324,062...116,328,978
Ensembl chr 8:116,324,040...116,328,978 		JBrowse link
G Ndufs6 NADH:ubiquinone oxidoreductase subunit S6 ISO MGI:4346527 (MGI:5319010|PMID:22474353) RGD PMID:22474353 MGI:5319010 NCBI chr 2:26,471,173...26,471,587
Ensembl chr 2:26,471,173...26,471,584 		JBrowse link
G Nr5a1 nuclear receptor subfamily 5, group A, member 1 ISO MGI:5292676 (MGI:5287526|PMID:21820362) RGD PMID:21820362 MGI:5287526 NCBI chr 3:22,998,900...23,020,441
Ensembl chr 3:22,999,616...23,020,441 		JBrowse link
G Pmp22 peripheral myelin protein 22 ISO MGI:2447704 (MGI:5311965|PMID:22337502) RGD PMID:22337502 MGI:5311965 NCBI chr10:49,538,588...49,568,583
Ensembl chr10:49,538,588...49,568,583 		JBrowse link
G Rnf165 ring finger protein 165 ISO MGI:5516581 (MGI:5499270|PMID:23610558) RGD PMID:23610558 MGI:5499270 NCBI chr18:73,831,289...73,873,246
Ensembl chr18:73,831,326...73,873,280 		JBrowse link
G Sec63 SEC63 homolog, protein translocation regulator ISO MGI:5442171 (MGI:5441703|PMID:21685914) RGD PMID:21685914 MGI:5441703 NCBI chr20:47,494,270...47,563,222
Ensembl chr20:47,494,270...47,563,222 		JBrowse link
G Serp1 stress-associated endoplasmic reticulum protein 1 ISO MGI:3652355 (MGI:3629369|PMID:16705175) RGD PMID:16705175 MGI:3629369 NCBI chr 2:148,718,279...148,722,263
Ensembl chr 2:148,718,280...148,722,263 		JBrowse link
G Slc1a2 solute carrier family 1 member 2 ISO MGI:2449707 (MGI:892703|PMID:9180080) RGD PMID:9180080 MGI:892703 NCBI chr 3:92,518,679...92,665,731
Ensembl chr 3:92,640,752...92,665,644 		JBrowse link
G Terc telomerase RNA component ISO MGI:109635 (MGI:3050262|PMID:15235603) RGD PMID:15235603 MGI:3050262 NCBI chr 2:116,432,723...116,433,110
Ensembl chr 2:116,432,691...116,433,110 		JBrowse link
G Th tyrosine hydroxylase IEP RGD PMID:17112516 RGD:5129108 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287 		JBrowse link
G Tp63 tumor protein p63 ISO MGI:2385473 (MGI:3588617|PMID:16107615) RGD PMID:16107615 MGI:3588617 NCBI chr11:78,234,853...78,456,559
Ensembl chr11:78,234,800...78,456,501 		JBrowse link
G Wrn WRN RecQ like helicase ISO
IBA		 (PMID:16673358)
PMID:21873635
MGI:109558 (MGI:3050262|PMID:15235603)		 RGD PMID:15235603 PMID:16673358, PMID:21873635 MGI:3050262, RGD:13792537 NCBI chr16:62,483,773...62,619,018
Ensembl chr16:62,483,761...62,615,375 		JBrowse link
determination of adult lifespan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ankle1 ankyrin repeat and LEM domain containing 1 NOT ISO (MGI:5800654|PMID:27010503) RGD PMID:27010503 MGI:5800654 NCBI chr16:19,799,943...19,826,057
Ensembl chr16:19,800,463...19,803,796 		JBrowse link
G Atm ATM serine/threonine kinase ISO MGI:3605986|MGI:894697 (MGI:3836659|PMID:19061978) RGD PMID:19061978 MGI:3836659 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045 		JBrowse link
G Atn1 atrophin 1 ISO MGI:4360645 (MGI:4359552|PMID:19681162) RGD PMID:19681162 MGI:4359552 NCBI chr 4:157,267,394...157,281,199
Ensembl chr 4:157,267,901...157,274,755
Ensembl chr 9:157,267,901...157,274,755 		JBrowse link
G Bbc3 Bcl-2 binding component 3 ISO UniProtKB:P02340 (MGI:4944151|PMID:20818388) RGD PMID:20818388 MGI:4944151 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Cfh complement factor H ISO (MGI:5883383|PMID:28057640) RGD PMID:28057640 MGI:5883383 NCBI chr13:56,979,155...57,080,540
Ensembl chr13:56,978,607...57,080,622 		JBrowse link
G Cgas cyclic GMP-AMP synthase ISO MGI:1328317 (MGI:5699498|PMID:26371324) RGD PMID:26371324 MGI:5699498 NCBI chr 8:85,789,515...85,804,008
Ensembl chr 8:85,789,763...85,803,433 		JBrowse link
G Coq7 coenzyme Q7, hydroxylase ISO
IBA		 MGI:2157003 (MGI:4359329|PMID:19478076)
PMID:21873635		 RGD PMID:19478076, PMID:21873635 MGI:4359329, RGD:13792537 NCBI chr 1:188,176,060...188,190,874
Ensembl chr 1:188,174,874...188,190,860 		JBrowse link
G Ercc5 ERCC excision repair 5, endonuclease ISO MGI:3043589 (MGI:3041918|PMID:15082767) RGD PMID:15082767 MGI:3041918 NCBI chr 9:50,928,847...50,970,962
Ensembl chr 9:50,925,619...50,970,955 		JBrowse link
G Gba glucosylceramidase beta ISO
IEA		 (MGI:3795074|PMID:18346921)
GO_REF:0000107		 RGD
Ensembl		 PMID:18346921 GO_REF:0000107 MGI:3795074 NCBI chr 2:188,511,781...188,522,602
Ensembl chr 2:188,516,582...188,522,601 		JBrowse link
G Ghrhr growth hormone releasing hormone receptor ISO MGI:1856425 (MGI:2135699|PMID:11371619) RGD PMID:11371619 MGI:2135699 NCBI chr 4:85,587,321...85,602,389
Ensembl chr 4:85,588,595...85,601,666 		JBrowse link
G Hdac9 histone deacetylase 9 ISO MGI:1890508 (MGI:5139938|PMID:21746928) RGD PMID:21746928 MGI:5139938 NCBI chr 6:53,487,367...54,358,694
Ensembl chr 6:53,488,883...54,059,119 		JBrowse link
G Htt huntingtin ISO MGI:2177757|MGI:2177767|MGI:2177768 (MGI:1926691|PMID:11062468), (MGI:1929816|PMID:11152661) RGD PMID:11062468 PMID:11152661 MGI:1926691 MGI:1929816 NCBI chr14:81,105,139...81,254,637
Ensembl chr14:81,105,139...81,254,637 		JBrowse link
G Icmt isoprenylcysteine carboxyl methyltransferase ISO MGI:1890508 (MGI:5500993|PMID:23686339) RGD PMID:23686339 MGI:5500993 NCBI chr 5:169,475,270...169,482,031
Ensembl chr 5:169,475,270...169,482,030 		JBrowse link
G Ide insulin degrading enzyme ISO (PMID:18448515) RGD PMID:18448515 NCBI chr 1:255,914,465...256,014,168
Ensembl chr 1:255,914,447...256,013,495 		JBrowse link
G Inpp5d inositol polyphosphate-5-phosphatase D IEA
ISO		 GO_REF:0000107
MGI:2386884 (MGI:1266928|PMID:9620849)		 Ensembl
RGD		 PMID:9620849 GO_REF:0000107 MGI:1266928 NCBI chr 9:94,745,220...94,850,778
Ensembl chr 9:94,745,217...94,850,771 		JBrowse link
G Lep leptin ISO MGI:1328317 (MGI:5829115|PMID:28069950) RGD PMID:28069950 MGI:5829115 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818 		JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 ISO (PMID:19692353) RGD PMID:19692353 NCBI chr 7:132,857,311...133,018,549
Ensembl chr 7:132,857,628...133,018,584 		JBrowse link
G Msh2 mutS homolog 2 IEA
ISO		 GO_REF:0000107
MGI:1858055 (MGI:1351797|PMID:10545954)		 Ensembl
RGD		 PMID:10545954 GO_REF:0000107 MGI:1351797 NCBI chr 6:11,215,951...11,274,916
Ensembl chr 6:11,215,963...11,274,932 		JBrowse link
G Msh6 mutS homolog 6 ISO MGI:1858014|MGI:2151803 (MGI:1100204|PMID:9390556), (MGI:1351797|PMID:10545954) RGD PMID:9390556 PMID:10545954 MGI:1100204 MGI:1351797 NCBI chr 6:11,644,565...11,662,389
Ensembl chr 6:11,644,578...11,662,499 		JBrowse link
G Pou1f1 POU class 1 homeobox 1 ISO MGI:1856024|MGI:1856025 (MGI:2135699|PMID:11371619) RGD PMID:11371619 MGI:2135699 NCBI chr11:2,645,659...2,662,581
Ensembl chr11:2,645,865...2,662,579 		JBrowse link
G Prdm2 PR/SET domain 2 IEA
ISO		 GO_REF:0000107
MGI:2388354 (MGI:2149923|PMID:11544182)		 Ensembl
RGD		 PMID:11544182 GO_REF:0000107 MGI:2149923 NCBI chr 5:161,769,587...161,879,150
Ensembl chr 5:161,770,653...161,879,133 		JBrowse link
G Rad54b RAD54 homolog B ISO MGI:107202|MGI:894697 (MGI:3836659|PMID:19061978) RGD PMID:19061978 MGI:3836659 NCBI chr 5:25,140,531...25,214,469
Ensembl chr 5:25,146,949...25,214,376 		JBrowse link
G Rad54l RAD54 like ISO MGI:107202|MGI:3605986 (MGI:3836659|PMID:19061978) RGD PMID:19061978 MGI:3836659 NCBI chr 5:134,948,511...134,978,125
Ensembl chr 5:134,948,512...134,978,125 		JBrowse link
G Suv39h1 suppressor of variegation 3-9 homolog 1 ISO MGI:1890508 (MGI:5913114|PMID:23695662) RGD PMID:23695662 MGI:5913114 NCBI chr  X:146,532,002...146,533,538 JBrowse link
G Tfcp2l1 transcription factor CP2-like 1 ISO MGI:3707684 (MGI:3703120|PMID:17079272) RGD PMID:17079272 MGI:3703120 NCBI chr13:34,610,689...34,671,617
Ensembl chr13:34,610,684...34,670,124 		JBrowse link
G Tp53 tumor protein p53 ISO (MGI:4944151|PMID:20818388) RGD PMID:20818388 MGI:4944151 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Trex1 three prime repair exonuclease 1 ISO MGI:104663|MGI:2442261|MGI:3052754 (MGI:3052278|PMID:15254239), (MGI:5699498|PMID:26371324), (MGI:5829115|PMID:28069950) RGD PMID:15254239 PMID:26371324 PMID:28069950 MGI:3052278 MGI:5699498 MGI:5829115 NCBI chr 8:117,796,127...117,797,427
Ensembl chr 8:117,796,128...117,797,427 		JBrowse link
G Zmpste24 zinc metallopeptidase STE24 ISO MGI:1099440|MGI:1888594|MGI:1931221|MGI:2180033 (MGI:2178865|PMID:11923874), (MGI:3583382|PMID:15980864), (MGI:3789238|PMID:16079796), (MGI:3797328|PMID:18443001), (MGI:5139938|PMID:21746928), (MGI:5500993|PMID:23686339), (MGI:5824440|PMID:27799555), (MGI:5913114|PMID:23695662) RGD PMID:11923874 PMID:15980864 PMID:16079796 PMID:18443001 PMID:21746928 PMID:23686339 PMID:23695662 PMID:27799555 MGI:2178865 MGI:3583382 MGI:3789238 MGI:3797328 MGI:5139938 MGI:5500993 MGI:5824440 MGI:5913114 NCBI chr 5:139,982,404...140,015,541
Ensembl chr 5:139,983,680...140,015,541 		JBrowse link
reproductive senescence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Inhbb inhibin subunit beta B IEP RGD PMID:17636211 RGD:9743910 NCBI chr13:35,436,532...35,442,222
Ensembl chr13:35,436,532...35,442,222 		JBrowse link
G Jmjd1c jumonji domain containing 1C ISO MGI:5544070 (MGI:5529185|PMID:24006281) RGD PMID:24006281 MGI:5529185 NCBI chr20:22,751,743...22,914,080
Ensembl chr20:22,751,743...22,882,672 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20045
    multicellular organismal process 9042
      multicellular organism development 5766
        multicellular organism aging 54
          determination of adult lifespan + 28
          menopause 0
          reproductive senescence 2
Path 2
Term Annotations click to browse term
  biological_process 20045
    developmental process 6824
      anatomical structure development 6290
        multicellular organism development 5766
          multicellular organism aging 54
            determination of adult lifespan + 28
            menopause 0
            reproductive senescence 2
paths to the root