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ONTOLOGY REPORT - ANNOTATIONS


Term:cardioblast differentiation
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Accession:GO:0010002 term browser browse the term
Definition:The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.
Synonyms:exact_synonym: cardiac precursor cell differentiation;   cardioblast cell differentiation
 related_synonym: cardiomyocyte generation


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cardioblast differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eomes eomesodermin acts_upstream_of_or_within ISO (MGI:5293253|PMID:21822279) MGI PMID:21822279 MGI:5293253 NCBI chrNW_004936473:18,825,969...18,833,179 JBrowse link
G Tgfb2 transforming growth factor beta 2 involved_in ISO (PMID:15896309) UniProt PMID:15896309 NCBI chrNW_004936628:310,720...394,002 JBrowse link
cardiac muscle cell myoblast differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Isl1 ISL LIM homeobox 1 acts_upstream_of_or_within ISO (MGI:4438134|PMID:19620969) MGI PMID:19620969 MGI:4438134 NCBI chrNW_004936480:15,805,259...15,817,854 JBrowse link
G Nrg1 neuregulin 1 involved_in ISO (PMID:17336907) BHF-UCL PMID:17336907 NCBI chrNW_004936766:1,104,841...1,306,368 JBrowse link
G Rest RE1 silencing transcription factor involved_in ISO (MGI:5009770|PMID:21199191) UniProt PMID:21199191 MGI:5009770 NCBI chrNW_004936482:19,018,454...19,040,438 JBrowse link
negative regulation of cardiac muscle cell myoblast differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prickle1 prickle planar cell polarity protein 1 involved_in ISO (PMID:21199191) UniProt PMID:21199191 NCBI chrNW_004936512:1,165,159...1,270,138 JBrowse link
negative regulation of heart induction by canonical Wnt signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt3a Wnt family member 3A involved_in ISO (PMID:19736317) BHF-UCL PMID:19736317 NCBI chrNW_004936864:150,742...179,205 JBrowse link
positive regulation of cardioblast differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhx36 DEAH-box helicase 36 involved_in ISO (MGI:6201954|PMID:26489465) UniProt PMID:26489465 MGI:6201954 NCBI chrNW_004936519:1,946,684...1,987,036 JBrowse link
G Gata4 GATA binding protein 4 acts_upstream_of_or_within ISO (PMID:16137232) BHF-UCL PMID:16137232 NCBI chrNW_004936675:3,408,549...3,420,828 JBrowse link
G Gata6 GATA binding protein 6 acts_upstream_of_or_within ISO (PMID:16137232) BHF-UCL PMID:16137232 NCBI chrNW_004936550:1,814,336...1,844,399 JBrowse link
G Nkx2-5 NK2 homeobox 5 involved_in ISO (MGI:3784761|PMID:11889119) BHF-UCL PMID:11889119 MGI:3784761 NCBI chrNW_004936609:2,406,004...2,408,980 JBrowse link
G Tbx5 T-box transcription factor 5 involved_in ISO (PMID:11431700) UniProt PMID:11431700 NCBI chrNW_004936558:7,408,229...7,454,897 JBrowse link
G Tgfb2 transforming growth factor beta 2 involved_in ISO (PMID:15896309) UniProt PMID:15896309 NCBI chrNW_004936628:310,720...394,002 JBrowse link
positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Grem1 gremlin 1, DAN family BMP antagonist involved_in ISO (MGI:5315691|PMID:18545679) BHF-UCL PMID:18545679 MGI:5315691 NCBI chrNW_004936673:1,394,743...1,399,726 JBrowse link
G Myocd myocardin involved_in ISO (PMID:15907818) BHF-UCL PMID:15907818 NCBI chrNW_004936595:5,256,615...5,356,563 JBrowse link
G Srf serum response factor involved_in ISO (PMID:19783823)
(MGI:5009475|PMID:19783823)
BHF-UCL PMID:19783823 MGI:5009475 NCBI chrNW_004936476:16,779,941...16,789,499 JBrowse link
G Tbxt T-box transcription factor T involved_in ISO (PMID:21632880)
(MGI:5307952|PMID:21632880)
BHF-UCL PMID:21632880 MGI:5307952 NCBI chrNW_004936489:16,027,359...16,035,041 JBrowse link
regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Notch1 notch receptor 1 involved_in ISO (MGI:4947514|PMID:20007915) BHF-UCL PMID:20007915 MGI:4947514 NCBI chrNW_004936669:1,292,016...1,334,061 JBrowse link
G Rbpj recombination signal binding protein for immunoglobulin kappa J region involved_in ISO (MGI:5298073|PMID:21311046) BHF-UCL PMID:21311046 MGI:5298073 NCBI chrNW_004936477:3,354,336...3,445,248 JBrowse link
G Tbx2 T-box transcription factor 2 involved_in ISO (MGI:3487212|PMID:15459098) BHF-UCL PMID:15459098 MGI:3487212 NCBI chrNW_004936490:2,769,264...2,778,342 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12130
    cellular process 11321
      cellular developmental process 3716
        cell differentiation 3653
          cardiocyte differentiation 174
            cardioblast differentiation 19
              cardiac muscle cell myoblast differentiation + 11
              cardioblast cell fate commitment + 1
              endocardial precursor cell differentiation + 0
              negative regulation of cardioblast differentiation + 2
              positive regulation of cardioblast differentiation + 6
              regulation of cardioblast differentiation + 8
Path 2
Term Annotations click to browse term
  biological_process 12130
    developmental process 5711
      anatomical structure development 5339
        multicellular organism development 4889
          system development 4606
            circulatory system development 1115
              heart development 637
                cardiocyte differentiation 174
                  cardioblast differentiation 19
                    cardiac muscle cell myoblast differentiation + 11
                    cardioblast cell fate commitment + 1
                    endocardial precursor cell differentiation + 0
                    negative regulation of cardioblast differentiation + 2
                    positive regulation of cardioblast differentiation + 6
                    regulation of cardioblast differentiation + 8
paths to the root