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ONTOLOGY REPORT - ANNOTATIONS


Term:cardioblast differentiation
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Accession:GO:0010002 term browser browse the term
Definition:The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.
Synonyms:exact_synonym: cardiac precursor cell differentiation;   cardioblast cell differentiation
 related_synonym: cardiomyocyte generation


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cardioblast differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EOMES eomesodermin acts_upstream_of_or_within ISO (MGI:5293253|PMID:21822279) MGI PMID:21822279 MGI:5293253 NCBI chr13:14,209,590...14,216,184
Ensembl chr13:14,210,083...14,215,797
JBrowse link
G TGFB2 transforming growth factor beta 2 involved_in ISS
IEA
UniProt
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr10:8,306,136...8,435,307
Ensembl chr10:8,305,424...8,405,771
JBrowse link
cardiac muscle cell myoblast differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ISL1 ISL LIM homeobox 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:4438134|PMID:19620969) Ensembl
MGI
PMID:19620969 GO_REF:0000107 MGI:4438134 NCBI chr16:30,962,994...30,974,201
Ensembl chr16:30,963,000...30,973,907
JBrowse link
G LOC100621006 RE1-silencing transcription factor-like involved_in ISS
IEA
UniProt
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr 8:56,048,280...56,215,011
Ensembl chr 8:56,035,150...56,215,013
JBrowse link
G NRG1 neuregulin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:52,625,550...53,688,003
Ensembl chr15:52,627,334...53,688,332
JBrowse link
G REST RE1 silencing transcription factor involved_in IEA
ISS
Ensembl
UniProt
GO_REF:0000024 GO_REF:0000107 NCBI chr 8:56,035,182...56,061,140
Ensembl chr 8:56,035,150...56,215,013
JBrowse link
negative regulation of cardiac muscle cell myoblast differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PRICKLE1 prickle planar cell polarity protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:73,707,026...73,826,529
Ensembl chr 5:73,707,022...73,826,431
JBrowse link
negative regulation of heart induction by canonical Wnt signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G WNT3A Wnt family member 3A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:51,153,978...51,203,678
Ensembl chr 2:51,154,086...51,202,176
JBrowse link
positive regulation of cardioblast differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DHX36 DEAH-box helicase 36 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:94,298,790...94,350,333
Ensembl chr13:94,298,790...94,350,312
JBrowse link
G GATA4 GATA binding protein 4 acts_upstream_of_or_within ISO (PMID:16137232) BHF-UCL PMID:16137232 NCBI chr14:14,858,470...14,938,156
Ensembl chr14:14,858,159...14,939,941
JBrowse link
G GATA6 GATA binding protein 6 acts_upstream_of_or_within ISO (PMID:16137232) BHF-UCL PMID:16137232 NCBI chr 6:107,282,709...107,314,725
Ensembl chr 6:107,282,847...107,314,634
JBrowse link
G NKX2-5 NK2 homeobox 5 involved_in ISO (MGI:3784761|PMID:11889119) BHF-UCL PMID:11889119 MGI:3784761 NCBI chr16:51,086,014...51,089,165
Ensembl chr16:51,086,011...51,089,165
JBrowse link
G TBX5 T-box transcription factor 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:37,772,205...37,826,015
Ensembl chr14:37,773,605...37,824,400
JBrowse link
G TGFB2 transforming growth factor beta 2 involved_in ISS
IEA
UniProt
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr10:8,306,136...8,435,307
Ensembl chr10:8,305,424...8,405,771
JBrowse link
positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GREM1 gremlin 1, DAN family BMP antagonist involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:136,617,041...136,629,293
Ensembl chr 1:136,617,069...136,629,292
JBrowse link
G MYOCD myocardin involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:56,931,628...57,029,258
Ensembl chr12:56,931,317...57,029,538
JBrowse link
G SRF serum response factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:38,213,300...38,223,686
Ensembl chr 7:38,213,063...38,222,140
JBrowse link
G TBXT T-box transcription factor T involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:2,717,165...2,725,561
Ensembl chr 1:2,717,165...2,724,976
JBrowse link
regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NOTCH1 notch receptor 1 involved_in IEA Ensembl GO_REF:0000107
G RBPJ recombination signal binding protein for immunoglobulin kappa J region involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:19,933,035...20,166,746
Ensembl chr 8:19,922,779...20,166,755
JBrowse link
G TBX2 T-box transcription factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:36,878,662...36,887,513
Ensembl chr12:36,878,675...36,887,513
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16534
    cellular process 15812
      cellular developmental process 4176
        cell differentiation 4088
          cardiocyte differentiation 183
            cardioblast differentiation 20
              cardiac muscle cell myoblast differentiation + 12
              cardioblast cell fate commitment + 1
              endocardial precursor cell differentiation + 0
              negative regulation of cardioblast differentiation + 2
              positive regulation of cardioblast differentiation + 6
              regulation of cardioblast differentiation + 8
Path 2
Term Annotations click to browse term
  biological_process 16534
    developmental process 6310
      anatomical structure development 5827
        multicellular organism development 5302
          system development 4994
            circulatory system development 1194
              heart development 675
                cardiocyte differentiation 183
                  cardioblast differentiation 20
                    cardiac muscle cell myoblast differentiation + 12
                    cardioblast cell fate commitment + 1
                    endocardial precursor cell differentiation + 0
                    negative regulation of cardioblast differentiation + 2
                    positive regulation of cardioblast differentiation + 6
                    regulation of cardioblast differentiation + 8
paths to the root