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ONTOLOGY REPORT - ANNOTATIONS


Term:cardioblast differentiation
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Accession:GO:0010002 term browser browse the term
Definition:The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.
Synonyms:exact_synonym: cardiac precursor cell differentiation;   cardioblast cell differentiation
 related_synonym: cardiomyocyte generation


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cardioblast differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EOMES eomesodermin acts_upstream_of_or_within ISO (MGI:5293253|PMID:21822279) MGI PMID:21822279 MGI:5293253 NCBI chr 3:27,601,829...27,608,701
Ensembl chr 3:27,925,086...27,930,274
JBrowse link
G TGFB2 transforming growth factor beta 2 involved_in ISO (PMID:15896309) UniProt PMID:15896309 NCBI chr 1:193,907,398...194,005,800
Ensembl chr 1:198,758,751...198,859,041
JBrowse link
cardiac muscle cell myoblast differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ISL1 ISL LIM homeobox 1 acts_upstream_of_or_within ISO (MGI:4438134|PMID:19620969) MGI PMID:19620969 MGI:4438134 NCBI chr 5:62,635,095...62,650,141
Ensembl chr 5:64,252,715...64,264,674
JBrowse link
G NRG1 neuregulin 1 involved_in ISO (PMID:17336907) BHF-UCL PMID:17336907 NCBI chr 8:30,954,852...32,084,411
Ensembl chr 8:29,050,222...29,263,977
JBrowse link
G REST RE1 silencing transcription factor involved_in ISO (MGI:5009770|PMID:21199191) UniProt PMID:21199191 MGI:5009770 NCBI chr 4:66,984,466...67,012,301
Ensembl chr 4:73,526,085...73,582,242
JBrowse link
negative regulation of cardiac muscle cell myoblast differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PRICKLE1 prickle planar cell polarity protein 1 involved_in ISO (PMID:21199191) UniProt PMID:21199191 NCBI chr12:46,127,673...46,262,333
Ensembl chr12:47,100,393...47,126,102
JBrowse link
negative regulation of heart induction by canonical Wnt signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G WNT3A Wnt family member 3A involved_in ISO (PMID:19736317) BHF-UCL PMID:19736317 NCBI chr 1:203,409,294...203,463,214
Ensembl chr 1:208,628,706...208,674,469
JBrowse link
positive regulation of cardioblast differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DHX36 DEAH-box helicase 36 involved_in ISO (MGI:6201954|PMID:26489465) UniProt PMID:26489465 MGI:6201954 NCBI chr 3:151,331,468...151,382,406
Ensembl chr 3:158,885,541...158,935,871
JBrowse link
G GATA4 GATA binding protein 4 acts_upstream_of_or_within ISO (PMID:16137232) BHF-UCL PMID:16137232 NCBI chr 8:7,442,921...7,526,731 JBrowse link
G GATA6 GATA binding protein 6 acts_upstream_of_or_within ISO (PMID:16137232) BHF-UCL PMID:16137232 NCBI chr18:15,411,764...15,444,402 JBrowse link
G NKX2-5 NK2 homeobox 5 involved_in ISO (MGI:3784761|PMID:11889119) BHF-UCL PMID:11889119 MGI:3784761 NCBI chr 5:168,584,197...168,589,406
Ensembl chr 5:175,492,288...175,495,514
JBrowse link
G TBX5 T-box transcription factor 5 involved_in ISO (PMID:11431700) UniProt PMID:11431700 NCBI chr12:111,954,222...112,009,261
Ensembl chr12:115,333,609...115,389,739
JBrowse link
G TGFB2 transforming growth factor beta 2 involved_in ISO (PMID:15896309) UniProt PMID:15896309 NCBI chr 1:193,907,398...194,005,800
Ensembl chr 1:198,758,751...198,859,041
JBrowse link
positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GREM1 gremlin 1, DAN family BMP antagonist involved_in ISO (MGI:5315691|PMID:18545679) BHF-UCL PMID:18545679 MGI:5315691 NCBI chr15:11,213,870...11,230,619 JBrowse link
G MYOCD myocardin involved_in ISO (PMID:15907818) BHF-UCL PMID:15907818 NCBI chr17:38,880,120...38,983,246
Ensembl chr17:43,584,259...43,681,659
JBrowse link
G SRF serum response factor involved_in ISO (PMID:19783823)
(MGI:5009475|PMID:19783823)
BHF-UCL PMID:19783823 MGI:5009475 NCBI chr 6:42,763,099...42,773,332
Ensembl chr 6:44,057,192...44,066,768
JBrowse link
G TBXT T-box transcription factor T involved_in ISO (PMID:21632880)
(MGI:5307952|PMID:21632880)
BHF-UCL PMID:21632880 MGI:5307952 NCBI chr 6:164,112,117...164,122,253
Ensembl chr 6:169,095,723...169,106,595
JBrowse link
regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NOTCH1 notch receptor 1 involved_in ISO (MGI:4947514|PMID:20007915) BHF-UCL PMID:20007915 MGI:4947514 NCBI chr 9:107,568,670...107,621,032
Ensembl chr 9:136,544,639...136,598,740
JBrowse link
G RBPJ recombination signal binding protein for immunoglobulin kappa J region involved_in ISO (MGI:5298073|PMID:21311046) BHF-UCL PMID:21311046 MGI:5298073 NCBI chr 4:20,719,548...20,835,439
Ensembl chr 4:25,995,263...26,107,683
JBrowse link
G TBX2 T-box transcription factor 2 involved_in ISO (MGI:3487212|PMID:15459098) BHF-UCL PMID:15459098 MGI:3487212 NCBI chr17:55,501,932...55,511,537
Ensembl chr17:60,622,098...60,630,189
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12612
    cellular process 11742
      cellular developmental process 3811
        cell differentiation 3744
          cardiocyte differentiation 176
            cardioblast differentiation 19
              cardiac muscle cell myoblast differentiation + 11
              cardioblast cell fate commitment + 1
              endocardial precursor cell differentiation + 0
              negative regulation of cardioblast differentiation + 2
              positive regulation of cardioblast differentiation + 6
              regulation of cardioblast differentiation + 8
Path 2
Term Annotations click to browse term
  biological_process 12612
    developmental process 5882
      anatomical structure development 5485
        multicellular organism development 5017
          system development 4723
            circulatory system development 1133
              heart development 644
                cardiocyte differentiation 176
                  cardioblast differentiation 19
                    cardiac muscle cell myoblast differentiation + 11
                    cardioblast cell fate commitment + 1
                    endocardial precursor cell differentiation + 0
                    negative regulation of cardioblast differentiation + 2
                    positive regulation of cardioblast differentiation + 6
                    regulation of cardioblast differentiation + 8
paths to the root