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ONTOLOGY REPORT - ANNOTATIONS


Term:response to cold
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Accession:GO:0009409 term browser browse the term
Definition:Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.
Synonyms:related_synonym: freezing tolerance


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response to cold term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acadl acyl-CoA dehydrogenase, long chain ISO (MGI:MGI:5660099|PMID:21151927) RGD PMID:21151927 MGI:MGI:5660099 NCBI chr 9:73,833,368...73,871,857
Ensembl chr 9:73,833,388...73,871,888
JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain ISO
IEA
MGI:MGI:3692446 (MGI:MGI:3692159|PMID:16121256)
GO_REF:0000107
RGD
Ensembl
PMID:16121256 GO_REF:0000107, MGI:MGI:3692159 NCBI chr 2:260,124,418...260,148,589
Ensembl chr 2:260,124,418...260,148,589
JBrowse link
G Acadvl acyl-CoA dehydrogenase, very long chain ISO
IEA
MGI:MGI:3606688 (MGI:MGI:5660099|PMID:21151927)
GO_REF:0000107
RGD
Ensembl
PMID:21151927 GO_REF:0000107, MGI:MGI:5660099 NCBI chr10:56,619,321...56,624,468
Ensembl chr10:56,619,303...56,624,526
JBrowse link
G Acot11 acyl-CoA thioesterase 11 ISO (PMID:11696000) RGD PMID:11696000 NCBI chr 5:126,347,478...126,395,655
Ensembl chr 5:126,347,435...126,395,668
JBrowse link
G Adm adrenomedullin IEP RGD PMID:16432587 RGD:1625324 NCBI chr 1:175,443,189...175,447,260
Ensembl chr 1:175,445,088...175,447,259
JBrowse link
G Adrb1 adrenoceptor beta 1 IEA
ISO
GO_REF:0000107
MGI:MGI:87938|MGI:MGI:87939 (MGI:MGI:2387786|PMID:12161655), (MGI:MGI:2388907|PMID:12387862)
Ensembl
RGD
PMID:12161655, PMID:12387862 GO_REF:0000107, MGI:MGI:2387786, MGI:MGI:2388907 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985
JBrowse link
G Adrb2 adrenoceptor beta 2 IEA
ISO
GO_REF:0000107
MGI:MGI:87937|MGI:MGI:87939 (MGI:MGI:2387786|PMID:12161655), (MGI:MGI:2388907|PMID:12387862)
Ensembl
RGD
PMID:12161655, PMID:12387862 GO_REF:0000107, MGI:MGI:2387786, MGI:MGI:2388907 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Adrb3 adrenoceptor beta 3 IEP
ISO
MGI:MGI:87937|MGI:MGI:87938 (MGI:MGI:2387786|PMID:12161655), (MGI:MGI:2388907|PMID:12387862) RGD PMID:12161655, PMID:12387862, PMID:9914406 MGI:MGI:2387786, MGI:MGI:2388907, RGD:2313169 NCBI chr16:69,003,541...69,006,632
Ensembl chr16:69,003,868...69,006,632
JBrowse link
G Agt angiotensinogen ISO MGI:MGI:1857121 (MGI:MGI:3608266|PMID:12574102) RGD PMID:12574102 MGI:MGI:3608266 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Atp2b1 ATPase plasma membrane Ca2+ transporting 1 IEP RGD PMID:10777776 RGD:2317731 NCBI chr 7:41,114,606...41,223,138
Ensembl chr 7:41,114,697...41,220,579
JBrowse link
G Casp12 caspase 12 IEP RGD PMID:18456407 RGD:2311457 NCBI chr 8:2,658,892...2,686,160
Ensembl chr 8:2,659,865...2,686,160
JBrowse link
G Casp8 caspase 8 IEP RGD PMID:18410517 RGD:2311437 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Cdh8 cadherin 8 ISO
IEA
MGI:MGI:3707077 (MGI:MGI:3703934|PMID:17392463)
GO_REF:0000107
RGD
Ensembl
PMID:17392463 GO_REF:0000107, MGI:MGI:3703934 NCBI chr19:6,031,654...6,431,502
Ensembl chr19:6,046,665...6,426,216
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit IEA
ISO
GO_REF:0000107
(MGI:MGI:3843740|PMID:19230830)
Ensembl
RGD
PMID:19230830 GO_REF:0000107, MGI:MGI:3843740 NCBI chr 1:123,897,341...124,039,263
Ensembl chr 1:123,899,657...124,039,196
JBrowse link
G Cirbp cold inducible RNA binding protein IEP RGD PMID:10641716 RGD:724747 NCBI chr 7:12,400,066...12,405,054
Ensembl chr 7:12,401,207...12,405,022
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 IEP RGD PMID:16469832 RGD:2311385 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Dio2 iodothyronine deiodinase 2 IDA RGD PMID:11934678 RGD:628323 NCBI chr 6:114,475,156...114,489,443
Ensembl chr 6:114,476,142...114,476,723
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit IEP RGD PMID:16169632 RGD:2293774 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fosl2 FOS like 2, AP-1 transcription factor subunit IEP RGD PMID:16169632 RGD:2293774 NCBI chr 6:25,598,936...25,616,995
Ensembl chr 6:25,598,936...25,616,995
JBrowse link
G Gk glycerol kinase IEP RGD PMID:12736183 RGD:2302184 NCBI chr  X:54,227,291...54,303,897
Ensembl chr  X:54,227,397...54,303,864
JBrowse link
G Gmpr guanosine monophosphate reductase IEP RGD PMID:9813009 RGD:70748 NCBI chr17:19,543,274...19,580,929
Ensembl chr17:19,543,275...19,580,929
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 ISS GO_REF:0000024 AgBase GO_REF:0000024 NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775
JBrowse link
G Hspa2 heat shock protein family A (Hsp70) member 2 ISS GO_REF:0000024 AgBase GO_REF:0000024 NCBI chr 6:99,433,575...99,436,288
Ensembl chr 6:99,433,550...99,436,289
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 ISS GO_REF:0000024 AgBase GO_REF:0000024 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956
JBrowse link
G Il18 interleukin 18 IEP RGD PMID:8999896 RGD:69858 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il6 interleukin 6 IEP RGD PMID:19406216 RGD:2306923 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Immt inner membrane mitochondrial protein IEP RGD PMID:17203945 RGD:1627621 NCBI chr 4:99,753,446...99,789,921
Ensembl chr 4:99,753,500...99,792,484
JBrowse link
G Impdh1 inosine monophosphate dehydrogenase 1 IEP RGD PMID:18036333 RGD:5144140 NCBI chr 4:56,478,383...56,493,987
Ensembl chr 4:56,478,384...56,493,923
JBrowse link
G LOC100909612 mitochondrial brown fat uncoupling protein 1-like IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr19:29,395,702...29,400,389
Ensembl chr19:29,396,157...29,400,355
JBrowse link
G LOC103690091 proSAAS ISO (MGI:MGI:3629450|PMID:16631141) RGD PMID:16631141 MGI:MGI:3629450 NCBI chr  X:15,324,261...15,328,617 JBrowse link
G LOC103692716 heat shock protein HSP 90-alpha ISS GO_REF:0000024 AgBase GO_REF:0000024 NCBI chr 6:135,044,833...135,050,417
Ensembl chr 6:135,045,363...135,049,728
JBrowse link
G Lpl lipoprotein lipase IEP RGD PMID:18722549 RGD:7241069 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
JBrowse link
G Lrp11 LDL receptor related protein 11 ISO (PMID:25262641) RGD PMID:25262641 NCBI chr 1:1,702,696...1,731,210
Ensembl chr 1:1,702,696...1,731,210
JBrowse link
G Metrnl meteorin-like, glial cell differentiation regulator ISO
IEA
ISS
(MGI:MGI:5574515|PMID:24906147)
GO_REF:0000002
GO_REF:0000024
RGD
InterPro
UniProt
PMID:24906147 GO_REF:0000002, GO_REF:0000024, MGI:MGI:5574515 NCBI chr10:110,893,261...110,907,256
Ensembl chr10:110,893,232...110,907,243
JBrowse link
G Mt-co2 mitochondrially encoded cytochrome c oxidase II IEP RGD PMID:8250848 RGD:2302299 NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689
JBrowse link
G P2rx3 purinergic receptor P2X 3 ISO MGI:MGI:1934019 (MGI:MGI:3610736|PMID:15927378) RGD PMID:15927378 MGI:MGI:3610736 NCBI chr 3:72,403,992...72,447,801
Ensembl chr 3:72,403,993...72,447,801
JBrowse link
G Plac8 placenta associated 8 ISO MGI:MGI:3834141 (MGI:MGI:5302795|PMID:21982742) RGD PMID:21982742 MGI:MGI:5302795 NCBI chr14:10,692,799...10,714,556
Ensembl chr14:10,692,764...10,714,524
JBrowse link
G Pmch pro-melanin-concentrating hormone IMP RGD PMID:12960043 RGD:1642490 NCBI chr 7:28,655,206...28,656,522
Ensembl chr 7:28,654,733...28,657,522
JBrowse link
G Pnmt phenylethanolamine-N-methyltransferase IEP RGD PMID:17356229 RGD:5130210 NCBI chr10:86,340,893...86,342,501
Ensembl chr10:86,340,940...86,342,858
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma IEP RGD PMID:10438514 RGD:727277 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha IEP RGD PMID:23100029 RGD:7242022 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Rbm3 RNA binding motif protein 3 ISO (MGI:MGI:3530692|PMID:15684048) RGD PMID:15684048 MGI:MGI:3530692 NCBI chr  X:15,098,880...15,102,344
Ensembl chr  X:15,098,904...15,102,340
JBrowse link
G Rgs7 regulator of G-protein signaling 7 IEP RGD PMID:18461718 RGD:13524837 NCBI chr13:93,095,659...93,534,452
Ensembl chr13:93,095,200...93,307,199
JBrowse link
G Slc25a27 solute carrier family 25, member 27 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:19,880,468...19,907,506
Ensembl chr 9:19,880,473...19,907,458
JBrowse link
G Slc27a1 solute carrier family 27 member 1 ISO
IBA
IEA
MGI:MGI:3038701 (MGI:MGI:3709117|PMID:17130465)
PMID:21873635
GO_REF:0000107
RGD
Ensembl
PMID:17130465, PMID:21873635 GO_REF:0000107, MGI:MGI:3709117, RGD:13792537 NCBI chr16:19,997,823...20,016,193
Ensembl chr16:19,999,112...20,016,190
JBrowse link
G Sod2 superoxide dismutase 2 IEP Acute and/or chronic stress RGD PMID:20020182 RGD:2317380 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Tgfb2 transforming growth factor, beta 2 IEP RGD PMID:15922484 RGD:1641989 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
JBrowse link
G Thra thyroid hormone receptor alpha ISO
IEA
MGI:MGI:2679056 (MGI:MGI:2677074|PMID:12869545)
GO_REF:0000107
RGD
Ensembl
PMID:12869545 GO_REF:0000107, MGI:MGI:2677074 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933
JBrowse link
G Tmem135 transmembrane protein 135 ISO (MGI:MGI:5660099|PMID:21151927) RGD PMID:21151927 MGI:MGI:5660099 NCBI chr 1:152,886,496...153,096,225
Ensembl chr 1:152,886,996...153,096,269
JBrowse link
G Trh thyrotropin releasing hormone IEP RGD PMID:16629836 RGD:1600416 NCBI chr 4:124,110,716...124,113,242
Ensembl chr 4:124,110,716...124,113,242
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 IEA
ISO
GO_REF:0000107
MGI:MGI:3624810 (MGI:MGI:3529637|PMID:12654248), (MGI:MGI:3623714|PMID:16630838)
Ensembl
RGD
PMID:12654248, PMID:16630838 GO_REF:0000107, MGI:MGI:3529637, MGI:MGI:3623714 NCBI chr 5:3,783,247...3,836,485
Ensembl chr 5:3,783,247...3,836,485
JBrowse link
G Trpm8 transient receptor potential cation channel, subfamily M, member 8 IDA
ISO
MGI:MGI:3716518|MGI:MGI:3716553|MGI:MGI:3716558 (MGI:MGI:3529637|PMID:12654248), (MGI:MGI:3696601|PMID:17015441), (MGI:MGI:3716025|PMID:17481392), (MGI:MGI:3716032|PMID:17481391), (MGI:MGI:3716047|PMID:17538622) RGD PMID:12654248, PMID:17015441, PMID:17481391, PMID:17481392, PMID:17538622, PMID:11882888 MGI:MGI:3529637, MGI:MGI:3696601, MGI:MGI:3716025, MGI:MGI:3716032, MGI:MGI:3716047, RGD:632416 NCBI chr 9:95,393,370...95,484,528
Ensembl chr 9:95,398,237...95,482,890
JBrowse link
G Ucp1 uncoupling protein 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr19:24,456,976...24,464,808
Ensembl chr19:24,456,976...24,464,807
JBrowse link
G Ucp2 uncoupling protein 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:165,506,375...165,512,744
Ensembl chr 1:165,506,361...165,512,744
JBrowse link
G Ucp3 uncoupling protein 3 IEP
IBA
PMID:21873635 RGD
GO_Central
PMID:9367914, PMID:21873635 RGD:2313537, RGD:13792537 NCBI chr 1:165,482,912...165,495,895
Ensembl chr 1:165,482,155...165,496,206
JBrowse link
G Vegfa vascular endothelial growth factor A IEP RGD PMID:10342292 RGD:2314329 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vgf VGF nerve growth factor inducible ISO (MGI:MGI:3629450|PMID:16631141) RGD PMID:16631141 MGI:MGI:3629450 NCBI chr12:22,677,302...22,680,630
Ensembl chr12:22,677,607...22,680,630
JBrowse link
G Zfp516 zinc finger protein 516 ISO (MGI:MGI:5616937|PMID:25578880) RGD PMID:25578880 MGI:MGI:5616937 NCBI chr18:79,768,387...79,857,909
Ensembl chr18:79,773,608...79,854,192
JBrowse link
cellular response to cold term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cidea cell death-inducing DFFA-like effector a ISO (MGI:MGI:5914794|PMID:28763438) RGD PMID:28763438 MGI:MGI:5914794 NCBI chr18:63,082,861...63,108,450
Ensembl chr18:63,098,144...63,108,051
JBrowse link
G Cirbp cold inducible RNA binding protein ISO (MGI:MGI:87836|PMID:9151692) RGD PMID:9151692 MGI:MGI:87836 NCBI chr 7:12,400,066...12,405,054
Ensembl chr 7:12,401,207...12,405,022
JBrowse link
G Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 ISO
ISS
(MGI:MGI:5617428|PMID:25329545)
GO_REF:0000024
RGD
UniProt
PMID:25329545 GO_REF:0000024, MGI:MGI:5617428 NCBI chr15:104,186,918...104,226,236
Ensembl chr15:104,186,792...104,226,329
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 ISO
ISS
(PMID:25329545)
GO_REF:0000024
RGD
UniProt
PMID:25329545 GO_REF:0000024 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 ISO (PMID:25329545) RGD PMID:25329545 NCBI chr 3:110,159,624...110,245,382
Ensembl chr 3:110,159,708...110,249,217
JBrowse link
G Nfe2l1 nuclear factor, erythroid 2-like 1 ISO MGI:MGI:6101514 (MGI:MGI:6198859|PMID:29400713) RGD PMID:29400713 MGI:MGI:6198859 NCBI chr10:84,686,762...84,699,313
Ensembl chr10:84,682,460...84,698,886
JBrowse link
G Rnf34 ring finger protein 34 ISO (MGI:MGI:5582154|PMID:22064484) RGD PMID:22064484 MGI:MGI:5582154 NCBI chr12:39,164,290...39,185,209
Ensembl chr12:39,164,290...39,185,168
JBrowse link
G Saxo1 stabilizer of axonemal microtubules 1 ISO (PMID:25673876) RGD PMID:25673876 NCBI chr 5:104,771,081...104,921,001
Ensembl chr 5:104,771,392...104,920,906
JBrowse link
G Saxol1 stabilizer of axonemal microtubules like 1 ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr  X:29,520,263...29,522,420
Ensembl chr  X:29,520,263...29,522,420
JBrowse link
G Slc9a1 solute carrier family 9 member A1 IEP RGD PMID:15452191 RGD:1625557 NCBI chr 5:151,573,122...151,626,360
Ensembl chr 5:151,573,092...151,627,316
JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 IMP RGD PMID:21068322 RGD:10043615 NCBI chr 5:3,783,247...3,836,485
Ensembl chr 5:3,783,247...3,836,485
JBrowse link
G Ucp1 uncoupling protein 1 ISO (MGI:MGI:5914794|PMID:28763438) RGD PMID:28763438 MGI:MGI:5914794 NCBI chr19:24,456,976...24,464,808
Ensembl chr19:24,456,976...24,464,807
JBrowse link
G Vwf von Willebrand factor IEP RGD PMID:12084999 RGD:11079231 NCBI chr 4:158,085,059...158,219,525
Ensembl chr 4:158,088,505...158,219,523
JBrowse link
cellular response to freezing term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abraxas2 abraxas 2, BRISC complex subunit ISO MGI:MGI:88096 (MGI:MGI:5467904|PMID:22974638) RGD PMID:22974638 MGI:MGI:5467904 NCBI chr 1:204,861,768...204,887,344
Ensembl chr 1:204,861,566...204,887,377
JBrowse link
cold acclimation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Appl2 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 ISO (MGI:MGI:6150753|PMID:29467283) RGD PMID:29467283 MGI:MGI:6150753 NCBI chr 7:26,256,179...26,306,128
Ensembl chr 7:26,256,459...26,306,126
JBrowse link
G Atp5f1b ATP synthase F1 subunit beta IEP RGD PMID:9163327 RGD:13799276 NCBI chr 7:2,504,708...2,511,748
Ensembl chr 7:2,504,695...2,511,749
JBrowse link
G Atp5mc1 ATP synthase membrane subunit c locus 1 IEP RGD PMID:9163327 RGD:13799276 NCBI chr10:83,895,941...83,898,640
Ensembl chr10:83,895,947...83,898,527
JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 IDA RGD PMID:21945600 RGD:6484546 NCBI chr 2:54,857,688...54,893,404
Ensembl chr 2:54,857,688...54,893,404
JBrowse link
G Saxo1 stabilizer of axonemal microtubules 1 ISO (PMID:25673876) RGD PMID:25673876 NCBI chr 5:104,771,081...104,921,001
Ensembl chr 5:104,771,392...104,920,906
JBrowse link
G Saxol1 stabilizer of axonemal microtubules like 1 ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr  X:29,520,263...29,522,420
Ensembl chr  X:29,520,263...29,522,420
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    response to stimulus 10583
      response to stress 4061
        response to cold 73
          cellular response to cold + 14
          cold acclimation 6
          response to freezing + 1
          vernalization response + 0
Path 2
Term Annotations click to browse term
  biological_process 20027
    response to stimulus 10583
      response to abiotic stimulus 1511
        response to temperature stimulus 235
          response to cold 73
            cellular response to cold + 14
            cold acclimation 6
            response to freezing + 1
            vernalization response + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.