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ONTOLOGY REPORT - ANNOTATIONS


Term:folic acid-containing compound biosynthetic process
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Accession:GO:0009396 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of folic acid and its derivatives.
Synonyms:exact_synonym: folate and derivative biosynthesis;   folate and derivative biosynthetic process;   folate-containing compound biosynthesis;   folate-containing compound biosynthetic process;   folic acid and derivative biosynthesis;   folic acid and derivative biosynthetic process;   folic acid-containing compound anabolism;   folic acid-containing compound biosynthesis;   folic acid-containing compound formation;   folic acid-containing compound synthesis;   vitamin B9 and derivative biosynthesis;   vitamin B9 and derivative biosynthetic process;   vitamin M and derivative biosynthesis;   vitamin M and derivative biosynthetic process


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folic acid-containing compound biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fpgs folylpolyglutamate synthase IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:11,717,667...11,729,694
Ensembl chr 3:11,717,667...11,723,327
JBrowse link
G Mthfs methenyltetrahydrofolate synthetase IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:96,564,877...96,614,386
Ensembl chr 8:96,564,877...96,614,348
JBrowse link
10-formyltetrahydrofolate biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 ISO (PMID:1881876)
(MGI:5503248|PMID:23704330)
RGD PMID:1881876, PMID:23704330 MGI:5503248 NCBI chr 6:99,282,850...99,350,367
Ensembl chr 6:99,282,850...99,350,340
JBrowse link
G Mthfd1l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like ISO (PMID:12937168) RGD PMID:12937168 NCBI chr 1:40,529,092...40,719,232
Ensembl chr 1:40,529,045...40,719,391
JBrowse link
tetrahydrofolate biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 TAS RGD PMID:14729668 RGD:1547843 NCBI chr 4:123,516,553...123,564,067
Ensembl chr 4:123,516,788...123,557,501
JBrowse link
G Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase IDA RGD PMID:7057182 RGD:2301991 NCBI chr 9:78,862,013...78,882,061
Ensembl chr 9:78,862,013...78,882,060
JBrowse link
G Dhfr dihydrofolate reductase IDA
IBA
ISO
IEA
PMID:21873635
(PMID:2303423)
GO_REF:0000041
RGD
UniProt
PMID:2303423, PMID:11502523, PMID:21873635 GO_REF:0000041, RGD:1298877, RGD:13792537 NCBI chr 2:21,931,887...21,958,927
Ensembl chr 2:21,931,493...21,962,453
JBrowse link
G Gart phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase IDA RGD PMID:4078017 RGD:2301990 NCBI chr11:31,780,477...31,805,728
Ensembl chr11:31,780,487...31,805,728
JBrowse link
G Gch1 GTP cyclohydrolase 1 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr15:23,935,011...23,968,971
Ensembl chr15:23,934,585...23,969,011
JBrowse link
tetrahydrofolylpolyglutamate biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fpgs folylpolyglutamate synthase ISO
IBA
IEA
(PMID:25164808), (PMID:3619447)
PMID:21873635
GO_REF:0000041
RGD
UniProt
PMID:3619447, PMID:25164808, PMID:21873635 GO_REF:0000041, RGD:13792537 NCBI chr 3:11,717,667...11,729,694
Ensembl chr 3:11,717,667...11,723,327
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    cellular process 18792
      cellular metabolic process 11073
        cellular modified amino acid metabolic process 190
          folic acid-containing compound metabolic process 28
            folic acid-containing compound biosynthetic process 9
              dihydrofolate biosynthetic process 0
              folic acid biosynthetic process 0
              tetrahydrofolate biosynthetic process + 7
              tetrahydrofolylpolyglutamate biosynthetic process 1
Path 2
Term Annotations click to browse term
  biological_process 20020
    metabolic process 12263
      biosynthetic process 6222
        cellular biosynthetic process 6056
          aromatic compound biosynthetic process 3973
            pteridine-containing compound biosynthetic process 15
              folic acid-containing compound biosynthetic process 9
                dihydrofolate biosynthetic process 0
                folic acid biosynthetic process 0
                tetrahydrofolate biosynthetic process + 7
                tetrahydrofolylpolyglutamate biosynthetic process 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.