ONTOLOGY REPORT - ANNOTATIONS
Term: amine biosynthetic process
Accession: GO:0009309
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Definition: The chemical reactions and pathways resulting in the formation of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.
Synonyms: exact_synonym: amine anabolism; amine biosynthesis; amine formation; amine synthesis
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Crhr2
corticotropin releasing hormone receptor 2
IMP
RGD
PMID:17194738
RGD:5131263
NCBI chr 4:84,222,897...84,265,924
Ensembl chr 4:84,224,002...84,265,904
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Ddc
dopa decarboxylase
involved_in
TAS IEA
GO_REF:0000043
UniProt RGD
PMID:12047348
GO_REF:0000043, RGD:727571
NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208
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Hdc
histidine decarboxylase
involved_in
IEA
GO_REF:0000043
UniProt
GO_REF:0000043
NCBI chr 3:113,847,256...113,865,334
Ensembl chr 3:113,847,260...113,865,341
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Pnmt
phenylethanolamine-N-methyltransferase
involved_in
IEA
GO_REF:0000043
UniProt
GO_REF:0000043
NCBI chr10:83,383,019...83,386,557
Ensembl chr10:83,384,923...83,386,556
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Th
tyrosine hydroxylase
IDA
RGD
PMID:20025246
RGD:4139888
NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
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Agtr1a
angiotensin II receptor, type 1a
IMP
RGD
PMID:20097214
RGD:6903884
NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
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Agtr2
angiotensin II receptor, type 2
IMP
RGD
PMID:20097214
RGD:6903884
NCBI chr X:112,119,876...112,124,060
Ensembl chr X:112,120,228...112,124,057
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Chrna7
cholinergic receptor nicotinic alpha 7 subunit
IEP
RGD
PMID:12438507
RGD:704388
NCBI chr 1:116,711,559...116,837,269
Ensembl chr 1:116,714,711...116,837,240
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Cyp2d4
cytochrome P450, family 2, subfamily d, polypeptide 4
IDA
RGD
PMID:19818757
RGD:5143981
NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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Dao
D-amino-acid oxidase
involved_in
ISO ISS
(PMID:17303072) (PMID:17042912) (MGI:7574172|PMID:17042912) GO_REF:0000024
RGD UniProt
PMID:17042912 PMID:17303072
GO_REF:0000024 MGI:7574172
NCBI chr12:42,592,342...42,613,046
Ensembl chr12:42,592,343...42,612,741
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Ddc
dopa decarboxylase
involved_in
IDA ISO IEA
(PMID:19703902) GO_REF:0000107 GO_REF:0000041
RGD Ensembl UniProt
PMID:19703902 PMID:12703659
GO_REF:0000041 GO_REF:0000107, RGD:4139893
NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208
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Gch1
GTP cyclohydrolase 1
involved_in
ISO
(PMID:16338639)
RGD
PMID:16338639
NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698
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Gpr37
G protein-coupled receptor 37
acts_upstream_of_or_within
ISO
MGI:3027995 (PMID:15218106)
RGD
PMID:15218106
NCBI chr 4:54,138,860...54,160,927
Ensembl chr 4:54,138,870...54,161,001
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Nr4a2
nuclear receptor subfamily 4, group A, member 2
involved_in acts_upstream_of_or_within
IEA ISO
GO_REF:0000107 MGI:2429971 (PMID:16782508), (PMID:9608532)
Ensembl RGD
PMID:9608532 PMID:16782508
GO_REF:0000107
NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877
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Slc6a3
solute carrier family 6 member 3
acts_upstream_of_or_within
ISO
MGI:2386303 (PMID:9520487)
RGD
PMID:9520487
NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413
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Snca
synuclein alpha
acts_upstream_of_or_within
ISO
MGI:1888382 (PMID:10707987)
RGD
PMID:10707987
NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
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Tgfb2
transforming growth factor, beta 2
involved_in
ISS ISO
GO_REF:0000024 (MGI:3622848|PMID:16257223)
UniProt RGD
PMID:16257223
GO_REF:0000024 MGI:3622848
NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
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Th
tyrosine hydroxylase
involved_in
IEA ISO
GO_REF:0000041 (PMID:12457228), (PMID:19703902)
UniProt RGD
PMID:12457228 PMID:19703902
GO_REF:0000041
NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
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Th
tyrosine hydroxylase
acts_upstream_of_or_within involved_in
IDA ISO IBA IMP
MGI:1860450 (PMID:7592982), (PMID:7715703), (PMID:9520487) GO_REF:0000033 PMID:11943812
RGD GO_Central
PMID:7592982 PMID:7715703 PMID:9520487 PMID:2427363 PMID:11943812 PMID:19584816 More...
GO_REF:0000033, RGD:1580046 , RGD:5129111 , RGD:5130972
NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
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Pnmt
phenylethanolamine-N-methyltransferase
involved_in
TAS IEA IDA IC
GO_REF:0000041
UniProt RGD
PMID:11514309 PMID:7914070 PMID:7503429
GO_REF:0000041, RGD:628457 , RGD:4139902 , RGD:4139901
NCBI chr10:83,383,019...83,386,557
Ensembl chr10:83,384,923...83,386,556
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Th
tyrosine hydroxylase
involved_in
ISO
(PMID:12457228)
RGD
PMID:12457228
NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
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Hdc
histidine decarboxylase
involved_in acts_upstream_of_or_within
ISO IBA IEA
(PMID:22767596) MGI:2182618 (PMID:11478947) GO_REF:0000033 GO_REF:0000107 GO_REF:0000041
RGD GO_Central Ensembl UniProt
PMID:11478947 PMID:22767596
GO_REF:0000033 GO_REF:0000041 GO_REF:0000107
NCBI chr 3:113,847,256...113,865,334
Ensembl chr 3:113,847,260...113,865,341
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Prg3
proteoglycan 3, pro eosinophil major basic protein 2
involved_in
ISO
(PMID:10318872)
RGD
PMID:10318872
NCBI chr 3:70,071,970...70,078,103
Ensembl chr 3:70,072,497...70,078,102
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Atp7a
ATPase copper transporting alpha
acts_upstream_of_or_within
ISO
MGI:1856097|MGI:1856098 (PMID:4405722), (PMID:4858102)
RGD
PMID:4405722 PMID:4858102
NCBI chr X:71,094,144...71,201,550
Ensembl chr X:71,094,202...71,198,354
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Dbh
dopamine beta-hydroxylase
involved_in acts_upstream_of_or_within
TAS IMP IEA ISS ISO IBA
GO_REF:0000041 GO_REF:0000024 (PMID:27148966) (MGI:5787847|PMID:27148966), (MGI:72180|PMID:7715704) GO_REF:0000033 MGI:1857556 (PMID:10051631), (PMID:9603211) (PMID:27148966), (PMID:7715704)
UniProt RGD GO_Central
PMID:7715704 PMID:9603211 PMID:10051631 PMID:27148966 PMID:11914591 PMID:10573542 More...
GO_REF:0000024 GO_REF:0000033 GO_REF:0000041 MGI:5787847 MGI:72180 , RGD:727567 , RGD:1625403
NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248
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Epas1
endothelial PAS domain protein 1
IMP
RGD
PMID:19457096
RGD:5128877
NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228
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Gata3
GATA binding protein 3
acts_upstream_of_or_within
ISO
MGI:2153826 (PMID:10835639)
RGD
PMID:10835639
NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391
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Hand2
heart and neural crest derivatives expressed 2
involved_in acts_upstream_of_positive_effect
IEA ISO
GO_REF:0000107 (PMID:19008477) (MGI:4413411|PMID:19008477)
Ensembl RGD
PMID:19008477
GO_REF:0000107 MGI:4413411
NCBI chr16:32,917,448...32,920,791
Ensembl chr16:32,917,823...32,919,891
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Insm1
INSM transcriptional repressor 1
involved_in
ISO
(MGI:3772428|PMID:18094025) (PMID:18094025)
RGD
PMID:18094025
MGI:3772428
NCBI chr 3:133,640,030...133,642,963
Ensembl chr 3:133,639,580...133,643,003
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Kl
Klotho
IMP
RGD
PMID:20086041
RGD:10403068
NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080
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Moxd1
monooxygenase, DBH-like 1
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 1:21,075,124...21,165,348
Ensembl chr 1:21,075,122...21,161,779
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Moxd2
monooxygenase, DBH-like 2
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 4:69,724,693...69,733,188
Ensembl chr 4:69,724,239...69,733,299
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Th
tyrosine hydroxylase
involved_in
ISO
(PMID:12457228)
RGD
PMID:12457228
NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
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Dbh
dopamine beta-hydroxylase
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248
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Moxd1
monooxygenase, DBH-like 1
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 1:21,075,124...21,165,348
Ensembl chr 1:21,075,122...21,161,779
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Moxd2
monooxygenase, DBH-like 2
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 4:69,724,693...69,733,188
Ensembl chr 4:69,724,239...69,733,299
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Azin1
antizyme inhibitor 1
involved_in
IEA
GO_REF:0000002
InterPro
GO_REF:0000002
NCBI chr 7:69,654,773...69,681,578
Ensembl chr 7:69,654,663...69,681,578
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Azin2
antizyme inhibitor 2
involved_in
IEA
GO_REF:0000002
InterPro
GO_REF:0000002
NCBI chr 5:141,281,310...141,310,415
Ensembl chr 5:141,281,249...141,310,397
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LOC120101528
spermidine synthase-like
involved_in
IEA
GO_REF:0000104
UniProt
GO_REF:0000104
NCBI chr 3:18,709,548...18,710,782
Ensembl chr 3:18,709,584...18,710,588
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Oaz1
ornithine decarboxylase antizyme 1
involved_in
IEA
GO_REF:0000043
UniProt
GO_REF:0000043
NCBI chr 7:8,883,855...8,886,315
Ensembl chr 7:8,883,851...8,886,310
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Sat1
spermidine/spermine N1-acetyl transferase 1
involved_in
ISO
(PMID:15283699)
RGD
PMID:15283699
NCBI chr X:40,158,354...40,161,641
Ensembl chr X:40,157,046...40,196,813
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Sat2
spermidine/spermine N1-acetyltransferase family member 2
NOT|involved_in
ISO
(PMID:15283699)
RGD
PMID:15283699
NCBI chr10:54,340,756...54,343,507
Ensembl chr10:54,340,372...54,343,224
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Epas1
endothelial PAS domain protein 1
IMP
RGD
PMID:19457096
RGD:5128877
NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228
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Park7
Parkinsonism associated deglycase
involved_in
ISS ISO IEA
GO_REF:0000024 (PMID:19703902) GO_REF:0000107
ParkinsonsUK-UCL RGD Ensembl
PMID:19703902
GO_REF:0000024 GO_REF:0000107
NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970
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Vps35
VPS35 retromer complex component
involved_in
ISO
(MGI:5694519|PMID:26203154) (PMID:26203154)
RGD
PMID:26203154
MGI:5694519
NCBI chr19:21,765,771...21,801,620
Ensembl chr19:21,765,749...21,801,618
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Paox
polyamine oxidase
involved_in
ISO
(PMID:16354669)
RGD
PMID:16354669
NCBI chr 1:194,919,655...194,928,498
Ensembl chr 1:194,903,273...194,928,504
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Odc1
ornithine decarboxylase 1
IDA
RGD
PMID:10430362 PMID:1415709
RGD:1578320 , RGD:7242912
NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
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Paox
polyamine oxidase
involved_in
ISO
(PMID:16354669)
RGD
PMID:16354669
NCBI chr 1:194,919,655...194,928,498
Ensembl chr 1:194,903,273...194,928,504
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Agmat
agmatinase
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 5:154,043,665...154,074,278
Ensembl chr 5:154,060,151...154,074,276
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Azin1
antizyme inhibitor 1
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 7:69,654,773...69,681,578
Ensembl chr 7:69,654,663...69,681,578
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Azin2
antizyme inhibitor 2
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 5:141,281,310...141,310,415
Ensembl chr 5:141,281,249...141,310,397
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Ldc1
leucine decarboxylase 1
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 5:142,551,120...142,563,217
Ensembl chr 5:142,552,008...142,563,074
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Odc1
ornithine decarboxylase 1
involved_in
ISS ISO IBA IEA
GO_REF:0000024 (PMID:24967154) GO_REF:0000033 (MGI:5574513|PMID:24967154) GO_REF:0000041
UniProt RGD GO_Central
PMID:24967154
GO_REF:0000024 GO_REF:0000033 GO_REF:0000041 MGI:5574513
NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
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Aldh2
aldehyde dehydrogenase 2 family member
involved_in
ISS ISO
GO_REF:0000024 (PMID:26711020) (MGI:6827320|PMID:26711020)
UniProt RGD
PMID:26711020
GO_REF:0000024 MGI:6827320
NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521
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Amd1
adenosylmethionine decarboxylase 1
involved_in
IDA IEA IBA IMP
GO_REF:0000002 GO_REF:0000033
InterPro GO_Central RGD
PMID:10430362 PMID:1415709 PMID:10712236
GO_REF:0000002 GO_REF:0000033, RGD:1578320 , RGD:7242912 , RGD:7242911
NCBI chr20:43,695,783...43,711,476
Ensembl chr20:43,697,237...43,711,476
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Srm
spermidine synthase
involved_in
IDA IBA ISO IMP
GO_REF:0000033 (PMID:17585781)
GO_Central RGD
PMID:17585781 PMID:12843627 PMID:8494549 PMID:16931179
GO_REF:0000033, RGD:1359042 , RGD:7242928 , RGD:7242920
NCBI chr 5:159,025,875...159,029,076
Ensembl chr 5:159,025,873...159,029,405
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Amd1
adenosylmethionine decarboxylase 1
involved_in
IDA IBA IEA IMP
GO_REF:0000033 GO_REF:0000002
GO_Central InterPro RGD
PMID:10430362 PMID:1415709 PMID:10712236
GO_REF:0000002 GO_REF:0000033, RGD:1578320 , RGD:7242912 , RGD:7242911
NCBI chr20:43,695,783...43,711,476
Ensembl chr20:43,697,237...43,711,476
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Sms
spermine synthase
involved_in
IMP IBA
GO_REF:0000033
GO_Central RGD
PMID:8494549
GO_REF:0000033, RGD:7242928
NCBI chr X:37,516,949...37,572,657
Ensembl chr X:37,516,931...37,570,822
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Smsl1
spermine synthase like 1
involved_in
IEA
GO_REF:0000002
InterPro
GO_REF:0000002
NCBI chr13:82,435,500...82,436,942
Ensembl chr13:82,435,520...82,437,158
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