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ONTOLOGY REPORT - ANNOTATIONS

Term:cyclic nucleotide metabolic process
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Accession:GO:0009187 term browser browse the term
Definition:The chemical reactions and pathways involving a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue.
Synonyms:exact_synonym: cyclic nucleotide metabolism


show annotations for term's descendants           Sort by:
cAMP biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADCY1 adenylate cyclase 1 involved_in ISO
IEA
IBA
ISS		 RGD
TreeGrafter
GO_Central
UniProt
InterPro
Ensembl		 PMID:14985420 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000043 GO_REF:0000107 GO_REF:0000118 RGD:2312640 NCBI chr 7:45,574,140...45,723,116
Ensembl chr 7:45,574,140...45,723,116 		JBrowse link
G ADCY10 adenylate cyclase 10 involved_in ISO
IEA
IDA
NAS		 (PMID:12609998), (PMID:15659711)
(PMID:9874775)		 RGD
InterPro
UniProt
Ensembl		 PMID:7225326 PMID:9874775 PMID:12609998 PMID:15659711 PMID:16627466 More... GO_REF:0000002 GO_REF:0000043 GO_REF:0000107 RGD:1299450 RGD:2313171 RGD:2313173 RGD:2313177 NCBI chr 1:167,809,386...167,914,134
Ensembl chr 1:167,809,386...167,914,215 		JBrowse link
G ADCY2 adenylate cyclase 2 involved_in ISO
IEA
IBA
ISS		 RGD
TreeGrafter
GO_Central
InterPro
BHF-UCL
UniProt		 PMID:11738086 PMID:12711600 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000043 GO_REF:0000118 RGD:2312641 RGD:2312674 NCBI chr 5:7,396,138...7,830,081
Ensembl chr 5:7,396,138...7,830,081 		JBrowse link
G ADCY3 adenylate cyclase 3 involved_in ISO
IEA
IBA
ISS		 RGD
TreeGrafter
GO_Central
Ensembl
UniProt
InterPro		 PMID:12711600 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000043 GO_REF:0000107 GO_REF:0000118 RGD:2312674 NCBI chr 2:24,819,169...24,920,237
Ensembl chr 2:24,819,169...24,920,237 		JBrowse link
G ADCY4 adenylate cyclase 4 involved_in ISO
IEA
IBA
ISS		 RGD
TreeGrafter
GO_Central
BHF-UCL
UniProt
InterPro		 PMID:11738086 PMID:12711600 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000043 GO_REF:0000118 RGD:2312641 RGD:2312674 NCBI chr14:24,318,359...24,335,071
Ensembl chr14:24,318,349...24,335,093 		JBrowse link
G ADCY5 adenylate cyclase 5 involved_in ISO
IBA
IEA
IMP
IDA		 (PMID:24740569)
(PMID:15385642), (PMID:24700542)		 RGD
GO_Central
UniProt
InterPro		 PMID:10894801 PMID:11738086 PMID:12711600 PMID:15385642 PMID:24700542 More... GO_REF:0000002 GO_REF:0000033 GO_REF:0000043 RGD:2312641 RGD:2312674 RGD:2315006 NCBI chr 3:123,282,296...123,449,090
Ensembl chr 3:123,282,296...123,449,090 		JBrowse link
G ADCY6 adenylate cyclase 6 involved_in ISO
IBA
IEA
IDA		 (PMID:17916776), (PMID:18403039) RGD
GO_Central
InterPro
BHF-UCL
UniProt		 PMID:10866989 PMID:10894801 PMID:11738086 PMID:12711600 PMID:15579502 More... GO_REF:0000002 GO_REF:0000033 GO_REF:0000043 RGD:1598749 RGD:2312641 RGD:2312654 RGD:2312674 RGD:2312678 RGD:2313211 RGD:2315006 NCBI chr12:48,766,194...48,789,974
Ensembl chr12:48,766,194...48,789,089 		JBrowse link
G ADCY7 adenylate cyclase 7 involved_in ISO
IBA
IEA
IDA		 (PMID:11113152), (PMID:17760784) RGD
GO_Central
TreeGrafter
UniProt
InterPro
Ensembl		 PMID:11113152 PMID:12711600 PMID:17760784 GO_REF:0000002 GO_REF:0000033 GO_REF:0000043 GO_REF:0000107 GO_REF:0000118 RGD:2312674 NCBI chr16:50,244,699...50,318,135
Ensembl chr16:50,246,137...50,318,135 		JBrowse link
G ADCY8 adenylate cyclase 8 involved_in ISO
IEA
IBA		 RGD
TreeGrafter
GO_Central
UniProt
InterPro		 PMID:16741924 PMID:19305019 PMID:19444869 GO_REF:0000002 GO_REF:0000033 GO_REF:0000043 GO_REF:0000118 RGD:2312769 RGD:2312785 RGD:7241269 NCBI chr 8:130,780,301...131,040,909
Ensembl chr 8:130,780,301...131,040,909 		JBrowse link
G ADCY9 adenylate cyclase 9 acts_upstream_of_or_within
involved_in		 ISO
IEA
IDA		 (PMID:7575502), (PMID:8662814)
(PMID:10987815), (PMID:9628827)		 RGD
MGI
Ensembl
UniProt		 PMID:7575502 PMID:8662814 PMID:9628827 PMID:10987815 PMID:19444869 GO_REF:0000043 GO_REF:0000107 RGD:2312785 NCBI chr16:3,953,387...4,116,442
Ensembl chr16:3,953,387...4,116,442 		JBrowse link
cAMP catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PDE10A phosphodiesterase 10A involved_in IEA UniProt GO_REF:0000041 NCBI chr 6:165,327,289...165,988,052
Ensembl chr 6:165,327,287...165,988,117 		JBrowse link
G PDE4A phosphodiesterase 4A involved_in IEA
IDA		 (PMID:11306681), (PMID:18095939), (PMID:7888306), (PMID:9677330) UniProt PMID:7888306 PMID:9677330 PMID:11306681 PMID:18095939 GO_REF:0000041 NCBI chr19:10,416,773...10,469,631
Ensembl chr19:10,416,773...10,469,630 		JBrowse link
G PDE4B phosphodiesterase 4B involved_in IEA UniProt GO_REF:0000041 NCBI chr 1:65,792,510...66,374,579
Ensembl chr 1:65,792,514...66,374,579 		JBrowse link
G PDE4C phosphodiesterase 4C involved_in IEA UniProt GO_REF:0000041 NCBI chr19:18,207,965...18,255,362
Ensembl chr19:18,207,965...18,248,200 		JBrowse link
G PDE4D phosphodiesterase 4D involved_in IEA UniProt GO_REF:0000041 NCBI chr 5:58,969,038...60,522,128
Ensembl chr 5:58,969,038...60,522,120 		JBrowse link
G PDE7A phosphodiesterase 7A involved_in IEA UniProt GO_REF:0000041 NCBI chr 8:65,714,334...65,842,064
Ensembl chr 8:65,714,334...65,842,322 		JBrowse link
G PDE7B phosphodiesterase 7B involved_in IEA UniProt GO_REF:0000041 NCBI chr 6:135,851,701...136,195,574
Ensembl chr 6:135,851,701...136,195,574 		JBrowse link
G PDE8A phosphodiesterase 8A involved_in IEA UniProt GO_REF:0000041 NCBI chr15:84,980,467...85,139,142
Ensembl chr15:84,980,440...85,139,145 		JBrowse link
G PDE8B phosphodiesterase 8B involved_in IEA UniProt GO_REF:0000041 NCBI chr 5:77,086,715...77,428,256
Ensembl chr 5:77,210,449...77,428,256
Ensembl chr 5:77,210,449...77,428,256 		JBrowse link
cAMP metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNB4 calcium voltage-gated channel auxiliary subunit beta 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:7595494) Ensembl
MGI		 PMID:7595494 GO_REF:0000107 NCBI chr 2:151,832,771...152,099,167
Ensembl chr 2:151,832,771...152,099,167 		JBrowse link
G EPHA2 EPH receptor A2 involved_in IMP (PMID:27385333) UniProt PMID:27385333 NCBI chr 1:16,124,337...16,156,069
Ensembl chr 1:16,124,337...16,156,069 		JBrowse link
G HRH3 histamine receptor H3 ISO RGD PMID:11130725 RGD:151708734 NCBI chr20:62,214,960...62,220,278
Ensembl chr20:62,214,960...62,220,278 		JBrowse link
G PTH parathyroid hormone involved_in TAS (PMID:9927325) PINC PMID:9927325 NCBI chr11:13,492,054...13,496,181
Ensembl chr11:13,492,054...13,496,181 		JBrowse link
G PTHLH parathyroid hormone like hormone involved_in TAS (PMID:2549037) PINC PMID:2549037 NCBI chr12:27,958,084...27,972,733
Ensembl chr12:27,958,084...27,972,733 		JBrowse link
cGMP biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA
IDA		 (PMID:16614755)
(PMID:23505436)		 Ensembl
TreeGrafter
MGI
GO_Central
UniProt
InterPro		 PMID:16614755 PMID:23505436 GO_REF:0000002 GO_REF:0000033 GO_REF:0000043 GO_REF:0000107 GO_REF:0000118 NCBI chr 4:155,666,848...155,737,059
Ensembl chr 4:155,666,726...155,737,059 		JBrowse link
G GUCY1A2 guanylate cyclase 1 soluble subunit alpha 2 involved_in IEA UniProt
InterPro		 GO_REF:0000002 GO_REF:0000043 NCBI chr11:106,674,019...107,018,476
Ensembl chr11:106,674,019...107,018,476 		JBrowse link
G GUCY1B1 guanylate cyclase 1 soluble subunit beta 1 involved_in IDA
IEA
IBA		 (PMID:23505436) UniProt
TreeGrafter
GO_Central
InterPro		 PMID:23505436 GO_REF:0000002 GO_REF:0000033 GO_REF:0000043 GO_REF:0000118 NCBI chr 4:155,759,021...155,807,811
Ensembl chr 4:155,758,992...155,807,811 		JBrowse link
G GUCY1B2 guanylate cyclase 1 soluble subunit beta 2 (pseudogene) involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000043 NCBI chr13:50,994,511...51,066,157
Ensembl chr13:50,994,511...51,080,862
Ensembl chr13:50,994,511...51,080,862 		JBrowse link
G GUCY2C guanylate cyclase 2C involved_in IEA
IBA		 UniProt
GO_Central		 GO_REF:0000033 GO_REF:0000043 NCBI chr12:14,612,632...14,696,599
Ensembl chr12:14,612,632...14,696,599 		JBrowse link
G GUCY2D guanylate cyclase 2D, retinal involved_in IEA
IBA		 Ensembl
GO_Central
UniProt
InterPro		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000043 GO_REF:0000107 NCBI chr17:8,002,615...8,020,342
Ensembl chr17:8,002,615...8,020,342 		JBrowse link
G GUCY2F guanylate cyclase 2F, retinal involved_in IEA
IBA		 InterPro
GO_Central
UniProt		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000043 NCBI chr  X:109,372,906...109,482,086
Ensembl chr  X:109,372,906...109,482,086 		JBrowse link
G NPPA natriuretic peptide A involved_in
acts_upstream_of		 ISO
IBA
IDA		 (PMID:1672777) RGD
GO_Central		 PMID:1672777 PMID:10559136 GO_REF:0000033 RGD:619660 NCBI chr 1:11,845,709...11,847,783
Ensembl chr 1:11,845,709...11,848,345 		JBrowse link
G NPPB natriuretic peptide B acts_upstream_of
involved_in		 IDA
IBA		 (PMID:1672777) GO_Central PMID:1672777 GO_REF:0000033 NCBI chr 1:11,857,464...11,858,945
Ensembl chr 1:11,857,464...11,858,945 		JBrowse link
G NPPC natriuretic peptide C involved_in
acts_upstream_of		 IEA
IBA
IDA		 (PMID:1672777) Ensembl
TreeGrafter
GO_Central		 PMID:1672777 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 2:231,921,809...231,926,396
Ensembl chr 2:231,921,809...231,926,396 		JBrowse link
G NPR1 natriuretic peptide receptor 1 involved_in
acts_upstream_of_or_within		 IEA
IBA
ISO
IDA		 (MGI:2179542|PMID:11997476)
(PMID:1672777)		 UniProt
GO_Central
TreeGrafter
GOC		 PMID:1672777 PMID:11997476 GO_REF:0000033 GO_REF:0000043 GO_REF:0000118 MGI:2179542 NCBI chr 1:153,678,688...153,693,992
Ensembl chr 1:153,678,688...153,693,992 		JBrowse link
G NPR2 natriuretic peptide receptor 2 involved_in
acts_upstream_of_or_within		 IEA
IBA
ISO
IDA		 (MGI:2682104|PMID:14514678)
(PMID:1672777)		 UniProt
GO_Central
TreeGrafter
GOC		 PMID:1672777 PMID:14514678 GO_REF:0000033 GO_REF:0000043 GO_REF:0000118 MGI:2682104 NCBI chr 9:35,791,591...35,809,731
Ensembl chr 9:35,791,003...35,809,732 		JBrowse link
cGMP catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PDE10A phosphodiesterase 10A involved_in IEA UniProt GO_REF:0000041 NCBI chr 6:165,327,289...165,988,052
Ensembl chr 6:165,327,287...165,988,117 		JBrowse link
G PDE1A phosphodiesterase 1A involved_in ISO
IEA		 RGD
Ensembl		 PMID:16514069 GO_REF:0000107 RGD:2312521 NCBI chr 2:182,140,041...182,716,797
Ensembl chr 2:182,139,968...182,523,359 		JBrowse link
G PDE2A phosphodiesterase 2A involved_in IDA
IBA
IEA		 (PMID:19828435) UniProt
GO_Central
TreeGrafter		 PMID:19828435 GO_REF:0000033 GO_REF:0000118 NCBI chr11:72,576,141...72,674,422
Ensembl chr11:72,576,141...72,674,591 		JBrowse link
G PDE5A phosphodiesterase 5A involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12554648) UniProt
MGI
TreeGrafter
Ensembl		 PMID:12554648 GO_REF:0000041 GO_REF:0000107 GO_REF:0000118 NCBI chr 4:119,494,403...119,628,804
Ensembl chr 4:119,494,397...119,628,804 		JBrowse link
G PDE9A phosphodiesterase 9A involved_in IEA
IBA
IDA		 (PMID:25799991) Ensembl
TreeGrafter
GO_Central
UniProt		 PMID:25799991 GO_REF:0000033 GO_REF:0000041 GO_REF:0000107 GO_REF:0000118 NCBI chr21:42,653,621...42,775,509
Ensembl chr21:42,653,621...42,775,509 		JBrowse link
cGMP metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP2B2 ATPase plasma membrane Ca2+ transporting 2 acts_upstream_of_or_within ISO (PMID:3038581), (PMID:7518067) MGI PMID:3038581 PMID:7518067 NCBI chr 3:10,324,023...10,708,007
Ensembl chr 3:10,324,023...10,708,007 		JBrowse link
G NPR2 natriuretic peptide receptor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:35,791,591...35,809,731
Ensembl chr 9:35,791,003...35,809,732 		JBrowse link
G PDE5A phosphodiesterase 5A involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19474061), (PMID:20511540) Ensembl
MGI		 PMID:19474061 PMID:20511540 GO_REF:0000107 NCBI chr 4:119,494,403...119,628,804
Ensembl chr 4:119,494,397...119,628,804 		JBrowse link
G PDE9A phosphodiesterase 9A involved_in IDA (PMID:9624146) UniProt PMID:9624146 NCBI chr21:42,653,621...42,775,509
Ensembl chr21:42,653,621...42,775,509 		JBrowse link
G RORA RAR related orphan receptor A involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:7518067) Ensembl
MGI		 PMID:7518067 GO_REF:0000107 NCBI chr15:60,488,284...61,229,302
Ensembl chr15:60,488,284...61,229,302 		JBrowse link
cyclic nucleotide biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADCY1 adenylate cyclase 1 involved_in IEA InterPro GO_REF:0000002 NCBI chr 7:45,574,140...45,723,116
Ensembl chr 7:45,574,140...45,723,116 		JBrowse link
G ADCY2 adenylate cyclase 2 involved_in IEA InterPro GO_REF:0000002 NCBI chr 5:7,396,138...7,830,081
Ensembl chr 5:7,396,138...7,830,081 		JBrowse link
G ADCY3 adenylate cyclase 3 involved_in IEA InterPro GO_REF:0000002 NCBI chr 2:24,819,169...24,920,237
Ensembl chr 2:24,819,169...24,920,237 		JBrowse link
G ADCY4 adenylate cyclase 4 involved_in IEA InterPro GO_REF:0000002 NCBI chr14:24,318,359...24,335,071
Ensembl chr14:24,318,349...24,335,093 		JBrowse link
G ADCY7 adenylate cyclase 7 involved_in IEA InterPro GO_REF:0000002 NCBI chr16:50,244,699...50,318,135
Ensembl chr16:50,246,137...50,318,135 		JBrowse link
G ADCY8 adenylate cyclase 8 involved_in IEA InterPro GO_REF:0000002 NCBI chr 8:130,780,301...131,040,909
Ensembl chr 8:130,780,301...131,040,909 		JBrowse link
G ADCY9 adenylate cyclase 9 involved_in IEA InterPro GO_REF:0000002 NCBI chr16:3,953,387...4,116,442
Ensembl chr16:3,953,387...4,116,442 		JBrowse link
G GUCY2C guanylate cyclase 2C involved_in IEA InterPro GO_REF:0000002 NCBI chr12:14,612,632...14,696,599
Ensembl chr12:14,612,632...14,696,599 		JBrowse link
G NPR1 natriuretic peptide receptor 1 involved_in IEA InterPro GO_REF:0000002 NCBI chr 1:153,678,688...153,693,992
Ensembl chr 1:153,678,688...153,693,992 		JBrowse link
G NPR2 natriuretic peptide receptor 2 involved_in IEA InterPro GO_REF:0000002 NCBI chr 9:35,791,591...35,809,731
Ensembl chr 9:35,791,003...35,809,732 		JBrowse link
cyclic nucleotide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CNP 2',3'-cyclic nucleotide 3' phosphodiesterase involved_in IEA InterPro GO_REF:0000002 NCBI chr17:41,966,795...41,977,740
Ensembl chr17:41,966,763...41,977,740 		JBrowse link
cyclic purine nucleotide metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AMPD2 adenosine monophosphate deaminase 2 involved_in IMP (PMID:23911318) UniProt PMID:23911318 NCBI chr 1:109,619,837...109,632,055
Ensembl chr 1:109,616,104...109,632,051 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19669
    metabolic process 12464
      small molecule metabolic process 2010
        nucleobase-containing small molecule metabolic process 743
          nucleoside phosphate metabolic process 665
            nucleotide metabolic process 659
              cyclic nucleotide metabolic process 44
                cyclic nucleotide biosynthetic process + 22
                cyclic nucleotide catabolic process + 14
                cyclic purine nucleotide metabolic process + 43
Path 2
Term Annotations click to browse term
  biological_process 19669
    metabolic process 12464
      organic substance metabolic process 11967
        organic cyclic compound metabolic process 7069
          nucleobase-containing compound metabolic process 6539
            nucleobase-containing small molecule metabolic process 743
              nucleoside phosphate metabolic process 665
                nucleotide metabolic process 659
                  cyclic nucleotide metabolic process 44
                    cyclic nucleotide biosynthetic process + 22
                    cyclic nucleotide catabolic process + 14
                    cyclic purine nucleotide metabolic process + 43
paths to the root