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ONTOLOGY REPORT - ANNOTATIONS


Term:cyclic nucleotide metabolic process
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Accession:GO:0009187 term browser browse the term
Definition:The chemical reactions and pathways involving a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue.
Synonyms:exact_synonym: cyclic nucleotide metabolism


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cAMP biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcy1 adenylate cyclase 1 involved_in IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:14985420, PMID:21873635 RGD:2312640, RGD:13792537 NCBI chr14:81,911,240...82,020,594 JBrowse link
G Adcy10 adenylate cyclase 10 involved_in IDA
ISO
IMP
(PMID:12609998), (PMID:15659711) RGD PMID:12609998 PMID:15659711, PMID:9874775, PMID:7225326, PMID:16627466, PMID:16964251 RGD:1299450, RGD:2313177, RGD:2313173, RGD:2313171 NCBI chr13:77,747,752...77,833,952 JBrowse link
G Adcy2 adenylate cyclase 2 involved_in IDA
IEA
PMID:18164588
PMID:10427002
GO_REF:0000002
InterPro PMID:11738086, PMID:18164588, PMID:10427002, PMID:12711600 GO_REF:0000002, RGD:2312641, RGD:8553431, RGD:10400857, RGD:2312674 NCBI chr 1:34,375,639...34,822,237 JBrowse link
G Adcy3 adenylate cyclase 3 involved_in IDA
ISO
IEA
IBA
(MGI:1889935|PMID:11055432)
PMID:24363043
GO_REF:0000107
PMID:21873635
RGD
Ensembl
PMID:11055432, PMID:12711600, PMID:24363043, PMID:21873635 GO_REF:0000107 MGI:1889935, RGD:2312674, RGD:10400870, RGD:13792537 NCBI chr 6:27,100,089...27,203,686 JBrowse link
G Adcy4 adenylate cyclase 4 involved_in IDA
IEA
PMID:8900209
GO_REF:0000043
UniProt PMID:11738086, PMID:8900209, PMID:12711600 GO_REF:0000043, RGD:2312641, RGD:8554340, RGD:2312674 NCBI chr15:29,266,280...29,282,153 JBrowse link
G Adcy5 adenylate cyclase 5 involved_in IDA
IBA
IEA
ISO
PMID:21873635
GO_REF:0000107
(PMID:15385642), (PMID:24700542), (PMID:24740569)
Ensembl
RGD
PMID:15385642 PMID:24700542 PMID:24740569, PMID:11738086, PMID:21873635, PMID:10894801, PMID:12711600 GO_REF:0000107, RGD:2312641, RGD:13792537, RGD:2315006, RGD:2312674 NCBI chr11:65,471,612...65,618,877 JBrowse link
G Adcy6 adenylate cyclase 6 involved_in IDA
IEA
ISO
IBA
IMP
GO_REF:0000107
(MGI:4457984|PMID:20466003)
GO_REF:0000043
(PMID:17916776), (PMID:18403039)
PMID:21873635
Ensembl
RGD
UniProt
PMID:17916776 PMID:18403039 PMID:20466003, PMID:15961389, PMID:21873635, PMID:10894801, PMID:15579502, PMID:12711600, PMID:10866989, PMID:18971210, PMID:11738086 GO_REF:0000043 GO_REF:0000107 MGI:4457984, RGD:1598749, RGD:13792537, RGD:2315006, RGD:2313211, RGD:2312674, RGD:2312678, RGD:2312654, RGD:2312641 NCBI chr 7:129,742,827...129,763,922 JBrowse link
G Adcy7 adenylate cyclase 7 involved_in IDA
ISO
(PMID:11113152), (PMID:17760784) RGD PMID:11113152 PMID:17760784, PMID:12711600 RGD:2312674 NCBI chr19:18,740,875...18,798,924 JBrowse link
G Adcy8 adenylate cyclase 8 involved_in IMP
IEA
IBA
IDA
GO_REF:0000043
PMID:21873635
UniProt PMID:16741924, PMID:21873635, PMID:19305019, PMID:19444869 GO_REF:0000043, RGD:2312769, RGD:13792537, RGD:7241269, RGD:2312785 NCBI chr 7:96,417,310...96,665,911 JBrowse link
G Adcy9 adenylate cyclase 9 acts_upstream_of_or_within
involved_in
IMP
ISO
(MGI:76465|PMID:7575502), (MGI:80863|PMID:8662814)
(PMID:10987815), (PMID:9628827)
RGD PMID:7575502 PMID:8662814 PMID:9628827 PMID:10987815, PMID:19444869 MGI:76465 MGI:80863, RGD:2312785 NCBI chr10:11,138,966...11,262,067 JBrowse link
cAMP catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pde10a phosphodiesterase 10A involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 1:51,765,743...52,218,086 JBrowse link
G Pde4a phosphodiesterase 4A involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 8:19,706,649...19,751,937 JBrowse link
G Pde4b phosphodiesterase 4B involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 5:116,799,827...117,367,707 JBrowse link
G Pde4c phosphodiesterase 4C involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr16:18,690,727...18,711,555 JBrowse link
G Pde4d phosphodiesterase 4D involved_in IEA
ISO
IBA
GO_REF:0000041
(PMID:20819076)
PMID:21873635
UniProt
RGD
PMID:20819076, PMID:21873635 GO_REF:0000041, RGD:13792537 NCBI chr 2:40,014,933...41,529,190 JBrowse link
G Pde7a phosphodiesterase 7A involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 2:101,714,767...101,806,853 JBrowse link
G Pde8a phosphodiesterase 8A involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 1:135,166,143...135,288,986 JBrowse link
G Pde8b phosphodiesterase 8B involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 2:26,275,117...26,479,725 JBrowse link
cAMP metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacnb4 calcium voltage-gated channel auxiliary subunit beta 4 acts_upstream_of_or_within ISO MGI:1856936 (MGI:76872|PMID:7595494) RGD PMID:7595494 MGI:76872 NCBI chr 3:36,906,771...37,169,191 JBrowse link
G Epha2 Eph receptor A2 involved_in ISO (PMID:27385333) RGD PMID:27385333 NCBI chr 5:153,605,644...153,634,115 JBrowse link
cGMP biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:3640802 (MGI:3640061|PMID:16614755)
(PMID:23505436)
Ensembl
RGD
PMID:16614755 PMID:23505436 GO_REF:0000107 MGI:3640061 NCBI chr 2:167,418,615...167,482,293 JBrowse link
G Gucy1a2 guanylate cyclase 1 soluble subunit alpha 2 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 8:500,212...900,201 JBrowse link
G Gucy1b1 guanylate cyclase 1 soluble subunit beta 1 involved_in ISO (PMID:23505436) RGD PMID:23505436 NCBI chr 2:167,348,824...167,398,983 JBrowse link
G Gucy1b2 guanylate cyclase 1 soluble subunit beta 2 involved_in IEA GO_REF:0000002
GO_REF:0000043
InterPro
UniProt
GO_REF:0000002 GO_REF:0000043 NCBI chr15:36,589,501...36,669,441 JBrowse link
G Gucy2c guanylate cyclase 2C involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:169,568,505...169,649,092 JBrowse link
G Gucy2d guanylate cyclase 2D, retinal involved_in IEA
ISO
IBA
GO_REF:0000107
(MGI:5049799|PMID:21598940)
PMID:21873635
Ensembl
RGD
PMID:21598940, PMID:21873635 GO_REF:0000107 MGI:5049799, RGD:13792537 NCBI chr10:53,954,918...53,975,576 JBrowse link
G Gucy2e guanylate cyclase 2E involved_in IBA
IDA
PMID:21873635
PMID:11580282
GO_Central
UniProt
PMID:21873635, PMID:11580282 RGD:13792537, RGD:15023466 NCBI chr 1:152,739,775...152,774,474 JBrowse link
G Gucy2f guanylate cyclase 2F involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:105,710,356...105,808,183 JBrowse link
G Gucy2g guanylate cyclase 2G involved_in IBA
IEA
PMID:21873635
GO_REF:0000043
UniProt PMID:21873635 GO_REF:0000043, RGD:13792537 NCBI chr 1:254,237,778...254,280,277 JBrowse link
G Nppa natriuretic peptide A involved_in
acts_upstream_of
IBA
ISO
PMID:21873635
(PMID:1672777)
RGD PMID:1672777, PMID:21873635 RGD:13792537 NCBI chr 5:158,429,042...158,430,351 JBrowse link
G Nppb natriuretic peptide B acts_upstream_of
involved_in
ISO
IBA
(PMID:1672777)
PMID:21873635
RGD PMID:1672777, PMID:21873635 RGD:13792537 NCBI chr 5:158,416,813...158,418,175 JBrowse link
G Nppc natriuretic peptide C involved_in
acts_upstream_of
IBA
ISO
PMID:21873635
(MGI:2177134|PMID:11259675)
(PMID:1672777)
RGD PMID:1672777 PMID:11259675, PMID:21873635 MGI:2177134, RGD:13792537 NCBI chr 9:87,320,051...87,324,251 JBrowse link
G Npr1 natriuretic peptide receptor 1 involved_in IBA
ISO
PMID:21873635
(PMID:1672777)
RGD PMID:1672777, PMID:21873635 RGD:13792537 NCBI chr 2:175,934,181...175,950,118 JBrowse link
G Npr2 natriuretic peptide receptor 2 acts_upstream_of
involved_in
ISO
IBA
(PMID:1672777)
PMID:21873635
RGD PMID:1672777, PMID:21873635 RGD:13792537 NCBI chr 5:57,883,171...57,901,590 JBrowse link
cGMP catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pde10a phosphodiesterase 10A involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 1:51,765,743...52,218,086 JBrowse link
G Pde1a phosphodiesterase 1A IMP RGD PMID:16514069 RGD:2312521 NCBI chr 3:64,745,140...65,025,178 JBrowse link
G Pde2a phosphodiesterase 2A involved_in ISO
IEA
IBA
(PMID:19828435)
(MGI:4420377|PMID:19632989)
GO_REF:0000107
PMID:21873635
RGD
Ensembl
PMID:19632989 PMID:19828435, PMID:21873635 GO_REF:0000107 MGI:4420377, RGD:13792537 NCBI chr 1:155,823,590...155,915,434 JBrowse link
G Pde5a phosphodiesterase 5A involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:2450821|PMID:12554648)
GO_REF:0000041
Ensembl
RGD
UniProt
PMID:12554648 GO_REF:0000041 GO_REF:0000107 MGI:2450821 NCBI chr 2:210,858,515...211,003,480 JBrowse link
G Pde9a phosphodiesterase 9A involved_in IEA
ISO
ISS
IBA
GO_REF:0000041
(MGI:1266874|PMID:9624145), (MGI:5634842|PMID:25799991)
GO_REF:0000024
(PMID:25799991)
PMID:21873635
UniProt
RGD
PMID:9624145 PMID:25799991, PMID:21873635 GO_REF:0000024 GO_REF:0000041 MGI:1266874 MGI:5634842, RGD:13792537 NCBI chr20:9,469,809...9,562,949 JBrowse link
cGMP metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2b2 ATPase plasma membrane Ca2+ transporting 2 acts_upstream_of_or_within ISO MGI:1857092 (MGI:66348|PMID:7518067), (MGI:68066|PMID:3038581) RGD PMID:3038581 PMID:7518067 MGI:66348 MGI:68066 NCBI chr 4:146,896,332...147,140,665 JBrowse link
G Pde5a phosphodiesterase 5A acts_upstream_of_or_within ISO (MGI:4361111|PMID:19474061), (MGI:4834094|PMID:20511540) RGD PMID:19474061 PMID:20511540 MGI:4361111 MGI:4834094 NCBI chr 2:210,858,515...211,003,480 JBrowse link
G Pde9a phosphodiesterase 9A involved_in ISO
ISS
(PMID:9624146)
GO_REF:0000024
RGD
UniProt
PMID:9624146 GO_REF:0000024 NCBI chr20:9,469,809...9,562,949 JBrowse link
G Rora RAR-related orphan receptor A acts_upstream_of_or_within ISO MGI:1857035 (MGI:66348|PMID:7518067) RGD PMID:7518067 MGI:66348 NCBI chr 8:69,301,635...70,034,741 JBrowse link
cyclic nucleotide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cnp 2',3'-cyclic nucleotide 3' phosphodiesterase involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:85,511,164...85,517,723 JBrowse link
cyclic purine nucleotide metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ampd2 adenosine monophosphate deaminase 2 involved_in ISS
ISO
GO_REF:0000024
(PMID:23911318)
UniProt
RGD
PMID:23911318 GO_REF:0000024 NCBI chr 2:195,707,609...195,720,454 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19492
    metabolic process 11795
      organic substance metabolic process 11334
        organophosphate metabolic process 936
          nucleoside phosphate metabolic process 510
            nucleotide metabolic process 502
              cyclic nucleotide metabolic process 42
                cAMP metabolic process + 20
                cGMP metabolic process + 21
                cyclic nucleotide biosynthetic process + 25
                cyclic nucleotide catabolic process + 13
Path 2
Term Annotations click to browse term
  biological_process 19492
    metabolic process 11795
      nitrogen compound metabolic process 10015
        cellular nitrogen compound metabolic process 6602
          nucleobase-containing compound metabolic process 5419
            nucleobase-containing small molecule metabolic process 577
              nucleoside phosphate metabolic process 510
                nucleotide metabolic process 502
                  cyclic nucleotide metabolic process 42
                    cAMP metabolic process + 20
                    cGMP metabolic process + 21
                    cyclic nucleotide biosynthetic process + 25
                    cyclic nucleotide catabolic process + 13
paths to the root