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ONTOLOGY REPORT - ANNOTATIONS


Term:cyclic nucleotide metabolic process
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Accession:GO:0009187 term browser browse the term
Definition:The chemical reactions and pathways involving a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue.
Synonyms:exact_synonym: cyclic nucleotide metabolism



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cAMP biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcy1 adenylate cyclase 1 involved_in IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:14985420 PMID:21873635 RGD:2312640, RGD:13792537 NCBI chr14:81,911,240...82,020,594
Ensembl chr14:81,911,099...82,028,969
JBrowse link
G Adcy10 adenylate cyclase 10 involved_in IDA
ISO
IMP
(PMID:12609998), (PMID:15659711) RGD PMID:12609998 PMID:15659711 PMID:9874775 PMID:7225326 PMID:16627466 More... RGD:1299450, RGD:2313177, RGD:2313173, RGD:2313171 NCBI chr13:77,747,752...77,833,952
Ensembl chr13:77,768,468...77,833,951
JBrowse link
G Adcy2 adenylate cyclase 2 involved_in IDA
IEA
GO_REF:0000117
PMID:18164588
PMID:10427002
UniProt
RGD
PMID:11738086 PMID:18164588 PMID:10427002 PMID:12711600 GO_REF:0000117, RGD:2312641, RGD:8553431, RGD:10400857, RGD:2312674 NCBI chr 1:34,375,639...34,822,237
Ensembl chr 1:34,375,895...34,822,236
JBrowse link
G Adcy3 adenylate cyclase 3 involved_in IDA
IEA
ISO
IBA
GO_REF:0000117
(MGI:1889935|PMID:11055432)
PMID:24363043
PMID:21873635
UniProt
RGD
PMID:11055432 PMID:12711600 PMID:24363043 PMID:21873635 GO_REF:0000117 MGI:1889935, RGD:2312674, RGD:10400870, RGD:13792537 NCBI chr 6:27,100,089...27,203,686
Ensembl chr 6:27,124,828...27,203,686
JBrowse link
G Adcy4 adenylate cyclase 4 involved_in IDA
IEA
PMID:8900209
GO_REF:0000117
UniProt
RGD
PMID:11738086 PMID:12711600 PMID:8900209 GO_REF:0000117, RGD:2312641, RGD:2312674, RGD:8554340 NCBI chr15:29,266,280...29,282,153
Ensembl chr15:29,266,287...29,282,108
JBrowse link
G Adcy5 adenylate cyclase 5 involved_in IDA
IEA
IBA
ISO
GO_REF:0000117
PMID:21873635
(PMID:15385642), (PMID:24700542), (PMID:24740569)
UniProt
RGD
PMID:15385642 PMID:24700542 PMID:24740569 PMID:11738086 PMID:21873635 More... GO_REF:0000117, RGD:2312641, RGD:13792537, RGD:2315006, RGD:2312674 NCBI chr11:65,471,612...65,618,877
Ensembl chr11:65,471,612...65,618,974
JBrowse link
G Adcy6 adenylate cyclase 6 involved_in IDA
IMP
IBA
ISO
IEA
PMID:21873635
(PMID:17916776), (PMID:18403039)
(MGI:4457984|PMID:20466003)
GO_REF:0000117
RGD
UniProt
PMID:17916776 PMID:18403039 PMID:20466003 PMID:15961389 PMID:11738086 More... GO_REF:0000117 MGI:4457984, RGD:1598749, RGD:2312641, RGD:2312654, RGD:2312678, RGD:2312674, RGD:2313211, RGD:2315006, RGD:13792537 NCBI chr 7:129,742,827...129,763,922
Ensembl chr 7:129,742,838...129,763,754
JBrowse link
G Adcy7 adenylate cyclase 7 involved_in IDA
ISO
(PMID:11113152), (PMID:17760784) RGD PMID:11113152 PMID:17760784 PMID:12711600 RGD:2312674 NCBI chr19:18,740,875...18,798,924
Ensembl chr19:18,740,875...18,776,311
JBrowse link
G Adcy8 adenylate cyclase 8 involved_in IMP
IDA
IBA
IEA
PMID:21873635
GO_REF:0000117
UniProt
RGD
PMID:16741924 PMID:19444869 PMID:19305019 PMID:21873635 GO_REF:0000117, RGD:2312769, RGD:2312785, RGD:7241269, RGD:13792537 NCBI chr 7:96,417,310...96,665,911
Ensembl chr 7:96,417,324...96,665,911
JBrowse link
G Adcy9 adenylate cyclase 9 acts_upstream_of_or_within
involved_in
IMP
ISO
(MGI:76465|PMID:7575502), (MGI:80863|PMID:8662814)
(PMID:10987815), (PMID:9628827)
RGD PMID:7575502 PMID:8662814 PMID:9628827 PMID:10987815 PMID:19444869 MGI:76465 MGI:80863, RGD:2312785 NCBI chr10:11,138,966...11,262,067
Ensembl chr10:11,139,446...11,262,066
JBrowse link
cAMP catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pde10a phosphodiesterase 10A involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 1:51,765,743...52,218,086
Ensembl chr 1:51,770,132...52,216,563
JBrowse link
G Pde4a phosphodiesterase 4A involved_in IEA
ISO
IDA
GO_REF:0000041
(MGI:1927461|PMID:11267656)
PMID:21323643
(PMID:18095939)
(PMID:9677330)
(PMID:7888306)
(PMID:11306681)
PMID:8557632
UniProt
RGD
PMID:7888306 PMID:9677330 PMID:11267656 PMID:11306681 PMID:18095939 More... GO_REF:0000041 MGI:1927461, RGD:151356649, RGD:633604 NCBI chr 8:19,706,649...19,751,937
Ensembl chr 8:19,703,290...19,751,961
JBrowse link
G Pde4b phosphodiesterase 4B involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 5:116,799,827...117,367,707
Ensembl chr 5:116,799,971...117,367,696
JBrowse link
G Pde4c phosphodiesterase 4C involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr16:18,690,727...18,711,555
Ensembl chr16:18,691,700...18,710,640
JBrowse link
G Pde4d phosphodiesterase 4D involved_in IEA
ISO
GO_REF:0000041
(PMID:20819076)
UniProt
RGD
PMID:20819076 GO_REF:0000041 NCBI chr 2:40,014,933...41,529,190
Ensembl chr 2:40,019,933...41,525,884
JBrowse link
G Pde7a phosphodiesterase 7A involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 2:101,714,767...101,806,853
Ensembl chr 2:101,718,444...101,806,681
JBrowse link
G Pde8a phosphodiesterase 8A involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 1:135,166,143...135,288,986
Ensembl chr 1:135,166,237...135,288,024
JBrowse link
G Pde8b phosphodiesterase 8B involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 2:26,275,117...26,479,725
Ensembl chr 2:26,276,635...26,509,209
JBrowse link
cAMP metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacnb4 calcium voltage-gated channel auxiliary subunit beta 4 acts_upstream_of_or_within ISO MGI:1856936 (MGI:76872|PMID:7595494) RGD PMID:7595494 MGI:76872 NCBI chr 3:36,906,771...37,169,191
Ensembl chr 3:36,910,427...37,168,944
JBrowse link
G Epha2 Eph receptor A2 involved_in ISO (PMID:27385333) RGD PMID:27385333 NCBI chr 5:153,605,644...153,634,115
Ensembl chr 5:153,605,644...153,634,117
JBrowse link
G Hrh3 histamine receptor H3 IDA RGD PMID:11130725 RGD:151708734 NCBI chr 3:167,191,551...167,196,642
Ensembl chr 3:167,191,558...167,196,642
JBrowse link
cGMP biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 involved_in
acts_upstream_of_or_within
IEA
IBA
ISO
GO_REF:0000107
PMID:21873635
MGI:3640802 (MGI:3640061|PMID:16614755)
(PMID:23505436)
Ensembl
RGD
PMID:16614755 PMID:23505436 PMID:21873635 GO_REF:0000107 MGI:3640061, RGD:13792537 NCBI chr 2:167,418,615...167,482,293
Ensembl chr 2:167,418,640...167,481,671
JBrowse link
G Gucy1a2 guanylate cyclase 1 soluble subunit alpha 2 involved_in IEA GO_REF:0000043
GO_REF:0000002
UniProt
InterPro
GO_REF:0000002 GO_REF:0000043 NCBI chr 8:500,212...900,201
Ensembl chr 8:500,212...889,203
JBrowse link
G Gucy1b1 guanylate cyclase 1 soluble subunit beta 1 involved_in ISO
IBA
(PMID:23505436)
PMID:21873635
RGD PMID:23505436 PMID:21873635 RGD:13792537 NCBI chr 2:167,348,824...167,398,983
Ensembl chr 2:167,348,825...167,398,916
JBrowse link
G Gucy1b2 guanylate cyclase 1 soluble subunit beta 2 involved_in IEA GO_REF:0000002
GO_REF:0000043
InterPro
UniProt
GO_REF:0000002 GO_REF:0000043 NCBI chr15:36,589,501...36,669,441
Ensembl chr15:36,598,883...36,669,441
JBrowse link
G Gucy2c guanylate cyclase 2C involved_in
acts_upstream_of_or_within
IBA
IEA
ISO
PMID:21873635
GO_REF:0000043
MGI:2665316 (MGI:1097012|PMID:9294128)
UniProt
RGD
PMID:9294128 PMID:21873635 GO_REF:0000043 MGI:1097012, RGD:13792537 NCBI chr 4:169,568,505...169,649,092
Ensembl chr 4:169,568,529...169,649,092
JBrowse link
G Gucy2d guanylate cyclase 2D, retinal involved_in IEA
IBA
ISO
GO_REF:0000107
PMID:21873635
(MGI:5049799|PMID:21598940)
Ensembl
RGD
PMID:21598940 PMID:21873635 GO_REF:0000107 MGI:5049799, RGD:13792537 NCBI chr10:53,954,918...53,975,576
Ensembl chr10:53,959,010...53,974,067
JBrowse link
G Gucy2e guanylate cyclase 2E involved_in IBA
IEA
IDA
PMID:21873635
GO_REF:0000043
PMID:11580282
UniProt PMID:21873635 PMID:11580282 GO_REF:0000043, RGD:13792537, RGD:15023466 NCBI chr 1:152,739,775...152,774,474
Ensembl chr 1:152,739,775...152,774,473
JBrowse link
G Gucy2f guanylate cyclase 2F involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:105,710,356...105,808,183
Ensembl chr  X:105,710,356...105,808,183
JBrowse link
G Gucy2g guanylate cyclase 2G involved_in IBA
IEA
PMID:21873635
GO_REF:0000043
UniProt PMID:21873635 GO_REF:0000043, RGD:13792537 NCBI chr 1:254,237,778...254,280,277
Ensembl chr 1:254,239,174...254,280,277
JBrowse link
G Nppa natriuretic peptide A acts_upstream_of
involved_in
ISO
IBA
IMP
(PMID:1672777)
PMID:21873635
RGD PMID:1672777 PMID:21873635 PMID:10559136 RGD:13792537, RGD:619660 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
JBrowse link
G Nppb natriuretic peptide B acts_upstream_of
involved_in
ISO
IBA
(PMID:1672777)
PMID:21873635
RGD PMID:1672777 PMID:21873635 RGD:13792537 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
JBrowse link
G Nppc natriuretic peptide C involved_in
acts_upstream_of
IBA
ISO
PMID:21873635
(MGI:2177134|PMID:11259675)
(PMID:1672777)
RGD PMID:1672777 PMID:11259675 PMID:21873635 MGI:2177134, RGD:13792537 NCBI chr 9:87,320,051...87,324,251
Ensembl chr 9:87,320,051...87,324,251
JBrowse link
G Npr1 natriuretic peptide receptor 1 involved_in
acts_upstream_of_or_within
IBA
IEA
ISO
PMID:21873635
GO_REF:0000043
(MGI:2179542|PMID:11997476)
(PMID:1672777)
UniProt
RGD
PMID:1672777 PMID:11997476 PMID:21873635 GO_REF:0000043 MGI:2179542, RGD:13792537 NCBI chr 2:175,934,181...175,950,118
Ensembl chr 2:175,934,181...175,949,505
JBrowse link
G Npr2 natriuretic peptide receptor 2 acts_upstream_of
involved_in
acts_upstream_of_or_within
ISO
IEA
IBA
(PMID:1672777)
GO_REF:0000043
(MGI:2682104|PMID:14514678)
PMID:21873635
RGD
UniProt
PMID:1672777 PMID:14514678 PMID:21873635 GO_REF:0000043 MGI:2682104, RGD:13792537 NCBI chr 5:57,883,171...57,901,590
Ensembl chr 5:57,883,171...57,901,580
JBrowse link
cGMP catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pde10a phosphodiesterase 10A involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 1:51,765,743...52,218,086
Ensembl chr 1:51,770,132...52,216,563
JBrowse link
G Pde1a phosphodiesterase 1A IMP RGD PMID:16514069 RGD:2312521 NCBI chr 3:64,745,140...65,025,178
Ensembl chr 3:64,747,269...65,024,874
JBrowse link
G Pde2a phosphodiesterase 2A involved_in ISO
IEA
IBA
(PMID:19828435)
(MGI:4420377|PMID:19632989)
GO_REF:0000107
PMID:21873635
RGD
Ensembl
PMID:19632989 PMID:19828435 PMID:21873635 GO_REF:0000107 MGI:4420377, RGD:13792537 NCBI chr 1:155,823,590...155,915,434
Ensembl chr 1:155,813,180...155,915,434
JBrowse link
G Pde5a phosphodiesterase 5A involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000041
(MGI:2450821|PMID:12554648)
UniProt
RGD
PMID:12554648 GO_REF:0000041 MGI:2450821 NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701
JBrowse link
G Pde9a phosphodiesterase 9A involved_in ISS
IEA
ISO
IBA
GO_REF:0000024
GO_REF:0000041
(MGI:1266874|PMID:9624145), (MGI:5634842|PMID:25799991)
(PMID:25799991)
PMID:21873635
UniProt
RGD
PMID:9624145 PMID:25799991 PMID:21873635 GO_REF:0000024 GO_REF:0000041 MGI:1266874 MGI:5634842, RGD:13792537 NCBI chr20:9,469,809...9,562,949
Ensembl chr20:9,469,848...9,562,948
JBrowse link
cGMP metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2b2 ATPase plasma membrane Ca2+ transporting 2 acts_upstream_of_or_within ISO MGI:1857092 (MGI:66348|PMID:7518067), (MGI:68066|PMID:3038581) RGD PMID:3038581 PMID:7518067 MGI:66348 MGI:68066 NCBI chr 4:146,896,332...147,140,665
Ensembl chr 4:146,896,332...147,140,665
JBrowse link
G Npr2 natriuretic peptide receptor 2 involved_in ISO MGI:1856702 (MGI:3579766|PMID:15722353) RGD PMID:15722353 MGI:3579766 NCBI chr 5:57,883,171...57,901,590
Ensembl chr 5:57,883,171...57,901,580
JBrowse link
G Pde5a phosphodiesterase 5A acts_upstream_of_or_within ISO (MGI:4361111|PMID:19474061), (MGI:4834094|PMID:20511540) RGD PMID:19474061 PMID:20511540 MGI:4361111 MGI:4834094 NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701
JBrowse link
G Pde9a phosphodiesterase 9A involved_in ISO
ISS
(PMID:9624146)
GO_REF:0000024
RGD
UniProt
PMID:9624146 GO_REF:0000024 NCBI chr20:9,469,809...9,562,949
Ensembl chr20:9,469,848...9,562,948
JBrowse link
G Rora RAR-related orphan receptor A acts_upstream_of_or_within ISO MGI:1857035 (MGI:66348|PMID:7518067) RGD PMID:7518067 MGI:66348 NCBI chr 8:69,301,635...70,034,741
Ensembl chr 8:69,301,733...70,025,931
JBrowse link
cyclic nucleotide catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cnp 2',3'-cyclic nucleotide 3' phosphodiesterase involved_in IEA GO_REF:0000002
GO_REF:0000104
InterPro
UniProt
GO_REF:0000002 GO_REF:0000104 NCBI chr10:85,511,164...85,517,723
Ensembl chr10:85,511,160...85,517,720
JBrowse link
cyclic purine nucleotide metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ampd2 adenosine monophosphate deaminase 2 involved_in ISS
ISO
GO_REF:0000024
(PMID:23911318)
UniProt
RGD
PMID:23911318 GO_REF:0000024 NCBI chr 2:195,707,609...195,720,454
Ensembl chr 2:195,707,610...195,720,271
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19874
    metabolic process 12191
      organic substance metabolic process 11722
        organophosphate metabolic process 1041
          nucleoside phosphate metabolic process 616
            nucleotide metabolic process 606
              cyclic nucleotide metabolic process 43
                cyclic nucleotide biosynthetic process + 24
                cyclic nucleotide catabolic process + 13
                cyclic purine nucleotide metabolic process + 42
Path 2
Term Annotations click to browse term
  biological_process 19874
    metabolic process 12191
      nitrogen compound metabolic process 10416
        cellular nitrogen compound metabolic process 6771
          nucleobase-containing compound metabolic process 5755
            nucleobase-containing small molecule metabolic process 690
              nucleoside phosphate metabolic process 616
                nucleotide metabolic process 606
                  cyclic nucleotide metabolic process 43
                    cyclic nucleotide biosynthetic process + 24
                    cyclic nucleotide catabolic process + 13
                    cyclic purine nucleotide metabolic process + 42
paths to the root