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ONTOLOGY REPORT - ANNOTATIONS


Term:cyclic nucleotide metabolic process
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Accession:GO:0009187 term browser browse the term
Definition:The chemical reactions and pathways involving a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue.
Synonyms:exact_synonym: cyclic nucleotide metabolism


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cAMP biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcy1 adenylate cyclase 1 IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:14985420, PMID:21873635 RGD:2312640, RGD:13792537 NCBI chr14:87,311,970...87,429,880
Ensembl chr14:87,312,203...87,421,659
JBrowse link
G Adcy10 adenylate cyclase 10 IDA
ISO
IMP
(PMID:12609998), (PMID:15659711) RGD PMID:12609998, PMID:15659711, PMID:9874775, PMID:7225326, PMID:16627466, PMID:16964251 RGD:1299450, RGD:2313177, RGD:2313173, RGD:2313171 NCBI chr13:83,701,952...83,787,010
Ensembl chr13:83,721,300...83,787,018
JBrowse link
G Adcy2 adenylate cyclase 2 IDA
IEA
PMID:10427002
GO_REF:0000002
PMID:18164588
GOC PMID:11738086, PMID:10427002, PMID:18164588, PMID:12711600 GO_REF:0000002, RGD:2312641, RGD:10400857, RGD:8553431, RGD:2312674 NCBI chr 1:37,043,071...37,698,390
Ensembl chr 1:37,507,276...37,698,390
JBrowse link
G Adcy3 adenylate cyclase 3 IDA
IBA
ISO
IEA
PMID:21873635
(MGI:MGI:1889935|PMID:11055432)
GO_REF:0000107
PMID:24363043
RGD
Ensembl
PMID:11055432, PMID:12711600, PMID:21873635, PMID:24363043 GO_REF:0000107, MGI:MGI:1889935, RGD:2312674, RGD:13792537, RGD:10400870 NCBI chr 6:28,570,941...28,648,848
Ensembl chr 6:28,571,351...28,650,148
JBrowse link
G Adcy4 adenylate cyclase 4 IDA
IEA
GO_REF:0000043
PMID:8900209
UniProt PMID:11738086, PMID:8900209, PMID:12711600 GO_REF:0000043, RGD:2312641, RGD:8554340, RGD:2312674 NCBI chr15:34,453,917...34,469,779
Ensembl chr15:34,453,915...34,469,746
JBrowse link
G Adcy5 adenylate cyclase 5 IDA
IBA
ISO
IEA
PMID:21873635
(PMID:15385642), (PMID:24700542), (PMID:24740569)
GO_REF:0000107
RGD
Ensembl
PMID:15385642, PMID:24700542, PMID:24740569, PMID:11738086, PMID:21873635, PMID:10894801, PMID:12711600 GO_REF:0000107, RGD:2312641, RGD:13792537, RGD:2315006, RGD:2312674 NCBI chr11:68,695,839...68,842,452
Ensembl chr11:68,695,839...68,842,320
JBrowse link
G Adcy6 adenylate cyclase 6 IDA
IBA
IEA
ISO
IMP
PMID:21873635
GO_REF:0000043
(PMID:17916776), (PMID:18403039)
(MGI:MGI:4457984|PMID:20466003)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:17916776, PMID:18403039, PMID:20466003, PMID:15961389, PMID:21873635, PMID:10894801, PMID:15579502, PMID:12711600, PMID:10866989, PMID:18971210, PMID:11738086 GO_REF:0000043, GO_REF:0000107, MGI:MGI:4457984, RGD:1598749, RGD:13792537, RGD:2315006, RGD:2313211, RGD:2312674, RGD:2312678, RGD:2312654, RGD:2312641 NCBI chr 7:140,270,678...140,291,722
Ensembl chr 7:140,270,692...140,291,620
JBrowse link
G Adcy7 adenylate cyclase 7 IDA
ISO
(PMID:11113152), (PMID:17760784) RGD PMID:11113152, PMID:17760784, PMID:12711600 RGD:2312674 NCBI chr19:19,702,307...19,762,973
Ensembl chr19:19,704,859...19,727,081
JBrowse link
G Adcy8 adenylate cyclase 8 IMP
IBA
IEA
IDA
PMID:21873635
GO_REF:0000043
UniProt PMID:16741924, PMID:21873635, PMID:19305019, PMID:19444869 GO_REF:0000043, RGD:2312769, RGD:13792537, RGD:7241269, RGD:2312785 NCBI chr 7:105,353,883...105,593,372
Ensembl chr 7:105,353,913...105,592,804
JBrowse link
G Adcy9 adenylate cyclase 9 IMP
ISO
(MGI:MGI:76465|PMID:7575502), (MGI:MGI:80863|PMID:8662814)
(PMID:10987815), (PMID:9628827)
RGD PMID:7575502, PMID:8662814, PMID:9628827, PMID:10987815, PMID:19444869 MGI:MGI:76465, MGI:MGI:80863, RGD:2312785 NCBI chr10:11,392,698...11,515,406
Ensembl chr10:11,392,625...11,512,600
JBrowse link
cAMP catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pde10a phosphodiesterase 10A IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 1:52,360,296...52,544,448
Ensembl chr 1:52,360,296...52,544,450
JBrowse link
G Pde4a phosphodiesterase 4A IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 8:22,189,533...22,234,036
Ensembl chr 8:22,189,600...22,233,748
JBrowse link
G Pde4b phosphodiesterase 4B IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 5:121,759,236...122,136,814
Ensembl chr 5:121,952,977...122,136,814
JBrowse link
G Pde4c phosphodiesterase 4C IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr16:20,442,305...20,466,386
Ensembl chr16:20,442,609...20,460,959
Ensembl chr16:20,442,609...20,460,959
JBrowse link
G Pde4d phosphodiesterase 4D IEA
IBA
ISO
GO_REF:0000041
PMID:21873635
(PMID:20819076)
UniProt
RGD
PMID:20819076, PMID:21873635 GO_REF:0000041, RGD:13792537 NCBI chr 2:40,219,999...41,468,551
Ensembl chr 2:40,554,146...41,464,264
JBrowse link
G Pde7a phosphodiesterase 7A IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 2:104,042,124...104,134,101
Ensembl chr 2:104,045,811...104,134,101
JBrowse link
G Pde8a phosphodiesterase 8A IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 1:143,036,083...143,160,395
Ensembl chr 1:143,036,218...143,159,433
JBrowse link
G Pde8b phosphodiesterase 8B IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 2:24,718,548...24,955,533
Ensembl chr 2:24,719,976...24,923,128
JBrowse link
cAMP metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacnb4 calcium voltage-gated channel auxiliary subunit beta 4 ISO MGI:MGI:1856936 (MGI:MGI:76872|PMID:7595494) RGD PMID:7595494 MGI:MGI:76872 NCBI chr 3:37,950,846...38,211,478
Ensembl chr 3:37,955,069...38,090,526
JBrowse link
G Epha2 Eph receptor A2 ISO (PMID:27385333) RGD PMID:27385333 NCBI chr 5:159,845,773...159,874,203
Ensembl chr 5:159,845,774...159,874,206
JBrowse link
cGMP biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 ISO
IEA
MGI:MGI:3640802 (MGI:MGI:3640061|PMID:16614755)
GO_REF:0000107
(PMID:23505436)
RGD
Ensembl
PMID:16614755, PMID:23505436 GO_REF:0000107, MGI:MGI:3640061 NCBI chr 2:181,045,694...181,103,321
Ensembl chr 2:181,045,703...181,102,918
JBrowse link
G Gucy1a2 guanylate cyclase 1 soluble subunit alpha 2 IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 8:408,001...899,851
Ensembl chr 8:408,001...899,974
JBrowse link
G Gucy1b1 guanylate cyclase 1 soluble subunit beta 1 ISO (PMID:23505436) RGD PMID:23505436 NCBI chr 2:180,976,939...181,026,001
Ensembl chr 2:180,976,939...181,026,024
JBrowse link
G Gucy1b2 guanylate cyclase 1 soluble subunit beta 2 IEA GO_REF:0000002
GO_REF:0000043
InterPro
UniProt
GO_REF:0000002, GO_REF:0000043 NCBI chr15:45,479,662...45,550,285
Ensembl chr15:45,479,658...45,550,285
JBrowse link
G Gucy2c guanylate cyclase 2C IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:170,659,993...170,740,274
Ensembl chr 4:170,659,998...170,740,274
JBrowse link
G Gucy2d guanylate cyclase 2D, retinal ISO
IBA
IEA
(MGI:MGI:5049799|PMID:21598940)
PMID:21873635
GO_REF:0000107
RGD
Ensembl
PMID:21598940, PMID:21873635 GO_REF:0000107, MGI:MGI:5049799, RGD:13792537 NCBI chr10:55,835,695...55,851,235
Ensembl chr10:55,835,695...55,851,235
JBrowse link
G Gucy2e guanylate cyclase 2E IDA
IBA
PMID:11580282
PMID:21873635
UniProt
GO_Central
PMID:11580282, PMID:21873635 RGD:15023466, RGD:13792537 NCBI chr 1:163,398,891...163,433,594
Ensembl chr 1:163,398,891...163,433,593
JBrowse link
G Gucy2f guanylate cyclase 2F IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:113,372,240...113,474,210
Ensembl chr  X:113,372,240...113,474,164
JBrowse link
G Gucy2g guanylate cyclase 2G IEA
IBA
GO_REF:0000043
PMID:21873635
UniProt PMID:21873635 GO_REF:0000043, RGD:13792537 NCBI chr 1:276,187,243...276,228,574
Ensembl chr 1:276,187,242...276,228,574
JBrowse link
G Nppa natriuretic peptide A ISO
IBA
(PMID:1672777)
PMID:21873635
RGD PMID:1672777, PMID:21873635 RGD:13792537 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Nppb natriuretic peptide B ISO
IBA
(PMID:1672777)
PMID:21873635
RGD PMID:1672777, PMID:21873635 RGD:13792537 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
JBrowse link
G Nppc natriuretic peptide C ISO
IBA
(PMID:1672777)
PMID:21873635
(MGI:MGI:2177134|PMID:11259675)
RGD PMID:1672777, PMID:11259675, PMID:21873635 MGI:MGI:2177134, RGD:13792537 NCBI chr 9:93,731,436...93,735,636
Ensembl chr 9:93,731,436...93,735,636
JBrowse link
G Npr1 natriuretic peptide receptor 1 ISO
IBA
(PMID:1672777)
PMID:21873635
RGD PMID:1672777, PMID:21873635 RGD:13792537 NCBI chr 2:189,840,403...189,857,032
Ensembl chr 2:189,840,403...189,856,090
JBrowse link
G Npr2 natriuretic peptide receptor 2 ISO
IBA
(PMID:1672777)
PMID:21873635
RGD PMID:1672777, PMID:21873635 RGD:13792537 NCBI chr 5:59,128,186...59,147,321
Ensembl chr 5:59,128,315...59,147,255
JBrowse link
cGMP catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pde10a phosphodiesterase 10A IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 1:52,360,296...52,544,448
Ensembl chr 1:52,360,296...52,544,450
JBrowse link
G Pde1a phosphodiesterase 1A IMP RGD PMID:16514069 RGD:2312521 NCBI chr 3:66,803,247...67,263,658
Ensembl chr 3:66,803,247...66,885,094
JBrowse link
G Pde2a phosphodiesterase 2A IEA
IBA
ISO
GO_REF:0000107
PMID:21873635
(MGI:MGI:4420377|PMID:19632989)
(PMID:19828435)
Ensembl
RGD
PMID:19632989, PMID:19828435, PMID:21873635 GO_REF:0000107, MGI:MGI:4420377, RGD:13792537 NCBI chr 1:166,534,643...166,626,158
Ensembl chr 1:166,534,643...166,626,158
JBrowse link
G Pde5a phosphodiesterase 5A ISO
IEA
(MGI:MGI:2450821|PMID:12554648)
GO_REF:0000107
GO_REF:0000041
RGD
Ensembl
UniProt
PMID:12554648 GO_REF:0000041, GO_REF:0000107, MGI:MGI:2450821 NCBI chr 2:226,899,604...227,044,916
Ensembl chr 2:226,900,619...227,041,576
JBrowse link
G Pde9a phosphodiesterase 9A IEA
IBA
ISO
ISS
GO_REF:0000041
PMID:21873635
(MGI:MGI:1266874|PMID:9624145), (MGI:MGI:5634842|PMID:25799991)
GO_REF:0000024
(PMID:25799991)
UniProt
RGD
PMID:9624145, PMID:25799991, PMID:21873635 GO_REF:0000024, GO_REF:0000041, MGI:MGI:1266874, MGI:MGI:5634842, RGD:13792537 NCBI chr20:10,123,624...10,216,325
Ensembl chr20:10,123,651...10,216,548
JBrowse link
cGMP metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2b2 ATPase plasma membrane Ca2+ transporting 2 ISO MGI:MGI:1857092 (MGI:MGI:66348|PMID:7518067), (MGI:MGI:68066|PMID:3038581) RGD PMID:3038581, PMID:7518067 MGI:MGI:66348, MGI:MGI:68066 NCBI chr 4:145,704,779...145,948,997
Ensembl chr 4:145,703,046...146,016,325
JBrowse link
G Pde5a phosphodiesterase 5A ISO (MGI:MGI:4361111|PMID:19474061), (MGI:MGI:4834094|PMID:20511540) RGD PMID:19474061, PMID:20511540 MGI:MGI:4361111, MGI:MGI:4834094 NCBI chr 2:226,899,604...227,044,916
Ensembl chr 2:226,900,619...227,041,576
JBrowse link
G Pde9a phosphodiesterase 9A ISO
ISS
(PMID:9624146)
GO_REF:0000024
RGD
UniProt
PMID:9624146 GO_REF:0000024 NCBI chr20:10,123,624...10,216,325
Ensembl chr20:10,123,651...10,216,548
JBrowse link
G Rora RAR-related orphan receptor A ISO MGI:MGI:1857035 (MGI:MGI:66348|PMID:7518067) RGD PMID:7518067 MGI:MGI:66348 NCBI chr 8:75,515,886...75,616,477
Ensembl chr 8:75,516,904...75,607,212
JBrowse link
cyclic nucleotide catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cnp 2',3'-cyclic nucleotide 3' phosphodiesterase IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:88,490,798...88,497,357
Ensembl chr10:88,490,798...88,497,356
JBrowse link
cyclic purine nucleotide metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ampd2 adenosine monophosphate deaminase 2 ISO
ISS
(PMID:23911318)
GO_REF:0000024
RGD
UniProt
PMID:23911318 GO_REF:0000024 NCBI chr 2:210,861,624...210,874,348
Ensembl chr 2:210,861,625...210,874,304
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20017
    metabolic process 12256
      organic substance metabolic process 11636
        organophosphate metabolic process 971
          nucleoside phosphate metabolic process 510
            nucleotide metabolic process 503
              cyclic nucleotide metabolic process 42
                cAMP metabolic process + 20
                cGMP metabolic process + 21
                cyclic nucleotide biosynthetic process + 25
                cyclic nucleotide catabolic process + 13
Path 2
Term Annotations click to browse term
  biological_process 20017
    metabolic process 12256
      nitrogen compound metabolic process 10342
        cellular nitrogen compound metabolic process 6683
          nucleobase-containing compound metabolic process 5483
            nucleobase-containing small molecule metabolic process 590
              nucleoside phosphate metabolic process 510
                nucleotide metabolic process 503
                  cyclic nucleotide metabolic process 42
                    cAMP metabolic process + 20
                    cGMP metabolic process + 21
                    cyclic nucleotide biosynthetic process + 25
                    cyclic nucleotide catabolic process + 13
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.