ONTOLOGY REPORT - ANNOTATIONS
Term: nucleobase metabolic process
Accession: GO:0009112
browse the term
Definition: The chemical reactions and pathways involving a nucleobase, a nitrogenous base that is a constituent of a nucleic acid, e.g. the purines: adenine, guanine, hypoxanthine, xanthine and the pyrimidines: cytosine, uracil, thymine.
Synonyms: exact_synonym: nucleobase metabolism
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CAD
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
involved_in
ISO IBA IEA ISS IDA
(PMID:24332717)
RGD GO_Central Ensembl InterPro BHF-UCL UniProt
PMID:1476792 PMID:24332717
GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 RGD:5132591
NCBI chr 2:27,217,369...27,243,943
Ensembl chr 2:27,217,369...27,243,943
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CMPK1
cytidine/uridine monophosphate kinase 1
involved_in
IEA
InterPro
GO_REF:0000002
NCBI chr 1:47,333,790...47,378,839
Ensembl chr 1:47,333,790...47,394,866
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CPS1
carbamoyl-phosphate synthase 1
involved_in
IEA
InterPro
GO_REF:0000002
NCBI chr 2:210,477,685...210,679,107
Ensembl chr 2:210,477,682...210,679,107
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DHODH
dihydroorotate dehydrogenase (quinone)
involved_in
ISO IBA IEA
RGD GO_Central InterPro
PMID:1476792
GO_REF:0000002 GO_REF:0000033 RGD:5132591
NCBI chr16:72,008,744...72,027,659
Ensembl chr16:72,008,588...72,027,664
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MTOR
mechanistic target of rapamycin kinase
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 1:11,106,535...11,262,551
Ensembl chr 1:11,106,535...11,262,556
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UMPS
uridine monophosphate synthetase
involved_in
IEA
InterPro
GO_REF:0000002
NCBI chr 3:124,730,452...124,749,273
Ensembl chr 3:124,730,433...124,749,273
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GART
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
involved_in
IBA
GO_Central
GO_REF:0000033
NCBI chr21:33,503,931...33,542,893
Ensembl chr21:33,503,931...33,543,491
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APRT
adenine phosphoribosyltransferase
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:8643571), (PMID:8894695) (PMID:8894695)
Ensembl MGI
PMID:8643571 PMID:8894695
GO_REF:0000107
NCBI chr16:88,809,339...88,811,928
Ensembl chr16:88,809,339...88,811,937
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HPRT1
hypoxanthine phosphoribosyltransferase 1
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:8894695)
Ensembl MGI
PMID:8894695
GO_REF:0000107
NCBI chr X:134,460,165...134,500,668
Ensembl chr X:134,460,165...134,520,513
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APRT
adenine phosphoribosyltransferase
involved_in
IEA IBA
InterPro GO_Central
GO_REF:0000002 GO_REF:0000033
NCBI chr16:88,809,339...88,811,928
Ensembl chr16:88,809,339...88,811,937
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CDA
cytidine deaminase
involved_in
TAS
(PMID:7923172)
UniProt
PMID:7923172
NCBI chr 1:20,589,097...20,618,903
Ensembl chr 1:20,589,086...20,618,903
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MAPK1
mitogen-activated protein kinase 1
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:15284227)
Ensembl MGI
PMID:15284227
GO_REF:0000107
NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
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TET2
tet methylcytosine dioxygenase 2
acts_upstream_of_or_within
ISO
(PMID:21803851)
MGI
PMID:21803851
NCBI chr 4:105,145,875...105,279,803
Ensembl chr 4:105,145,875...105,279,816
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NT5C2
5'-nucleotidase, cytosolic II
involved_in
ISO
(PMID:5560407)
MGI
PMID:5560407
NCBI chr10:103,088,017...103,193,272
Ensembl chr10:103,087,185...103,277,605
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GDA
guanine deaminase
involved_in
IEA
InterPro UniProt Ensembl
GO_REF:0000002 GO_REF:0000041 GO_REF:0000107
NCBI chr 9:72,114,608...72,259,869
Ensembl chr 9:72,114,595...72,257,193
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UOX
urate oxidase (pseudogene)
involved_in
ISO
(PMID:16462750)
MGI
PMID:16462750
NCBI chr 1:84,364,958...84,384,801
Ensembl chr 1:84,365,428...84,397,831
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URAD
ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase
involved_in
ISO
(PMID:16462750)
MGI
PMID:16462750
NCBI chr13:27,977,717...27,988,693
Ensembl chr13:27,977,717...27,988,693
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URAHP
urate (hydroxyiso-) hydrolase, pseudogene
involved_in
ISO
(PMID:16462750)
MGI
PMID:16462750
NCBI chr16:90,039,761...90,047,783
Ensembl chr16:90,043,914...90,047,597 Ensembl chr16:90,043,914...90,047,597
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XDH
xanthine dehydrogenase
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 2:31,334,321...31,414,742
Ensembl chr 2:31,334,321...31,414,742
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GDA
guanine deaminase
involved_in
IBA
GO_Central
GO_REF:0000033
NCBI chr 9:72,114,608...72,259,869
Ensembl chr 9:72,114,595...72,257,193
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KDM1A
lysine demethylase 1A
involved_in
ISO IEA
RGD Ensembl
PMID:20418916
GO_REF:0000107 RGD:9588315
NCBI chr 1:23,019,468...23,083,689
Ensembl chr 1:23,019,443...23,083,689
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HPRT1
hypoxanthine phosphoribosyltransferase 1
involved_in
IDA IBA
(PMID:19527031)
UniProt GO_Central
PMID:19527031
GO_REF:0000033
NCBI chr X:134,460,165...134,500,668
Ensembl chr X:134,460,165...134,520,513
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PRTFDC1
phosphoribosyl transferase domain containing 1
NOT|involved_in
IDA
(PMID:21054786)
UniProt
PMID:21054786
NCBI chr10:24,848,614...24,952,606
Ensembl chr10:24,848,614...24,952,606
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ADA
adenosine deaminase
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:10720488)
Ensembl MGI
PMID:10720488
GO_REF:0000107
NCBI chr20:44,619,522...44,651,699
Ensembl chr20:44,584,896...44,652,252
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PRPS1
phosphoribosyl pyrophosphate synthetase 1
involved_in
IMP
(PMID:17701896)
UniProt
PMID:17701896
NCBI chr X:107,628,510...107,651,026
Ensembl chr X:107,628,428...107,651,993
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UOX
urate oxidase (pseudogene)
involved_in
ISO
(PMID:16462750)
MGI
PMID:16462750
NCBI chr 1:84,364,958...84,384,801
Ensembl chr 1:84,365,428...84,397,831
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URAD
ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase
involved_in
ISO
(PMID:16462750)
MGI
PMID:16462750
NCBI chr13:27,977,717...27,988,693
Ensembl chr13:27,977,717...27,988,693
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URAHP
urate (hydroxyiso-) hydrolase, pseudogene
involved_in
ISO
(PMID:16462750)
MGI
PMID:16462750
NCBI chr16:90,039,761...90,047,783
Ensembl chr16:90,043,914...90,047,597 Ensembl chr16:90,043,914...90,047,597
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XDH
xanthine dehydrogenase
involved_in
ISO IEA IDA
(PMID:1619276)
RGD Ensembl MGI
PMID:232638 PMID:1619276
GO_REF:0000107 RGD:13210503
NCBI chr 2:31,334,321...31,414,742
Ensembl chr 2:31,334,321...31,414,742
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HPRT1
hypoxanthine phosphoribosyltransferase 1
acts_upstream_of_or_within involved_in
ISO IBA IMP IEA
(PMID:10037486) (PMID:3029599) (PMID:9824441)
RGD MGI GO_Central UniProt Ensembl
PMID:3029599 PMID:6206848 PMID:9824441 PMID:10037486
GO_REF:0000033 GO_REF:0000107 RGD:1580844
NCBI chr X:134,460,165...134,500,668
Ensembl chr X:134,460,165...134,520,513
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ADA
adenosine deaminase
involved_in
IBA
GO_Central
GO_REF:0000033
NCBI chr20:44,619,522...44,651,699
Ensembl chr20:44,584,896...44,652,252
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HPRT1
hypoxanthine phosphoribosyltransferase 1
involved_in
IDA
(PMID:19527031)
UniProt
PMID:19527031
NCBI chr X:134,460,165...134,500,668
Ensembl chr X:134,460,165...134,520,513
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GART
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
involved_in
IEA
UniProt InterPro
GO_REF:0000002 GO_REF:0000104
NCBI chr21:33,503,931...33,542,893
Ensembl chr21:33,503,931...33,543,491
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GMPS
guanine monophosphate synthase
involved_in
TAS
(PMID:8089153)
PINC
PMID:8089153
NCBI chr 3:155,869,430...155,944,020
Ensembl chr 3:155,870,650...155,944,020
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PAICS
phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
involved_in
TAS IDA
(PMID:2253271) (PMID:31600779)
PINC UniProt
PMID:2253271 PMID:31600779
NCBI chr 4:56,410,507...56,464,578
Ensembl chr 4:56,435,741...56,464,578
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PPAT
phosphoribosyl pyrophosphate amidotransferase
involved_in
IEA
InterPro
GO_REF:0000002
NCBI chr 4:56,393,362...56,435,615
Ensembl chr 4:56,393,362...56,435,615
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SHMT1
serine hydroxymethyltransferase 1
involved_in
IDA
(PMID:11516159)
UniProt
PMID:11516159
NCBI chr17:18,327,873...18,363,550
Ensembl chr17:18,327,873...18,363,550
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DPYD
dihydropyrimidine dehydrogenase
involved_in
IMP
(PMID:11988088)
UniProt
PMID:11988088
NCBI chr 1:97,077,743...97,921,059
Ensembl chr 1:97,077,743...97,995,000
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ACP3
acid phosphatase 3
involved_in
IEA
Ensembl
GO_REF:0000107
NCBI chr 3:132,317,407...132,368,302
Ensembl chr 3:132,317,369...132,368,302
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ADK
adenosine kinase
involved_in
IBA
GO_Central
GO_REF:0000033
NCBI chr10:74,151,221...74,709,290
Ensembl chr10:74,151,202...74,709,963
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GMPR
guanosine monophosphate reductase
involved_in
IEA
UniProt
GO_REF:0000043
NCBI chr 6:16,238,587...16,295,549
Ensembl chr 6:16,238,587...16,295,549
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GMPR2
guanosine monophosphate reductase 2
involved_in
IEA
UniProt
GO_REF:0000043
NCBI chr14:24,232,622...24,239,242
Ensembl chr14:24,232,422...24,239,242
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PRPS1
phosphoribosyl pyrophosphate synthetase 1
involved_in
IMP
(PMID:8253776)
UniProt
PMID:8253776
NCBI chr X:107,628,510...107,651,026
Ensembl chr X:107,628,428...107,651,993
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TTR
transthyretin
involved_in
IBA
GO_Central
GO_REF:0000033
NCBI chr18:31,591,877...31,598,821
Ensembl chr18:31,557,009...31,598,833
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URAD
ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase
involved_in
IEA
UniProt
GO_REF:0000043
NCBI chr13:27,977,717...27,988,693
Ensembl chr13:27,977,717...27,988,693
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CTPS1
CTP synthase 1
involved_in
IBA
GO_Central
GO_REF:0000033
NCBI chr 1:40,979,696...41,012,565
Ensembl chr 1:40,979,300...41,012,565
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CTPS2
CTP synthase 2
involved_in
IBA
GO_Central
GO_REF:0000033
NCBI chr X:16,587,999...16,712,910
Ensembl chr X:16,587,999...16,712,936
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UMPS
uridine monophosphate synthetase
involved_in
IBA
GO_Central
GO_REF:0000033
NCBI chr 3:124,730,452...124,749,273
Ensembl chr 3:124,730,433...124,749,273
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CRMP1
collapsin response mediator protein 1
NOT|involved_in
IBA
GO_Central
GO_REF:0000033
NCBI chr 4:5,820,764...5,893,086
Ensembl chr 4:5,748,084...5,893,086
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DPYD
dihydropyrimidine dehydrogenase
acts_upstream_of_or_within involved_in
ISO IEA ISS IMP
(PMID:12651209) (PMID:11988088)
RGD MGI Ensembl UniProt
PMID:1629785 PMID:11988088 PMID:12651209
GO_REF:0000024 GO_REF:0000107 RGD:1599794
NCBI chr 1:97,077,743...97,921,059
Ensembl chr 1:97,077,743...97,995,000
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DPYS
dihydropyrimidinase
involved_in
IDA IBA
(PMID:9718352)
UniProt GO_Central
PMID:9718352
GO_REF:0000033
NCBI chr 8:104,379,431...104,467,055
Ensembl chr 8:104,330,324...104,467,055
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DPYSL2
dihydropyrimidinase like 2
NOT|involved_in
IBA
GO_Central
GO_REF:0000033
NCBI chr 8:26,514,031...26,658,175
Ensembl chr 8:26,514,031...26,658,178
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DPYSL3
dihydropyrimidinase like 3
NOT|involved_in
IBA
GO_Central
GO_REF:0000033
NCBI chr 5:147,390,808...147,510,068
Ensembl chr 5:147,390,808...147,510,068
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DPYSL4
dihydropyrimidinase like 4
NOT|involved_in
IBA
GO_Central
GO_REF:0000033
NCBI chr10:132,186,948...132,205,759
Ensembl chr10:132,186,948...132,205,759
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DPYSL5
dihydropyrimidinase like 5
NOT|involved_in
IBA
GO_Central
GO_REF:0000033
NCBI chr 2:26,847,995...26,950,351
Ensembl chr 2:26,847,747...26,950,351
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RRM1
ribonucleotide reductase catalytic subunit M1
involved_in
ISO IEA
orotic acid
RGD Ensembl
PMID:10204803
GO_REF:0000107 RGD:5133695
NCBI chr11:4,094,685...4,138,932
Ensembl chr11:4,094,707...4,138,932
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RRM2
ribonucleotide reductase regulatory subunit M2
ISO
orotic acid
RGD
PMID:10204803
RGD:5133695
NCBI chr 2:10,122,568...10,211,010
Ensembl chr 2:10,120,698...10,211,725
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TYMP
thymidine phosphorylase
involved_in
IEA
InterPro
GO_REF:0000002
NCBI chr22:50,525,752...50,530,085
Ensembl chr22:50,525,752...50,530,032
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TYMS
thymidylate synthetase
involved_in
ISO IEA
5-fluorocytosine
RGD Ensembl
PMID:9524100
GO_REF:0000107 RGD:5133447
NCBI chr18:657,653...673,578
Ensembl chr18:657,653...673,578
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ALDH6A1
aldehyde dehydrogenase 6 family member A1
involved_in
ISO IBA IMP
(PMID:23835272)
RGD GO_Central BHF-UCL
PMID:2768248 PMID:23835272
GO_REF:0000033 RGD:1599052
NCBI chr14:74,056,847...74,084,453
Ensembl chr14:74,056,847...74,084,492
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DPYD
dihydropyrimidine dehydrogenase
involved_in
IDA IBA
(PMID:10410956)
UniProt GO_Central
PMID:10410956
GO_REF:0000033
NCBI chr 1:97,077,743...97,921,059
Ensembl chr 1:97,077,743...97,995,000
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DPYS
dihydropyrimidinase
involved_in
ISS
UniProt
GO_REF:0000024
NCBI chr 8:104,379,431...104,467,055
Ensembl chr 8:104,330,324...104,467,055
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ALDH6A1
aldehyde dehydrogenase 6 family member A1
involved_in
ISS
UniProt
GO_REF:0000024
NCBI chr14:74,056,847...74,084,453
Ensembl chr14:74,056,847...74,084,492
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DPYD
dihydropyrimidine dehydrogenase
involved_in
IDA IBA
(PMID:1512248), (PMID:18075467)
UniProt GO_Central
PMID:1512248 PMID:18075467
GO_REF:0000033
NCBI chr 1:97,077,743...97,921,059
Ensembl chr 1:97,077,743...97,995,000
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DPYS
dihydropyrimidinase
involved_in
IMP IDA
(PMID:18075467) (PMID:10410956)
UniProt
PMID:10410956 PMID:18075467
NCBI chr 8:104,379,431...104,467,055
Ensembl chr 8:104,330,324...104,467,055
G
DPYD
dihydropyrimidine dehydrogenase
ISO
RGD
PMID:7626590
RGD:1624989
NCBI chr 1:97,077,743...97,921,059
Ensembl chr 1:97,077,743...97,995,000
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DPYS
dihydropyrimidinase
ISO
RGD
PMID:7626590 PMID:8307005
RGD:1624989 RGD:1624990
NCBI chr 8:104,379,431...104,467,055
Ensembl chr 8:104,330,324...104,467,055
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TYMS
thymidylate synthetase
involved_in
ISO IEA
RGD Ensembl
PMID:2043679
GO_REF:0000107 RGD:5133426
NCBI chr18:657,653...673,578
Ensembl chr18:657,653...673,578
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ADA
adenosine deaminase
involved_in acts_upstream_of_or_within
IEA ISO
(PMID:10720488)
Ensembl MGI
PMID:10720488
GO_REF:0000107
NCBI chr20:44,619,522...44,651,699
Ensembl chr20:44,584,896...44,652,252
G
UOX
urate oxidase (pseudogene)
involved_in
ISO
(PMID:4207016)
MGI
PMID:4207016
NCBI chr 1:84,364,958...84,384,801
Ensembl chr 1:84,365,428...84,397,831
G
URAD
ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase
involved_in
ISO
(PMID:16462750)
MGI
PMID:16462750
NCBI chr13:27,977,717...27,988,693
Ensembl chr13:27,977,717...27,988,693
G
URAHP
urate (hydroxyiso-) hydrolase, pseudogene
involved_in
ISO
(PMID:16462750)
MGI
PMID:16462750
NCBI chr16:90,039,761...90,047,783
Ensembl chr16:90,043,914...90,047,597 Ensembl chr16:90,043,914...90,047,597
G
XDH
xanthine dehydrogenase
involved_in
IDA IBA IEA
(PMID:17301077), (PMID:8670112)
UniProt GO_Central Ensembl
PMID:8670112 PMID:17301077
GO_REF:0000033 GO_REF:0000107
NCBI chr 2:31,334,321...31,414,742
Ensembl chr 2:31,334,321...31,414,742
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