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ONTOLOGY REPORT - ANNOTATIONS

Term:nucleobase metabolic process
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Accession:GO:0009112 term browser browse the term
Definition:The chemical reactions and pathways involving a nucleobase, a nitrogenous base that is a constituent of a nucleic acid, e.g. the purines: adenine, guanine, hypoxanthine, xanthine and the pyrimidines: cytosine, uracil, thymine.
Synonyms:exact_synonym: nucleobase metabolism


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'de novo' pyrimidine nucleobase biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase involved_in ISO
IEA		 RGD
Ensembl
InterPro		 PMID:1476792 GO_REF:0000002 GO_REF:0000107 RGD:5132591 NCBI chr17:21,198,839...21,221,897
Ensembl chr17:21,197,826...21,221,635 		JBrowse link
G CMPK1 cytidine/uridine monophosphate kinase 1 involved_in IEA InterPro GO_REF:0000002 NCBI chr15:13,324,235...13,357,387
Ensembl chr15:13,326,185...13,358,152 		JBrowse link
G CPS1 carbamoyl-phosphate synthase 1 involved_in IEA InterPro GO_REF:0000002 NCBI chr37:18,308,164...18,428,487
Ensembl chr37:18,143,986...18,427,697 		JBrowse link
G DHODH dihydroorotate dehydrogenase (quinone) involved_in ISO
IEA		 RGD
InterPro		 PMID:1476792 GO_REF:0000002 RGD:5132591 NCBI chr 5:77,756,411...77,766,207
Ensembl chr 5:77,756,407...77,774,090 		JBrowse link
G LOC479668 haptoglobin-like involved_in IEA InterPro GO_REF:0000002 NCBI chr 5:77,795,183...77,800,034 JBrowse link
G MTOR mechanistic target of rapamycin kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:84,818,893...84,939,283
Ensembl chr 2:84,787,708...84,939,114 		JBrowse link
G TRIM54 tripartite motif containing 54 involved_in IEA InterPro GO_REF:0000002 NCBI chr17:21,257,660...21,278,410
Ensembl chr17:21,257,706...21,278,274 		JBrowse link
G UMPS uridine monophosphate synthetase involved_in IEA InterPro GO_REF:0000002 NCBI chr33:27,754,592...27,782,517
Ensembl chr33:27,754,643...27,782,514 		JBrowse link
adenine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APRT adenine phosphoribosyltransferase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:8894695)
(PMID:8643571), (PMID:8894695)		 Ensembl
MGI		 PMID:8643571 PMID:8894695 GO_REF:0000107 NCBI chr 5:64,563,154...64,565,537
Ensembl chr 5:64,563,192...64,565,445 		JBrowse link
G HPRT1 hypoxanthine phosphoribosyltransferase 1 acts_upstream_of_or_within ISO (PMID:8894695) MGI PMID:8894695 NCBI chr  X:105,115,732...105,153,702
Ensembl chr  X:105,115,732...105,153,702 		JBrowse link
adenine salvage term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APRT adenine phosphoribosyltransferase involved_in IEA InterPro GO_REF:0000002 NCBI chr 5:64,563,154...64,565,537
Ensembl chr 5:64,563,192...64,565,445 		JBrowse link
cytosine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MAPK1 mitogen-activated protein kinase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15284227) Ensembl
MGI		 PMID:15284227 GO_REF:0000107 NCBI chr26:31,013,607...31,132,998
Ensembl chr26:31,013,607...31,132,998 		JBrowse link
G TET2 tet methylcytosine dioxygenase 2 acts_upstream_of_or_within ISO (PMID:21803851) MGI PMID:21803851 NCBI chr32:26,021,745...26,145,109
Ensembl chr32:26,059,693...26,143,536 		JBrowse link
GMP catabolic process to guanine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NT5C2 5'-nucleotidase, cytosolic II involved_in ISO (PMID:5560407) MGI PMID:5560407 NCBI chr28:15,525,581...15,621,287
Ensembl chr28:15,526,790...15,621,235 		JBrowse link
guanine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GDA guanine deaminase involved_in IEA UniProt
Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000041 GO_REF:0000104 GO_REF:0000107 NCBI chr 1:85,506,598...85,586,212
Ensembl chr 1:85,444,917...85,586,163 		JBrowse link
G UOX urate oxidase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:63,482,384...63,513,538
Ensembl chr 6:63,436,236...63,513,478 		JBrowse link
G URAD ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:11,682,304...11,693,143
Ensembl chr25:11,581,206...11,692,284 		JBrowse link
G XDH xanthine dehydrogenase involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:24,900,708...24,960,748
Ensembl chr17:24,901,447...24,971,935 		JBrowse link
guanine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KDM1A lysine demethylase 1A ISO RGD PMID:20418916 RGD:9588315 NCBI chr 2:76,313,742...76,375,716
Ensembl chr 2:76,156,434...76,375,632 		JBrowse link
guanine salvage term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HPRT1 hypoxanthine phosphoribosyltransferase 1 involved_in ISS
IBA		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000033 NCBI chr  X:105,115,732...105,153,702
Ensembl chr  X:105,115,732...105,153,702 		JBrowse link
G PRTFDC1 phosphoribosyl transferase domain containing 1 NOT|involved_in ISO (PMID:21054786) UniProt PMID:21054786 NCBI chr 2:8,551,008...8,643,710
Ensembl chr 2:8,559,319...8,642,533 		JBrowse link
hypoxanthine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADA adenosine deaminase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10720488) Ensembl
MGI		 PMID:10720488 GO_REF:0000107 NCBI chr24:32,083,786...32,119,810
Ensembl chr24:32,083,931...32,111,160 		JBrowse link
G PRPS1 phosphoribosyl pyrophosphate synthetase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:81,150,537...81,171,521
Ensembl chr  X:81,150,536...81,212,689 		JBrowse link
hypoxanthine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G UOX urate oxidase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:63,482,384...63,513,538
Ensembl chr 6:63,436,236...63,513,478 		JBrowse link
G URAD ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:11,682,304...11,693,143
Ensembl chr25:11,581,206...11,692,284 		JBrowse link
G XDH xanthine dehydrogenase involved_in ISO
IEA		 RGD
Ensembl		 PMID:232638 GO_REF:0000107 RGD:13210503 NCBI chr17:24,900,708...24,960,748
Ensembl chr17:24,901,447...24,971,935 		JBrowse link
hypoxanthine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HPRT1 hypoxanthine phosphoribosyltransferase 1 involved_in
acts_upstream_of_or_within		 ISO
ISS
IBA		 (PMID:3029599)
(PMID:10037486)		 RGD
UniProt
GO_Central
MGI		 PMID:3029599 PMID:6206848 PMID:10037486 GO_REF:0000024 GO_REF:0000033 RGD:1580844 NCBI chr  X:105,115,732...105,153,702
Ensembl chr  X:105,115,732...105,153,702 		JBrowse link
hypoxanthine salvage term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HPRT1 hypoxanthine phosphoribosyltransferase 1 involved_in ISS UniProt GO_REF:0000024 NCBI chr  X:105,115,732...105,153,702
Ensembl chr  X:105,115,732...105,153,702 		JBrowse link
purine nucleobase biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC100856570 phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000104 NCBI chr31:28,133,546...28,165,595 JBrowse link
G PAICS phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase involved_in ISO (PMID:31600779) UniProt PMID:31600779 NCBI chr13:48,296,232...48,682,650 JBrowse link
G PPAT phosphoribosyl pyrophosphate amidotransferase involved_in IEA InterPro GO_REF:0000002 NCBI chr13:48,618,460...48,656,164
Ensembl chr13:48,620,714...48,655,780 		JBrowse link
G SHMT1 serine hydroxymethyltransferase 1 involved_in ISO (PMID:11516159) UniProt PMID:11516159 NCBI chr 5:41,221,531...41,248,653
Ensembl chr 5:41,221,562...41,253,166 		JBrowse link
purine nucleobase catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DPYD dihydropyrimidine dehydrogenase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:51,789,786...52,564,802
Ensembl chr 6:51,814,573...52,580,923 		JBrowse link
G UOX urate oxidase involved_in IBA GO_Central GO_REF:0000033 NCBI chr 6:63,482,384...63,513,538
Ensembl chr 6:63,436,236...63,513,478 		JBrowse link
purine nucleobase metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACP3 acid phosphatase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:29,294,641...29,353,970
Ensembl chr23:29,294,843...29,343,499 		JBrowse link
G GMPR guanosine monophosphate reductase involved_in IEA UniProt GO_REF:0000043 NCBI chr35:15,400,937...15,449,157
Ensembl chr35:15,401,003...15,448,022 		JBrowse link
G GMPR2 guanosine monophosphate reductase 2 involved_in IEA UniProt GO_REF:0000043 NCBI chr 8:4,213,238...4,220,740
Ensembl chr 8:4,213,373...4,220,740 		JBrowse link
G LOC489647 cadherin-1-like involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000043 NCBI chr 5:63,571,991...63,589,031 JBrowse link
G PRPS1 phosphoribosyl pyrophosphate synthetase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:81,150,537...81,171,521
Ensembl chr  X:81,150,536...81,212,689 		JBrowse link
G UOX urate oxidase involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000043 NCBI chr 6:63,482,384...63,513,538
Ensembl chr 6:63,436,236...63,513,478 		JBrowse link
G URAD ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase involved_in IEA UniProt GO_REF:0000043 NCBI chr25:11,682,304...11,693,143
Ensembl chr25:11,581,206...11,692,284 		JBrowse link
pyrimidine nucleobase catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DPYD dihydropyrimidine dehydrogenase acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:12651209) RGD
MGI
Ensembl		 PMID:1629785 PMID:12651209 GO_REF:0000107 RGD:1599794 NCBI chr 6:51,789,786...52,564,802
Ensembl chr 6:51,814,573...52,580,923 		JBrowse link
G DPYS dihydropyrimidinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:5,583,795...5,659,355
Ensembl chr13:5,583,801...5,659,463 		JBrowse link
pyrimidine nucleobase metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RRM1 ribonucleotide reductase catalytic subunit M1 ISO orotic acid RGD PMID:10204803 RGD:5133695 NCBI chr21:26,595,838...26,631,476
Ensembl chr21:26,595,914...26,631,135 		JBrowse link
G RRM2 ribonucleotide reductase regulatory subunit M2 ISO orotic acid RGD PMID:10204803 RGD:5133695 NCBI chr17:7,106,515...7,113,868
Ensembl chr17:7,104,961...7,122,939 		JBrowse link
G TYMS thymidylate synthetase ISO 5-fluorocytosine RGD PMID:9524100 RGD:5133447 NCBI chr 7:67,487,927...67,497,747
Ensembl chr 7:67,487,927...67,497,747 		JBrowse link
thymine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH6A1 aldehyde dehydrogenase 6 family member A1 involved_in ISO
IEA		 RGD
Ensembl		 PMID:2768248 GO_REF:0000107 RGD:1599052 NCBI chr 8:47,280,872...47,304,460
Ensembl chr 8:47,282,235...47,304,283 		JBrowse link
G DPYD dihydropyrimidine dehydrogenase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:51,789,786...52,564,802
Ensembl chr 6:51,814,573...52,580,923 		JBrowse link
G DPYS dihydropyrimidinase involved_in ISO PMID:8307005 UniProt PMID:8307005 RGD:1624990 NCBI chr13:5,583,795...5,659,355
Ensembl chr13:5,583,801...5,659,463 		JBrowse link
thymine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH6A1 aldehyde dehydrogenase 6 family member A1 involved_in ISO PMID:2768248 UniProt PMID:2768248 RGD:1599052 NCBI chr 8:47,280,872...47,304,460
Ensembl chr 8:47,282,235...47,304,283 		JBrowse link
uracil catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DPYD dihydropyrimidine dehydrogenase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:51,789,786...52,564,802
Ensembl chr 6:51,814,573...52,580,923 		JBrowse link
G DPYS dihydropyrimidinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:5,583,795...5,659,355
Ensembl chr13:5,583,801...5,659,463 		JBrowse link
uracil metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DPYD dihydropyrimidine dehydrogenase ISO RGD PMID:7626590 RGD:1624989 NCBI chr 6:51,789,786...52,564,802
Ensembl chr 6:51,814,573...52,580,923 		JBrowse link
G DPYS dihydropyrimidinase ISO RGD PMID:7626590 PMID:8307005 RGD:1624989 RGD:1624990 NCBI chr13:5,583,795...5,659,355
Ensembl chr13:5,583,801...5,659,463 		JBrowse link
G TYMS thymidylate synthetase ISO RGD PMID:2043679 RGD:5133426 NCBI chr 7:67,487,927...67,497,747
Ensembl chr 7:67,487,927...67,497,747 		JBrowse link
xanthine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADA adenosine deaminase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10720488) Ensembl
MGI		 PMID:10720488 GO_REF:0000107 NCBI chr24:32,083,786...32,119,810
Ensembl chr24:32,083,931...32,111,160 		JBrowse link
xanthine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G UOX urate oxidase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:63,482,384...63,513,538
Ensembl chr 6:63,436,236...63,513,478 		JBrowse link
G URAD ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:11,682,304...11,693,143
Ensembl chr25:11,581,206...11,692,284 		JBrowse link
G XDH xanthine dehydrogenase involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:24,900,708...24,960,748
Ensembl chr17:24,901,447...24,971,935 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17101
    cellular process 16595
      metabolic process 10708
        small molecule metabolic process 1734
          nucleobase-containing small molecule metabolic process 668
            nucleobase metabolic process 35
              nucleobase biosynthetic process + 17
              nucleobase catabolic process + 7
              purine nucleobase metabolic process + 20
              pyrimidine nucleobase metabolic process + 16
Path 2
Term Annotations click to browse term
  biological_process 17101
    cellular process 16595
      metabolic process 10708
        primary metabolic process 9413
          nucleobase-containing compound metabolic process 5142
            nucleobase-containing small molecule metabolic process 668
              nucleobase metabolic process 35
                nucleobase biosynthetic process + 17
                nucleobase catabolic process + 7
                purine nucleobase metabolic process + 20
                pyrimidine nucleobase metabolic process + 16
paths to the root