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ONTOLOGY REPORT - ANNOTATIONS

Term:methionine biosynthetic process
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Accession:GO:0009086 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.
Synonyms:exact_synonym: methionine anabolism;   methionine biosynthesis;   methionine formation;   methionine synthesis


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methionine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bhmt betaine-homocysteine S-methyltransferase acts_upstream_of_or_within IDA
ISO		 (MGI:3510291|PMID:15217352) RGD PMID:15217352 PMID:15845641 MGI:3510291, RGD:1359026 NCBI chr 2:24,859,871...24,879,449
Ensembl chr 2:24,859,873...24,879,742 		JBrowse link
G Bhmt2 betaine-homocysteine S-methyltransferase 2 involved_in IEA GO_REF:0000117 UniProt GO_REF:0000117 NCBI chr 2:24,895,525...24,912,475
Ensembl chr 2:24,895,533...24,912,475 		JBrowse link
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 involved_in ISO
IEA		 (PMID:25633902)
GO_REF:0000107		 RGD
Ensembl		 PMID:25633902 GO_REF:0000107 NCBI chr 6:94,977,862...95,045,375
Ensembl chr 6:94,977,862...95,045,372 		JBrowse link
G Mthfd2l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr14:17,089,947...17,170,036
Ensembl chr14:17,089,952...17,170,112 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase acts_upstream_of_or_within
involved_in		 ISO
IBA		 MGI:2385823 (MGI:3510291|PMID:15217352)
PMID:21873635		 RGD PMID:15217352 PMID:21873635 MGI:3510291, RGD:13792537 NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase involved_in
acts_upstream_of_or_within		 IDA
ISO
IEA
IBA		 (PMID:23825108)
MGI:2180496 (MGI:1930456|PMID:11158293)
GO_REF:0000117
PMID:21873635		 RGD
UniProt		 PMID:11158293 PMID:23825108 PMID:15845641 PMID:11730351 PMID:21873635 GO_REF:0000117 MGI:1930456, RGD:1359026, RGD:1601423, RGD:13792537 NCBI chr17:58,219,998...58,308,560
Ensembl chr17:58,220,071...58,304,822 		JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase involved_in ISO
IBA		 (PMID:11466310)
(MGI:3710265|PMID:17369066)
PMID:21873635		 RGD PMID:11466310 PMID:17369066 PMID:21873635 MGI:3710265, RGD:13792537 NCBI chr 1:34,866,991...34,899,425
Ensembl chr 1:34,867,089...34,899,425 		JBrowse link
'de novo' L-methionine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bhmt betaine-homocysteine S-methyltransferase involved_in ISO
IEA		 (PMID:10529246)
GO_REF:0000107		 RGD
Ensembl		 PMID:10529246 GO_REF:0000107 NCBI chr 2:24,859,871...24,879,449
Ensembl chr 2:24,859,873...24,879,742 		JBrowse link
L-methionine salvage term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bhmt betaine-homocysteine S-methyltransferase involved_in ISO
IEA
IBA		 (PMID:18230605)
GO_REF:0000107
PMID:21873635		 RGD
Ensembl		 PMID:18230605 PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr 2:24,859,871...24,879,449
Ensembl chr 2:24,859,873...24,879,742 		JBrowse link
G Bhmt2 betaine-homocysteine S-methyltransferase 2 involved_in IEA
ISO
IBA		 GO_REF:0000107
(PMID:18230605)
PMID:21873635		 Ensembl
RGD		 PMID:18230605 PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr 2:24,895,525...24,912,475
Ensembl chr 2:24,895,533...24,912,475 		JBrowse link
L-methionine salvage from methylthioadenosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adi1 acireductone dioxygenase 1 involved_in IEA
ISS
ISO		 GO_REF:0000041
GO_REF:0000024
(PMID:15938715)		 UniProt
RGD		 PMID:15938715 GO_REF:0000024 GO_REF:0000041 NCBI chr 6:45,306,885...45,313,847
Ensembl chr 6:45,306,841...45,313,842 		JBrowse link
G Apip APAF1 interacting protein involved_in IEA
IBA
ISO		 GO_REF:0000041
PMID:21873635
(PMID:22837397), (PMID:23285211)		 UniProt
RGD		 PMID:22837397 PMID:23285211 PMID:21873635 GO_REF:0000041, RGD:13792537 NCBI chr 3:89,431,964...89,458,000
Ensembl chr 3:89,432,037...89,458,340 		JBrowse link
G Enoph1 enolase-phosphatase 1 involved_in IEA
ISO
IBA
ISS		 GO_REF:0000041
(PMID:15843022)
PMID:21873635
GO_REF:0000024		 UniProt
RGD		 PMID:15843022 PMID:21873635 GO_REF:0000024 GO_REF:0000041, RGD:13792537 NCBI chr14:9,531,336...9,557,797
Ensembl chr14:9,531,339...9,569,273 		JBrowse link
G Mri1 methylthioribose-1-phosphate isomerase 1 involved_in IBA
IEA		 PMID:21873635
GO_REF:0000041		 UniProt PMID:21873635 GO_REF:0000041, RGD:13792537 NCBI chr19:23,907,327...23,913,721
Ensembl chr19:23,907,335...23,913,320 		JBrowse link
G Mtap methylthioadenosine phosphorylase involved_in IBA
IEA		 PMID:21873635
GO_REF:0000041		 UniProt PMID:21873635 GO_REF:0000041, RGD:13792537 NCBI chr 5:103,874,460...103,920,684
Ensembl chr 5:103,873,020...103,939,406 		JBrowse link
L-methionine salvage from S-adenosylmethionine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apip APAF1 interacting protein involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 3:89,431,964...89,458,000
Ensembl chr 3:89,432,037...89,458,340 		JBrowse link
G Enoph1 enolase-phosphatase 1 involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr14:9,531,336...9,557,797
Ensembl chr14:9,531,339...9,569,273 		JBrowse link
G Mri1 methylthioribose-1-phosphate isomerase 1 involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr19:23,907,327...23,913,721
Ensembl chr19:23,907,335...23,913,320 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19553
    metabolic process 11538
      cellular metabolic process 10124
        sulfur compound metabolic process 298
          sulfur compound biosynthetic process 131
            sulfur amino acid biosynthetic process 15
              methionine biosynthetic process 12
                L-methionine biosynthetic process + 7
Path 2
Term Annotations click to browse term
  biological_process 19553
    metabolic process 11538
      cellular metabolic process 10124
        organic acid metabolic process 1070
          oxoacid metabolic process 1059
            carboxylic acid metabolic process 1044
              amino acid metabolic process 293
                alpha-amino acid metabolic process 213
                  aspartate family amino acid metabolic process 43
                    methionine metabolic process 14
                      methionine biosynthetic process 12
                        L-methionine biosynthetic process + 7
paths to the root