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ONTOLOGY REPORT - ANNOTATIONS

Term:branched-chain amino acid catabolic process
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Accession:GO:0009083 term browser browse the term
Definition:The chemical reactions and pathways resulting in the breakdown of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine.
Synonyms:exact_synonym: branched chain family amino acid breakdown;   branched chain family amino acid catabolic process;   branched chain family amino acid catabolism;   branched chain family amino acid degradation


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branched-chain amino acid catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcat1 branched chain amino acid transaminase 1 acts_upstream_of_or_within ISO (PMID:14755340) RGD PMID:14755340 NCBI chr 4:177,964,834...178,046,573
Ensembl chr 4:177,964,834...178,046,597 		JBrowse link
G Bcat2 branched chain amino acid transaminase 2 acts_upstream_of_or_within IDA
ISO		 MGI:3028726 (PMID:14755340) RGD PMID:14755340 PMID:11733007 RGD:1582175 NCBI chr 1:96,040,407...96,060,008
Ensembl chr 1:96,042,625...96,060,007 		JBrowse link
G Bckdha branched chain keto acid dehydrogenase E1 subunit alpha involved_in TAS
ISS
IEA
ISO
IBA		 GO_REF:0000024
GO_REF:0000107
(PMID:10745006), (PMID:3593587), (PMID:7883996), (PMID:9582350)
GO_REF:0000118
GO_REF:0000033		 HGNC-UCL
Ensembl
RGD
TreeGrafter
GO_Central		 PMID:3593587 PMID:7883996 PMID:9582350 PMID:10745006 PMID:2822716 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118, RGD:631719 NCBI chr 1:81,138,946...81,167,765
Ensembl chr 1:81,138,947...81,167,862 		JBrowse link
G Bckdhb branched chain keto acid dehydrogenase E1 subunit beta involved_in ISS
IEA
ISO
IBA		 GO_REF:0000024
GO_REF:0000107
(PMID:10745006), (PMID:2022752), (PMID:3593587)
GO_REF:0000033		 UniProt
Ensembl
RGD
GO_Central		 PMID:2022752 PMID:3593587 PMID:10745006 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 8:84,845,264...85,027,812
Ensembl chr 8:84,845,264...85,027,812 		JBrowse link
G Bckdk branched chain ketoacid dehydrogenase kinase involved_in TAS
IDA		 PMID:1377677 RGD
HGNC-UCL		 PMID:11562470 PMID:1377677 RGD:68918, RGD:68712 NCBI chr 1:182,515,335...182,520,007
Ensembl chr 1:182,515,327...182,536,633 		JBrowse link
G Dbt dihydrolipoamide branched chain transacylase E2 involved_in ISO (PMID:3593587) RGD PMID:3593587 NCBI chr 2:204,481,744...204,510,612
Ensembl chr 2:204,481,737...204,510,609 		JBrowse link
G Dld dihydrolipoamide dehydrogenase involved_in ISO (PMID:3593587) RGD PMID:3593587 NCBI chr 6:47,904,153...47,924,814
Ensembl chr 6:47,903,914...47,924,795 		JBrowse link
G Ivd isovaleryl-CoA dehydrogenase involved_in ISO (PMID:7640268) RGD PMID:7640268 NCBI chr 3:105,851,710...105,872,144
Ensembl chr 3:105,851,683...105,872,575 		JBrowse link
G Ppm1k protein phosphatase, Mg2+/Mn2+ dependent, 1K involved_in ISO (PMID:29779826) RGD PMID:29779826 NCBI chr 4:87,612,198...87,638,993
Ensembl chr 4:87,612,204...87,636,152 		JBrowse link
G Slc25a44 solute carrier family 25, member 44 involved_in ISO (PMID:31435015)
(MGI:6359503|PMID:31435015)		 RGD PMID:31435015 MGI:6359503 NCBI chr 2:173,868,317...173,883,137
Ensembl chr 2:173,868,320...173,883,020 		JBrowse link
isoleucine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acadsb acyl-CoA dehydrogenase, short/branched chain involved_in ISO
IEA
ISS		 (PMID:11013134)
GO_REF:0000107
GO_REF:0000041
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:11013134 GO_REF:0000024 GO_REF:0000041 GO_REF:0000107 NCBI chr 1:186,188,939...186,227,796
Ensembl chr 1:186,188,987...186,230,379 		JBrowse link
G Acat1 acetyl-CoA acetyltransferase 1 involved_in ISO (PMID:1979337), (PMID:8103405) RGD PMID:1979337 PMID:8103405 NCBI chr 8:53,979,813...54,008,861
Ensembl chr 8:53,979,813...54,008,855 		JBrowse link
G Bcat2 branched chain amino acid transaminase 2 acts_upstream_of_or_within
involved_in		 IDA
ISO
IEA		 MGI:3772355 (PMID:17767905)
GO_REF:0000107		 RGD
Ensembl		 PMID:17767905 PMID:11733007 GO_REF:0000107, RGD:1582175 NCBI chr 1:96,040,407...96,060,008
Ensembl chr 1:96,042,625...96,060,007 		JBrowse link
G Bckdk branched chain ketoacid dehydrogenase kinase IMP RGD PMID:27472223 RGD:39131293 NCBI chr 1:182,515,335...182,520,007
Ensembl chr 1:182,515,327...182,536,633 		JBrowse link
G Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 involved_in ISO
IEA
ISS		 (PMID:18996107), (PMID:19706438)
GO_REF:0000107
GO_REF:0000041
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:18996107 PMID:19706438 GO_REF:0000024 GO_REF:0000041 GO_REF:0000107 NCBI chr  X:21,089,142...21,091,603
Ensembl chr  X:21,089,122...21,109,488 		JBrowse link
L-leucine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acad9 acyl-CoA dehydrogenase family, member 9 involved_in IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 NCBI chr 2:118,943,170...118,966,150
Ensembl chr 2:118,943,174...118,966,547 		JBrowse link
G Acadl acyl-CoA dehydrogenase, long chain involved_in IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 NCBI chr 9:68,333,981...68,372,149
Ensembl chr 9:68,333,980...68,372,220 		JBrowse link
G Auh AU RNA binding methylglutaconyl-CoA hydratase involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr17:12,329,522...12,424,882
Ensembl chr17:12,329,524...12,424,896 		JBrowse link
G Bckdk branched chain ketoacid dehydrogenase kinase IMP RGD PMID:27472223 RGD:39131293 NCBI chr 1:182,515,335...182,520,007
Ensembl chr 1:182,515,327...182,536,633 		JBrowse link
G Hmgcl 3-hydroxy-3-methylglutaryl-CoA lyase involved_in IBA
IEA		 GO_REF:0000033
GO_REF:0000118		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr 5:148,178,203...148,192,072
Ensembl chr 5:148,178,252...148,192,068 		JBrowse link
G Hmgcll1 3-hydroxy-3-methylglutaryl-CoA lyase like 1 involved_in IBA
IEA		 GO_REF:0000033
GO_REF:0000118		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr 8:76,757,301...76,887,300
Ensembl chr 8:76,757,497...76,886,816 		JBrowse link
G Ivd isovaleryl-CoA dehydrogenase involved_in IEA
IBA
IDA
ISO		 GO_REF:0000041
GO_REF:0000033
GO_REF:0000118
PMID:6401713
(PMID:7640268)		 UniProt
GO_Central
TreeGrafter
RGD		 PMID:7640268 PMID:6401713 GO_REF:0000033 GO_REF:0000041 GO_REF:0000118, RGD:8554099 NCBI chr 3:105,851,710...105,872,144
Ensembl chr 3:105,851,683...105,872,575 		JBrowse link
G Mccc1 methylcrotonyl-CoA carboxylase subunit 1 involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 2:118,799,147...118,851,181
Ensembl chr 2:118,799,150...118,851,222 		JBrowse link
G Mccc2 methylcrotonyl-CoA carboxylase subunit 2 involved_in IEA
IBA		 GO_REF:0000041
GO_REF:0000118
GO_REF:0000033		 UniProt
TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000041 GO_REF:0000118 NCBI chr 2:31,304,927...31,375,978
Ensembl chr 2:31,304,932...31,375,972 		JBrowse link
valine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh6a1 aldehyde dehydrogenase 6 family, member A1 involved_in IDA
IBA
IEA
ISO		 GO_REF:0000033
GO_REF:0000118
GO_REF:0000107
(PMID:23835272)		 GO_Central
TreeGrafter
Ensembl
RGD		 PMID:23835272 PMID:2768248 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118, RGD:1599052 NCBI chr 6:104,077,975...104,098,636
Ensembl chr 6:104,077,979...104,098,656 		JBrowse link
G Bckdk branched chain ketoacid dehydrogenase kinase IMP RGD PMID:27472223 RGD:39131293 NCBI chr 1:182,515,335...182,520,007
Ensembl chr 1:182,515,327...182,536,633 		JBrowse link
G Hibadh 3-hydroxyisobutyrate dehydrogenase involved_in IEA
IBA
ISS
ISO		 GO_REF:0000041
GO_REF:0000033
GO_REF:0000024
(PMID:16466957)		 UniProt
GO_Central
RGD		 PMID:16466957 GO_REF:0000024 GO_REF:0000033 GO_REF:0000041 NCBI chr 4:81,649,180...81,747,244
Ensembl chr 4:81,649,175...81,780,617 		JBrowse link
G Hibch 3-hydroxyisobutyryl-CoA hydrolase involved_in IEA
IBA		 GO_REF:0000041
GO_REF:0000033		 UniProt
GO_Central		 GO_REF:0000033 GO_REF:0000041 NCBI chr 9:48,590,097...48,669,896
Ensembl chr 9:48,590,099...48,669,824 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20413
    metabolic process 11835
      primary metabolic process 10352
        amino acid metabolic process 302
          amino acid catabolic process 113
            branched-chain amino acid catabolic process 23
              D-leucine catabolic process 0
              L-leucine catabolic process 9
              branched-chain amino acid catabolic process to alcohol via Ehrlich pathway 0
              branched-chain amino acid catabolic process to carboxylic acid via Ehrlich pathway 0
              isoleucine catabolic process 5
              valine catabolic process + 4
Path 2
Term Annotations click to browse term
  biological_process 20413
    metabolic process 11835
      small molecule metabolic process 1952
        organic acid metabolic process 1077
          oxoacid metabolic process 1059
            carboxylic acid metabolic process 1040
              branched-chain amino acid metabolic process 27
                branched-chain amino acid catabolic process 23
                  D-leucine catabolic process 0
                  L-leucine catabolic process 9
                  branched-chain amino acid catabolic process to alcohol via Ehrlich pathway 0
                  branched-chain amino acid catabolic process to carboxylic acid via Ehrlich pathway 0
                  isoleucine catabolic process 5
                  valine catabolic process + 4
paths to the root