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ONTOLOGY REPORT - ANNOTATIONS


Term:branched-chain amino acid catabolic process
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Accession:GO:0009083 term browser browse the term
Definition:The chemical reactions and pathways resulting in the breakdown of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine.
Synonyms:exact_synonym: branched chain family amino acid breakdown;   branched chain family amino acid catabolic process;   branched chain family amino acid catabolism;   branched chain family amino acid degradation


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branched-chain amino acid catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcat1 branched chain amino acid transaminase 1 ISO (MGI:MGI:3027291|PMID:14755340) RGD PMID:14755340 MGI:MGI:3027291 NCBI chr 4:179,259,305...179,340,021
Ensembl chr 4:179,259,308...179,339,795
JBrowse link
G Bcat2 branched chain amino acid transaminase 2 IDA
ISO
MGI:MGI:3028726 (MGI:MGI:3027291|PMID:14755340) RGD PMID:14755340, PMID:11733007 MGI:MGI:3027291, RGD:1582175 NCBI chr 1:101,553,900...101,572,103
Ensembl chr 1:101,554,642...101,572,080
JBrowse link
G Bckdha branched chain keto acid dehydrogenase E1 subunit alpha TAS
IBA
IEA
ISS
ISO
PMID:21873635
GO_REF:0000002
GO_REF:0000024
(PMID:7883996)
InterPro
HGNC
RGD
PMID:7883996, PMID:2822716, PMID:21873635 GO_REF:0000002, GO_REF:0000024, RGD:631719, RGD:13792537 NCBI chr 1:82,423,291...82,452,094
Ensembl chr 1:82,423,277...82,452,281
JBrowse link
G Bckdhb branched chain keto acid dehydrogenase E1 subunit beta ISO
IBA
ISS
IEA
(PMID:2022752)
PMID:21873635
GO_REF:0000024
GO_REF:0000107
RGD
HGNC
Ensembl
PMID:2022752, PMID:21873635 GO_REF:0000024, GO_REF:0000107, RGD:13792537 NCBI chr 8:91,464,229...91,656,134
Ensembl chr 8:91,464,229...91,656,134
JBrowse link
G Bckdk branched chain ketoacid dehydrogenase kinase TAS
IDA
PMID:1377677 RGD
HGNC
PMID:11562470, PMID:1377677 RGD:68918, RGD:68712 NCBI chr 1:199,351,628...199,356,299
Ensembl chr 1:199,351,628...199,356,881
JBrowse link
G Ivd isovaleryl-CoA dehydrogenase ISO (PMID:7640268) RGD PMID:7640268 NCBI chr 3:110,669,355...110,689,789
Ensembl chr 3:110,669,312...110,690,173
JBrowse link
G Slc25a44 solute carrier family 25, member 44 ISO (PMID:31435015)
(MGI:MGI:6359503|PMID:31435015)
RGD PMID:31435015 MGI:MGI:6359503 NCBI chr 2:187,772,013...187,786,829
Ensembl chr 2:187,774,062...187,786,731
JBrowse link
isoleucine catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acadsb acyl-CoA dehydrogenase, short/branched chain ISO
ISS
(PMID:11013134)
GO_REF:0000024
RGD
UniProt
PMID:11013134 GO_REF:0000024 NCBI chr 1:201,981,362...202,022,771
Ensembl chr 1:201,981,357...202,021,008
JBrowse link
G Acat1 acetyl-CoA acetyltransferase 1 ISO (PMID:1979337), (PMID:8103405) RGD PMID:1979337, PMID:8103405 NCBI chr 8:58,166,990...58,195,884
Ensembl chr 8:58,166,990...58,195,884
JBrowse link
G Bcat2 branched chain amino acid transaminase 2 IDA
IEA
ISO
GO_REF:0000107
MGI:MGI:3772355 (MGI:MGI:3770498|PMID:17767905)
Ensembl
RGD
PMID:17767905, PMID:11733007 GO_REF:0000107, MGI:MGI:3770498, RGD:1582175 NCBI chr 1:101,553,900...101,572,103
Ensembl chr 1:101,554,642...101,572,080
JBrowse link
G Bckdk branched chain ketoacid dehydrogenase kinase IDA RGD PMID:27472223 RGD:39131293 NCBI chr 1:199,351,628...199,356,299
Ensembl chr 1:199,351,628...199,356,881
JBrowse link
G Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 ISO
ISS
(PMID:18996107), (PMID:19706438)
GO_REF:0000024
RGD
UniProt
PMID:18996107, PMID:19706438 GO_REF:0000024 NCBI chr  X:21,696,796...21,699,241
Ensembl chr  X:21,696,772...21,699,241
JBrowse link
leucine catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Auh AU RNA binding methylglutaconyl-CoA hydratase IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr17:12,310,178...12,405,224
Ensembl chr17:12,310,214...12,405,205
JBrowse link
G Bckdk branched chain ketoacid dehydrogenase kinase IDA RGD PMID:27472223 RGD:39131293 NCBI chr 1:199,351,628...199,356,299
Ensembl chr 1:199,351,628...199,356,881
JBrowse link
G Hmgcl 3-hydroxy-3-methylglutaryl-CoA lyase IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:154,294,841...154,308,582
Ensembl chr 5:154,294,806...154,308,640
JBrowse link
G Hmgcll1 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:83,069,837...83,204,778
Ensembl chr 8:83,070,545...83,205,441
JBrowse link
G Ivd isovaleryl-CoA dehydrogenase IEA
ISO
IDA
GO_REF:0000041
(PMID:7640268)
PMID:6401713
UniProt
RGD
PMID:7640268, PMID:6401713 GO_REF:0000041, RGD:8554099 NCBI chr 3:110,669,355...110,689,789
Ensembl chr 3:110,669,312...110,690,173
JBrowse link
G Mccc1 methylcrotonoyl-CoA carboxylase 1 IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 2:122,550,777...122,690,540
Ensembl chr 2:122,550,775...122,690,617
JBrowse link
G Mccc2 methylcrotonoyl-CoA carboxylase 2 IEA
IBA
GO_REF:0000041
PMID:21873635
UniProt PMID:21873635 GO_REF:0000041, RGD:13792537 NCBI chr 2:30,175,017...30,246,028
Ensembl chr 2:30,175,018...30,246,010
JBrowse link
valine catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh6a1 aldehyde dehydrogenase 6 family, member A1 IDA
IBA
IEA
ISO
PMID:21873635
GO_REF:0000107
(PMID:23835272)
Ensembl
RGD
PMID:23835272, PMID:2768248, PMID:21873635 GO_REF:0000107, RGD:1599052, RGD:13792537 NCBI chr 6:108,146,552...108,167,185
Ensembl chr 6:108,146,582...108,167,185
JBrowse link
G Bckdk branched chain ketoacid dehydrogenase kinase IDA RGD PMID:27472223 RGD:39131293 NCBI chr 1:199,351,628...199,356,299
Ensembl chr 1:199,351,628...199,356,881
JBrowse link
G Hibadh 3-hydroxyisobutyrate dehydrogenase IEA
IBA
ISS
ISO
GO_REF:0000041
PMID:21873635
GO_REF:0000024
(PMID:16466957)
UniProt
RGD
PMID:16466957, PMID:21873635 GO_REF:0000024, GO_REF:0000041, RGD:13792537 NCBI chr 4:82,604,369...82,702,429
Ensembl chr 4:82,604,373...82,702,429
JBrowse link
G Hibch 3-hydroxyisobutyryl-CoA hydrolase IEA
IBA
GO_REF:0000041
PMID:21873635
UniProt PMID:21873635 GO_REF:0000041, RGD:13792537 NCBI chr 9:53,446,185...53,526,727
Ensembl chr 9:53,446,194...53,526,728
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    metabolic process 12278
      primary metabolic process 10941
        cellular amino acid metabolic process 276
          branched-chain amino acid metabolic process 22
            branched-chain amino acid catabolic process 18
              branched-chain amino acid catabolic process to alcohol via Ehrlich pathway 0
              branched-chain amino acid catabolic process to carboxylic acid via Ehrlich pathway 0
              isoleucine catabolic process 5
              leucine catabolic process + 7
              valine catabolic process + 4
Path 2
Term Annotations click to browse term
  biological_process 20027
    metabolic process 12278
      organic substance metabolic process 11660
        organic acid metabolic process 1095
          oxoacid metabolic process 1066
            carboxylic acid metabolic process 1009
              carboxylic acid catabolic process 245
                cellular amino acid catabolic process 106
                  branched-chain amino acid catabolic process 18
                    branched-chain amino acid catabolic process to alcohol via Ehrlich pathway 0
                    branched-chain amino acid catabolic process to carboxylic acid via Ehrlich pathway 0
                    isoleucine catabolic process 5
                    leucine catabolic process + 7
                    valine catabolic process + 4
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.