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ONTOLOGY REPORT - ANNOTATIONS


Term:aromatic amino acid family metabolic process
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Accession:GO:0009072 term browser browse the term
Definition:The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).
Synonyms:exact_synonym: aromatic amino acid family metabolism


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aromatic amino acid family metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HPD 4-hydroxyphenylpyruvate dioxygenase IEA InterPro GO_REF:0000002 NCBI chr14:30,845,608...30,857,658
Ensembl chr14:30,845,613...30,857,667
JBrowse link
G IL4I1 interleukin 4 induced 1 ISO (MGI:3505621|PMID:15383589) MGI PMID:15383589 MGI:3505621 NCBI chr 6:54,906,401...54,945,840
Ensembl chr 6:54,906,401...54,946,202
JBrowse link
G PAH phenylalanine hydroxylase IEA InterPro GO_REF:0000002 NCBI chr 5:81,385,401...81,460,569
Ensembl chr 5:81,236,096...81,463,452
JBrowse link
G TPH1 tryptophan hydroxylase 1 IEA InterPro GO_REF:0000002 NCBI chr 2:41,075,623...41,109,005
Ensembl chr 2:41,028,692...41,108,928
JBrowse link
G TPH2 tryptophan hydroxylase 2 IEA InterPro GO_REF:0000002 NCBI chr 5:35,917,159...36,016,981
Ensembl chr 5:35,918,569...36,017,514
JBrowse link
'de novo' NAD biosynthetic process from tryptophan term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AFMID arylformamidase IEA UniProt GO_REF:0000104 NCBI chr12:3,759,688...3,785,829
Ensembl chr12:3,759,708...3,785,836
JBrowse link
G HAAO 3-hydroxyanthranilate 3,4-dioxygenase IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 3:97,580,756...97,595,033
Ensembl chr 3:97,580,851...97,595,021
JBrowse link
G IDO1 indoleamine 2,3-dioxygenase 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr17:9,245,283...9,260,140
Ensembl chr17:9,245,196...9,260,491
JBrowse link
G IDO2 indoleamine 2,3-dioxygenase 2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr17:9,277,039...9,344,405
Ensembl chr17:9,277,069...9,343,749
JBrowse link
G KMO kynurenine 3-monooxygenase IEA UniProt GO_REF:0000104 NCBI chr10:12,442,877...12,489,417
Ensembl chr10:12,431,982...12,490,409
JBrowse link
G KYNU kynureninase IEA UniProt GO_REF:0000104 NCBI chr15:8,847,335...8,982,951
Ensembl chr15:8,850,665...8,982,945
JBrowse link
anthranilate metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HAAO 3-hydroxyanthranilate 3,4-dioxygenase IEA UniProt GO_REF:0000104 NCBI chr 3:97,580,756...97,595,033
Ensembl chr 3:97,580,851...97,595,021
JBrowse link
G KMO kynurenine 3-monooxygenase IEA UniProt GO_REF:0000104 NCBI chr10:12,442,877...12,489,417
Ensembl chr10:12,431,982...12,490,409
JBrowse link
G KYNU kynureninase IBA
IEA
(PMID:21873635) GO_Central
UniProt
PMID:21873635 GO_REF:0000104 NCBI chr15:8,847,335...8,982,951
Ensembl chr15:8,850,665...8,982,945
JBrowse link
dopamine biosynthetic process from tyrosine term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TH tyrosine hydroxylase IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 2:1,499,628...1,506,180
Ensembl chr 2:1,499,618...1,506,615
JBrowse link
L-phenylalanine catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FAH fumarylacetoacetate hydrolase IEA
IBA
(PMID:21873635) UniProt
GO_Central
PMID:21873635 GO_REF:0000041 NCBI chr 7:49,047,833...49,087,790
Ensembl chr 7:49,047,983...49,105,598
JBrowse link
G GSTZ1 glutathione S-transferase zeta 1 IBA
IEA
(PMID:21873635) GO_Central
UniProt
PMID:21873635 GO_REF:0000041 NCBI chr 7:100,392,217...100,404,025
Ensembl chr 7:100,392,271...100,408,423
JBrowse link
G HGD homogentisate 1,2-dioxygenase IBA
IEA
(PMID:21873635) GO_Central
UniProt
PMID:21873635 GO_REF:0000041 NCBI chr13:139,660,315...139,710,402
Ensembl chr13:139,660,343...139,710,405
JBrowse link
G HPD 4-hydroxyphenylpyruvate dioxygenase IEA UniProt GO_REF:0000041 NCBI chr14:30,845,608...30,857,658
Ensembl chr14:30,845,613...30,857,667
JBrowse link
G PAH phenylalanine hydroxylase IEA UniProt GO_REF:0000041 NCBI chr 5:81,385,401...81,460,569
Ensembl chr 5:81,236,096...81,463,452
JBrowse link
G QDPR quinoid dihydropteridine reductase IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 8:12,529,500...12,549,471
Ensembl chr 8:12,335,252...12,549,603
JBrowse link
G TAT tyrosine aminotransferase IEA UniProt GO_REF:0000041 NCBI chr 6:14,571,311...14,583,203
Ensembl chr 6:14,570,587...14,583,177
JBrowse link
L-phenylalanine metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PAH phenylalanine hydroxylase ISO RGD PMID:16953590 RGD:1601531 NCBI chr 5:81,385,401...81,460,569
Ensembl chr 5:81,236,096...81,463,452
JBrowse link
G PCBD1 pterin-4 alpha-carbinolamine dehydratase 1 ISO PMID:1465414 CAFA PMID:1465414 RGD:12792994 NCBI chr14:73,769,339...73,807,278
Ensembl chr14:73,772,835...73,807,281
JBrowse link
G SPR sepiapterin reductase ISO (MGI:3722569|PMID:16532389) MGI PMID:16532389 MGI:3722569 NCBI chr 3:69,889,448...69,894,747
Ensembl chr 3:69,887,386...69,894,758
JBrowse link
melanin biosynthetic process from tyrosine term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DCT dopachrome tautomerase ISS
IBA
(PMID:21873635) UniProt
GO_Central
PMID:21873635 GO_REF:0000024 NCBI chr11:63,584,865...63,647,486
Ensembl chr11:63,584,866...63,678,314
JBrowse link
positive regulation of L-dopa biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PARK7 Parkinsonism associated deglycase IEA Ensembl GO_REF:0000107 NCBI chr 6:68,629,327...68,645,147
Ensembl chr 6:68,629,214...68,645,520
JBrowse link
serotonin biosynthetic process from tryptophan term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2D25 vitamin D3 25-Hydroxylase ISO RGD PMID:23098818 RGD:11353778 NCBI chr 5:6,539,021...6,543,643
Ensembl chr 5:6,538,907...6,543,643
JBrowse link
tryptophan catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACMSD aminocarboxymuconate semialdehyde decarboxylase ISO RGD PMID:11802786 RGD:70243 NCBI chr15:17,121,950...17,164,005
Ensembl chr15:17,106,724...17,163,899
JBrowse link
G HAAO 3-hydroxyanthranilate 3,4-dioxygenase IEA UniProt GO_REF:0000104 NCBI chr 3:97,580,756...97,595,033
Ensembl chr 3:97,580,851...97,595,021
JBrowse link
G KMO kynurenine 3-monooxygenase IEA UniProt GO_REF:0000104 NCBI chr10:12,442,877...12,489,417
Ensembl chr10:12,431,982...12,490,409
JBrowse link
G KYNU kynureninase IEA UniProt GO_REF:0000104 NCBI chr15:8,847,335...8,982,951
Ensembl chr15:8,850,665...8,982,945
JBrowse link
tryptophan catabolic process to acetyl-CoA term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KYNU kynureninase ISO RGD PMID:7236232 RGD:2303721 NCBI chr15:8,847,335...8,982,951
Ensembl chr15:8,850,665...8,982,945
JBrowse link
G TDO2 tryptophan 2,3-dioxygenase IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 8:44,708,722...44,725,954
Ensembl chr 8:44,708,746...44,740,980
JBrowse link
tryptophan catabolic process to kynurenine term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AFMID arylformamidase IEA
IBA
(PMID:21873635) UniProt
GO_Central
PMID:21873635 GO_REF:0000041 NCBI chr12:3,759,688...3,785,829
Ensembl chr12:3,759,708...3,785,836
JBrowse link
G IDO1 indoleamine 2,3-dioxygenase 1 IEA
IBA
(PMID:21873635) InterPro
GO_Central
PMID:21873635 GO_REF:0000002 NCBI chr17:9,245,283...9,260,140
Ensembl chr17:9,245,196...9,260,491
JBrowse link
G IDO2 indoleamine 2,3-dioxygenase 2 IEA
IBA
(PMID:21873635) Ensembl
GO_Central
PMID:21873635 GO_REF:0000107 NCBI chr17:9,277,039...9,344,405
Ensembl chr17:9,277,069...9,343,749
JBrowse link
G KYNU kynureninase IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr15:8,847,335...8,982,951
Ensembl chr15:8,850,665...8,982,945
JBrowse link
G TDO2 tryptophan 2,3-dioxygenase IEA UniProt
InterPro
GO_REF:0000002, GO_REF:0000041 NCBI chr 8:44,708,722...44,725,954
Ensembl chr 8:44,708,746...44,740,980
JBrowse link
tryptophan metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP7A ATPase copper transporting alpha ISO (MGI:53851|PMID:4147174) MGI PMID:4147174 MGI:53851 NCBI chr  X:61,972,544...62,110,058
Ensembl chr  X:61,972,874...62,110,058
JBrowse link
G GCDH glutaryl-CoA dehydrogenase IEA UniProt GO_REF:0000041 NCBI chr 2:66,131,154...66,138,963
Ensembl chr 2:66,130,625...66,138,868
JBrowse link
G TDO2 tryptophan 2,3-dioxygenase ISO RGD PMID:3400092, PMID:3899109, PMID:10719243 RGD:2290190, RGD:2290313, RGD:2291804 NCBI chr 8:44,708,722...44,725,954
Ensembl chr 8:44,708,746...44,740,980
JBrowse link
tyrosine biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PAH phenylalanine hydroxylase IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 5:81,385,401...81,460,569
Ensembl chr 5:81,236,096...81,463,452
JBrowse link
tyrosine biosynthetic process, by oxidation of phenylalanine term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PAH phenylalanine hydroxylase ISO RGD PMID:10839989 RGD:1601535 NCBI chr 5:81,385,401...81,460,569
Ensembl chr 5:81,236,096...81,463,452
JBrowse link
tyrosine catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FAH fumarylacetoacetate hydrolase IBA
IEA
(PMID:21873635) GO_Central
UniProt
PMID:21873635 GO_REF:0000104 NCBI chr 7:49,047,833...49,087,790
Ensembl chr 7:49,047,983...49,105,598
JBrowse link
G GSTZ1 glutathione S-transferase zeta 1 IEA UniProt GO_REF:0000043 NCBI chr 7:100,392,217...100,404,025
Ensembl chr 7:100,392,271...100,408,423
JBrowse link
G HPD 4-hydroxyphenylpyruvate dioxygenase ISS
IBA
(PMID:21873635) UniProt
GO_Central
PMID:21873635 GO_REF:0000024 NCBI chr14:30,845,608...30,857,658
Ensembl chr14:30,845,613...30,857,667
JBrowse link
G TAT tyrosine aminotransferase IEA Ensembl GO_REF:0000107 NCBI chr 6:14,571,311...14,583,203
Ensembl chr 6:14,570,587...14,583,177
JBrowse link
tyrosine metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP7A ATPase copper transporting alpha ISO (MGI:53851|PMID:4147174) MGI PMID:4147174 MGI:53851 NCBI chr  X:61,972,544...62,110,058
Ensembl chr  X:61,972,874...62,110,058
JBrowse link
G HGD homogentisate 1,2-dioxygenase IEA InterPro GO_REF:0000002 NCBI chr13:139,660,315...139,710,402
Ensembl chr13:139,660,343...139,710,405
JBrowse link
G IYD iodotyrosine deiodinase IDA
IBA
(PMID:25395621)
(PMID:21873635)
UniProt
GO_Central
PMID:21873635, PMID:25395621 NCBI chr 1:15,756,536...15,779,380
Ensembl chr 1:15,756,550...15,779,164
JBrowse link
G THAP4 THAP domain containing 4 IEA Ensembl GO_REF:0000107 NCBI chr15:140,190,198...140,223,454
Ensembl chr15:140,185,680...140,223,477
JBrowse link
G TTC36 tetratricopeptide repeat domain 36 ISO (MGI:6362140|PMID:31537781) MGI PMID:31537781 MGI:6362140 NCBI chr 9:45,829,014...45,838,978
Ensembl chr 9:45,829,191...45,838,979
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16548
    metabolic process 10584
      cellular metabolic process 9574
        organic acid metabolic process 868
          aromatic amino acid family metabolic process 29
            L-dopa metabolic process + 1
            L-phenylalanine metabolic process + 9
            anthranilate metabolic process + 3
            aromatic amino acid family biosynthetic process + 2
            aromatic amino acid family catabolic process + 15
            gliotoxin biosynthetic process + 0
            para-aminobenzoic acid metabolic process + 0
            tryptophan metabolic process + 11
            tyrosine metabolic process + 12
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.