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ONTOLOGY REPORT - ANNOTATIONS


Term:aromatic amino acid family metabolic process
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Accession:GO:0009072 term browser browse the term
Definition:The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).
Synonyms:exact_synonym: aromatic amino acid family metabolism


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aromatic amino acid family metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HPDL 4-hydroxyphenylpyruvate dioxygenase like IEA InterPro GO_REF:0000002 NCBI chr 1:45,326,895...45,328,679
Ensembl chr 1:45,326,895...45,328,679
JBrowse link
G IL4I1 interleukin 4 induced 1 ISO (MGI:3505621|PMID:15383589) MGI PMID:15383589 MGI:3505621 NCBI chr19:49,889,654...49,929,504
Ensembl chr19:49,889,654...49,929,539
JBrowse link
G PAH phenylalanine hydroxylase IEA InterPro GO_REF:0000002 NCBI chr12:102,836,889...102,958,441
Ensembl chr12:102,836,889...102,958,410
JBrowse link
G TH tyrosine hydroxylase IEA InterPro GO_REF:0000002 NCBI chr11:2,163,929...2,174,081
Ensembl chr11:2,163,929...2,171,877
Ensembl chr11:2,163,929...2,171,877
JBrowse link
G TPH1 tryptophan hydroxylase 1 IEA InterPro GO_REF:0000002 NCBI chr11:18,017,555...18,046,269
Ensembl chr11:18,017,564...18,042,426
JBrowse link
G TPH2 tryptophan hydroxylase 2 IEA InterPro GO_REF:0000002 NCBI chr12:71,938,845...72,032,440
Ensembl chr12:71,938,845...72,186,618
JBrowse link
'de novo' NAD biosynthetic process from tryptophan term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AFMID arylformamidase IEA UniProt GO_REF:0000104 NCBI chr17:78,185,102...78,207,702
Ensembl chr17:78,187,317...78,207,701
JBrowse link
G HAAO 3-hydroxyanthranilate 3,4-dioxygenase IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 2:42,767,087...42,801,002
Ensembl chr 2:42,767,089...42,792,593
JBrowse link
G IDO1 indoleamine 2,3-dioxygenase 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 8:39,913,891...39,928,790
Ensembl chr 8:39,902,275...39,928,790
JBrowse link
G IDO2 indoleamine 2,3-dioxygenase 2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 8:39,934,955...40,016,391
Ensembl chr 8:39,934,614...40,016,391
JBrowse link
G KMO kynurenine 3-monooxygenase IEA UniProt GO_REF:0000104 NCBI chr 1:241,531,883...241,595,642
Ensembl chr 1:241,532,134...241,595,642
JBrowse link
G KYNU kynureninase IEA UniProt GO_REF:0000104 NCBI chr 2:142,877,664...143,055,833
Ensembl chr 2:142,877,657...143,055,833
JBrowse link
anthranilate metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HAAO 3-hydroxyanthranilate 3,4-dioxygenase IEA UniProtKB GO_REF:0000104 NCBI chr 2:42,767,087...42,801,002
Ensembl chr 2:42,767,089...42,792,593
JBrowse link
G KMO kynurenine 3-monooxygenase IEA UniProtKB GO_REF:0000104 NCBI chr 1:241,531,883...241,595,642
Ensembl chr 1:241,532,134...241,595,642
JBrowse link
G KYNU kynureninase IDA
IBA
(PMID:11985583)
(PMID:21873635)
UniProtKB
GO_Central
PMID:11985583, PMID:21873635 NCBI chr 2:142,877,664...143,055,833
Ensembl chr 2:142,877,657...143,055,833
JBrowse link
dopamine biosynthetic process from tyrosine term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TH tyrosine hydroxylase NAS
IBA
(PMID:10907721)
(PMID:21873635)
BHF-UCL
GO_Central
PMID:10907721, PMID:21873635 NCBI chr11:2,163,929...2,174,081
Ensembl chr11:2,163,929...2,171,877
Ensembl chr11:2,163,929...2,171,877
JBrowse link
L-phenylalanine catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ASRGL1 asparaginase and isoaspartyl peptidase 1 TAS Reactome Reactome:R-HSA-71182 NCBI chr11:62,337,430...62,401,401
Ensembl chr11:62,337,448...62,393,412
JBrowse link
G FAH fumarylacetoacetate hydrolase TAS
IBA
IEA
(PMID:21873635) Reactome
GO_Central
UniProtKB
PMID:21873635 GO_REF:0000041, Reactome:R-HSA-71182 NCBI chr15:80,152,789...80,186,949
Ensembl chr15:80,152,490...80,186,946
JBrowse link
G GSTZ1 glutathione S-transferase zeta 1 TAS
IBA
IEA
(PMID:21873635) Reactome
GO_Central
UniProtKB
PMID:21873635 GO_REF:0000041, Reactome:R-HSA-71182 NCBI chr14:77,321,002...77,331,597
Ensembl chr14:77,320,996...77,331,597
JBrowse link
G HGD homogentisate 1,2-dioxygenase TAS
IBA
IEA
(PMID:21873635) Reactome
GO_Central
UniProtKB
PMID:21873635 GO_REF:0000041, Reactome:R-HSA-71182 NCBI chr 3:120,628,168...120,682,555
Ensembl chr 3:120,628,172...120,682,269
JBrowse link
G HPD 4-hydroxyphenylpyruvate dioxygenase TAS
IEA
Reactome
UniProtKB
GO_REF:0000041, Reactome:R-HSA-71182 NCBI chr12:121,839,527...121,888,611
Ensembl chr12:121,839,527...121,863,596
JBrowse link
G IL4I1 interleukin 4 induced 1 TAS Reactome Reactome:R-HSA-71182 NCBI chr19:49,889,654...49,929,504
Ensembl chr19:49,889,654...49,929,539
JBrowse link
G KYAT1 kynurenine aminotransferase 1 TAS Reactome Reactome:R-HSA-71182 NCBI chr 9:128,832,942...128,882,523
Ensembl chr 9:128,819,663...128,881,931
Ensembl chr 9:128,819,663...128,881,931
JBrowse link
G PAH phenylalanine hydroxylase TAS
IEA
Reactome
UniProtKB
GO_REF:0000041, Reactome:R-HSA-71182 NCBI chr12:102,836,889...102,958,441
Ensembl chr12:102,836,889...102,958,410
JBrowse link
G PCBD1 pterin-4 alpha-carbinolamine dehydratase 1 TAS Reactome Reactome:R-HSA-71182 NCBI chr10:70,882,280...70,888,565
Ensembl chr10:70,882,280...70,888,565
JBrowse link
G QDPR quinoid dihydropteridine reductase TAS
IBA
(PMID:21873635) Reactome
GO_Central
PMID:21873635 Reactome:R-HSA-71182 NCBI chr 4:17,486,395...17,512,090
Ensembl chr 4:17,460,261...17,512,206
JBrowse link
G TAT tyrosine aminotransferase TAS
IEA
Reactome
UniProtKB
GO_REF:0000041, Reactome:R-HSA-71182 NCBI chr16:71,565,660...71,577,092
Ensembl chr16:71,565,660...71,577,092
JBrowse link
L-phenylalanine metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PAH phenylalanine hydroxylase ISO RGD PMID:16953590 RGD:1601531 NCBI chr12:102,836,889...102,958,441
Ensembl chr12:102,836,889...102,958,410
JBrowse link
G PCBD1 pterin-4 alpha-carbinolamine dehydratase 1 ISO PMID:1465414 CAFA PMID:1465414 RGD:12792994 NCBI chr10:70,882,280...70,888,565
Ensembl chr10:70,882,280...70,888,565
JBrowse link
G SPR sepiapterin reductase ISO (MGI:3722569|PMID:16532389) MGI PMID:16532389 MGI:3722569 NCBI chr 2:72,887,408...72,892,158
Ensembl chr 2:72,887,382...72,892,158
JBrowse link
melanin biosynthetic process from tyrosine term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DCT dopachrome tautomerase ISS
IBA
(PMID:21873635) UniProtKB
GO_Central
PMID:21873635 GO_REF:0000024 NCBI chr13:94,436,811...94,549,406
Ensembl chr13:94,436,811...94,479,682
JBrowse link
G TYR tyrosinase TAS (PMID:7704033) PINC PMID:7704033 NCBI chr11:89,177,565...89,295,759
Ensembl chr11:89,177,875...89,295,759
JBrowse link
positive regulation of L-dopa biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PARK7 Parkinsonism associated deglycase IMP (PMID:16731528) ParkinsonsUK-UCL PMID:16731528 NCBI chr 1:7,961,711...7,985,505
Ensembl chr 1:7,954,291...7,985,505
JBrowse link
regulation of 'de novo' NAD biosynthetic process from tryptophan term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACMSD aminocarboxymuconate semialdehyde decarboxylase TAS (PMID:12140278), (PMID:19843166) ParkinsonsUK-UCL PMID:12140278, PMID:19843166 NCBI chr 2:134,838,319...134,902,906
Ensembl chr 2:134,838,616...134,902,034
JBrowse link
serotonin biosynthetic process from tryptophan term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 ISO RGD PMID:23098818 RGD:11353778 NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,881
JBrowse link
tryptophan catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AADAT aminoadipate aminotransferase TAS Reactome Reactome:R-HSA-71240 NCBI chr 4:170,060,222...170,091,699
Ensembl chr 4:170,060,222...170,091,699
JBrowse link
G ACMSD aminocarboxymuconate semialdehyde decarboxylase TAS (PMID:12140278), (PMID:19843166) ParkinsonsUK-UCL PMID:12140278, PMID:19843166 NCBI chr 2:134,838,319...134,902,906
Ensembl chr 2:134,838,616...134,902,034
JBrowse link
G HAAO 3-hydroxyanthranilate 3,4-dioxygenase TAS Reactome Reactome:R-HSA-71240 NCBI chr 2:42,767,087...42,801,002
Ensembl chr 2:42,767,089...42,792,593
JBrowse link
G IDO1 indoleamine 2,3-dioxygenase 1 TAS Reactome Reactome:R-HSA-71240 NCBI chr 8:39,913,891...39,928,790
Ensembl chr 8:39,902,275...39,928,790
JBrowse link
G IDO2 indoleamine 2,3-dioxygenase 2 TAS Reactome Reactome:R-HSA-71240 NCBI chr 8:39,934,955...40,016,391
Ensembl chr 8:39,934,614...40,016,391
JBrowse link
G KMO kynurenine 3-monooxygenase TAS Reactome Reactome:R-HSA-71240 NCBI chr 1:241,531,883...241,595,642
Ensembl chr 1:241,532,134...241,595,642
JBrowse link
G KYAT1 kynurenine aminotransferase 1 TAS Reactome Reactome:R-HSA-71240 NCBI chr 9:128,832,942...128,882,523
Ensembl chr 9:128,819,663...128,881,931
Ensembl chr 9:128,819,663...128,881,931
JBrowse link
G KYNU kynureninase IEA
IMP
TAS
(PMID:17334708) InterPro
UniProtKB
Reactome
PMID:17334708 GO_REF:0000002, Reactome:R-HSA-71240 NCBI chr 2:142,877,664...143,055,833
Ensembl chr 2:142,877,657...143,055,833
JBrowse link
G TDO2 tryptophan 2,3-dioxygenase TAS Reactome Reactome:R-HSA-71240 NCBI chr 4:155,903,696...155,920,406
Ensembl chr 4:155,854,738...155,920,406
JBrowse link
tryptophan catabolic process to acetyl-CoA term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KYNU kynureninase IEA Ensembl GO_REF:0000107 NCBI chr 2:142,877,664...143,055,833
Ensembl chr 2:142,877,657...143,055,833
JBrowse link
G TDO2 tryptophan 2,3-dioxygenase IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 4:155,903,696...155,920,406
Ensembl chr 4:155,854,738...155,920,406
JBrowse link
tryptophan catabolic process to kynurenine term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AFMID arylformamidase IEA
IBA
(PMID:21873635) UniProtKB
GO_Central
PMID:21873635 GO_REF:0000041 NCBI chr17:78,185,102...78,207,702
Ensembl chr17:78,187,317...78,207,701
JBrowse link
G IDO1 indoleamine 2,3-dioxygenase 1 IEA
IBA
(PMID:21873635) InterPro
GO_Central
UniProtKB
PMID:21873635 GO_REF:0000002, GO_REF:0000041 NCBI chr 8:39,913,891...39,928,790
Ensembl chr 8:39,902,275...39,928,790
JBrowse link
G IDO2 indoleamine 2,3-dioxygenase 2 IEA
IBA
ISS
IDA
(PMID:21873635)
(PMID:17499941)
(PMID:17671174)
InterPro
GO_Central
UniProtKB
PMID:17499941, PMID:17671174, PMID:21873635 GO_REF:0000002, GO_REF:0000041 NCBI chr 8:39,934,955...40,016,391
Ensembl chr 8:39,934,614...40,016,391
JBrowse link
G KYNU kynureninase IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 2:142,877,664...143,055,833
Ensembl chr 2:142,877,657...143,055,833
JBrowse link
G TDO2 tryptophan 2,3-dioxygenase IEA
IDA
(PMID:27762317) InterPro
UniProtKB
PMID:27762317 GO_REF:0000002, GO_REF:0000041 NCBI chr 4:155,903,696...155,920,406
Ensembl chr 4:155,854,738...155,920,406
JBrowse link
tryptophan metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP7A ATPase copper transporting alpha ISS UniProtKB GO_REF:0000024 NCBI chr  X:77,910,693...78,050,395
Ensembl chr  X:77,910,656...78,050,395
JBrowse link
G GCDH glutaryl-CoA dehydrogenase IEA UniProtKB GO_REF:0000041 NCBI chr19:12,891,129...12,899,999
Ensembl chr19:12,891,160...12,914,207
JBrowse link
G TDO2 tryptophan 2,3-dioxygenase ISO RGD PMID:3400092, PMID:3899109, PMID:10719243 RGD:2290190, RGD:2290313, RGD:2291804 NCBI chr 4:155,903,696...155,920,406
Ensembl chr 4:155,854,738...155,920,406
JBrowse link
tyrosine biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PAH phenylalanine hydroxylase IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr12:102,836,889...102,958,441
Ensembl chr12:102,836,889...102,958,410
JBrowse link
tyrosine biosynthetic process, by oxidation of phenylalanine term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PAH phenylalanine hydroxylase ISO RGD PMID:10839989 RGD:1601535 NCBI chr12:102,836,889...102,958,441
Ensembl chr12:102,836,889...102,958,410
JBrowse link
tyrosine catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FAH fumarylacetoacetate hydrolase IBA
IEA
(PMID:21873635) GO_Central
UniProt
PMID:21873635 GO_REF:0000104 NCBI chr15:80,152,789...80,186,949
Ensembl chr15:80,152,490...80,186,946
JBrowse link
G GSTZ1 glutathione S-transferase zeta 1 IEA UniProt GO_REF:0000043 NCBI chr14:77,321,002...77,331,597
Ensembl chr14:77,320,996...77,331,597
JBrowse link
G HGD homogentisate 1,2-dioxygenase IEA UniProt GO_REF:0000043 NCBI chr 3:120,628,168...120,682,555
Ensembl chr 3:120,628,172...120,682,269
JBrowse link
G HPD 4-hydroxyphenylpyruvate dioxygenase IEA
IBA
ISS
(PMID:21873635) Ensembl
GO_Central
UniProtKB
PMID:21873635 GO_REF:0000024, GO_REF:0000107 NCBI chr12:121,839,527...121,888,611
Ensembl chr12:121,839,527...121,863,596
JBrowse link
G TAT tyrosine aminotransferase IDA (PMID:7999802) UniProtKB PMID:7999802 NCBI chr16:71,565,660...71,577,092
Ensembl chr16:71,565,660...71,577,092
JBrowse link
tyrosine metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP7A ATPase copper transporting alpha ISO (MGI:53851|PMID:4147174) MGI PMID:4147174 MGI:53851 NCBI chr  X:77,910,693...78,050,395
Ensembl chr  X:77,910,656...78,050,395
JBrowse link
G HGD homogentisate 1,2-dioxygenase IEA InterPro GO_REF:0000002 NCBI chr 3:120,628,168...120,682,555
Ensembl chr 3:120,628,172...120,682,269
JBrowse link
G IYD iodotyrosine deiodinase IDA
IBA
(PMID:25395621)
(PMID:21873635)
UniProtKB
GO_Central
PMID:21873635, PMID:25395621 NCBI chr 6:150,368,854...150,405,969
Ensembl chr 6:150,368,892...150,405,969
JBrowse link
G THAP4 THAP domain containing 4 IDA (PMID:30524950) UniProt PMID:30524950 NCBI chr 2:241,584,405...241,637,543
Ensembl chr 2:241,584,405...241,637,158
JBrowse link
G TTC36 tetratricopeptide repeat domain 36 ISO (MGI:6362140|PMID:31537781) MGI PMID:31537781 MGI:6362140 NCBI chr11:118,527,474...118,530,993
Ensembl chr11:118,527,472...118,531,197
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18672
    metabolic process 12302
      cellular metabolic process 11278
        organic acid metabolic process 1143
          aromatic amino acid family metabolic process 34
            L-dopa metabolic process + 1
            L-phenylalanine metabolic process + 12
            anthranilate metabolic process + 3
            aromatic amino acid family biosynthetic process + 2
            aromatic amino acid family catabolic process + 20
            gliotoxin biosynthetic process + 0
            para-aminobenzoic acid metabolic process + 0
            tryptophan metabolic process + 13
            tyrosine metabolic process + 13
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.