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ONTOLOGY REPORT - ANNOTATIONS


Term:aromatic amino acid family metabolic process
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Accession:GO:0009072 term browser browse the term
Definition:The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).
Synonyms:exact_synonym: aromatic amino acid family metabolism


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aromatic amino acid family metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HPD 4-hydroxyphenylpyruvate dioxygenase IEA InterPro GO_REF:0000002 NCBI chr26:7,430,891...7,440,643
Ensembl chr26:7,430,933...7,440,611
JBrowse link
G HPDL 4-hydroxyphenylpyruvate dioxygenase like IEA InterPro GO_REF:0000002 NCBI chr15:15,019,273...15,028,932
Ensembl chr15:15,027,472...15,028,671
JBrowse link
G TH tyrosine hydroxylase IEA InterPro GO_REF:0000002 NCBI chr18:46,327,136...46,334,973
Ensembl chr18:46,327,137...46,335,602
JBrowse link
G TPH1 tryptophan hydroxylase 1 IEA InterPro GO_REF:0000002 NCBI chr21:40,545,379...40,571,620
Ensembl chr21:40,547,682...40,566,572
JBrowse link
G TPH2 tryptophan hydroxylase 2 IEA InterPro GO_REF:0000002 NCBI chr10:13,442,611...13,526,537
Ensembl chr10:13,442,611...13,527,243
JBrowse link
'de novo' NAD biosynthetic process from tryptophan term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BIRC5 baculoviral IAP repeat containing 5 IEA UniProt GO_REF:0000104 NCBI chr 9:2,930,308...2,959,307 JBrowse link
G HAAO 3-hydroxyanthranilate 3,4-dioxygenase IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr10:45,368,157...45,379,521
Ensembl chr10:45,368,178...45,379,160
JBrowse link
G IDO1 indoleamine 2,3-dioxygenase 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr16:25,391,759...25,407,161
Ensembl chr16:25,391,754...25,407,048
JBrowse link
G IDO2 indoleamine 2,3-dioxygenase 2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr16:25,319,035...25,375,085
Ensembl chr16:25,319,035...25,385,515
JBrowse link
G KMO kynurenine 3-monooxygenase IEA UniProt GO_REF:0000104 NCBI chr 7:32,941,487...32,994,541
Ensembl chr 7:32,941,487...32,994,541
JBrowse link
G KYNU kynureninase IEA UniProt GO_REF:0000104 NCBI chr19:45,022,450...45,150,977
Ensembl chr19:45,022,072...45,149,339
JBrowse link
anthranilate metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KMO kynurenine 3-monooxygenase IEA UniProtKB GO_REF:0000104 NCBI chr 7:32,941,487...32,994,541
Ensembl chr 7:32,941,487...32,994,541
JBrowse link
G KYNU kynureninase IBA
IEA
(PMID:21873635) GO_Central
UniProt
PMID:21873635 GO_REF:0000104 NCBI chr19:45,022,450...45,150,977
Ensembl chr19:45,022,072...45,149,339
JBrowse link
dopamine biosynthetic process from tyrosine term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TH tyrosine hydroxylase IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr18:46,327,136...46,334,973
Ensembl chr18:46,327,137...46,335,602
JBrowse link
L-phenylalanine catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FAH fumarylacetoacetate hydrolase IEA
IBA
(PMID:21873635) UniProt
GO_Central
PMID:21873635 GO_REF:0000041 NCBI chr 3:57,300,422...57,326,546
Ensembl chr 3:57,300,441...57,326,486
JBrowse link
G GSTZ1 glutathione S-transferase zeta 1 IBA
IEA
(PMID:21873635) GO_Central
UniProt
PMID:21873635 GO_REF:0000041 NCBI chr 8:50,133,496...50,143,487
Ensembl chr 8:50,133,714...50,143,439
JBrowse link
G HGD homogentisate 1,2-dioxygenase IBA
IEA
(PMID:21873635) GO_Central
UniProt
PMID:21873635 GO_REF:0000041 NCBI chr33:24,066,099...24,107,827
Ensembl chr33:24,066,306...24,151,354
JBrowse link
G PAH phenylalanine hydroxylase IEA InterPro
UniProt
GO_REF:0000002, GO_REF:0000041 NCBI chr15:41,590,253...41,670,156
Ensembl chr15:41,592,876...41,670,837
JBrowse link
G QDPR quinoid dihydropteridine reductase IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 3:62,970,850...62,987,512
Ensembl chr 3:62,970,121...63,028,395
JBrowse link
G RABL3 RAB, member of RAS oncogene family like 3 IEA UniProt GO_REF:0000041 NCBI chr33:24,107,754...24,151,378
Ensembl chr33:24,066,306...24,151,354
JBrowse link
G TAT tyrosine aminotransferase IEA UniProt GO_REF:0000041 NCBI chr 5:77,365,589...77,378,474
Ensembl chr 5:77,366,138...77,378,419
JBrowse link
L-phenylalanine metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PAH phenylalanine hydroxylase ISO RGD PMID:16953590 RGD:1601531 NCBI chr15:41,590,253...41,670,156
Ensembl chr15:41,592,876...41,670,837
JBrowse link
G PCBD1 pterin-4 alpha-carbinolamine dehydratase 1 ISO PMID:1465414 CAFA PMID:1465414 RGD:12792994 NCBI chr 4:21,719,863...21,723,493
Ensembl chr 4:21,719,863...21,721,574
JBrowse link
G SPR sepiapterin reductase ISO (MGI:3722569|PMID:16532389) MGI PMID:16532389 MGI:3722569 NCBI chr17:49,950,192...49,957,455
Ensembl chr17:49,950,800...49,957,417
JBrowse link
melanin biosynthetic process from tyrosine term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DCT dopachrome tautomerase IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr22:45,271,709...45,305,272
Ensembl chr22:45,271,709...45,305,346
JBrowse link
positive regulation of L-dopa biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PARK7 Parkinsonism associated deglycase ISO (PMID:16731528) ParkinsonsUK-UCL PMID:16731528 NCBI chr 5:61,576,219...61,592,325
Ensembl chr 5:61,576,069...61,592,303
JBrowse link
serotonin biosynthetic process from tryptophan term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2D15 cytochrome P450 2D ISO RGD PMID:23098818 RGD:11353778 NCBI chr10:23,255,259...23,259,380
Ensembl chr10:23,255,249...23,259,298
JBrowse link
tryptophan catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACMSD aminocarboxymuconate semialdehyde decarboxylase ISO RGD PMID:11802786 RGD:70243 NCBI chr19:37,658,999...37,725,426
Ensembl chr19:37,659,226...37,725,172
JBrowse link
G KMO kynurenine 3-monooxygenase IEA UniProtKB GO_REF:0000104 NCBI chr 7:32,941,487...32,994,541
Ensembl chr 7:32,941,487...32,994,541
JBrowse link
G KYNU kynureninase IEA UniProt GO_REF:0000104 NCBI chr19:45,022,450...45,150,977
Ensembl chr19:45,022,072...45,149,339
JBrowse link
tryptophan catabolic process to acetyl-CoA term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KYNU kynureninase ISO RGD PMID:7236232 RGD:2303721 NCBI chr19:45,022,450...45,150,977
Ensembl chr19:45,022,072...45,149,339
JBrowse link
G TDO2 tryptophan 2,3-dioxygenase IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr15:53,406,110...53,424,260
Ensembl chr15:53,405,957...53,423,958
JBrowse link
tryptophan catabolic process to kynurenine term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BIRC5 baculoviral IAP repeat containing 5 IEA
IBA
(PMID:21873635) UniProt
GO_Central
PMID:21873635 GO_REF:0000041 NCBI chr 9:2,930,308...2,959,307 JBrowse link
G IDO1 indoleamine 2,3-dioxygenase 1 IEA
IBA
(PMID:21873635) Ensembl
GO_Central
PMID:21873635 GO_REF:0000107 NCBI chr16:25,391,759...25,407,161
Ensembl chr16:25,391,754...25,407,048
JBrowse link
G IDO2 indoleamine 2,3-dioxygenase 2 IEA
IBA
(PMID:21873635) InterPro
GO_Central
Ensembl
PMID:21873635 GO_REF:0000002, GO_REF:0000107 NCBI chr16:25,319,035...25,375,085
Ensembl chr16:25,319,035...25,385,515
JBrowse link
G KYNU kynureninase IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr19:45,022,450...45,150,977
Ensembl chr19:45,022,072...45,149,339
JBrowse link
G TDO2 tryptophan 2,3-dioxygenase IEA UniProtKB GO_REF:0000041 NCBI chr15:53,406,110...53,424,260
Ensembl chr15:53,405,957...53,423,958
JBrowse link
tryptophan metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP7A ATPase copper transporting alpha ISO (MGI:53851|PMID:4147174) MGI PMID:4147174 MGI:53851 NCBI chr  X:60,203,336...60,356,525
Ensembl chr  X:60,203,270...60,352,869
JBrowse link
G TDO2 tryptophan 2,3-dioxygenase ISO RGD PMID:3400092, PMID:3899109, PMID:10719243 RGD:2290190, RGD:2290313, RGD:2291804 NCBI chr15:53,406,110...53,424,260
Ensembl chr15:53,405,957...53,423,958
JBrowse link
tyrosine biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PAH phenylalanine hydroxylase IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr15:41,590,253...41,670,156
Ensembl chr15:41,592,876...41,670,837
JBrowse link
tyrosine biosynthetic process, by oxidation of phenylalanine term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PAH phenylalanine hydroxylase ISO RGD PMID:10839989 RGD:1601535 NCBI chr15:41,590,253...41,670,156
Ensembl chr15:41,592,876...41,670,837
JBrowse link
tyrosine catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FAH fumarylacetoacetate hydrolase IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 3:57,300,422...57,326,546
Ensembl chr 3:57,300,441...57,326,486
JBrowse link
G GSTZ1 glutathione S-transferase zeta 1 IEA UniProt GO_REF:0000043 NCBI chr 8:50,133,496...50,143,487
Ensembl chr 8:50,133,714...50,143,439
JBrowse link
G HPD 4-hydroxyphenylpyruvate dioxygenase IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr26:7,430,891...7,440,643
Ensembl chr26:7,430,933...7,440,611
JBrowse link
G TAT tyrosine aminotransferase IEA Ensembl GO_REF:0000107 NCBI chr 5:77,365,589...77,378,474
Ensembl chr 5:77,366,138...77,378,419
JBrowse link
tyrosine metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP7A ATPase copper transporting alpha ISO (MGI:53851|PMID:4147174) MGI PMID:4147174 MGI:53851 NCBI chr  X:60,203,336...60,356,525
Ensembl chr  X:60,203,270...60,352,869
JBrowse link
G HGD homogentisate 1,2-dioxygenase IEA InterPro GO_REF:0000002 NCBI chr33:24,066,099...24,107,827
Ensembl chr33:24,066,306...24,151,354
JBrowse link
G IYD iodotyrosine deiodinase IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 1:40,890,402...40,908,437
Ensembl chr 1:40,890,435...40,908,439
JBrowse link
G RABL3 RAB, member of RAS oncogene family like 3 IEA InterPro GO_REF:0000002 NCBI chr33:24,107,754...24,151,378
Ensembl chr33:24,066,306...24,151,354
JBrowse link
G THAP4 THAP domain containing 4 IEA Ensembl GO_REF:0000107 NCBI chr25:51,456,349...51,480,753
Ensembl chr25:51,456,344...51,494,367
JBrowse link
G TTC36 tetratricopeptide repeat domain 36 ISO (MGI:6362140|PMID:31537781) MGI PMID:31537781 MGI:6362140 NCBI chr 5:15,207,400...15,211,905
Ensembl chr 5:15,207,403...15,211,853
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16190
    metabolic process 10657
      cellular metabolic process 9645
        organic acid metabolic process 865
          aromatic amino acid family metabolic process 29
            L-dopa metabolic process + 1
            L-phenylalanine metabolic process + 9
            anthranilate metabolic process + 2
            aromatic amino acid family biosynthetic process + 2
            aromatic amino acid family catabolic process + 15
            gliotoxin biosynthetic process + 0
            para-aminobenzoic acid metabolic process + 0
            tryptophan metabolic process + 10
            tyrosine metabolic process + 13
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.