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ONTOLOGY REPORT - ANNOTATIONS


Term:aromatic amino acid family metabolic process
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Accession:GO:0009072 term browser browse the term
Definition:The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).
Synonyms:exact_synonym: aromatic amino acid family metabolism


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aromatic amino acid family metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hpdl 4-hydroxyphenylpyruvate dioxygenase-like IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 5:135,675,826...135,677,432
Ensembl chr 5:135,675,832...135,677,432
JBrowse link
G Tph2 tryptophan hydroxylase 2 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 7:58,042,279...58,149,220
Ensembl chr 7:58,042,281...58,149,061
JBrowse link
'de novo' NAD biosynthetic process from tryptophan term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afmid arylformamidase IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr10:106,828,963...106,844,314
Ensembl chr10:106,828,981...106,844,314
JBrowse link
G Haao 3-hydroxyanthranilate 3,4-dioxygenase IBA
IEA
PMID:21873635
GO_REF:0000104
UniProt PMID:21873635 GO_REF:0000104, RGD:13792537 NCBI chr 6:7,045,145...7,059,227
Ensembl chr 6:7,045,152...7,058,314
JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr16:72,216,326...72,228,098
Ensembl chr16:72,216,326...72,228,098
JBrowse link
G Ido2 indoleamine 2,3-dioxygenase 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr16:72,232,852...72,291,227
Ensembl chr16:72,268,943...72,289,156
JBrowse link
G Kmo kynurenine 3-monooxygenase IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr13:93,684,324...93,715,378
Ensembl chr13:93,684,437...93,716,227
JBrowse link
G Kynu kynureninase IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 3:28,416,926...28,566,939
Ensembl chr 3:28,416,954...28,566,928
JBrowse link
anthranilate metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Haao 3-hydroxyanthranilate 3,4-dioxygenase IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 6:7,045,145...7,059,227
Ensembl chr 6:7,045,152...7,058,314
JBrowse link
G Kmo kynurenine 3-monooxygenase IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr13:93,684,324...93,715,378
Ensembl chr13:93,684,437...93,716,227
JBrowse link
G Kynu kynureninase ISO
IBA
(PMID:11985583)
PMID:21873635
RGD PMID:11985583, PMID:21873635 RGD:13792537 NCBI chr 3:28,416,926...28,566,939
Ensembl chr 3:28,416,954...28,566,928
JBrowse link
dopamine biosynthetic process from tyrosine term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Th tyrosine hydroxylase IDA
IBA
ISO
IMP
PMID:21873635
MGI:MGI:1860450 (MGI:MGI:2386819|PMID:9520487), (MGI:MGI:72094|PMID:7715703), (MGI:MGI:77787|PMID:7592982)
PMID:11943812
RGD PMID:7592982, PMID:7715703, PMID:9520487, PMID:2427363, PMID:21873635, PMID:11943812, PMID:19584816 MGI:MGI:2386819, MGI:MGI:72094, MGI:MGI:77787, RGD:1580046, RGD:13792537, RGD:5129111, RGD:5130972 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
histidine biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 6:99,282,850...99,350,367
Ensembl chr 6:99,282,850...99,350,340
JBrowse link
G Mthfd2l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr14:18,640,274...18,721,298
Ensembl chr14:18,640,277...18,720,357
JBrowse link
histidine catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amdhd1 amidohydrolase domain containing 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:34,362,635...34,406,282
Ensembl chr 7:34,361,633...34,406,318
JBrowse link
G Hal histidine ammonia lyase ISO
IBA
(MGI:MGI:52899|PMID:8486363)
PMID:21873635
RGD PMID:8486363, PMID:21873635 MGI:MGI:52899, RGD:13792537 NCBI chr 7:34,326,087...34,356,413
Ensembl chr 7:34,326,087...34,356,413
JBrowse link
G Hdc histidine decarboxylase ISO
IBA
IEA
(MGI:MGI:2138019|PMID:11478947)
PMID:21873635
(PMID:22767596)
GO_REF:0000107
RGD
Ensembl
PMID:11478947, PMID:22767596, PMID:21873635 GO_REF:0000107, MGI:MGI:2138019, RGD:13792537 NCBI chr 3:119,057,524...119,075,599
Ensembl chr 3:119,057,517...119,075,619
JBrowse link
G Uroc1 urocanate hydratase 1 ISO
IBA
(PMID:19304569)
PMID:21873635
RGD PMID:19304569, PMID:21873635 RGD:13792537 NCBI chr 4:122,244,744...122,276,357
Ensembl chr 4:122,244,711...122,276,361
JBrowse link
histidine catabolic process to glutamate and formamide term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amdhd1 amidohydrolase domain containing 1 IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 7:34,362,635...34,406,282
Ensembl chr 7:34,361,633...34,406,318
JBrowse link
G Ftcd formimidoyltransferase cyclodeaminase IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr20:12,806,957...12,820,466
Ensembl chr20:12,806,957...12,820,466
JBrowse link
G Hal histidine ammonia lyase IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 7:34,326,087...34,356,413
Ensembl chr 7:34,326,087...34,356,413
JBrowse link
G Uroc1 urocanate hydratase 1 IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 4:122,244,744...122,276,357
Ensembl chr 4:122,244,711...122,276,361
JBrowse link
histidine catabolic process to glutamate and formate term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amdhd1 amidohydrolase domain containing 1 IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 7:34,362,635...34,406,282
Ensembl chr 7:34,361,633...34,406,318
JBrowse link
G Ftcd formimidoyltransferase cyclodeaminase IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr20:12,806,957...12,820,466
Ensembl chr20:12,806,957...12,820,466
JBrowse link
G Hal histidine ammonia lyase IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 7:34,326,087...34,356,413
Ensembl chr 7:34,326,087...34,356,413
JBrowse link
G Uroc1 urocanate hydratase 1 IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 4:122,244,744...122,276,357
Ensembl chr 4:122,244,711...122,276,361
JBrowse link
histidine metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hal histidine ammonia lyase TAS RGD PMID:12376330 RGD:628345 NCBI chr 7:34,326,087...34,356,413
Ensembl chr 7:34,326,087...34,356,413
JBrowse link
G Hdc histidine decarboxylase IDA RGD PMID:4449071, PMID:9525922, PMID:12204113, PMID:14622303, PMID:7075603, PMID:5898 RGD:2303726, RGD:2303735, RGD:2303734, RGD:2303733, RGD:2303728, RGD:2303727 NCBI chr 3:119,057,524...119,075,599
Ensembl chr 3:119,057,517...119,075,619
JBrowse link
L-phenylalanine catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fah fumarylacetoacetate hydrolase IEA
IBA
GO_REF:0000041
PMID:21873635
UniProt PMID:21873635 GO_REF:0000041, RGD:13792537 NCBI chr 1:146,713,663...146,736,339
Ensembl chr 1:146,713,676...146,736,261
JBrowse link
G Gstz1 glutathione S-transferase zeta 1 IEA
IBA
GO_REF:0000041
PMID:21873635
UniProt PMID:21873635 GO_REF:0000041, RGD:13792537 NCBI chr 6:111,176,798...111,187,246
Ensembl chr 6:111,176,798...111,187,244
JBrowse link
G Hgd homogentisate 1, 2-dioxygenase IBA
IEA
PMID:21873635
GO_REF:0000041
UniProt PMID:21873635 GO_REF:0000041, RGD:13792537 NCBI chr11:65,983,221...66,034,555
Ensembl chr11:65,983,221...66,034,573
JBrowse link
G Hpd 4-hydroxyphenylpyruvate dioxygenase IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr12:38,828,606...38,839,956
Ensembl chr12:38,828,444...38,839,969
JBrowse link
G Pah phenylalanine hydroxylase IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 7:28,066,639...28,129,772
Ensembl chr 7:28,066,635...28,129,769
JBrowse link
G Qdpr quinoid dihydropteridine reductase IEP
IBA
PMID:21873635 RGD
GO_Central
PMID:4155291, PMID:21873635 RGD:5128604, RGD:13792537 NCBI chr14:70,164,682...70,178,284
Ensembl chr14:70,164,650...70,178,284
JBrowse link
G Tat tyrosine aminotransferase IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr19:41,675,639...41,686,195
Ensembl chr19:41,675,355...41,686,229
JBrowse link
L-phenylalanine metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pah phenylalanine hydroxylase IDA RGD PMID:16953590 RGD:1601531 NCBI chr 7:28,066,639...28,129,772
Ensembl chr 7:28,066,635...28,129,769
JBrowse link
G Pcbd1 pterin-4 alpha-carbinolamine dehydratase 1 IDA PMID:1465414 CAFA PMID:1465414 RGD:12792994 NCBI chr20:30,689,690...30,696,465
Ensembl chr20:30,690,810...30,696,476
JBrowse link
G Spr sepiapterin reductase ISO MGI:MGI:3757641 (MGI:MGI:3722569|PMID:16532389) RGD PMID:16532389 MGI:MGI:3722569 NCBI chr 4:116,912,343...116,916,073
Ensembl chr 4:116,912,351...116,916,236
JBrowse link
melanin biosynthetic process from tyrosine term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dct dopachrome tautomerase ISO (MGI:MGI:3690794|PMID:2169885) RGD PMID:2169885 MGI:MGI:3690794 NCBI chr15:103,208,174...103,245,033
Ensembl chr15:103,208,258...103,244,494
JBrowse link
positive regulation of L-dopa biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Park7 Parkinsonism associated deglycase ISO
ISS
IEA
(PMID:16731528)
GO_REF:0000024
GO_REF:0000107
RGD
ParkinsonsUK-UCL
Ensembl
PMID:16731528 GO_REF:0000024, GO_REF:0000107 NCBI chr 5:167,982,438...168,004,724
Ensembl chr 5:167,982,439...168,004,724
JBrowse link
serotonin biosynthetic process from tryptophan term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 IDA RGD PMID:23098818 RGD:11353778 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Tph1 tryptophan hydroxylase 1 TAS RGD PMID:12153488 RGD:625621 NCBI chr 1:102,669,868...102,699,442
Ensembl chr 1:102,669,868...102,699,442
JBrowse link
tryptophan catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acmsd aminocarboxymuconate semialdehyde decarboxylase IDA RGD PMID:11802786 RGD:70243 NCBI chr13:44,424,689...44,468,734
Ensembl chr13:44,424,689...44,468,734
JBrowse link
G Haao 3-hydroxyanthranilate 3,4-dioxygenase IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 6:7,045,145...7,059,227
Ensembl chr 6:7,045,152...7,058,314
JBrowse link
G Kmo kynurenine 3-monooxygenase IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr13:93,684,324...93,715,378
Ensembl chr13:93,684,437...93,716,227
JBrowse link
G Kynu kynureninase ISO (PMID:17334708) RGD PMID:17334708 NCBI chr 3:28,416,926...28,566,939
Ensembl chr 3:28,416,954...28,566,928
JBrowse link
tryptophan catabolic process to acetyl-CoA term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kynu kynureninase IDA RGD PMID:7236232 RGD:2303721 NCBI chr 3:28,416,926...28,566,939
Ensembl chr 3:28,416,954...28,566,928
JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:7236232, PMID:21873635 RGD:2303721, RGD:13792537 NCBI chr 2:180,897,059...180,914,919
Ensembl chr 2:180,897,011...180,914,940
JBrowse link
tryptophan catabolic process to kynurenine term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afmid arylformamidase ISO
IBA
IEA
(MGI:MGI:3587527|PMID:15866519)
PMID:21873635
GO_REF:0000041
RGD
UniProt
PMID:15866519, PMID:21873635 GO_REF:0000041, MGI:MGI:3587527, RGD:13792537 NCBI chr10:106,828,963...106,844,314
Ensembl chr10:106,828,981...106,844,314
JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 IDA
IBA
ISO
IEA
PMID:21873635
(MGI:MGI:2151782|PMID:2419335), (MGI:MGI:2156954|PMID:11751753)
GO_REF:0000107
RGD
Ensembl
PMID:2419335, PMID:11751753, PMID:10719243, PMID:21873635, PMID:11513477 GO_REF:0000107, MGI:MGI:2151782, MGI:MGI:2156954, RGD:2290190, RGD:13792537, RGD:2290543 NCBI chr16:72,216,326...72,228,098
Ensembl chr16:72,216,326...72,228,098
JBrowse link
G Ido2 indoleamine 2,3-dioxygenase 2 IEA
IBA
ISO
GO_REF:0000041
PMID:21873635
(MGI:MGI:3712725|PMID:17499941), (MGI:MGI:3719924|PMID:17671174)
(PMID:17671174)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:17499941, PMID:17671174, PMID:21873635 GO_REF:0000041, GO_REF:0000107, MGI:MGI:3712725, MGI:MGI:3719924, RGD:13792537 NCBI chr16:72,232,852...72,291,227
Ensembl chr16:72,268,943...72,289,156
JBrowse link
G Kynu kynureninase IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:28,416,926...28,566,939
Ensembl chr 3:28,416,954...28,566,928
JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase IEA
ISS
ISO
GO_REF:0000041
GO_REF:0000024
(PMID:27762317)
UniProt
RGD
PMID:27762317 GO_REF:0000024, GO_REF:0000041 NCBI chr 2:180,897,059...180,914,919
Ensembl chr 2:180,897,011...180,914,940
JBrowse link
tryptophan metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp7a ATPase copper transporting alpha ISO MGI:MGI:1856102 (MGI:MGI:53851|PMID:4147174) RGD PMID:4147174 MGI:MGI:53851 NCBI chr  X:77,076,085...77,193,644
Ensembl chr  X:77,076,106...77,193,644
JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase IDA RGD PMID:10719243, PMID:3899109, PMID:3400092 RGD:2290190, RGD:2291804, RGD:2290313 NCBI chr 2:180,897,059...180,914,919
Ensembl chr 2:180,897,011...180,914,940
JBrowse link
tyrosine biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pah phenylalanine hydroxylase IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:16953590, PMID:21873635 RGD:1601531, RGD:13792537 NCBI chr 7:28,066,639...28,129,772
Ensembl chr 7:28,066,635...28,129,769
JBrowse link
tyrosine biosynthetic process, by oxidation of phenylalanine term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pah phenylalanine hydroxylase IDA RGD PMID:10839989 RGD:1601535 NCBI chr 7:28,066,639...28,129,772
Ensembl chr 7:28,066,635...28,129,769
JBrowse link
tyrosine catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fah fumarylacetoacetate hydrolase IBA
IEA
PMID:21873635
GO_REF:0000104
UniProt PMID:21873635 GO_REF:0000104, RGD:13792537 NCBI chr 1:146,713,663...146,736,339
Ensembl chr 1:146,713,676...146,736,261
JBrowse link
G Gstz1 glutathione S-transferase zeta 1 IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 6:111,176,798...111,187,246
Ensembl chr 6:111,176,798...111,187,244
JBrowse link
G Hpd 4-hydroxyphenylpyruvate dioxygenase TAS
IBA
IDA
PMID:21873635
PMID:8814303
RGD
GO_Central
UniProt
PMID:12867153, PMID:21873635, PMID:8814303 RGD:632936, RGD:13792537, RGD:8554707 NCBI chr12:38,828,606...38,839,956
Ensembl chr12:38,828,444...38,839,969
JBrowse link
G Tat tyrosine aminotransferase ISO
ISS
(PMID:7999802)
GO_REF:0000024
(MGI:MGI:5430853|PMID:21153519)
RGD
UniProt
PMID:7999802, PMID:21153519 GO_REF:0000024, MGI:MGI:5430853 NCBI chr19:41,675,639...41,686,195
Ensembl chr19:41,675,355...41,686,229
JBrowse link
tyrosine metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp7a ATPase copper transporting alpha ISO MGI:MGI:1856102 (MGI:MGI:53851|PMID:4147174) RGD PMID:4147174 MGI:MGI:53851 NCBI chr  X:77,076,085...77,193,644
Ensembl chr  X:77,076,106...77,193,644
JBrowse link
G Hgd homogentisate 1, 2-dioxygenase IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr11:65,983,221...66,034,555
Ensembl chr11:65,983,221...66,034,573
JBrowse link
G Iyd iodotyrosine deiodinase ISO
IBA
ISS
(PMID:25395621)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:25395621, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 1:40,086,513...40,100,966
Ensembl chr 1:40,086,470...40,101,840
JBrowse link
G Thap4 THAP domain containing 4 ISO
ISS
(PMID:30524950)
GO_REF:0000024
RGD
UniProt
PMID:30524950 GO_REF:0000024 NCBI chr 9:100,848,597...100,888,107
Ensembl chr 9:100,848,598...100,888,107
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20017
    metabolic process 12256
      primary metabolic process 10901
        cellular amino acid metabolic process 274
          aromatic amino acid family metabolic process 34
            L-dopa metabolic process + 1
            L-phenylalanine metabolic process + 9
            anthranilate metabolic process + 3
            aromatic amino acid family biosynthetic process + 4
            aromatic amino acid family catabolic process + 20
            gliotoxin biosynthetic process + 0
            glucosinolate biosynthetic process from phenylalanine 0
            histidine metabolic process + 7
            para-aminobenzoic acid metabolic process + 0
            tryptophan metabolic process + 11
            tyrosine metabolic process + 11
Path 2
Term Annotations click to browse term
  biological_process 20017
    metabolic process 12256
      small molecule metabolic process 1869
        organic acid metabolic process 1089
          oxoacid metabolic process 1060
            carboxylic acid metabolic process 1004
              cellular amino acid metabolic process 274
                aromatic amino acid family metabolic process 34
                  L-dopa metabolic process + 1
                  L-phenylalanine metabolic process + 9
                  anthranilate metabolic process + 3
                  aromatic amino acid family biosynthetic process + 4
                  aromatic amino acid family catabolic process + 20
                  gliotoxin biosynthetic process + 0
                  glucosinolate biosynthetic process from phenylalanine 0
                  histidine metabolic process + 7
                  para-aminobenzoic acid metabolic process + 0
                  tryptophan metabolic process + 11
                  tyrosine metabolic process + 11
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.