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ONTOLOGY REPORT - ANNOTATIONS


Term:aromatic amino acid family metabolic process
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Accession:GO:0009072 term browser browse the term
Definition:The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan).
Synonyms:exact_synonym: aromatic amino acid family metabolism


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aromatic amino acid family metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hpdl 4-hydroxyphenylpyruvate dioxygenase-like involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 5:135,675,826...135,677,432
Ensembl chr 5:135,675,832...135,677,432
JBrowse link
G Tph2 tryptophan hydroxylase 2 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 7:58,042,279...58,149,220
Ensembl chr 7:58,042,281...58,149,061
JBrowse link
'de novo' NAD biosynthetic process from tryptophan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afmid arylformamidase involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr10:106,828,963...106,844,314
Ensembl chr10:106,828,981...106,844,314
JBrowse link
G Haao 3-hydroxyanthranilate 3,4-dioxygenase involved_in IEA
IBA
GO_REF:0000104
PMID:21873635
UniProt PMID:21873635 GO_REF:0000104, RGD:13792537 NCBI chr 6:7,045,145...7,059,227
Ensembl chr 6:7,045,152...7,058,314
JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr16:72,216,326...72,228,098
Ensembl chr16:72,216,326...72,228,098
JBrowse link
G Ido2 indoleamine 2,3-dioxygenase 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr16:72,232,852...72,291,227
Ensembl chr16:72,268,943...72,289,156
JBrowse link
G Kmo kynurenine 3-monooxygenase involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr13:93,684,324...93,715,378
Ensembl chr13:93,684,437...93,716,227
JBrowse link
G Kynu kynureninase involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 3:28,416,926...28,566,939
Ensembl chr 3:28,416,954...28,566,928
JBrowse link
anthranilate metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Haao 3-hydroxyanthranilate 3,4-dioxygenase involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 6:7,045,145...7,059,227
Ensembl chr 6:7,045,152...7,058,314
JBrowse link
G Kmo kynurenine 3-monooxygenase involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr13:93,684,324...93,715,378
Ensembl chr13:93,684,437...93,716,227
JBrowse link
G Kynu kynureninase involved_in IBA
ISO
PMID:21873635
(PMID:11985583)
RGD PMID:11985583, PMID:21873635 RGD:13792537 NCBI chr 3:28,416,926...28,566,939
Ensembl chr 3:28,416,954...28,566,928
JBrowse link
dopamine biosynthetic process from tyrosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Th tyrosine hydroxylase acts_upstream_of_or_within
involved_in
IDA
ISO
IMP
IBA
MGI:1860450 (MGI:2386819|PMID:9520487), (MGI:72094|PMID:7715703), (MGI:77787|PMID:7592982)
PMID:11943812
PMID:21873635
RGD PMID:7592982 PMID:7715703 PMID:9520487, PMID:2427363, PMID:11943812, PMID:21873635, PMID:19584816 MGI:2386819 MGI:72094 MGI:77787, RGD:1580046, RGD:5129111, RGD:13792537, RGD:5130972 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
L-phenylalanine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fah fumarylacetoacetate hydrolase involved_in IEA
IBA
GO_REF:0000041
PMID:21873635
UniProt PMID:21873635 GO_REF:0000041, RGD:13792537 NCBI chr 1:146,713,663...146,736,339
Ensembl chr 1:146,713,676...146,736,261
JBrowse link
G Gstz1 glutathione S-transferase zeta 1 involved_in IEA
IBA
GO_REF:0000041
PMID:21873635
UniProt PMID:21873635 GO_REF:0000041, RGD:13792537 NCBI chr 6:111,176,798...111,187,246
Ensembl chr 6:111,176,798...111,187,244
JBrowse link
G Hgd homogentisate 1, 2-dioxygenase involved_in IEA
IBA
GO_REF:0000041
PMID:21873635
UniProt PMID:21873635 GO_REF:0000041, RGD:13792537 NCBI chr11:65,983,221...66,034,555
Ensembl chr11:65,983,221...66,034,573
JBrowse link
G Hpd 4-hydroxyphenylpyruvate dioxygenase involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr12:38,828,606...38,839,956
Ensembl chr12:38,828,444...38,839,969
JBrowse link
G Il4i1 interleukin 4 induced 1 involved_in ISO (PMID:17356132), (PMID:25767141) RGD PMID:17356132 PMID:25767141 NCBI chr 1:100,811,727...100,836,901
Ensembl chr 1:100,830,064...100,836,677
JBrowse link
G Pah phenylalanine hydroxylase involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 7:28,066,639...28,129,772
Ensembl chr 7:28,066,635...28,129,769
JBrowse link
G Qdpr quinoid dihydropteridine reductase involved_in IEP
IBA
PMID:21873635 RGD
GO_Central
PMID:4155291, PMID:21873635 RGD:5128604, RGD:13792537 NCBI chr14:70,164,682...70,178,284
Ensembl chr14:70,164,650...70,178,284
JBrowse link
G Tat tyrosine aminotransferase involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr19:41,675,639...41,686,195
Ensembl chr19:41,675,355...41,686,229
JBrowse link
L-phenylalanine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pah phenylalanine hydroxylase IDA RGD PMID:16953590 RGD:1601531 NCBI chr 7:28,066,639...28,129,772
Ensembl chr 7:28,066,635...28,129,769
JBrowse link
G Pcbd1 pterin-4 alpha-carbinolamine dehydratase 1 involved_in IDA PMID:1465414 CAFA PMID:1465414 RGD:12792994 NCBI chr20:30,689,690...30,696,465
Ensembl chr20:30,690,810...30,696,476
JBrowse link
G Spr sepiapterin reductase acts_upstream_of_or_within ISO MGI:3757641 (MGI:3722569|PMID:16532389) RGD PMID:16532389 MGI:3722569 NCBI chr 4:116,912,343...116,916,073
Ensembl chr 4:116,912,351...116,916,236
JBrowse link
melanin biosynthetic process from tyrosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dct dopachrome tautomerase involved_in ISO (MGI:3690794|PMID:2169885) RGD PMID:2169885 MGI:3690794 NCBI chr15:103,208,174...103,245,033
Ensembl chr15:103,208,258...103,244,494
JBrowse link
positive regulation of L-dopa biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Park7 Parkinsonism associated deglycase involved_in IEA
ISO
ISS
GO_REF:0000107
(PMID:16731528)
GO_REF:0000024
Ensembl
RGD
ParkinsonsUK-UCL
PMID:16731528 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:167,982,438...168,004,724
Ensembl chr 5:167,982,439...168,004,724
JBrowse link
serotonin biosynthetic process from tryptophan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 IDA RGD PMID:23098818 RGD:11353778 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Tph1 tryptophan hydroxylase 1 TAS RGD PMID:12153488 RGD:625621 NCBI chr 1:102,669,868...102,699,442
Ensembl chr 1:102,669,868...102,699,442
JBrowse link
tryptophan catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acmsd aminocarboxymuconate semialdehyde decarboxylase IDA RGD PMID:11802786 RGD:70243 NCBI chr13:44,424,689...44,468,734
Ensembl chr13:44,424,689...44,468,734
JBrowse link
G Haao 3-hydroxyanthranilate 3,4-dioxygenase involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 6:7,045,145...7,059,227
Ensembl chr 6:7,045,152...7,058,314
JBrowse link
G Il4i1 interleukin 4 induced 1 involved_in ISO (PMID:17356132), (PMID:25767141) RGD PMID:17356132 PMID:25767141 NCBI chr 1:100,811,727...100,836,901
Ensembl chr 1:100,830,064...100,836,677
JBrowse link
G Kmo kynurenine 3-monooxygenase involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr13:93,684,324...93,715,378
Ensembl chr13:93,684,437...93,716,227
JBrowse link
G Kynu kynureninase involved_in ISO (PMID:17334708) RGD PMID:17334708 NCBI chr 3:28,416,926...28,566,939
Ensembl chr 3:28,416,954...28,566,928
JBrowse link
tryptophan catabolic process to acetyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kynu kynureninase IDA RGD PMID:7236232 RGD:2303721 NCBI chr 3:28,416,926...28,566,939
Ensembl chr 3:28,416,954...28,566,928
JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase involved_in IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:7236232, PMID:21873635 RGD:2303721, RGD:13792537 NCBI chr 2:180,897,059...180,914,919
Ensembl chr 2:180,897,011...180,914,940
JBrowse link
tryptophan catabolic process to indole-3-acetate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il4i1 interleukin 4 induced 1 involved_in ISO (PMID:32818467), (PMID:32866000) RGD PMID:32818467 PMID:32866000 NCBI chr 1:100,811,727...100,836,901
Ensembl chr 1:100,830,064...100,836,677
JBrowse link
tryptophan catabolic process to kynurenine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afmid arylformamidase involved_in
acts_upstream_of_or_within
IBA
ISO
IEA
PMID:21873635
(MGI:3587527|PMID:15866519)
GO_REF:0000041
RGD
UniProt
PMID:15866519, PMID:21873635 GO_REF:0000041 MGI:3587527, RGD:13792537 NCBI chr10:106,828,963...106,844,314
Ensembl chr10:106,828,981...106,844,314
JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 involved_in
acts_upstream_of_or_within
IDA
IEA
ISO
IBA
GO_REF:0000002
(MGI:2151782|PMID:2419335), (MGI:2156954|PMID:11751753)
PMID:21873635
InterPro
RGD
PMID:2419335 PMID:11751753, PMID:10719243, PMID:21873635, PMID:11513477 GO_REF:0000002 MGI:2151782 MGI:2156954, RGD:2290190, RGD:13792537, RGD:2290543 NCBI chr16:72,216,326...72,228,098
Ensembl chr16:72,216,326...72,228,098
JBrowse link
G Ido2 indoleamine 2,3-dioxygenase 2 involved_in
acts_upstream_of_or_within
IBA
ISO
IEA
PMID:21873635
(MGI:3712725|PMID:17499941), (MGI:3719924|PMID:17671174)
(PMID:17671174)
GO_REF:0000041
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:17499941 PMID:17671174, PMID:21873635 GO_REF:0000041 GO_REF:0000107 MGI:3712725 MGI:3719924, RGD:13792537 NCBI chr16:72,232,852...72,291,227
Ensembl chr16:72,268,943...72,289,156
JBrowse link
G Kynu kynureninase involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:28,416,926...28,566,939
Ensembl chr 3:28,416,954...28,566,928
JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase involved_in ISS
ISO
IEA
GO_REF:0000024
(PMID:27762317)
GO_REF:0000041
UniProt
RGD
PMID:27762317 GO_REF:0000024 GO_REF:0000041 NCBI chr 2:180,897,059...180,914,919
Ensembl chr 2:180,897,011...180,914,940
JBrowse link
tryptophan metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp7a ATPase copper transporting alpha acts_upstream_of_or_within ISO MGI:1856102 (MGI:53851|PMID:4147174) RGD PMID:4147174 MGI:53851 NCBI chr  X:77,076,085...77,193,644
Ensembl chr  X:77,076,106...77,193,644
JBrowse link
G Tdo2 tryptophan 2,3-dioxygenase IDA RGD PMID:10719243, PMID:3899109, PMID:3400092 RGD:2290190, RGD:2291804, RGD:2290313 NCBI chr 2:180,897,059...180,914,919
Ensembl chr 2:180,897,011...180,914,940
JBrowse link
tyrosine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pah phenylalanine hydroxylase involved_in IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:16953590, PMID:21873635 RGD:1601531, RGD:13792537 NCBI chr 7:28,066,639...28,129,772
Ensembl chr 7:28,066,635...28,129,769
JBrowse link
tyrosine biosynthetic process, by oxidation of phenylalanine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pah phenylalanine hydroxylase involved_in IDA
IEA
GO_REF:0000108 GOC PMID:10839989 GO_REF:0000108, RGD:1601535 NCBI chr 7:28,066,639...28,129,772
Ensembl chr 7:28,066,635...28,129,769
JBrowse link
G Pcbd1 pterin-4 alpha-carbinolamine dehydratase 1 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr20:30,689,690...30,696,465
Ensembl chr20:30,690,810...30,696,476
JBrowse link
G Pcbd2 pterin-4 alpha-carbinolamine dehydratase 2 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr17:8,929,675...8,980,712
Ensembl chr17:8,929,810...8,980,571
JBrowse link
tyrosine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fah fumarylacetoacetate hydrolase involved_in IEA
IBA
GO_REF:0000104
PMID:21873635
UniProt PMID:21873635 GO_REF:0000104, RGD:13792537 NCBI chr 1:146,713,663...146,736,339
Ensembl chr 1:146,713,676...146,736,261
JBrowse link
G Gstz1 glutathione S-transferase zeta 1 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 6:111,176,798...111,187,246
Ensembl chr 6:111,176,798...111,187,244
JBrowse link
G Hpd 4-hydroxyphenylpyruvate dioxygenase acts_upstream_of_or_within
involved_in
TAS
ISO
IBA
IDA
(PMID:31537781)
PMID:21873635
PMID:8814303
RGD PMID:31537781, PMID:12867153, PMID:21873635, PMID:8814303 RGD:632936, RGD:13792537, RGD:8554707 NCBI chr12:38,828,606...38,839,956
Ensembl chr12:38,828,444...38,839,969
JBrowse link
G Il4i1 interleukin 4 induced 1 involved_in ISO (PMID:17356132) RGD PMID:17356132 NCBI chr 1:100,811,727...100,836,901
Ensembl chr 1:100,830,064...100,836,677
JBrowse link
G Tat tyrosine aminotransferase involved_in ISO
ISS
(PMID:7999802)
(MGI:5430853|PMID:21153519)
GO_REF:0000024
RGD
UniProt
PMID:7999802 PMID:21153519 GO_REF:0000024 MGI:5430853 NCBI chr19:41,675,639...41,686,195
Ensembl chr19:41,675,355...41,686,229
JBrowse link
tyrosine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp7a ATPase copper transporting alpha acts_upstream_of_or_within ISO MGI:1856102 (MGI:53851|PMID:4147174) RGD PMID:4147174 MGI:53851 NCBI chr  X:77,076,085...77,193,644
Ensembl chr  X:77,076,106...77,193,644
JBrowse link
G Hgd homogentisate 1, 2-dioxygenase involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr11:65,983,221...66,034,555
Ensembl chr11:65,983,221...66,034,573
JBrowse link
G Iyd iodotyrosine deiodinase involved_in ISO
ISS
IBA
(PMID:25395621)
GO_REF:0000024
PMID:21873635
RGD
UniProt
PMID:25395621, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 1:40,086,513...40,100,966
Ensembl chr 1:40,086,470...40,101,840
JBrowse link
G Thap4 THAP domain containing 4 involved_in ISO
ISS
(PMID:30524950)
GO_REF:0000024
RGD
UniProt
PMID:30524950 GO_REF:0000024 NCBI chr 9:100,848,597...100,888,107
Ensembl chr 9:100,848,598...100,888,107
JBrowse link
G Ttc36 tetratricopeptide repeat domain 36 acts_upstream_of_or_within ISO MGI:5588394 (MGI:6362140|PMID:31537781) RGD PMID:31537781 MGI:6362140 NCBI chr 8:49,106,374...49,109,981
Ensembl chr 8:49,106,374...49,109,981
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19491
    metabolic process 11797
      primary metabolic process 10565
        cellular amino acid metabolic process 271
          aromatic amino acid family metabolic process 30
            L-dopa metabolic process + 1
            L-phenylalanine metabolic process + 10
            anthranilate metabolic process + 3
            aromatic amino acid family biosynthetic process + 4
            aromatic amino acid family catabolic process + 16
            para-aminobenzoic acid metabolic process + 0
            tryptophan metabolic process + 12
            tyrosine metabolic process + 15
Path 2
Term Annotations click to browse term
  biological_process 19491
    metabolic process 11797
      small molecule metabolic process 1790
        organic acid metabolic process 1010
          oxoacid metabolic process 978
            carboxylic acid metabolic process 959
              cellular amino acid metabolic process 271
                aromatic amino acid family metabolic process 30
                  L-dopa metabolic process + 1
                  L-phenylalanine metabolic process + 10
                  anthranilate metabolic process + 3
                  aromatic amino acid family biosynthetic process + 4
                  aromatic amino acid family catabolic process + 16
                  para-aminobenzoic acid metabolic process + 0
                  tryptophan metabolic process + 12
                  tyrosine metabolic process + 15
paths to the root