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ONTOLOGY REPORT - ANNOTATIONS


Term:serine family amino acid biosynthetic process
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Accession:GO:0009070 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine.
Synonyms:exact_synonym: serine family amino acid anabolism;   serine family amino acid biosynthesis;   serine family amino acid formation;   serine family amino acid synthesis


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serine family amino acid biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 ISO (PMID:25633902) RGD PMID:25633902 NCBI chr 6:99,282,850...99,350,367
Ensembl chr 6:99,282,850...99,350,340
JBrowse link
G Phgdh phosphoglycerate dehydrogenase TAS RGD PMID:9163325 RGD:61693 NCBI chr 2:200,484,245...200,513,564
Ensembl chr 2:200,484,246...200,513,564
JBrowse link
cysteine biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbs cystathionine beta synthase ISO (PMID:24416422)
MGI:1857139 (MGI:3044255|PMID:15030387)
RGD PMID:15030387, PMID:24416422 MGI:3044255 NCBI chr20:10,361,987...10,386,663
Ensembl chr20:10,361,988...10,386,751
JBrowse link
G Cth cystathionine gamma-lyase IDA
IEA
ISO
ISS
GO_REF:0000041
(PMID:10212249)
GO_REF:0000024
UniProt
RGD
PMID:10212249, PMID:9359866 GO_REF:0000024, GO_REF:0000041, RGD:1359024 NCBI chr 2:264,266,959...264,293,040
Ensembl chr 2:264,266,984...264,293,046
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 ISO (MGI:5294309|PMID:12468440) RGD PMID:12468440 MGI:5294309 NCBI chr20:14,019,723...14,045,781
Ensembl chr20:14,019,723...14,025,068
JBrowse link
G LOC103691744 cystathionine gamma-lyase IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 2:264,747,068...264,765,112
Ensembl chr 2:264,746,485...264,765,085
JBrowse link
cysteine biosynthetic process from serine term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbs cystathionine beta synthase TAS RGD PMID:9359866 RGD:1359024 NCBI chr20:10,361,987...10,386,663
Ensembl chr20:10,361,988...10,386,751
JBrowse link
cysteine biosynthetic process via cystathionine term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbs cystathionine beta synthase IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr20:10,361,987...10,386,663
Ensembl chr20:10,361,988...10,386,751
JBrowse link
G Cth cystathionine gamma-lyase ISO
IBA
(PMID:19428278)
PMID:21873635
RGD PMID:19428278, PMID:21873635 RGD:13792537 NCBI chr 2:264,266,959...264,293,040
Ensembl chr 2:264,266,984...264,293,046
JBrowse link
D-serine biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Srr serine racemase ISO
IBA
(PMID:11054547), (PMID:15193426)
(MGI:1347751|PMID:10557334), (MGI:1926659|PMID:11054547), (MGI:2183617|PMID:12021263), (MGI:3529732|PMID:15710237)
PMID:21873635
RGD PMID:10557334, PMID:11054547, PMID:12021263, PMID:15193426, PMID:15710237, PMID:21873635 MGI:1347751, MGI:1926659, MGI:2183617, MGI:3529732, RGD:13792537 NCBI chr10:61,756,138...61,772,327
Ensembl chr10:61,756,138...61,772,293
JBrowse link
glycine biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC688286 similar to threonine aldolase 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:106,877,585...106,883,706
Ensembl chr10:106,878,085...106,883,423
JBrowse link
G Sardh sarcosine dehydrogenase TAS RGD PMID:9839943 RGD:634034 NCBI chr 3:5,737,203...5,802,153
Ensembl chr 3:5,737,200...5,802,129
JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 IDA from L-allothreonine in the absence of tetrahydrofolate RGD PMID:3110140 RGD:2300383 NCBI chr10:47,030,813...47,059,216
Ensembl chr10:47,031,050...47,059,216
JBrowse link
G Shmt2 serine hydroxymethyltransferase 2 IDA from L-allothreonine in the absence of tetrahydrofolate RGD PMID:3110140 RGD:2300383 NCBI chr 7:70,824,718...70,829,822
Ensembl chr 7:70,824,715...70,829,815
JBrowse link
glycine biosynthetic process from serine term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Shmt1 serine hydroxymethyltransferase 1 IDA
IBA
in the presence of tetrahydrofolate
PMID:21873635
RGD
GO_Central
PMID:3110140, PMID:21873635 RGD:2300383, RGD:13792537 NCBI chr10:47,030,813...47,059,216
Ensembl chr10:47,031,050...47,059,216
JBrowse link
G Shmt2 serine hydroxymethyltransferase 2 IDA
IBA
in the presence of tetrahydrofolate
PMID:21873635
RGD
GO_Central
PMID:3110140, PMID:21873635 RGD:2300383, RGD:13792537 NCBI chr 7:70,824,718...70,829,822
Ensembl chr 7:70,824,715...70,829,815
JBrowse link
glycine biosynthetic process, by transamination of glyoxylate term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agxt alanine--glyoxylate and serine--pyruvate aminotransferase IDA
IBA
ISO
PMID:21873635
(PMID:22198249)
RGD PMID:22198249, PMID:12383475, PMID:21873635 RGD:1599457, RGD:13792537 NCBI chr 9:100,281,339...100,291,292
Ensembl chr 9:100,281,339...100,291,291
JBrowse link
G Agxt2 alanine-glyoxylate aminotransferase 2 ISO (PMID:20018850) RGD PMID:20018850 NCBI chr 2:60,337,667...60,379,144
Ensembl chr 2:60,337,667...60,379,420
JBrowse link
L-serine biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Phgdh phosphoglycerate dehydrogenase IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 2:200,484,245...200,513,564
Ensembl chr 2:200,484,246...200,513,564
JBrowse link
G Psat1 phosphoserine aminotransferase 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:233,124,089...233,145,941
Ensembl chr 1:233,124,092...233,145,941
JBrowse link
G Psph phosphoserine phosphatase IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:30,514,128...30,526,551
Ensembl chr12:30,514,112...30,526,557
JBrowse link
G Shmt2 serine hydroxymethyltransferase 2 IDA RGD PMID:10457370 RGD:2300380 NCBI chr 7:70,824,718...70,829,822
Ensembl chr 7:70,824,715...70,829,815
JBrowse link
selenocysteine biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sephs1 selenophosphate synthetase 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:77,312,562...77,340,934
Ensembl chr17:77,312,562...77,340,934
JBrowse link
G Sephs2 selenophosphate synthetase 2 ISO (MGI:3711593|PMID:17346238) RGD PMID:17346238 MGI:3711593 NCBI chr 1:198,719,158...198,721,476
Ensembl chr 1:198,719,162...198,721,476
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20030
    metabolic process 12185
      nitrogen compound metabolic process 10212
        organonitrogen compound metabolic process 6949
          organonitrogen compound biosynthetic process 2023
            alpha-amino acid biosynthetic process 64
              serine family amino acid biosynthetic process 17
                D-serine biosynthetic process 1
                L-homocysteine biosynthetic process 0
                L-serine biosynthetic process 4
                cysteine biosynthetic process + 4
                glycine biosynthetic process + 6
                homoserine biosynthetic process + 0
                selenocysteine biosynthetic process 2
Path 2
Term Annotations click to browse term
  biological_process 20030
    metabolic process 12185
      cellular metabolic process 10964
        organic acid metabolic process 1007
          oxoacid metabolic process 969
            carboxylic acid metabolic process 950
              cellular amino acid metabolic process 268
                alpha-amino acid metabolic process 190
                  alpha-amino acid biosynthetic process 64
                    serine family amino acid biosynthetic process 17
                      D-serine biosynthetic process 1
                      L-homocysteine biosynthetic process 0
                      L-serine biosynthetic process 4
                      cysteine biosynthetic process + 4
                      glycine biosynthetic process + 6
                      homoserine biosynthetic process + 0
                      selenocysteine biosynthetic process 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.