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ONTOLOGY REPORT - ANNOTATIONS

Term:aspartate family amino acid metabolic process
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Accession:GO:0009066 term browser browse the term
Definition:The chemical reactions and pathways involving amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine.
Synonyms:exact_synonym: aspartate family amino acid metabolism


show annotations for term's descendants           Sort by:
aspartate family amino acid metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ASPG asparaginase involved_in IEA UniProt GO_REF:0000117
'de novo' L-methionine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BHMT betaine--homocysteine S-methyltransferase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:87,911,093...87,935,252
Ensembl chr 2:87,910,603...87,935,252 		JBrowse link
asparagine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ASNS asparagine synthetase (glutamine-hydrolyzing) involved_in
acts_upstream_of_or_within		 ISO
IBA
IEA		 (PMID:2573597) RGD
GO_Central
MGI
InterPro
Ensembl
UniProt		 PMID:2573597 PMID:2887559 GO_REF:0000002 GO_REF:0000033 GO_REF:0000043 GO_REF:0000107 RGD:2316002 NCBI chr 9:77,318,341...77,336,290
Ensembl chr 9:77,318,213...77,343,035 		JBrowse link
G ASNSD1 asparagine synthetase domain containing 1 involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000043 NCBI chr15:94,261,910...94,272,129
Ensembl chr15:94,266,701...94,272,119 		JBrowse link
asparagine catabolic process via L-aspartate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ASRGL1 asparaginase and isoaspartyl peptidase 1 acts_upstream_of_or_within
involved_in		 ISO
IBA
IEA		 PMID:12753071 MGI
GO_Central
Ensembl		 PMID:12753071 GO_REF:0000033 GO_REF:0000107 RGD:1299508 NCBI chr 2:9,328,260...9,353,384
Ensembl chr 2:9,328,269...9,353,340 		JBrowse link
asparagine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ASPG asparaginase involved_in ISO PMID:9575212 UniProt PMID:9575212 RGD:1299414
G NIT2 nitrilase family member 2 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr13:158,630,997...158,653,164
Ensembl chr13:158,630,913...158,653,147 		JBrowse link
aspartate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GOT1 glutamic-oxaloacetic transaminase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 (PMID:4193185) Ensembl
MGI
GO_Central		 PMID:4193185 GO_REF:0000033 GO_REF:0000107 NCBI chr14:110,608,422...110,635,825
Ensembl chr14:110,608,430...110,635,874 		JBrowse link
G GOT2 glutamic-oxaloacetic transaminase 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:4193185) Ensembl
MGI		 PMID:4193185 GO_REF:0000107 NCBI chr 6:20,407,203...20,431,849
Ensembl chr 6:20,407,200...20,432,067 		JBrowse link
aspartate catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DDO D-aspartate oxidase involved_in IBA GO_Central GO_REF:0000033 NCBI chr 1:76,391,112...76,417,147
Ensembl chr 1:76,391,116...76,417,301 		JBrowse link
G GOT1 glutamic-oxaloacetic transaminase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:110,608,422...110,635,825
Ensembl chr14:110,608,430...110,635,874 		JBrowse link
G GOT2 glutamic-oxaloacetic transaminase 2 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 6:20,407,203...20,431,849
Ensembl chr 6:20,407,200...20,432,067 		JBrowse link
aspartate metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADSS1 adenylosuccinate synthase 1 ISO RGD PMID:3759987 RGD:5135303
G ADSS2 adenylosuccinate synthase 2 ISO RGD PMID:71897 RGD:5135533 NCBI chr10:17,220,081...17,259,141
Ensembl chr10:17,220,207...17,259,182 		JBrowse link
G ASPA aspartoacylase involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:49,612,845...49,630,303
Ensembl chr12:49,610,519...49,641,864 		JBrowse link
G ASS1 argininosuccinate synthase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:270,531,434...270,586,364
Ensembl chr 1:270,531,589...270,586,364 		JBrowse link
G DDO D-aspartate oxidase acts_upstream_of_or_within ISO (PMID:16525061) MGI PMID:16525061 NCBI chr 1:76,391,112...76,417,147
Ensembl chr 1:76,391,116...76,417,301 		JBrowse link
G GOT1 glutamic-oxaloacetic transaminase 1 involved_in ISO
ISS		 RGD
UniProt		 PMID:2837211 GO_REF:0000024 RGD:2289377 NCBI chr14:110,608,422...110,635,825
Ensembl chr14:110,608,430...110,635,874 		JBrowse link
G GOT2 glutamic-oxaloacetic transaminase 2 involved_in ISO
ISS		 RGD
UniProt		 PMID:12686151 GO_REF:0000024 RGD:2289396 NCBI chr 6:20,407,203...20,431,849
Ensembl chr 6:20,407,200...20,432,067 		JBrowse link
G NAT8L N-acetyltransferase 8 like involved_in ISO (PMID:28077719) MGI PMID:28077719 NCBI chr 8:1,063,917...1,072,191
Ensembl chr 8:1,063,824...1,072,189 		JBrowse link
glutamate catabolic process to aspartate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GOT1 glutamic-oxaloacetic transaminase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:4193185) Ensembl
MGI		 PMID:4193185 GO_REF:0000107 NCBI chr14:110,608,422...110,635,825
Ensembl chr14:110,608,430...110,635,874 		JBrowse link
G GOT2 glutamic-oxaloacetic transaminase 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:4193185) Ensembl
MGI		 PMID:4193185 GO_REF:0000107 NCBI chr 6:20,407,203...20,431,849
Ensembl chr 6:20,407,200...20,432,067 		JBrowse link
hydroxylysine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PLOD2 procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:86,402,673...86,513,167
Ensembl chr13:86,401,244...86,513,105 		JBrowse link
G PLOD3 procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:8,911,787...8,919,525
Ensembl chr 3:8,911,791...8,919,516 		JBrowse link
L-asparagine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ASNS asparagine synthetase (glutamine-hydrolyzing) involved_in IEA UniProt GO_REF:0000041 NCBI chr 9:77,318,341...77,336,290
Ensembl chr 9:77,318,213...77,343,035 		JBrowse link
L-asparagine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF4 activating transcription factor 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:8,742,964...8,745,752
Ensembl chr 5:8,742,967...8,745,368 		JBrowse link
L-lysine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AASS aminoadipate-semialdehyde synthase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10567240) Ensembl
MGI		 PMID:10567240 GO_REF:0000107 NCBI chr18:24,938,366...25,039,197
Ensembl chr18:24,974,754...25,039,195 		JBrowse link
L-lysine catabolic process to acetyl-CoA via L-pipecolate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC100515508 peroxisomal sarcosine oxidase involved_in IBA GO_Central GO_REF:0000033 NCBI chr12:45,306,327...45,319,938
Ensembl chr12:45,257,188...45,322,767 		JBrowse link
G PIPOX pipecolic acid and sarcosine oxidase involved_in IBA GO_Central GO_REF:0000033 NCBI chr12:45,256,806...45,270,755
Ensembl chr12:45,257,188...45,322,767 		JBrowse link
L-lysine catabolic process to acetyl-CoA via saccharopine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AASS aminoadipate-semialdehyde synthase involved_in IEA UniProt GO_REF:0000041 NCBI chr18:24,938,366...25,039,197
Ensembl chr18:24,974,754...25,039,195 		JBrowse link
G DLST dihydrolipoamide S-succinyltransferase involved_in IEA UniProt GO_REF:0000041 NCBI chr 7:98,091,161...98,111,267
Ensembl chr 7:98,091,124...98,111,572 		JBrowse link
L-methionine salvage term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BHMT betaine--homocysteine S-methyltransferase involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:87,911,093...87,935,252
Ensembl chr 2:87,910,603...87,935,252 		JBrowse link
G BHMT2 betaine--homocysteine S-methyltransferase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:87,866,631...87,882,623
Ensembl chr 2:87,866,621...87,882,716 		JBrowse link
L-methionine salvage from methylthioadenosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADI1 acireductone dioxygenase 1 involved_in IEA UniProt
InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000041 GO_REF:0000104 GO_REF:0000107 NCBI chr 3:131,295,257...131,303,663
Ensembl chr 3:131,295,257...131,304,309 		JBrowse link
G APIP APAF1 interacting protein involved_in IEA
IBA		 InterPro
GO_Central
UniProt
Ensembl		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000041 GO_REF:0000107 NCBI chr 2:26,095,020...26,115,462
Ensembl chr 2:26,095,038...26,115,464 		JBrowse link
G ENOPH1 enolase-phosphatase 1 involved_in IEA UniProt
InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000041 GO_REF:0000107 NCBI chr 8:135,775,743...135,802,404
Ensembl chr 8:135,775,745...135,802,388 		JBrowse link
G MRI1 methylthioribose-1-phosphate isomerase 1 involved_in IEA UniProt GO_REF:0000041 NCBI chr 2:65,348,609...65,354,892
Ensembl chr 2:65,348,006...65,355,118 		JBrowse link
G MTAP methylthioadenosine phosphorylase involved_in IEA
IBA		 UniProt
GO_Central		 GO_REF:0000033 GO_REF:0000041 GO_REF:0000104 NCBI chr 1:200,882,954...200,934,389
Ensembl chr 1:200,882,956...200,934,445 		JBrowse link
G RNASEH1 ribonuclease H1 involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000041 GO_REF:0000104 NCBI chr 3:131,268,908...131,277,072
Ensembl chr 3:131,268,926...131,281,930 		JBrowse link
L-methionine salvage from S-adenosylmethionine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APIP APAF1 interacting protein involved_in IEA UniProt GO_REF:0000104 NCBI chr 2:26,095,020...26,115,462
Ensembl chr 2:26,095,038...26,115,464 		JBrowse link
G ENOPH1 enolase-phosphatase 1 involved_in IEA UniProt GO_REF:0000104 NCBI chr 8:135,775,743...135,802,404
Ensembl chr 8:135,775,745...135,802,388 		JBrowse link
G MRI1 methylthioribose-1-phosphate isomerase 1 involved_in IEA UniProt GO_REF:0000104 NCBI chr 2:65,348,609...65,354,892
Ensembl chr 2:65,348,006...65,355,118 		JBrowse link
L-threonine catabolic process to glycine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TDH L-threonine dehydrogenase involved_in IEA UniProt GO_REF:0000041 NCBI chr14:14,577,009...14,597,695 JBrowse link
lysine biosynthetic process via aminoadipic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase involved_in IBA GO_Central GO_REF:0000033 NCBI chr 9:35,903,902...35,948,573
Ensembl chr 9:35,839,917...35,948,575 		JBrowse link
G AASS aminoadipate-semialdehyde synthase involved_in IBA GO_Central GO_REF:0000033 NCBI chr18:24,938,366...25,039,197
Ensembl chr18:24,974,754...25,039,195 		JBrowse link
methionine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADI1 acireductone dioxygenase 1 involved_in IEA UniProt GO_REF:0000043 NCBI chr 3:131,295,257...131,303,663
Ensembl chr 3:131,295,257...131,304,309 		JBrowse link
G APIP APAF1 interacting protein involved_in IEA UniProt GO_REF:0000043 NCBI chr 2:26,095,020...26,115,462
Ensembl chr 2:26,095,038...26,115,464 		JBrowse link
G BHMT betaine--homocysteine S-methyltransferase acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:15217352) RGD
MGI
InterPro		 PMID:15217352 PMID:15845641 GO_REF:0000002 RGD:1359026 NCBI chr 2:87,911,093...87,935,252
Ensembl chr 2:87,910,603...87,935,252 		JBrowse link
G BHMT2 betaine--homocysteine S-methyltransferase 2 involved_in IEA InterPro GO_REF:0000002 NCBI chr 2:87,866,631...87,882,623
Ensembl chr 2:87,866,621...87,882,716 		JBrowse link
G ENOPH1 enolase-phosphatase 1 involved_in IEA UniProt GO_REF:0000043 NCBI chr 8:135,775,743...135,802,404
Ensembl chr 8:135,775,745...135,802,388 		JBrowse link
G MRI1 methylthioribose-1-phosphate isomerase 1 involved_in IEA UniProt GO_REF:0000043 NCBI chr 2:65,348,609...65,354,892
Ensembl chr 2:65,348,006...65,355,118 		JBrowse link
G MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:88,471,317...88,533,690
Ensembl chr 7:88,471,414...88,537,387 		JBrowse link
G MTHFR methylenetetrahydrofolate reductase involved_in
acts_upstream_of_or_within		 IBA
ISO		 (PMID:15217352) GO_Central
MGI		 PMID:15217352 GO_REF:0000033 NCBI chr 6:71,863,637...71,882,118
Ensembl chr 6:71,863,637...71,881,820 		JBrowse link
G MTR 5-methyltetrahydrofolate-homocysteine methyltransferase acts_upstream_of_or_within
involved_in		 ISO
IBA
IEA		 (PMID:11158293) RGD
MGI
GO_Central
Ensembl
UniProt
InterPro		 PMID:11158293 PMID:11730351 PMID:15845641 GO_REF:0000002 GO_REF:0000033 GO_REF:0000043 GO_REF:0000107 RGD:1359026 RGD:1601423 NCBI chr14:54,546,978...54,652,780
Ensembl chr14:54,546,978...54,652,763 		JBrowse link
G MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase involved_in IEA Ensembl
UniProt		 GO_REF:0000043 GO_REF:0000107 NCBI chr16:74,245,214...74,270,828
Ensembl chr16:74,245,228...74,270,783 		JBrowse link
G RNASEH1 ribonuclease H1 involved_in IEA UniProt GO_REF:0000043 NCBI chr 3:131,268,908...131,277,072
Ensembl chr 3:131,268,926...131,281,930 		JBrowse link
methionine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MAT1A methionine adenosyltransferase 1A involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:82,109,405...82,126,487
Ensembl chr14:82,107,390...82,127,049 		JBrowse link
methionine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADI1 acireductone dioxygenase 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 3:131,295,257...131,303,663
Ensembl chr 3:131,295,257...131,304,309 		JBrowse link
G GNMT glycine N-methyltransferase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17937387) Ensembl
MGI		 PMID:17937387 GO_REF:0000107 NCBI chr 7:38,038,359...38,041,218
Ensembl chr 7:38,038,358...38,041,217 		JBrowse link
G MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 involved_in ISO (MGI:5621260|PMID:23190757)
(PMID:23190757)		 BHF-UCL PMID:23190757 MGI:5621260 NCBI chr 7:88,471,317...88,533,690
Ensembl chr 7:88,471,414...88,537,387 		JBrowse link
G MTHFR methylenetetrahydrofolate reductase involved_in IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr 6:71,863,637...71,882,118
Ensembl chr 6:71,863,637...71,881,820 		JBrowse link
G MTR 5-methyltetrahydrofolate-homocysteine methyltransferase ISO RGD PMID:21121936 RGD:7207080 NCBI chr14:54,546,978...54,652,780
Ensembl chr14:54,546,978...54,652,763 		JBrowse link
threonine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G THNSL2 threonine synthase like 2 NOT|acts_upstream_of_or_within ISO (PMID:17034760) MGI PMID:17034760 NCBI chr 3:57,800,976...57,821,296
Ensembl chr 3:57,799,026...57,823,440 		JBrowse link
threonine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GCAT glycine C-acetyltransferase involved_in IEA InterPro GO_REF:0000002 NCBI chr 5:10,027,133...10,038,494
Ensembl chr 5:10,027,044...10,038,433 		JBrowse link
G TDH L-threonine dehydrogenase involved_in
acts_upstream_of_or_within		 ISS
ISO
IBA		 (PMID:21896756) UniProt
MGI
GO_Central		 PMID:21896756 GO_REF:0000024 GO_REF:0000033 NCBI chr14:14,577,009...14,597,695 JBrowse link
G THA1 threonine aldolase 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr12:3,728,742...3,734,209 JBrowse link
threonine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PHGDH phosphoglycerate dehydrogenase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19114063) Ensembl
MGI		 PMID:19114063 GO_REF:0000107 NCBI chr 4:101,445,977...101,478,144
Ensembl chr 4:101,444,693...101,478,144 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17651
    cellular process 17214
      metabolic process 10729
        primary metabolic process 9447
          amino acid metabolic process 295
            proteinogenic amino acid metabolic process 167
              aspartate family amino acid metabolic process 40
                L-lysine metabolic process + 4
                asparagine metabolic process + 6
                aspartate family amino acid biosynthetic process + 21
                aspartate family amino acid catabolic process + 12
                aspartate metabolic process + 8
                hydroxylysine metabolic process + 2
                methionine metabolic process + 14
                threonine metabolic process + 5
Path 2
Term Annotations click to browse term
  biological_process 17651
    cellular process 17214
      metabolic process 10729
        small molecule metabolic process 1668
          organic acid metabolic process 897
            oxoacid metabolic process 888
              carboxylic acid metabolic process 872
                alpha-amino acid metabolic process 212
                  L-amino acid metabolic process 183
                    aspartate family amino acid metabolic process 40
                      L-lysine metabolic process + 4
                      asparagine metabolic process + 6
                      aspartate family amino acid biosynthetic process + 21
                      aspartate family amino acid catabolic process + 12
                      aspartate metabolic process + 8
                      hydroxylysine metabolic process + 2
                      methionine metabolic process + 14
                      threonine metabolic process + 5
paths to the root