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ONTOLOGY REPORT - ANNOTATIONS

Term:aspartate family amino acid metabolic process
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Accession:GO:0009066 term browser browse the term
Definition:The chemical reactions and pathways involving amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine.
Synonyms:exact_synonym: aspartate family amino acid metabolism

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aspartate family amino acid metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ASPG asparaginase involved_in IEA UniProt GO_REF:0000117 NCBI chr24:82,021,590...82,049,281
Ensembl chr24:82,021,726...82,049,355 		JBrowse link
'de novo' L-methionine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BHMT betaine--homocysteine S-methyltransferase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:73,331,551...73,352,259
Ensembl chr 4:73,332,259...73,352,434 		JBrowse link
asparagine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ASNS asparagine synthetase (glutamine-hydrolyzing) involved_in
acts_upstream_of_or_within		 ISO
IEA		 (PMID:2573597) RGD
TreeGrafter
InterPro
UniProt
Ensembl
MGI		 PMID:2573597 PMID:2887559 GO_REF:0000002 GO_REF:0000043 GO_REF:0000107 GO_REF:0000118 RGD:2316002 NCBI chr21:51,244,514...51,264,694
Ensembl chr21:51,247,742...51,265,241 		JBrowse link
G ASNSD1 asparagine synthetase domain containing 1 involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000043 NCBI chr10:75,179,921...75,189,552
Ensembl chr10:75,184,721...75,191,046 		JBrowse link
asparagine catabolic process via L-aspartate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ASRGL1 asparaginase and isoaspartyl peptidase 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 PMID:12753071 MGI
Ensembl
TreeGrafter		 PMID:12753071 GO_REF:0000107 GO_REF:0000118 RGD:1299508 NCBI chr 1:11,503,137...11,529,745
Ensembl chr 1:11,502,578...11,529,598 		JBrowse link
asparagine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ASPG asparaginase involved_in ISO PMID:9575212 UniProt PMID:9575212 RGD:1299414 NCBI chr24:82,021,590...82,049,281
Ensembl chr24:82,021,726...82,049,355 		JBrowse link
G NIT2 nitrilase family member 2 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr22:80,524,856...80,545,615
Ensembl chr22:80,524,860...80,542,148 		JBrowse link
aspartate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GOT1 glutamic-oxaloacetic transaminase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:4193185) Ensembl
TreeGrafter
MGI		 PMID:4193185 GO_REF:0000107 GO_REF:0000118 NCBI chr 9:92,463,017...92,489,227
Ensembl chr 9:92,462,782...92,488,310 		JBrowse link
G GOT1L1 glutamic-oxaloacetic transaminase 1 like 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 8:35,966,349...35,972,471
Ensembl chr 8:35,966,361...35,972,042 		JBrowse link
G GOT2 glutamic-oxaloacetic transaminase 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:4193185) Ensembl
MGI		 PMID:4193185 GO_REF:0000107 NCBI chr 5:44,645,721...44,670,917
Ensembl chr 5:44,645,602...44,670,918 		JBrowse link
aspartate catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DDO D-aspartate oxidase involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr13:63,484,726...63,510,181 JBrowse link
G GOT1 glutamic-oxaloacetic transaminase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:92,463,017...92,489,227
Ensembl chr 9:92,462,782...92,488,310 		JBrowse link
G GOT2 glutamic-oxaloacetic transaminase 2 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 5:44,645,721...44,670,917
Ensembl chr 5:44,645,602...44,670,918 		JBrowse link
aspartate metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADSS1 adenylosuccinate synthase 1 ISO RGD PMID:3759987 RGD:5135303 NCBI chr24:82,662,232...82,684,690
Ensembl chr24:82,662,319...82,684,874 		JBrowse link
G ADSS2 adenylosuccinate synthase 2 ISO RGD PMID:71897 RGD:5135533 NCBI chr25:81,441,792...81,485,344
Ensembl chr25:81,442,787...81,485,292 		JBrowse link
G ASPA aspartoacylase involved_in ISO (PMID:28077719) MGI PMID:28077719 NCBI chr16:2,980,325...3,005,632
Ensembl chr16:2,982,459...3,009,885 		JBrowse link
G ASS1 argininosuccinate synthase 1 involved_in ISO (PMID:7977368) BHF-UCL PMID:7977368 NCBI chr12:7,643,484...7,701,334 JBrowse link
G DDO D-aspartate oxidase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16525061) Ensembl
MGI		 PMID:16525061 GO_REF:0000107 NCBI chr13:63,484,726...63,510,181 JBrowse link
G GOT1 glutamic-oxaloacetic transaminase 1 ISO RGD PMID:2837211 RGD:2289377 NCBI chr 9:92,463,017...92,489,227
Ensembl chr 9:92,462,782...92,488,310 		JBrowse link
G GOT2 glutamic-oxaloacetic transaminase 2 ISO RGD PMID:12686151 RGD:2289396 NCBI chr 5:44,645,721...44,670,917
Ensembl chr 5:44,645,602...44,670,918 		JBrowse link
G NAT8L N-acetyltransferase 8 like involved_in ISO (PMID:28077719) MGI PMID:28077719 NCBI chr27:46,697,086...46,703,494
Ensembl chr27:46,698,845...46,703,413 		JBrowse link
glutamate catabolic process to aspartate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GOT1 glutamic-oxaloacetic transaminase 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:4193185) MGI
Ensembl		 PMID:4193185 GO_REF:0000107 NCBI chr 9:92,463,017...92,489,227
Ensembl chr 9:92,462,782...92,488,310 		JBrowse link
G GOT2 glutamic-oxaloacetic transaminase 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:4193185) Ensembl
MGI		 PMID:4193185 GO_REF:0000107 NCBI chr 5:44,645,721...44,670,917
Ensembl chr 5:44,645,602...44,670,918 		JBrowse link
hydroxylysine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PLOD2 procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:44,489,804...44,590,284
Ensembl chr15:44,490,042...44,591,526 		JBrowse link
G PLOD3 procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr28:11,962,394...11,974,206
Ensembl chr28:11,962,286...11,975,228 		JBrowse link
L-asparagine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ASNS asparagine synthetase (glutamine-hydrolyzing) involved_in IEA UniProt GO_REF:0000041 NCBI chr21:51,244,514...51,264,694
Ensembl chr21:51,247,742...51,265,241 		JBrowse link
L-asparagine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF4 activating transcription factor 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:22,092,046...22,094,184
Ensembl chr19:22,091,667...22,095,230 		JBrowse link
L-lysine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AASS aminoadipate-semialdehyde synthase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10567240) Ensembl
MGI		 PMID:10567240 GO_REF:0000107 NCBI chr21:90,891,781...90,959,351
Ensembl chr21:90,892,023...90,959,343 		JBrowse link
L-lysine catabolic process to acetyl-CoA via L-pipecolate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PIPOX pipecolic acid and sarcosine oxidase involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr16:22,805,369...22,820,015
Ensembl chr16:22,805,740...22,820,537 		JBrowse link
L-lysine catabolic process to acetyl-CoA via saccharopine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AASS aminoadipate-semialdehyde synthase involved_in IEA UniProt GO_REF:0000041 NCBI chr21:90,891,781...90,959,351
Ensembl chr21:90,892,023...90,959,343 		JBrowse link
G DLST dihydrolipoamide S-succinyltransferase involved_in IEA UniProt GO_REF:0000041 NCBI chr24:52,098,270...52,121,560
Ensembl chr24:52,098,349...52,120,121 		JBrowse link
L-methionine salvage term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BHMT betaine--homocysteine S-methyltransferase involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 4:73,331,551...73,352,259
Ensembl chr 4:73,332,259...73,352,434 		JBrowse link
G BHMT2 betaine--homocysteine S-methyltransferase 2 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 4:73,289,836...73,310,312
Ensembl chr 4:73,289,652...73,312,358 		JBrowse link
L-methionine salvage from methylthioadenosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADI1 acireductone dioxygenase 1 involved_in IEA UniProt
InterPro		 GO_REF:0000002 GO_REF:0000041 GO_REF:0000104 NCBI chr14:104,140,027...104,172,782
Ensembl chr14:104,139,952...104,172,271 		JBrowse link
G APIP APAF1 interacting protein involved_in IEA UniProt
TreeGrafter
InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000041 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:30,344,658...30,374,741
Ensembl chr 1:30,344,690...30,374,737 		JBrowse link
G ENOPH1 enolase-phosphatase 1 involved_in IEA UniProt
TreeGrafter
Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000041 GO_REF:0000107 GO_REF:0000118 NCBI chr 7:30,810,727...30,843,252
Ensembl chr 7:30,810,816...30,844,852 		JBrowse link
G MRI1 methylthioribose-1-phosphate isomerase 1 involved_in IEA UniProt
TreeGrafter		 GO_REF:0000041 GO_REF:0000118 NCBI chr 6:12,424,835...12,431,911
Ensembl chr 6:12,425,052...12,431,844 		JBrowse link
G MTAP methylthioadenosine phosphorylase involved_in IEA UniProt
TreeGrafter		 GO_REF:0000041 GO_REF:0000104 GO_REF:0000118 NCBI chr15:84,196,548...84,198,357
Ensembl chr12:57,997,427...58,050,241 		JBrowse link
L-methionine salvage from S-adenosylmethionine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APIP APAF1 interacting protein involved_in IEA UniProt GO_REF:0000104 NCBI chr 1:30,344,658...30,374,741
Ensembl chr 1:30,344,690...30,374,737 		JBrowse link
G ENOPH1 enolase-phosphatase 1 involved_in IEA UniProt GO_REF:0000104 NCBI chr 7:30,810,727...30,843,252
Ensembl chr 7:30,810,816...30,844,852 		JBrowse link
G MRI1 methylthioribose-1-phosphate isomerase 1 involved_in IEA UniProt GO_REF:0000104 NCBI chr 6:12,424,835...12,431,911
Ensembl chr 6:12,425,052...12,431,844 		JBrowse link
lysine biosynthetic process via aminoadipic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 1:97,475,415...97,498,522
Ensembl chr 1:97,475,481...97,499,573 		JBrowse link
G AASS aminoadipate-semialdehyde synthase involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr21:90,891,781...90,959,351
Ensembl chr21:90,892,023...90,959,343 		JBrowse link
methionine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADI1 acireductone dioxygenase 1 involved_in IEA UniProt GO_REF:0000043 NCBI chr14:104,140,027...104,172,782
Ensembl chr14:104,139,952...104,172,271 		JBrowse link
G APIP APAF1 interacting protein involved_in IEA UniProt GO_REF:0000043 NCBI chr 1:30,344,658...30,374,741
Ensembl chr 1:30,344,690...30,374,737 		JBrowse link
G BHMT betaine--homocysteine S-methyltransferase acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:15217352) RGD
MGI
UniProt
InterPro		 PMID:15217352 PMID:15845641 GO_REF:0000002 GO_REF:0000117 RGD:1359026 NCBI chr 4:73,331,551...73,352,259
Ensembl chr 4:73,332,259...73,352,434 		JBrowse link
G BHMT2 betaine--homocysteine S-methyltransferase 2 involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000117 NCBI chr 4:73,289,836...73,310,312
Ensembl chr 4:73,289,652...73,312,358 		JBrowse link
G ENOPH1 enolase-phosphatase 1 involved_in IEA UniProt GO_REF:0000043 NCBI chr 7:30,810,727...30,843,252
Ensembl chr 7:30,810,816...30,844,852 		JBrowse link
G MRI1 methylthioribose-1-phosphate isomerase 1 involved_in IEA UniProt GO_REF:0000043 NCBI chr 6:12,424,835...12,431,911
Ensembl chr 6:12,425,052...12,431,844 		JBrowse link
G MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:41,590,655...41,663,551
Ensembl chr24:41,590,590...41,666,952 		JBrowse link
G MTHFR methylenetetrahydrofolate reductase acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:15217352) MGI
TreeGrafter		 PMID:15217352 GO_REF:0000118 NCBI chr20:119,987,667...120,003,611
Ensembl chr20:119,990,133...120,002,950 		JBrowse link
G MTR 5-methyltetrahydrofolate-homocysteine methyltransferase involved_in
acts_upstream_of_or_within		 ISO
IEA		 (PMID:11158293) RGD
TreeGrafter
MGI
UniProt
InterPro		 PMID:11158293 PMID:11730351 PMID:15845641 GO_REF:0000002 GO_REF:0000043 GO_REF:0000117 GO_REF:0000118 RGD:1359026 RGD:1601423 NCBI chr25:73,935,666...74,039,872
Ensembl chr25:73,935,225...74,038,741 		JBrowse link
G MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase involved_in IEA UniProt
Ensembl
TreeGrafter		 GO_REF:0000043 GO_REF:0000107 GO_REF:0000118 NCBI chr 4:7,461,521...7,493,032
Ensembl chr 4:7,461,526...7,493,840 		JBrowse link
methionine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MAT1A methionine adenosyltransferase 1A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:51,540,162...51,558,076
Ensembl chr 9:51,540,162...51,558,576 		JBrowse link
methionine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADI1 acireductone dioxygenase 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr14:104,140,027...104,172,782
Ensembl chr14:104,139,952...104,172,271 		JBrowse link
G GNMT glycine N-methyltransferase acts_upstream_of_or_within ISO (PMID:17937387) MGI PMID:17937387 NCBI chr17:29,196,142...29,199,728
Ensembl chr17:29,196,321...29,198,947 		JBrowse link
G MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:41,590,655...41,663,551
Ensembl chr24:41,590,590...41,666,952 		JBrowse link
G MTHFR methylenetetrahydrofolate reductase involved_in IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr20:119,987,667...120,003,611
Ensembl chr20:119,990,133...120,002,950 		JBrowse link
G MTR 5-methyltetrahydrofolate-homocysteine methyltransferase ISO RGD PMID:21121936 RGD:7207080 NCBI chr25:73,935,666...74,039,872
Ensembl chr25:73,935,225...74,038,741 		JBrowse link
threonine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G THNSL2 threonine synthase like 2 NOT|acts_upstream_of_or_within ISO (PMID:17034760) MGI PMID:17034760 NCBI chr14:18,603,376...18,619,711
Ensembl chr14:18,600,437...18,619,762 		JBrowse link
threonine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GCAT glycine C-acetyltransferase involved_in IEA InterPro GO_REF:0000002 NCBI chr19:20,508,082...20,516,911
Ensembl chr19:20,508,506...20,516,732 		JBrowse link
G LOC103215330 L-threonine 3-dehydrogenase, mitochondrial involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 8:7,742,425...7,762,078 JBrowse link
G SDS serine dehydratase involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr11:108,643,198...108,654,927
Ensembl chr11:108,642,694...108,654,620 		JBrowse link
G SDSL serine dehydratase like involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr11:108,673,058...108,693,748
Ensembl chr11:108,673,075...108,693,815 		JBrowse link
threonine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PHGDH phosphoglycerate dehydrogenase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19114063) Ensembl
MGI		 PMID:19114063 GO_REF:0000107 NCBI chr20:14,045,395...14,075,935
Ensembl chr20:14,045,346...14,076,177 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17098
    cellular process 16624
      metabolic process 11180
        primary metabolic process 9998
          amino acid metabolic process 295
            proteinogenic amino acid metabolic process 168
              aspartate family amino acid metabolic process 40
                L-lysine metabolic process + 3
                asparagine metabolic process + 6
                aspartate family amino acid biosynthetic process + 21
                aspartate family amino acid catabolic process + 12
                aspartate metabolic process + 9
                hydroxylysine metabolic process + 2
                methionine metabolic process + 13
                threonine metabolic process + 6
Path 2
Term Annotations click to browse term
  biological_process 17098
    cellular process 16624
      metabolic process 11180
        small molecule metabolic process 1709
          organic acid metabolic process 913
            oxoacid metabolic process 906
              carboxylic acid metabolic process 890
                alpha-amino acid metabolic process 221
                  L-amino acid metabolic process 187
                    aspartate family amino acid metabolic process 40
                      L-lysine metabolic process + 3
                      asparagine metabolic process + 6
                      aspartate family amino acid biosynthetic process + 21
                      aspartate family amino acid catabolic process + 12
                      aspartate metabolic process + 9
                      hydroxylysine metabolic process + 2
                      methionine metabolic process + 13
                      threonine metabolic process + 6
paths to the root