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ONTOLOGY REPORT - ANNOTATIONS


Term:aspartate family amino acid metabolic process
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Accession:GO:0009066 term browser browse the term
Definition:The chemical reactions and pathways involving amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine.
Synonyms:exact_synonym: aspartate family amino acid metabolism



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asparagine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ASNS asparagine synthetase (glutamine-hydrolyzing) involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:21873635)
(PMID:2573597)
GO_Central
MGI
RGD
PMID:2573597 PMID:2887559 PMID:21873635 RGD:2316002 NCBI chr14:22,718,020...22,734,109
Ensembl chr14:22,718,042...22,734,054
JBrowse link
asparagine catabolic process via L-aspartate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ASRGL1 asparaginase and isoaspartyl peptidase 1 acts_upstream_of_or_within
involved_in
ISO PMID:12753071
(PMID:19839645)
MGI
UniProt
PMID:12753071 PMID:19839645 RGD:1299508 NCBI chr18:54,215,920...54,238,094
Ensembl chr18:54,216,926...54,238,059
JBrowse link
asparagine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ASPG asparaginase involved_in ISO PMID:9575212 UniProt PMID:9575212 RGD:1299414 NCBI chr 8:71,747,319...71,764,570
Ensembl chr 8:71,753,164...71,765,349
JBrowse link
G NIT2 nitrilase family member 2 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr33:6,944,340...6,960,540
Ensembl chr33:6,944,374...6,959,074
JBrowse link
aspartate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GOT1 glutamic-oxaloacetic transaminase 1 involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:21873635)
(MGI:53641|PMID:4193185)
GO_Central
MGI
PMID:4193185 PMID:21873635 MGI:53641 NCBI chr28:12,352,658...12,377,960
Ensembl chr28:12,352,659...12,414,579
JBrowse link
G GOT2 glutamic-oxaloacetic transaminase 2 acts_upstream_of_or_within ISO (MGI:53641|PMID:4193185) MGI PMID:4193185 MGI:53641 NCBI chr 2:57,968,833...57,994,219
Ensembl chr 2:57,968,833...57,994,218
JBrowse link
aspartate catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DDO D-aspartate oxidase involved_in ISO (PMID:9163533) UniProt PMID:9163533 NCBI chr12:67,080,646...67,104,429
Ensembl chr12:67,081,329...67,104,397
Ensembl chr12:67,081,329...67,104,397
JBrowse link
G GOT1 glutamic-oxaloacetic transaminase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr28:12,352,658...12,377,960
Ensembl chr28:12,352,659...12,414,579
JBrowse link
G GOT2 glutamic-oxaloacetic transaminase 2 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 2:57,968,833...57,994,219
Ensembl chr 2:57,968,833...57,994,218
JBrowse link
aspartate metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADSS1 adenylosuccinate synthase 1 ISO RGD PMID:3759987 RGD:5135303 NCBI chr 8:72,288,246...72,305,479
Ensembl chr 8:72,288,323...72,305,479
JBrowse link
G ADSS2 adenylosuccinate synthase 2 ISO RGD PMID:71897 RGD:5135533 NCBI chr 7:35,440,250...35,477,470
Ensembl chr 7:35,440,676...35,476,795
JBrowse link
G ASS1 argininosuccinate synthase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:53,425,228...53,478,007
Ensembl chr 9:53,425,448...53,477,904
JBrowse link
G DDO D-aspartate oxidase acts_upstream_of_or_within ISO (MGI:3617951|PMID:16525061) MGI PMID:16525061 MGI:3617951 NCBI chr12:67,080,646...67,104,429
Ensembl chr12:67,081,329...67,104,397
Ensembl chr12:67,081,329...67,104,397
JBrowse link
G GOT1 glutamic-oxaloacetic transaminase 1 ISO RGD PMID:2837211 RGD:2289377 NCBI chr28:12,352,658...12,377,960
Ensembl chr28:12,352,659...12,414,579
JBrowse link
G GOT2 glutamic-oxaloacetic transaminase 2 ISO RGD PMID:12686151 RGD:2289396 NCBI chr 2:57,968,833...57,994,219
Ensembl chr 2:57,968,833...57,994,218
JBrowse link
glutamate catabolic process to aspartate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GOT1 glutamic-oxaloacetic transaminase 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:53641|PMID:4193185) Ensembl
MGI
PMID:4193185 GO_REF:0000107 MGI:53641 NCBI chr28:12,352,658...12,377,960
Ensembl chr28:12,352,659...12,414,579
JBrowse link
G GOT2 glutamic-oxaloacetic transaminase 2 acts_upstream_of_or_within ISO (MGI:53641|PMID:4193185) MGI PMID:4193185 MGI:53641 NCBI chr 2:57,968,833...57,994,219
Ensembl chr 2:57,968,833...57,994,218
JBrowse link
hydroxylysine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PLOD2 procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 involved_in ISO (PMID:10934207) CAFA PMID:10934207 NCBI chr23:41,290,183...41,382,917
Ensembl chr23:41,290,567...41,382,807
JBrowse link
G PLOD3 procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 involved_in ISO (MGI:6202004|PMID:16447251) UniProt PMID:16447251 MGI:6202004 NCBI chr 6:8,664,135...8,671,637
Ensembl chr 6:8,664,358...8,671,620
JBrowse link
L-asparagine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ASNS asparagine synthetase (glutamine-hydrolyzing) involved_in IEA UniProt GO_REF:0000041 NCBI chr14:22,718,020...22,734,109
Ensembl chr14:22,718,042...22,734,054
JBrowse link
L-asparagine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF4 activating transcription factor 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:25,528,880...25,531,018
Ensembl chr10:25,528,874...25,530,993
JBrowse link
L-lysine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AASS aminoadipate-semialdehyde synthase acts_upstream_of_or_within ISO (MGI:1350812|PMID:10567240) MGI PMID:10567240 MGI:1350812 NCBI chr14:59,950,123...59,993,457
Ensembl chr14:59,951,216...60,000,212
JBrowse link
L-lysine catabolic process to acetyl-CoA via L-pipecolate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PIPOX pipecolic acid and sarcosine oxidase involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:43,200,343...43,212,288
Ensembl chr 9:43,200,371...43,212,288
JBrowse link
L-lysine catabolic process to acetyl-CoA via saccharopine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DLST dihydrolipoamide S-succinyltransferase involved_in IEA UniProt GO_REF:0000041 NCBI chr 8:48,003,730...48,025,001
Ensembl chr 8:48,002,211...48,024,999
JBrowse link
L-methionine salvage term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BHMT betaine--homocysteine S-methyltransferase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:27,732,381...27,752,168
Ensembl chr 3:27,734,108...27,752,046
JBrowse link
G BHMT2 betaine--homocysteine S-methyltransferase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:27,775,779...27,804,603
Ensembl chr 3:27,776,084...27,789,960
JBrowse link
L-methionine salvage from methylthioadenosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADI1 acireductone dioxygenase 1 involved_in ISO (PMID:15938715) UniProt PMID:15938715 NCBI chr17:2,087,107...2,095,576 JBrowse link
G APIP APAF1 interacting protein involved_in IBA
IEA
(PMID:21873635) GO_Central
UniProt
PMID:21873635 GO_REF:0000041 NCBI chr18:33,012,049...33,033,453
Ensembl chr18:33,011,121...33,033,435
JBrowse link
G ENOPH1 enolase-phosphatase 1 involved_in ISO (PMID:15843022) UniProt PMID:15843022 NCBI chr32:6,408,778...6,451,606
Ensembl chr32:6,407,460...6,450,790
JBrowse link
L-methionine salvage from S-adenosylmethionine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APIP APAF1 interacting protein involved_in IEA UniProt GO_REF:0000104 NCBI chr18:33,012,049...33,033,453
Ensembl chr18:33,011,121...33,033,435
JBrowse link
lysine biosynthetic process via aminoadipic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 5:26,172,888...26,193,639
Ensembl chr 5:26,169,716...26,193,952
JBrowse link
methionine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BHMT betaine--homocysteine S-methyltransferase acts_upstream_of_or_within ISO (MGI:3510291|PMID:15217352) RGD
MGI
PMID:15217352 PMID:15845641 MGI:3510291 RGD:1359026 NCBI chr 3:27,732,381...27,752,168
Ensembl chr 3:27,734,108...27,752,046
JBrowse link
G MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 involved_in ISO (PMID:25633902) BHF-UCL PMID:25633902 NCBI chr 8:38,831,672...38,889,607
Ensembl chr 8:38,831,860...38,889,453
JBrowse link
G MTHFR methylenetetrahydrofolate reductase acts_upstream_of_or_within ISO (MGI:3510291|PMID:15217352) MGI PMID:15217352 MGI:3510291 NCBI chr 2:84,445,526...84,457,435
Ensembl chr 2:84,380,919...84,536,818
JBrowse link
G MTR 5-methyltetrahydrofolate-homocysteine methyltransferase involved_in
acts_upstream_of_or_within
ISO (PMID:23825108)
(MGI:1930456|PMID:11158293)
RGD
BHF-UCL
MGI
PMID:11158293 PMID:11730351 PMID:15845641 PMID:23825108 MGI:1930456 RGD:1359026 RGD:1601423 NCBI chr 4:3,219,851...3,328,000
Ensembl chr 4:3,215,090...3,328,115
JBrowse link
G MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr34:6,068,572...6,119,580
Ensembl chr34:6,070,046...6,098,312
JBrowse link
methionine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MAT1A methionine adenosyltransferase 1A involved_in ISO (PMID:10677294) UniProt PMID:10677294 NCBI chr 4:29,450,857...29,467,251
Ensembl chr 4:29,452,601...29,466,929
JBrowse link
methionine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GNMT glycine N-methyltransferase acts_upstream_of_or_within ISO (MGI:3842675|PMID:17937387) MGI PMID:17937387 MGI:3842675 NCBI chr12:11,500,363...11,503,075
Ensembl chr12:11,500,392...11,503,481
JBrowse link
G MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 involved_in ISO (MGI:5621260|PMID:23190757) BHF-UCL PMID:23190757 MGI:5621260 NCBI chr 8:38,831,672...38,889,607
Ensembl chr 8:38,831,860...38,889,453
JBrowse link
G MTHFR methylenetetrahydrofolate reductase involved_in ISO (PMID:10551815) BHF-UCL PMID:10551815 NCBI chr 2:84,445,526...84,457,435
Ensembl chr 2:84,380,919...84,536,818
JBrowse link
G MTR 5-methyltetrahydrofolate-homocysteine methyltransferase ISO RGD PMID:21121936 RGD:7207080 NCBI chr 4:3,219,851...3,328,000
Ensembl chr 4:3,215,090...3,328,115
JBrowse link
threonine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G THNSL2 threonine synthase like 2 NOT|acts_upstream_of_or_within ISO (MGI:3690523|PMID:17034760) MGI PMID:17034760 MGI:3690523 NCBI chr17:38,196,605...38,212,624
Ensembl chr17:38,191,494...38,212,809
JBrowse link
threonine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC477365 L-threonine 3-dehydrogenase, mitochondrial acts_upstream_of_or_within
involved_in
ISO (MGI:5292271|PMID:21896756)
(MGI:5905531|PMID:26492815)
MGI
UniProt
PMID:21896756 PMID:26492815 MGI:5292271 MGI:5905531 NCBI chr25:26,541,717...26,560,366 JBrowse link
G LOC491550 probable low-specificity L-threonine aldolase 2 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:2,909,869...2,917,921 JBrowse link
G SDSL serine dehydratase like involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr26:10,731,972...10,759,768
Ensembl chr26:10,743,947...10,759,777
JBrowse link
threonine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PHGDH phosphoglycerate dehydrogenase acts_upstream_of_or_within ISO (MGI:3835979|PMID:19114063) MGI PMID:19114063 MGI:3835979 NCBI chr17:56,806,912...56,833,765 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 13969
    metabolic process 9103
      primary metabolic process 7996
        cellular amino acid metabolic process 222
          alpha-amino acid metabolic process 163
            aspartate family amino acid metabolic process 33
              asparagine metabolic process + 5
              aspartate family amino acid biosynthetic process + 16
              aspartate family amino acid catabolic process + 11
              aspartate metabolic process + 6
              hydroxylysine metabolic process + 2
              lysine metabolic process + 4
              methionine metabolic process + 11
              threonine metabolic process + 5
Path 2
Term Annotations click to browse term
  biological_process 13969
    metabolic process 9103
      cellular metabolic process 8264
        organic acid metabolic process 775
          oxoacid metabolic process 750
            carboxylic acid metabolic process 735
              cellular amino acid metabolic process 222
                alpha-amino acid metabolic process 163
                  aspartate family amino acid metabolic process 33
                    asparagine metabolic process + 5
                    aspartate family amino acid biosynthetic process + 16
                    aspartate family amino acid catabolic process + 11
                    aspartate metabolic process + 6
                    hydroxylysine metabolic process + 2
                    lysine metabolic process + 4
                    methionine metabolic process + 11
                    threonine metabolic process + 5
paths to the root