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ONTOLOGY REPORT - ANNOTATIONS

Term:aspartate family amino acid metabolic process
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Accession:GO:0009066 term browser browse the term
Definition:The chemical reactions and pathways involving amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine.
Synonyms:exact_synonym: aspartate family amino acid metabolism


show annotations for term's descendants           Sort by:
aspartate family amino acid metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ASPG asparaginase involved_in IEA UniProt GO_REF:0000117 NCBI chr 8:71,747,319...71,764,570
Ensembl chr 8:71,753,164...71,765,349 		JBrowse link
'de novo' L-methionine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BHMT betaine--homocysteine S-methyltransferase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:27,732,381...27,752,168
Ensembl chr 3:27,734,108...27,752,046 		JBrowse link
asparagine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ASNS asparagine synthetase (glutamine-hydrolyzing) involved_in
acts_upstream_of_or_within		 ISO
IEA		 (PMID:2573597) RGD
UniProt
InterPro
MGI		 PMID:2573597 PMID:2887559 GO_REF:0000002 GO_REF:0000043 RGD:2316002 NCBI chr14:22,718,020...22,734,109
Ensembl chr14:22,718,042...22,734,054 		JBrowse link
G ASNSD1 asparagine synthetase domain containing 1 involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000043 NCBI chr37:426,366...430,668
Ensembl chr37:426,367...439,619 		JBrowse link
asparagine catabolic process via L-aspartate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ASRGL1 asparaginase and isoaspartyl peptidase 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 PMID:12753071 MGI
Ensembl		 PMID:12753071 GO_REF:0000107 RGD:1299508 NCBI chr18:54,215,920...54,238,094
Ensembl chr18:54,216,926...54,238,059 		JBrowse link
G SCGB1A1 secretoglobin family 1A member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:54,187,487...54,191,493
Ensembl chr18:54,187,487...54,191,482 		JBrowse link
asparagine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ASPG asparaginase involved_in ISO PMID:9575212 UniProt PMID:9575212 RGD:1299414 NCBI chr 8:71,747,319...71,764,570
Ensembl chr 8:71,753,164...71,765,349 		JBrowse link
G NIT2 nitrilase family member 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr33:6,944,340...6,960,540
Ensembl chr33:6,944,374...6,959,074 		JBrowse link
aspartate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GOT1 glutamic-oxaloacetic transaminase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:4193185) Ensembl
MGI		 PMID:4193185 GO_REF:0000107 NCBI chr28:12,352,658...12,377,960
Ensembl chr28:12,352,659...12,414,579 		JBrowse link
G GOT2 glutamic-oxaloacetic transaminase 2 acts_upstream_of_or_within ISO (PMID:4193185) MGI PMID:4193185 NCBI chr 2:57,968,833...57,994,219
Ensembl chr 2:57,968,833...57,994,218 		JBrowse link
aspartate catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DDO D-aspartate oxidase involved_in ISO (PMID:9163533) UniProt PMID:9163533 NCBI chr12:67,080,646...67,104,429
Ensembl chr12:67,081,329...67,104,397
Ensembl chr12:67,081,329...67,104,397 		JBrowse link
G GOT1 glutamic-oxaloacetic transaminase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr28:12,352,658...12,377,960
Ensembl chr28:12,352,659...12,414,579 		JBrowse link
G GOT2 glutamic-oxaloacetic transaminase 2 involved_in ISO (PMID:2567216) UniProt PMID:2567216 NCBI chr 2:57,968,833...57,994,219
Ensembl chr 2:57,968,833...57,994,218 		JBrowse link
aspartate metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADSS1 adenylosuccinate synthase 1 ISO RGD PMID:3759987 RGD:5135303 NCBI chr 8:72,288,246...72,305,479
Ensembl chr 8:72,288,323...72,305,479 		JBrowse link
G ADSS2 adenylosuccinate synthase 2 ISO RGD PMID:71897 RGD:5135533 NCBI chr 7:35,440,250...35,477,470
Ensembl chr 7:35,440,676...35,476,795 		JBrowse link
G ASPA aspartoacylase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:47,338,435...47,361,974
Ensembl chr 9:47,343,120...47,360,914 		JBrowse link
G ASS1 argininosuccinate synthase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:53,425,228...53,478,007
Ensembl chr 9:53,425,448...53,477,904 		JBrowse link
G DDO D-aspartate oxidase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16525061) Ensembl
MGI		 PMID:16525061 GO_REF:0000107 NCBI chr12:67,080,646...67,104,429
Ensembl chr12:67,081,329...67,104,397
Ensembl chr12:67,081,329...67,104,397 		JBrowse link
G GOT1 glutamic-oxaloacetic transaminase 1 ISO RGD PMID:2837211 RGD:2289377 NCBI chr28:12,352,658...12,377,960
Ensembl chr28:12,352,659...12,414,579 		JBrowse link
G GOT2 glutamic-oxaloacetic transaminase 2 ISO RGD PMID:12686151 RGD:2289396 NCBI chr 2:57,968,833...57,994,219
Ensembl chr 2:57,968,833...57,994,218 		JBrowse link
G NAT8L N-acetyltransferase 8 like involved_in ISO (PMID:28077719) MGI PMID:28077719 NCBI chr 3:62,107,060...62,113,807
Ensembl chr 3:62,108,003...62,113,737 		JBrowse link
glutamate catabolic process to aspartate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GOT1 glutamic-oxaloacetic transaminase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:4193185) Ensembl
MGI		 PMID:4193185 GO_REF:0000107 NCBI chr28:12,352,658...12,377,960
Ensembl chr28:12,352,659...12,414,579 		JBrowse link
G GOT2 glutamic-oxaloacetic transaminase 2 acts_upstream_of_or_within ISO (PMID:4193185) MGI PMID:4193185 NCBI chr 2:57,968,833...57,994,219
Ensembl chr 2:57,968,833...57,994,218 		JBrowse link
hydroxylysine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PLOD2 procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:41,290,183...41,382,917
Ensembl chr23:41,290,567...41,382,807 		JBrowse link
G PLOD3 procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:8,664,135...8,671,637
Ensembl chr 6:8,664,358...8,671,620 		JBrowse link
L-asparagine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ASNS asparagine synthetase (glutamine-hydrolyzing) involved_in IEA UniProt GO_REF:0000041 NCBI chr14:22,718,020...22,734,109
Ensembl chr14:22,718,042...22,734,054 		JBrowse link
L-asparagine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF4 activating transcription factor 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:25,528,880...25,531,018
Ensembl chr10:25,528,874...25,530,993 		JBrowse link
L-lysine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AASS aminoadipate-semialdehyde synthase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10567240) Ensembl
MGI		 PMID:10567240 GO_REF:0000107 NCBI chr14:59,950,123...59,993,457
Ensembl chr14:59,951,216...60,000,212 		JBrowse link
L-lysine catabolic process to acetyl-CoA via L-pipecolate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PIPOX pipecolic acid and sarcosine oxidase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:43,200,343...43,212,288
Ensembl chr 9:43,200,371...43,212,288 		JBrowse link
L-lysine catabolic process to acetyl-CoA via saccharopine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AASS aminoadipate-semialdehyde synthase involved_in IEA UniProt GO_REF:0000041 NCBI chr14:59,950,123...59,993,457
Ensembl chr14:59,951,216...60,000,212 		JBrowse link
G DLST dihydrolipoamide S-succinyltransferase involved_in IEA UniProt GO_REF:0000041 NCBI chr 8:48,003,730...48,025,001
Ensembl chr 8:48,002,211...48,024,999 		JBrowse link
L-methionine salvage term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BHMT betaine--homocysteine S-methyltransferase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:27,732,381...27,752,168
Ensembl chr 3:27,734,108...27,752,046 		JBrowse link
G BHMT2 betaine--homocysteine S-methyltransferase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:27,775,779...27,804,603
Ensembl chr 3:27,776,084...27,789,960 		JBrowse link
L-methionine salvage from methylthioadenosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADI1 acireductone dioxygenase 1 involved_in IEA UniProt
InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000041 GO_REF:0000104 GO_REF:0000107 NCBI chr17:2,087,107...2,095,576 JBrowse link
G APIP APAF1 interacting protein involved_in IEA InterPro
UniProt		 GO_REF:0000002 GO_REF:0000041 NCBI chr18:33,012,049...33,033,453
Ensembl chr18:33,011,121...33,033,435 		JBrowse link
G ENOPH1 enolase-phosphatase 1 involved_in IEA InterPro
Ensembl
UniProt		 GO_REF:0000002 GO_REF:0000041 GO_REF:0000107 NCBI chr32:6,408,778...6,451,606
Ensembl chr32:6,407,460...6,450,790 		JBrowse link
G MRI1 methylthioribose-1-phosphate isomerase 1 involved_in IEA UniProt GO_REF:0000041 NCBI chr20:48,648,987...48,658,231
Ensembl chr20:48,653,152...48,658,160 		JBrowse link
G MTAP methylthioadenosine phosphorylase involved_in IEA UniProt GO_REF:0000041 GO_REF:0000104 NCBI chr11:41,148,389...41,200,635
Ensembl chr11:41,148,404...41,264,504 		JBrowse link
L-methionine salvage from S-adenosylmethionine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APIP APAF1 interacting protein involved_in IEA UniProt GO_REF:0000104 NCBI chr18:33,012,049...33,033,453
Ensembl chr18:33,011,121...33,033,435 		JBrowse link
G ENOPH1 enolase-phosphatase 1 involved_in IEA UniProt GO_REF:0000104 NCBI chr32:6,408,778...6,451,606
Ensembl chr32:6,407,460...6,450,790 		JBrowse link
G MRI1 methylthioribose-1-phosphate isomerase 1 involved_in IEA UniProt GO_REF:0000104 NCBI chr20:48,648,987...48,658,231
Ensembl chr20:48,653,152...48,658,160 		JBrowse link
methionine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADI1 acireductone dioxygenase 1 involved_in IEA UniProt GO_REF:0000043 NCBI chr17:2,087,107...2,095,576 JBrowse link
G APIP APAF1 interacting protein involved_in IEA UniProt GO_REF:0000043 NCBI chr18:33,012,049...33,033,453
Ensembl chr18:33,011,121...33,033,435 		JBrowse link
G BHMT betaine--homocysteine S-methyltransferase acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:15217352) RGD
MGI
InterPro		 PMID:15217352 PMID:15845641 GO_REF:0000002 RGD:1359026 NCBI chr 3:27,732,381...27,752,168
Ensembl chr 3:27,734,108...27,752,046 		JBrowse link
G BHMT2 betaine--homocysteine S-methyltransferase 2 involved_in IEA InterPro GO_REF:0000002 NCBI chr 3:27,775,779...27,804,603
Ensembl chr 3:27,776,084...27,789,960 		JBrowse link
G ENOPH1 enolase-phosphatase 1 involved_in IEA UniProt GO_REF:0000043 NCBI chr32:6,408,778...6,451,606
Ensembl chr32:6,407,460...6,450,790 		JBrowse link
G MRI1 methylthioribose-1-phosphate isomerase 1 involved_in IEA UniProt GO_REF:0000043 NCBI chr20:48,648,987...48,658,231
Ensembl chr20:48,653,152...48,658,160 		JBrowse link
G MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 involved_in ISO (PMID:25633902) BHF-UCL PMID:25633902 NCBI chr 8:38,831,672...38,889,607
Ensembl chr 8:38,831,860...38,889,453 		JBrowse link
G MTHFR methylenetetrahydrofolate reductase acts_upstream_of_or_within ISO (PMID:15217352) MGI PMID:15217352 NCBI chr 2:84,445,526...84,457,435
Ensembl chr 2:84,380,919...84,536,818 		JBrowse link
G MTR 5-methyltetrahydrofolate-homocysteine methyltransferase acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:11158293) RGD
MGI
Ensembl
InterPro
UniProt		 PMID:11158293 PMID:11730351 PMID:15845641 GO_REF:0000002 GO_REF:0000043 GO_REF:0000107 RGD:1359026 RGD:1601423 NCBI chr 4:3,219,851...3,328,000
Ensembl chr 4:3,215,090...3,328,115 		JBrowse link
G MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase involved_in IEA Ensembl
UniProt		 GO_REF:0000043 GO_REF:0000107 NCBI chr34:6,068,572...6,119,580
Ensembl chr34:6,070,046...6,098,312 		JBrowse link
methionine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MAT1A methionine adenosyltransferase 1A involved_in ISO (PMID:10677294) UniProt PMID:10677294 NCBI chr 4:29,450,857...29,467,251
Ensembl chr 4:29,452,601...29,466,929 		JBrowse link
methionine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GNMT glycine N-methyltransferase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17937387) Ensembl
MGI		 PMID:17937387 GO_REF:0000107 NCBI chr12:11,500,363...11,503,075
Ensembl chr12:11,500,392...11,503,481 		JBrowse link
G MTHFD1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 involved_in ISO (MGI:5621260|PMID:23190757)
(PMID:23190757)		 BHF-UCL PMID:23190757 MGI:5621260 NCBI chr 8:38,831,672...38,889,607
Ensembl chr 8:38,831,860...38,889,453 		JBrowse link
G MTHFR methylenetetrahydrofolate reductase involved_in IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chr 2:84,445,526...84,457,435
Ensembl chr 2:84,380,919...84,536,818 		JBrowse link
G MTR 5-methyltetrahydrofolate-homocysteine methyltransferase ISO RGD PMID:21121936 RGD:7207080 NCBI chr 4:3,219,851...3,328,000
Ensembl chr 4:3,215,090...3,328,115 		JBrowse link
threonine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G THNSL2 threonine synthase like 2 NOT|acts_upstream_of_or_within ISO (PMID:17034760) MGI PMID:17034760 NCBI chr17:38,196,605...38,212,624
Ensembl chr17:38,191,494...38,212,809 		JBrowse link
threonine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GCAT glycine C-acetyltransferase involved_in IEA InterPro GO_REF:0000002 NCBI chr10:26,821,121...26,827,496
Ensembl chr10:26,821,027...26,827,707 		JBrowse link
G TDH L-threonine dehydrogenase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21896756) Ensembl
MGI		 PMID:21896756 GO_REF:0000107 NCBI chr25:26,541,717...26,560,366 JBrowse link
threonine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PHGDH phosphoglycerate dehydrogenase acts_upstream_of_or_within ISO (PMID:19114063) MGI PMID:19114063 NCBI chr17:56,806,912...56,833,765 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17088
    cellular process 16614
      metabolic process 10876
        primary metabolic process 9596
          amino acid metabolic process 292
            proteinogenic amino acid metabolic process 168
              aspartate family amino acid metabolic process 37
                L-lysine metabolic process + 3
                asparagine metabolic process + 7
                aspartate family amino acid biosynthetic process + 18
                aspartate family amino acid catabolic process + 11
                aspartate metabolic process + 8
                hydroxylysine metabolic process + 2
                methionine metabolic process + 13
                threonine metabolic process + 4
Path 2
Term Annotations click to browse term
  biological_process 17088
    cellular process 16614
      metabolic process 10876
        small molecule metabolic process 1704
          organic acid metabolic process 906
            oxoacid metabolic process 899
              carboxylic acid metabolic process 884
                alpha-amino acid metabolic process 209
                  L-amino acid metabolic process 184
                    aspartate family amino acid metabolic process 37
                      L-lysine metabolic process + 3
                      asparagine metabolic process + 7
                      aspartate family amino acid biosynthetic process + 18
                      aspartate family amino acid catabolic process + 11
                      aspartate metabolic process + 8
                      hydroxylysine metabolic process + 2
                      methionine metabolic process + 13
                      threonine metabolic process + 4
paths to the root