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ONTOLOGY REPORT - ANNOTATIONS

Term:methionine synthase activity
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Accession:GO:0008705 term browser browse the term
Definition:Catalysis of the reaction: (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine.
Synonyms:related_synonym: 5-methyltetrahydrofolate--homocysteine S-methyltransferase activity;   5-methyltetrahydrofolate--homocysteine transmethylase activity;   5-methyltetrahydrofolate:L-homocysteine S-methyltransferase activity;   B12 N(5)-methyltetrahydrofolate homocysteine methyltransferase activity;   B12 N5-methyltetrahydrofolate homocysteine methyltransferase activity;   MetH;   N(5)-methyltetrahydrofolate methyltransferase activity;   N(5)-methyltetrahydrofolate--homocysteine cobalamin methyltransferase activity;   N(5)-methyltetrahydrofolic--homocysteine vitamin B12 transmethylase activity;   N-methyltetrahydrofolate:L-homocysteine methyltransferase activity;   N5-methyltetrahydrofolate methyltransferase activity;   N5-methyltetrahydrofolate-homocysteine cobalamin methyltransferase activity;   N5-methyltetrahydrofolic-homocysteine vitamin B12 transmethylase activity;   cobalamin-dependent methionine synthase activity;   methyltetrahydrofolate--homocysteine vitamin B12 methyltransferase activity;   tetrahydrofolate methyltransferase activity;   tetrahydropteroylglutamate methyltransferase activity;   tetrahydropteroylglutamic methyltransferase activity;   vitamin B12 methyltransferase activity
 xref: EC:2.1.1.13;   KEGG_REACTION:R00946;   MetaCyc:HOMOCYSMETB12-RXN;   RHEA:11172;   Reactome:R-HSA-3149539 "MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin";   reactome:R-HSA-174374 "MTR transfers CH3 from MeCbl to HCYS"


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methionine synthase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase enables IDA
IMP
ISO
IBA		 PMID:20424322
(PMID:16769880), (PMID:23825108)
GO_REF:0000033
MGI:2180496 (PMID:11158293)		 RGD
GO_Central		 PMID:11158293 PMID:16769880 PMID:23825108 PMID:9972236 PMID:11730351 More... GO_REF:0000033, RGD:633492, RGD:1601423, RGD:7207080, RGD:10054082 NCBI chr17:62,911,705...62,996,544
Ensembl chr17:58,220,071...58,304,822 		JBrowse link
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Term Annotations click to browse term
  molecular_function 21091
    catalytic activity 6174
      transferase activity 2443
        transferase activity, transferring one-carbon groups 214
          methyltransferase activity 203
            5-methyltetrahydrofolate-dependent methyltransferase activity 1
              methionine synthase activity 1
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