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ONTOLOGY REPORT - ANNOTATIONS

Term:apoptotic mitochondrial changes
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Accession:GO:0008637 term browser browse the term
Definition:The morphological and physiological alterations undergone by mitochondria during apoptosis.
Comment:This term was created to reflect the fundamental role of the mitochondrial compartment in apoptosis. Most processes under this node occur during the signaling phase of apoptosis, but e.g. GO:0043653 'mitochondrial fragmentation involved in apoptotic process' cannot be confidently placed under the signaling phase. For this reason, the parent term GO:0008637 'apoptotic mitochondrial changes' is not linked to the signaling or execution phase specifically, but its descendants are when current knowledge allows for it.

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apoptotic mitochondrial changes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm2 AIF family member 2 involved_in
acts_upstream_of_or_within 		IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936521:8,466,089...8,474,198
Ensembl chrNW_004936521:8,466,086...8,474,198 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936621:620,163...639,115
Ensembl chrNW_004936621:620,074...639,093 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member ISO RGD PMID:30131474 RGD:15036798 NCBI chrNW_004936558:4,362,693...4,387,705
Ensembl chrNW_004936558:4,362,654...4,390,414 		JBrowse link
G Atp2a1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936501:11,818,301...11,836,221
Ensembl chrNW_004936501:11,816,585...11,836,231 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator involved_in
acts_upstream_of_or_within 		IEA Ensembl GO_REF:0000107 NCBI chrNW_004936664:2,968,103...2,973,652
Ensembl chrNW_004936664:2,967,865...2,973,820 		JBrowse link
G Bcl2 BCL2 apoptosis regulator acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936497:2,209,136...2,373,580
Ensembl chrNW_004936497:2,210,334...2,210,921 		JBrowse link
G Bid BH3 interacting domain death agonist involved_in IEA UniProt
TreeGrafter		 GO_REF:0000104 GO_REF:0000118 NCBI chrNW_004936807:708,340...750,127
Ensembl chrNW_004936807:708,276...750,093 		JBrowse link
G Bik BCL2 interacting killer acts_upstream_of_or_within ISO (PMID:9525867) MGI PMID:9525867
G Dap3 death associated protein 3 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936580:4,996,703...5,032,203
Ensembl chrNW_004936580:4,997,969...5,031,956 		JBrowse link
G Hk2 hexokinase 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936556:1,054,143...1,113,425
Ensembl chrNW_004936556:1,054,021...1,113,450 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 ISO RGD PMID:21854881 RGD:10402841 NCBI chrNW_004936506:1,678,069...1,687,632 JBrowse link
G Jtb jumping translocation breakpoint acts_upstream_of_or_within ISO (PMID:17369841) MGI PMID:17369841 NCBI chrNW_004936580:3,720,252...3,722,375
Ensembl chrNW_004936580:3,720,252...3,722,358 		JBrowse link
G LOC101977655 glutamate--cysteine ligase regulatory subunit acts_upstream_of_or_within ISO (PMID:15288121) MGI PMID:15288121 NCBI chrNW_004936537:5,356,914...5,378,998
Ensembl chrNW_004936537:5,356,914...5,376,138 		JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 acts_upstream_of_or_within ISO (PMID:15882989) MGI PMID:15882989 NCBI chrNW_004936480:11,082,811...11,156,691
Ensembl chrNW_004936480:11,083,605...11,156,691 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member acts_upstream_of_or_within ISO (PMID:19919825) MGI PMID:19919825 NCBI chrNW_004936580:803,452...806,966
Ensembl chrNW_004936580:804,903...806,796 		JBrowse link
G Pim2 Pim-2 proto-oncogene, serine/threonine kinase acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936721:839,876...844,488
Ensembl chrNW_004936721:839,874...844,488 		JBrowse link
G Ppif peptidylprolyl isomerase F acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936521:404,574...411,381
Ensembl chrNW_004936521:404,544...411,539 		JBrowse link
G Ppp2cb protein phosphatase 2 catalytic subunit beta acts_upstream_of_or_within ISO (PMID:16717086) MGI PMID:16717086 NCBI chrNW_004936792:622,105...633,800
Ensembl chrNW_004936792:622,166...633,335 		JBrowse link
G Rnf7 ring finger protein 7 acts_upstream_of_or_within ISO (PMID:10082581) MGI PMID:10082581 NCBI chrNW_004936540:3,484,422...3,491,162
Ensembl chrNW_004936540:3,484,053...3,491,162 		JBrowse link
G Slc25a4 solute carrier family 25 member 4 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936554:4,130,461...4,135,046
Ensembl chrNW_004936554:4,130,459...4,135,044 		JBrowse link
G Sod2 superoxide dismutase 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936489:11,178,338...11,191,601
Ensembl chrNW_004936489:11,178,015...11,191,781 		JBrowse link
mitochondrial fragmentation involved in apoptotic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg3 autophagy related 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936536:232,343...257,949
Ensembl chrNW_004936536:232,192...257,954 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936664:2,968,103...2,973,652
Ensembl chrNW_004936664:2,967,865...2,973,820 		JBrowse link
G Bnip3 BCL2 interacting protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936486:18,449,371...18,460,435
Ensembl chrNW_004936486:18,448,494...18,455,927 		JBrowse link
G Ccar2 cell cycle and apoptosis regulator 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936555:6,341,455...6,356,677
Ensembl chrNW_004936555:6,341,390...6,356,668 		JBrowse link
G Dnm1l dynamin 1 like involved_in ISO
IEA 		RGD
UniProt
TreeGrafter
Ensembl		 PMID:17443673 GO_REF:0000107 GO_REF:0000117 GO_REF:0000118 RGD:12738363 NCBI chrNW_004936607:3,576,357...3,632,423
Ensembl chrNW_004936607:3,576,392...3,632,554 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936586:4,065,767...5,100,690
Ensembl chrNW_004936586:4,066,498...5,100,035 		JBrowse link
G Fis1 fission, mitochondrial 1 involved_in ISO
IEA 		RGD
TreeGrafter		 PMID:18940801 GO_REF:0000118 RGD:2314538 NCBI chrNW_004936543:1,112,746...1,116,521
Ensembl chrNW_004936543:1,112,742...1,116,518 		JBrowse link
G Nptx1 neuronal pentraxin 1 ISO RGD PMID:22279230 RGD:6903322 NCBI chrNW_004936594:4,373,500...4,384,394
Ensembl chrNW_004936594:4,373,473...4,384,461 		JBrowse link
G Ppp2r2b protein phosphatase 2 regulatory subunit Bbeta ISO RGD PMID:18940801 RGD:2314538 NCBI chrNW_004936504:7,655,924...8,097,125
Ensembl chrNW_004936504:7,656,298...8,097,276 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase ISO RGD PMID:28761318 RGD:13432138 NCBI chrNW_004936489:12,118,538...12,913,664
Ensembl chrNW_004936489:12,120,678...13,327,872 		JBrowse link
G Ptpmt1 protein tyrosine phosphatase mitochondrial 1 involved_in ISO (PMID:39279645) UniProt PMID:39279645 NCBI chrNW_004936562:1,680,131...1,689,125
Ensembl chrNW_004936562:1,680,164...1,690,062 		JBrowse link
G Vps35 VPS35 retromer complex component involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936475:50,476...77,797
Ensembl chrNW_004936475:50,321...78,097 		JBrowse link
mitochondrial outer membrane permeabilization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bid BH3 interacting domain death agonist acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936807:708,340...750,127
Ensembl chrNW_004936807:708,276...750,093 		JBrowse link
G Bloc1s2 biogenesis of lysosomal organelles complex 1 subunit 2 involved_in ISO (PMID:18188704) UniProt PMID:18188704 NCBI chrNW_004939661:2,128...6,384 JBrowse link
G Bnip3 BCL2 interacting protein 3 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936486:18,449,371...18,460,435
Ensembl chrNW_004936486:18,448,494...18,455,927 		JBrowse link
G Bnip3l BCL2 interacting protein 3 like involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936757:499,485...523,494
Ensembl chrNW_004936757:499,147...523,541 		JBrowse link
G Eya2 EYA transcriptional coactivator and phosphatase 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936514:6,223,745...6,401,985
Ensembl chrNW_004936514:6,223,719...6,341,326 		JBrowse link
G Rhot1 ras homolog family member T1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936538:2,658,225...2,725,889
Ensembl chrNW_004936538:2,658,172...2,726,092 		JBrowse link
G Rhot2 ras homolog family member T2 involved_in ISO (PMID:12482879) UniProt PMID:12482879 NCBI chrNW_004936501:336,506...341,671 JBrowse link
G Rtl10 retrotransposon Gag like 10 involved_in ISO (PMID:23055042) UniProt PMID:23055042 NCBI chrNW_004936619:3,755,537...3,760,909 JBrowse link
G Vdac2 voltage dependent anion channel 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936521:4,122,447...4,136,228
Ensembl chrNW_004936521:4,122,270...4,136,380 		JBrowse link
negative regulation of mitochondrial membrane permeability involved in apoptotic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaa2 acetyl-CoA acyltransferase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936497:13,242,644...13,269,007
Ensembl chrNW_004936497:13,242,644...13,269,532 		JBrowse link
G Bnip3 BCL2 interacting protein 3 ISO RGD PMID:17980495 RGD:11561965 NCBI chrNW_004936486:18,449,371...18,460,435
Ensembl chrNW_004936486:18,448,494...18,455,927 		JBrowse link
G Nol3 nucleolar protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936475:17,644,299...17,648,213
Ensembl chrNW_004936475:17,644,653...17,648,211 		JBrowse link
G Slc25a4 solute carrier family 25 member 4 ISO RGD PMID:22564366 RGD:9681467 NCBI chrNW_004936554:4,130,461...4,135,046
Ensembl chrNW_004936554:4,130,459...4,135,044 		JBrowse link
negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaa2 acetyl-CoA acyltransferase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936497:13,242,644...13,269,007
Ensembl chrNW_004936497:13,242,644...13,269,532 		JBrowse link
G Bak1 BCL2 antagonist/killer 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936476:25,347,608...25,354,772
Ensembl chrNW_004936476:25,347,545...25,355,789 		JBrowse link
G Bcl2l1 BCL2 like 1 involved_in ISO (PMID:15901672), (PMID:9393856) ComplexPortal PMID:9393856 PMID:15901672 NCBI chrNW_004936485:18,654,046...18,707,324
Ensembl chrNW_004936485:18,654,003...18,707,339 		JBrowse link
G Bok BCL2 family apoptosis regulator BOK involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936745:344,837...350,950
Ensembl chrNW_004936745:345,635...351,749 		JBrowse link
G Ckmt1a creatine kinase, mitochondrial 1A involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936471:6,754,514...6,760,025
Ensembl chrNW_004936471:6,753,305...6,760,430 		JBrowse link
G Gclc glutamate-cysteine ligase catalytic subunit acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936476:7,371,270...7,418,756
Ensembl chrNW_004936476:7,371,149...7,418,958 		JBrowse link
G Ier3 immediate early response 3 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936837:401,475...402,769
Ensembl chrNW_004936837:401,524...402,741 		JBrowse link
G LOC101955831 heat shock 70 kDa protein 1 involved_in ISO (PMID:20625543) ParkinsonsUK-UCL PMID:20625543 NCBI chrNW_004936727:1,718,952...1,721,691
Ensembl chrNW_004936727:1,719,317...1,721,242 		JBrowse link
G LOC101956126 heat shock 70 kDa protein 1 involved_in ISO (PMID:20625543) ParkinsonsUK-UCL PMID:20625543 NCBI chrNW_004936727:1,732,323...1,735,128
Ensembl chrNW_004936727:1,733,018...1,734,943 		JBrowse link
G Mpv17l MPV17 mitochondrial inner membrane protein like involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936501:3,017,071...3,028,294
Ensembl chrNW_004936501:3,017,012...3,027,181 		JBrowse link
G Slc25a31 solute carrier family 25 member 31 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936642:2,921,629...2,945,577
Ensembl chrNW_004936642:2,921,852...3,025,083 		JBrowse link
G Slc25a4 solute carrier family 25 member 4 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936554:4,130,461...4,135,046
Ensembl chrNW_004936554:4,130,459...4,135,044 		JBrowse link
G Slc25a5 solute carrier family 25 member 5 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936479:10,432,172...10,435,154
Ensembl chrNW_004936479:10,430,984...10,435,269 		JBrowse link
G Slc25a6 solute carrier family 25 member 6 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936644:3,793,434...3,795,182
Ensembl chrNW_004936644:3,792,919...3,796,788 		JBrowse link
G Slc35f6 solute carrier family 35 member F6 involved_in IEA UniProt
Ensembl		 GO_REF:0000104 GO_REF:0000107 NCBI chrNW_004936493:5,731,106...5,747,270
Ensembl chrNW_004936493:5,731,058...5,760,987 		JBrowse link
G Tmem14a transmembrane protein 14A involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936476:8,179,949...8,198,204
Ensembl chrNW_004936476:8,180,141...8,185,884 		JBrowse link
negative regulation of release of cytochrome c from mitochondria term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936621:620,163...639,115
Ensembl chrNW_004936621:620,074...639,093 		JBrowse link
G Arrb2 arrestin beta 2 ISO RGD PMID:19171933 RGD:5510006 NCBI chrNW_004936677:3,173,054...3,181,475
Ensembl chrNW_004936677:3,172,925...3,181,520 		JBrowse link
G Bak1 BCL2 antagonist/killer 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936476:25,347,608...25,354,772
Ensembl chrNW_004936476:25,347,545...25,355,789 		JBrowse link
G Bcl2l1 BCL2 like 1 involved_in ISO (PMID:15901672), (PMID:9393856) ComplexPortal PMID:9393856 PMID:15901672 NCBI chrNW_004936485:18,654,046...18,707,324
Ensembl chrNW_004936485:18,654,003...18,707,339 		JBrowse link
G Fxn frataxin involved_in ISO (PMID:16608849) UniProt PMID:16608849 NCBI chrNW_004936503:5,323,206...5,343,228 JBrowse link
G Ghitm growth hormone inducible transmembrane protein involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936767:769,189...782,279
Ensembl chrNW_004936767:769,155...785,899 		JBrowse link
G Gpx1 glutathione peroxidase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936529:997,943...999,123
Ensembl chrNW_004936529:998,150...998,987 		JBrowse link
G Hgf hepatocyte growth factor involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936734:354,798...428,356
Ensembl chrNW_004936734:356,115...428,779 		JBrowse link
G Higd1a HIG1 hypoxia inducible domain family member 1A acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936695:2,330,939...2,341,387
Ensembl chrNW_004936695:2,330,465...2,341,681 		JBrowse link
G Igf1 insulin like growth factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936492:11,709,623...11,784,028
Ensembl chrNW_004936492:11,709,222...11,778,351 		JBrowse link
G Lmna lamin A/C acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936580:5,374,208...5,395,442
Ensembl chrNW_004936580:5,373,974...5,395,468 		JBrowse link
G LOC101955831 heat shock 70 kDa protein 1 ISO RGD PMID:16397188 RGD:1626654 NCBI chrNW_004936727:1,718,952...1,721,691
Ensembl chrNW_004936727:1,719,317...1,721,242 		JBrowse link
G Mfn2 mitofusin 2 ISO RGD PMID:18006463 RGD:12738362 NCBI chrNW_004936474:767,754...795,258
Ensembl chrNW_004936474:767,671...796,556 		JBrowse link
G Nol3 nucleolar protein 3 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936475:17,644,299...17,648,213
Ensembl chrNW_004936475:17,644,653...17,648,211 		JBrowse link
G Opa1 OPA1 mitochondrial dynamin like GTPase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936711:1,027,531...1,113,796
Ensembl chrNW_004936711:1,032,935...1,106,847 		JBrowse link
G Pam16 presequence translocase associated motor 16 ISO RGD PMID:24069394 RGD:13462066 NCBI chrNW_004936694:153,958...161,635
Ensembl chrNW_004936694:153,959...161,635 		JBrowse link
G Parl presenilin associated rhomboid like involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936578:5,945,765...5,992,972
Ensembl chrNW_004936578:5,945,635...5,993,143 		JBrowse link
G Ppif peptidylprolyl isomerase F involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936521:404,574...411,381
Ensembl chrNW_004936521:404,544...411,539 		JBrowse link
G Prelid1 PRELI domain containing 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936597:1,580,849...1,584,445
Ensembl chrNW_004936597:1,580,850...1,584,445 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936489:12,118,538...12,913,664
Ensembl chrNW_004936489:12,120,678...13,327,872 		JBrowse link
G Psmd10 proteasome 26S subunit, non-ATPase 10 involved_in ISO (PMID:19729910) UniProt PMID:19729910 NCBI chrNW_004936499:6,691,758...6,698,515
Ensembl chrNW_004936499:6,691,476...6,702,986 		JBrowse link
G Triap1 TP53 regulated inhibitor of apoptosis 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936668:500,815...503,158
Ensembl chrNW_004936668:500,813...503,148 		JBrowse link
positive regulation of mitochondrial membrane permeability involved in apoptotic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf2 activating transcription factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936509:4,729,984...4,826,367
Ensembl chrNW_004936509:4,732,930...4,826,443 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936664:2,968,103...2,973,652
Ensembl chrNW_004936664:2,967,865...2,973,820 		JBrowse link
G Bcl2l11 BCL2 like 11 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936783:15,493...50,959
Ensembl chrNW_004936783:18,194...50,983 		JBrowse link
G Bid BH3 interacting domain death agonist involved_in ISO
IEA 		RGD
UniProt		 PMID:17893612 GO_REF:0000117 RGD:408346749 NCBI chrNW_004936807:708,340...750,127
Ensembl chrNW_004936807:708,276...750,093 		JBrowse link
G Stpg1 sperm tail PG-rich repeat containing 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936474:9,358,114...9,398,379
Ensembl chrNW_004936474:9,358,116...9,398,271 		JBrowse link
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp5if1 ATP synthase inhibitory factor subunit 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936474:12,396,416...12,399,760
Ensembl chrNW_004936474:12,396,023...12,401,023 		JBrowse link
G Bok BCL2 family apoptosis regulator BOK involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936745:344,837...350,950
Ensembl chrNW_004936745:345,635...351,749 		JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936706:266,462...277,256
Ensembl chrNW_004936706:269,126...277,256 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta involved_in ISO (PMID:16543145) UniProt PMID:16543145 NCBI chrNW_004936536:6,730,070...6,893,818
Ensembl chrNW_004936536:6,730,062...6,894,303 		JBrowse link
G Hip1r huntingtin interacting protein 1 related involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936558:1,778,862...1,804,071
Ensembl chrNW_004936558:1,778,888...1,791,610 		JBrowse link
G Lrrk2 leucine rich repeat kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936607:628,469...761,117
Ensembl chrNW_004936607:626,991...761,123 		JBrowse link
G Siva1 SIVA1 apoptosis inducing factor involved_in ISO (PMID:15034012) BHF-UCL PMID:15034012 NCBI chrNW_004936621:641,456...650,067
Ensembl chrNW_004936621:644,852...650,132 		JBrowse link
G Znf205 zinc finger protein 205 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936694:1,072,633...1,084,923
Ensembl chrNW_004936694:1,072,653...1,081,755 		JBrowse link
positive regulation of release of cytochrome c from mitochondria term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bad BCL2 associated agonist of cell death involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936599:4,924,349...4,933,683
Ensembl chrNW_004936599:4,924,789...4,933,368 		JBrowse link
G Bak1 BCL2 antagonist/killer 1 ISO RGD PMID:12485416 RGD:2317097 NCBI chrNW_004936476:25,347,608...25,354,772
Ensembl chrNW_004936476:25,347,545...25,355,789 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936664:2,968,103...2,973,652
Ensembl chrNW_004936664:2,967,865...2,973,820 		JBrowse link
G Bbc3 BCL2 binding component 3 involved_in ISO (PMID:21041309) BHF-UCL PMID:21041309 NCBI chrNW_004936664:962,115...966,797 JBrowse link
G Bcl2l11 BCL2 like 11 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936783:15,493...50,959
Ensembl chrNW_004936783:18,194...50,983 		JBrowse link
G Bid BH3 interacting domain death agonist involved_in IEA
ISO 		Ensembl
UniProt
RGD
TreeGrafter		 PMID:25623406 GO_REF:0000107 GO_REF:0000117 GO_REF:0000118 RGD:408345233 NCBI chrNW_004936807:708,340...750,127
Ensembl chrNW_004936807:708,276...750,093 		JBrowse link
G Bik BCL2 interacting killer involved_in ISO (PMID:21041309) BHF-UCL PMID:21041309
G Bmf Bcl2 modifying factor involved_in ISO (PMID:21041309) BHF-UCL PMID:21041309 NCBI chrNW_004936471:3,573,437...3,594,438
Ensembl chrNW_004936471:3,577,221...3,594,981 		JBrowse link
G Bnip3 BCL2 interacting protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936486:18,449,371...18,460,435
Ensembl chrNW_004936486:18,448,494...18,455,927 		JBrowse link
G Casp6 caspase 6 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936563:912,502...920,025
Ensembl chrNW_004936563:911,304...919,119 		JBrowse link
G Fam162a family with sequence similarity 162 member A involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936536:8,697,631...8,725,667
Ensembl chrNW_004936536:8,697,595...8,730,329 		JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 involved_in ISO PMID:23907461 UniProt PMID:23907461 RGD:8553942 NCBI chrNW_004936754:1,288,891...1,293,555
Ensembl chrNW_004936754:1,288,912...1,293,427 		JBrowse link
G Gzmk granzyme K involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936480:12,720,873...12,730,832
Ensembl chrNW_004936480:12,720,661...12,730,905 		JBrowse link
G Mllt11 MLLT11 transcription factor 7 cofactor involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936580:1,274,658...1,283,505
Ensembl chrNW_004936580:1,275,599...1,282,420 		JBrowse link
G Mmp9 matrix metallopeptidase 9 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936514:7,038,240...7,045,873
Ensembl chrNW_004936514:7,037,639...7,045,793 		JBrowse link
G Moap1 modulator of apoptosis 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936733:1,111,256...1,113,651
Ensembl chrNW_004936733:1,111,958...1,113,010 		JBrowse link
G Pink1 PTEN induced kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936474:6,574,471...6,589,478
Ensembl chrNW_004936474:6,573,623...6,589,478 		JBrowse link
G Pla2g6 phospholipase A2 group VI ISO RGD PMID:18936091 RGD:6482750 NCBI chrNW_004936492:3,011,752...3,060,962
Ensembl chrNW_004936492:3,011,772...3,060,986 		JBrowse link
G Plaur plasminogen activator, urokinase receptor involved_in ISO (PMID:22984561) CACAO PMID:22984561 NCBI chrNW_004936706:840,968...855,552 JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 involved_in ISO (PMID:15705586), (PMID:17289999)
(PMID:14500711), (PMID:14699081), (PMID:15705586) 		BHF-UCL
UniProt		 PMID:14500711 PMID:14699081 PMID:15705586 PMID:17289999 NCBI chrNW_004936497:4,985,995...4,986,720 JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936522:4,872,360...4,939,873
Ensembl chrNW_004936522:4,875,046...4,939,879 		JBrowse link
G Pycard PYD and CARD domain containing involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936501:13,550,702...13,552,774
Ensembl chrNW_004936501:13,550,679...13,552,805 		JBrowse link
G Tnfsf10 TNF superfamily member 10 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936593:212,642...230,645
Ensembl chrNW_004936593:212,532...230,651 		JBrowse link
G Tp53 tumor protein p53 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936595:919,807...935,367
Ensembl chrNW_004936595:919,428...925,425 		JBrowse link
G Wdr35 WD repeat domain 35 ISO RGD PMID:23289926 RGD:11553920 NCBI chrNW_004936493:11,374,681...11,435,792
Ensembl chrNW_004936493:11,374,671...11,436,233 		JBrowse link
regulation of mitochondrial membrane permeability involved in apoptotic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936664:2,968,103...2,973,652
Ensembl chrNW_004936664:2,967,865...2,973,820 		JBrowse link
G Bid BH3 interacting domain death agonist acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936807:708,340...750,127
Ensembl chrNW_004936807:708,276...750,093 		JBrowse link
G Camk2a calcium/calmodulin dependent protein kinase II alpha acts_upstream_of_or_within ISO (PMID:23051746) MGI PMID:23051746 NCBI chrNW_004936504:4,636,863...4,700,887
Ensembl chrNW_004936504:4,638,176...4,700,984 		JBrowse link
G Mtch2 mitochondrial carrier 2 acts_upstream_of_or_within ISO (PMID:20436477)
(PMID:23744079) 		MGI PMID:20436477 PMID:23744079 NCBI chrNW_004936562:1,622,341...1,644,191
Ensembl chrNW_004936562:1,622,335...1,644,191 		JBrowse link
G Naif1 nuclear apoptosis inducing factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936487:15,655,571...15,660,300
Ensembl chrNW_004936487:15,655,449...15,660,314 		JBrowse link
G Ppm1k protein phosphatase, Mg2+/Mn2+ dependent 1K involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936685:742,081...765,728
Ensembl chrNW_004936685:742,075...766,307 		JBrowse link
G Them4 thioesterase superfamily member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936580:2,058,960...2,085,919
Ensembl chrNW_004936580:2,058,643...2,085,945 		JBrowse link
G Tp53 tumor protein p53 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936595:919,807...935,367
Ensembl chrNW_004936595:919,428...925,425 		JBrowse link
regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mul1 mitochondrial E3 ubiquitin protein ligase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936474:6,479,640...6,486,080
Ensembl chrNW_004936474:6,477,504...6,486,660 		JBrowse link
G Tmem102 transmembrane protein 102 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936595:718,513...720,553
Ensembl chrNW_004936595:718,923...720,553 		JBrowse link
regulation of release of cytochrome c from mitochondria term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Plscr3 phospholipid scramblase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936595:674,754...679,979
Ensembl chrNW_004936595:672,642...679,622 		JBrowse link
release of cytochrome c from mitochondria term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp7a ATPase copper transporting alpha acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936683:2,874,022...2,936,214
Ensembl chrNW_004936683:2,874,042...2,935,040 		JBrowse link
G Bad BCL2 associated agonist of cell death involved_in
acts_upstream_of_or_within 		IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936599:4,924,349...4,933,683
Ensembl chrNW_004936599:4,924,789...4,933,368 		JBrowse link
G Bak1 BCL2 antagonist/killer 1 involved_in ISO
IEA 		positive regulation RGD
UniProt
TreeGrafter
Ensembl		 PMID:18252800 GO_REF:0000107 GO_REF:0000117 GO_REF:0000118 RGD:2313987 NCBI chrNW_004936476:25,347,608...25,354,772
Ensembl chrNW_004936476:25,347,545...25,355,789 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator involved_in
acts_upstream_of_or_within 		ISO
IEA 		RGD
UniProt
Ensembl
TreeGrafter		 PMID:10724126 GO_REF:0000107 GO_REF:0000117 GO_REF:0000118 RGD:14394498 NCBI chrNW_004936664:2,968,103...2,973,652
Ensembl chrNW_004936664:2,967,865...2,973,820 		JBrowse link
G Bbc3 BCL2 binding component 3 involved_in ISO (PMID:11463392) UniProt PMID:11463392 NCBI chrNW_004936664:962,115...966,797 JBrowse link
G Bcl2 BCL2 apoptosis regulator involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936497:2,209,136...2,373,580
Ensembl chrNW_004936497:2,210,334...2,210,921 		JBrowse link
G Bcl2a1 BCL2 related protein A1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936471:37,981,851...37,993,097
Ensembl chrNW_004936471:37,981,772...37,993,116 		JBrowse link
G Bcl2l1 BCL2 like 1 acts_upstream_of_or_within
involved_in 		ISO
IEA 		(PMID:17052454) MGI
TreeGrafter		 PMID:17052454 GO_REF:0000118 NCBI chrNW_004936485:18,654,046...18,707,324
Ensembl chrNW_004936485:18,654,003...18,707,339 		JBrowse link
G Bid BH3 interacting domain death agonist involved_in
acts_upstream_of_or_within 		ISO
IEA 		(PMID:11369777) RGD
UniProt
MGI
Ensembl		 PMID:11369777 PMID:18252800 GO_REF:0000107 GO_REF:0000117 RGD:2313987 NCBI chrNW_004936807:708,340...750,127
Ensembl chrNW_004936807:708,276...750,093 		JBrowse link
G Bok BCL2 family apoptosis regulator BOK involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936745:344,837...350,950
Ensembl chrNW_004936745:345,635...351,749 		JBrowse link
G Cck cholecystokinin ISO RGD PMID:11964411 RGD:625521 NCBI chrNW_004936695:2,776,705...2,782,280
Ensembl chrNW_004936695:2,776,831...2,782,061 		JBrowse link
G Ggct gamma-glutamylcyclotransferase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936478:6,786,392...6,794,088
Ensembl chrNW_004936478:6,785,018...6,794,199 		JBrowse link
G Ifi27l2 interferon alpha inducible protein 27 like 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936733:1,964,545...1,966,157
Ensembl chrNW_004936733:1,961,616...1,966,265 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit ISO induces release following removal of NGF from sympathetic neurons RGD PMID:11301023 RGD:2290592 NCBI chrNW_004936522:3,034,364...3,037,632
Ensembl chrNW_004936522:3,035,346...3,036,350 		JBrowse link
G LOC101972259 interferon alpha-inducible protein 27, mitochondrial-like involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936733:1,953,449...1,959,283 JBrowse link
G LOC101973872 bcl-2-like protein 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936722:1,039,970...1,044,942
Ensembl chrNW_004936722:1,053,326...1,059,477
Ensembl chrNW_004936722:1,053,326...1,059,477 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 ISO RGD PMID:15504737 RGD:2298783 NCBI chrNW_004936739:551,678...602,027
Ensembl chrNW_004936739:551,629...602,047 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936580:803,452...806,966
Ensembl chrNW_004936580:804,903...806,796 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 acts_upstream_of_or_within
involved_in 		ISO (PMID:12952892)
(PMID:14699081) 		MGI
UniProt		 PMID:12952892 PMID:14699081 NCBI chrNW_004936497:4,985,995...4,986,720 JBrowse link
G Sfn stratifin involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936474:11,274,927...11,279,427
Ensembl chrNW_004936474:11,246,534...11,279,433 		JBrowse link
G Smad3 SMAD family member 3 ISO RGD PMID:11839804 RGD:2301029 NCBI chrNW_004936471:27,080,662...27,185,861
Ensembl chrNW_004936471:27,080,575...27,189,793 		JBrowse link
G Sod2 superoxide dismutase 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936489:11,178,338...11,191,601
Ensembl chrNW_004936489:11,178,015...11,191,781 		JBrowse link
G Timm50 translocase of inner mitochondrial membrane 50 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936661:2,310,169...2,318,035
Ensembl chrNW_004936661:2,310,125...2,318,258 		JBrowse link
G Tp53 tumor protein p53 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936595:919,807...935,367
Ensembl chrNW_004936595:919,428...925,425 		JBrowse link
G Tp73 tumor protein p73 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936737:171,894...211,464
Ensembl chrNW_004936737:172,467...211,464 		JBrowse link
release of matrix enzymes from mitochondria term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936664:2,968,103...2,973,652
Ensembl chrNW_004936664:2,967,865...2,973,820 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17733
    cellular process 17274
      cell death 1949
        programmed cell death 1949
          apoptotic process 1866
            apoptotic mitochondrial changes 120
              mitochondrial fragmentation involved in apoptotic process 12
              regulation of mitochondrial membrane permeability involved in apoptotic process + 45
              release of cytochrome c from mitochondria + 64
              release of matrix enzymes from mitochondria 1
Path 2
Term Annotations click to browse term
  biological_process 17733
    cellular process 17274
      cellular component organization or biogenesis 7582
        cellular component organization 7384
          organelle organization 3474
            mitochondrion organization 438
              apoptotic mitochondrial changes 120
                mitochondrial fragmentation involved in apoptotic process 12
                regulation of mitochondrial membrane permeability involved in apoptotic process + 45
                release of cytochrome c from mitochondria + 64
                release of matrix enzymes from mitochondria 1
paths to the root