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ONTOLOGY REPORT - ANNOTATIONS


Term:intrinsic apoptotic signaling pathway in response to oxidative stress
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Accession:GO:0008631 term browser browse the term
Definition:A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, and ends when the execution phase of apoptosis is triggered.
Synonyms:exact_synonym: oxidative stress-induced intrinsic apoptotic signaling pathway
 related_synonym: induction of apoptosis by oxidative stress


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intrinsic apoptotic signaling pathway in response to oxidative stress term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arl6ip5 ADP-ribosylation factor like GTPase 6 interacting protein 5 JBrowse link 4 129,574,363 129,598,240 RGD:1600115
RGD:1624291
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:1624291
RGD:1600115
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 JBrowse link 6 2,308,179 2,316,739 RGD:1600115
RGD:1624291
G Diablo diablo, IAP-binding mitochondrial protein JBrowse link 12 38,490,230 38,503,344 RGD:1624291
RGD:13792537
G Gpx1 glutathione peroxidase 1 JBrowse link 8 117,117,430 117,118,528 RGD:1624291
G Gskip GSK3B interacting protein JBrowse link 6 129,512,950 129,536,320 RGD:1600115
RGD:1624291
G Jak2 Janus kinase 2 JBrowse link 1 247,398,667 247,457,521 RGD:1641883
G LOC100360940 diablo-like JBrowse link 5 147,607,350 147,608,936 RGD:13792537
G Map3k5 mitogen-activated protein kinase kinase kinase 5 JBrowse link 1 15,412,603 15,613,752 RGD:1624291
RGD:13792537
G Mapt microtubule-associated protein tau JBrowse link 10 92,289,002 92,386,517 RGD:8158111
G Melk maternal embryonic leucine zipper kinase JBrowse link 5 59,783,835 59,844,356 RGD:1624291
G Pdk1 pyruvate dehydrogenase kinase 1 JBrowse link 3 58,530,870 58,561,494 RGD:1600115
RGD:1624291
G Pml promyelocytic leukemia JBrowse link 8 63,002,515 63,034,310 RGD:1624291
RGD:1600115
G Rnf7 ring finger protein 7 JBrowse link 8 104,326,719 104,336,098 RGD:1624291
G Sod2 superoxide dismutase 2 JBrowse link 1 47,914,757 47,921,587 RGD:1624291
RGD:1600115
G Stk24 serine/threonine kinase 24 JBrowse link 15 106,629,258 106,678,917 RGD:1600115
RGD:1624291
G Uaca uveal autoantigen with coiled-coil domains and ankyrin repeats JBrowse link 8 65,686,586 65,774,940 RGD:1624291
G Zfp622 zinc finger protein 622 JBrowse link 2 78,407,312 78,421,152 RGD:1624291
intrinsic apoptotic signaling pathway in response to hydrogen peroxide term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pdcd10 programmed cell death 10 JBrowse link 2 173,966,701 174,012,730 RGD:1624291
RGD:1600115
G Stk25 serine/threonine kinase 25 JBrowse link 9 100,767,578 100,779,715 RGD:1624291
RGD:1600115
negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Park7 Parkinsonism associated deglycase JBrowse link 5 167,982,438 168,004,724 RGD:1624291
RGD:1600115
G Pink1 PTEN induced kinase 1 JBrowse link 5 156,677,146 156,689,258 RGD:1624291
RGD:1600115
negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hsph1 heat shock protein family H (Hsp110) member 1 JBrowse link 12 6,322,685 6,341,898 RGD:1624291
G Pink1 PTEN induced kinase 1 JBrowse link 5 156,677,146 156,689,258 RGD:8693356
RGD:1624291
G Trap1 TNF receptor-associated protein 1 JBrowse link 10 11,724,032 11,757,682 RGD:8693356
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bag5 BCL2-associated athanogene 5 JBrowse link 6 136,180,640 136,185,651 RGD:1624291
G Gpx1 glutathione peroxidase 1 JBrowse link 8 117,117,430 117,118,528 RGD:1624291
RGD:1600115
G Hspb1 heat shock protein family B (small) member 1 JBrowse link 12 23,839,390 23,841,051 RGD:1624291
RGD:1600115
G Mapk7 mitogen-activated protein kinase 7 JBrowse link 10 47,768,592 47,775,130 RGD:1624291
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:1624291
RGD:1600115
G Nme5 NME/NM23 family member 5 JBrowse link 18 27,357,460 27,374,641 RGD:1624291
RGD:13792537
G Nol3 nucleolar protein 3 JBrowse link 19 37,232,567 37,236,668 RGD:1624291
G Sirt1 sirtuin 1 JBrowse link 20 26,831,971 26,851,587 RGD:1624291
G Sod2 superoxide dismutase 2 JBrowse link 1 47,914,757 47,921,587 RGD:1624291
G Vnn1 vanin 1 JBrowse link 1 22,614,832 22,625,134 RGD:1624291
RGD:1600115
negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hif1a hypoxia inducible factor 1 subunit alpha JBrowse link 6 96,810,868 96,856,303 RGD:1624291
RGD:1600115
G Nono non-POU domain containing, octamer-binding JBrowse link X 71,324,365 71,342,225 RGD:1624291
RGD:1600115
G Park7 Parkinsonism associated deglycase JBrowse link 5 167,982,438 168,004,724 RGD:1624291
RGD:1600115
G Prkn parkin RBR E3 ubiquitin protein ligase JBrowse link 1 48,880,015 50,069,998 RGD:1624291
RGD:1600115
positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nox1 NADPH oxidase 1 JBrowse link X 104,909,328 104,932,508 RGD:1624291
RGD:1600115
G Park7 Parkinsonism associated deglycase JBrowse link 5 167,982,438 168,004,724 RGD:1624291
G Sfpq splicing factor proline and glutamine rich JBrowse link 5 145,079,803 145,088,517 RGD:1624291
RGD:1600115
G Sod1 superoxide dismutase 1 JBrowse link 11 30,363,282 30,368,858 RGD:1624291
RGD:1600115
positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fbxw7 F-box and WD repeat domain containing 7 JBrowse link 2 184,230,191 184,309,805 RGD:1624291
RGD:1600115
G Mcl1 MCL1 apoptosis regulator, BCL2 family member JBrowse link 2 197,786,212 197,788,992 RGD:1624291
G Ralbp1 ralA binding protein 1 JBrowse link 9 113,579,107 113,598,477 RGD:12904719
regulation of oxidative stress-induced intrinsic apoptotic signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G P4hb prolyl 4-hydroxylase subunit beta JBrowse link 10 109,736,459 109,748,070 RGD:1624291
RGD:1600115
G Ubqln1 ubiquilin 1 JBrowse link 17 6,840,441 6,878,842 RGD:1624291
RGD:1600115
regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:10414071

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18166
    cellular process 16266
      cell death 2119
        cell death in response to oxidative stress 100
          intrinsic apoptotic signaling pathway in response to oxidative stress 44
            intrinsic apoptotic signaling pathway in response to hydrogen peroxide + 6
            negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway + 17
            neuron intrinsic apoptotic signaling pathway in response to oxidative stress + 9
            positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway + 7
            regulation of oxidative stress-induced intrinsic apoptotic signaling pathway + 26
Path 2
Term Annotations click to browse term
  biological_process 18166
    cellular process 16266
      cell death 2119
        programmed cell death 1942
          apoptotic process 1896
            apoptotic signaling pathway 621
              intrinsic apoptotic signaling pathway 296
                intrinsic apoptotic signaling pathway in response to oxidative stress 44
                  intrinsic apoptotic signaling pathway in response to hydrogen peroxide + 6
                  negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway + 17
                  neuron intrinsic apoptotic signaling pathway in response to oxidative stress + 9
                  positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway + 7
                  regulation of oxidative stress-induced intrinsic apoptotic signaling pathway + 26
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.