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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:intrinsic apoptotic signaling pathway in response to osmotic stress
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Accession:GO:0008627 term browser browse the term
Definition:The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to changes in intracellular ion homeostasis, and ends when the execution phase of apoptosis is triggered.
Synonyms:related_synonym: induction of apoptosis by ionic changes


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intrinsic apoptotic signaling pathway in response to osmotic stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 involved_in ISO (PMID:21716255)
(MGI:5474549|PMID:21716255)		 RGD PMID:21716255 MGI:5474549 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Scn2a sodium voltage-gated channel alpha subunit 2 acts_upstream_of_or_within
involved_in		 ISS
ISO
IEA		 GO_REF:0000024
MGI:2180186 (PMID:10827969)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:10827969 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:50,302,781...50,437,504
Ensembl chr 3:50,302,877...50,437,214 		JBrowse link
intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdkrb2 bradykinin receptor B2 involved_in
acts_upstream_of		 IEA
ISO		 GO_REF:0000107
MGI:98834|MGI:99702 (PMID:16571598)		 Ensembl
RGD		 PMID:16571598 GO_REF:0000107 NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497 		JBrowse link
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arhgef2 Rho/Rac guanine nucleotide exchange factor 2 involved_in ISO (PMID:22711822) RGD PMID:22711822 NCBI chr 2:174,061,126...174,118,355
Ensembl chr 2:174,062,976...174,118,355 		JBrowse link
G Bdkrb2 bradykinin receptor B2 acts_upstream_of_or_within ISO MGI:1857135 (PMID:16571598) RGD PMID:16571598 NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497 		JBrowse link
G Epo erythropoietin involved_in ISO (PMID:14569084) RGD PMID:14569084 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946 		JBrowse link
G Ptger2 prostaglandin E receptor 2 involved_in ISO (PMID:21716255) RGD PMID:21716255 NCBI chr15:18,215,013...18,228,714
Ensembl chr15:18,217,285...18,228,714 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 involved_in ISO (PMID:21716255)
(MGI:5474549|PMID:21716255)		 RGD PMID:21716255 MGI:5474549 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ybx3 Y box binding protein 3 involved_in IEA
ISO		 GO_REF:0000107
(PMID:22711822)		 Ensembl
RGD		 PMID:22711822 GO_REF:0000107 NCBI chr 4:165,129,747...165,153,101
Ensembl chr 4:165,129,758...165,153,161 		JBrowse link
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdkrb2 bradykinin receptor B2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:98834|MGI:99702 (PMID:16571598)		 Ensembl
RGD		 PMID:16571598 GO_REF:0000107 NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497 		JBrowse link
positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bad BCL2-associated agonist of cell death involved_in ISO
IEA		 (PMID:21716255)
GO_REF:0000107
(MGI:5474549|PMID:21716255)		 RGD
Ensembl		 PMID:21716255 GO_REF:0000107 MGI:5474549 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823 		JBrowse link
regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tifab TIFA inhibitor acts_upstream_of_or_within ISO (PMID:32101751) RGD PMID:32101751 NCBI chr17:8,433,406...8,436,541
Ensembl chr17:8,431,635...8,436,592 		JBrowse link
G Usp15 ubiquitin specific peptidase 15 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:32101751)		 Ensembl
RGD		 PMID:32101751 GO_REF:0000107 NCBI chr 7:58,756,714...58,848,778
Ensembl chr 7:58,756,872...58,848,721 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20413
    response to stimulus 10920
      response to abiotic stimulus 1598
        cellular response to abiotic stimulus 445
          cellular response to osmotic stress 70
            intrinsic apoptotic signaling pathway in response to osmotic stress 11
              intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator + 3
              negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress + 6
              positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress + 1
              regulation of intrinsic apoptotic signaling pathway in response to osmotic stress + 9
Path 2
Term Annotations click to browse term
  biological_process 20413
    cellular process 18812
      cell death 2208
        programmed cell death 2208
          apoptotic process 2126
            apoptotic signaling pathway 690
              intrinsic apoptotic signaling pathway 342
                intrinsic apoptotic signaling pathway in response to osmotic stress 11
                  intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator + 3
                  negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress + 6
                  positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress + 1
                  regulation of intrinsic apoptotic signaling pathway in response to osmotic stress + 9
paths to the root