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ONTOLOGY REPORT - ANNOTATIONS

Term:extrinsic apoptotic signaling pathway via death domain receptors
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Accession:GO:0008625 term browser browse the term
Definition:The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with a ligand binding to a death domain receptor on the cell surface, and ends when the execution phase of apoptosis is triggered.
Comment:Gene products that may be annotated to this term include: 1) ligands such as FASL; 2) receptors such as FAS/CD95 (though care should be taken because FAS can also act as a non-apoptotic signal transducer); 3) signaling molecules such as FADD (FAS-associated protein with a death domain), cIAPs (cellular inhibitor of apoptosis proteins), c-FLIPs and caspases 8 and 10. Examples are TWEAK (TNF12) and FN14 (TNFRSF12A) (UniProt symbols O43508 and Q9NP84) in PMID:21525013.
Synonyms:exact_synonym: induction of apoptosis via death receptors
 narrow_synonym: death receptor-mediated apoptosis
 related_synonym: induction of apoptosis via death domain receptors


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extrinsic apoptotic signaling pathway via death domain receptors term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAD BCL2 associated agonist of cell death involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12431371) Ensembl
MGI		 PMID:12431371 GO_REF:0000107 NCBI chr11:59,626,981...59,641,824
Ensembl chr11:62,971,808...62,986,257 		JBrowse link
G BAG3 BAG cochaperone 3 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:10597216) MGI
Ensembl		 PMID:10597216 GO_REF:0000107 NCBI chr10:116,221,747...116,248,692
Ensembl chr10:119,643,963...119,665,964 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10597216) Ensembl
MGI		 PMID:10597216 GO_REF:0000107 NCBI chr19:45,955,926...45,962,870
Ensembl chr19:54,793,594...54,800,468 		JBrowse link
G BCL2 BCL2 apoptosis regulator acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:10597216) MGI
Ensembl		 PMID:10597216 GO_REF:0000107 NCBI chr18:56,481,212...56,679,012
Ensembl chr18:59,802,443...59,992,100 		JBrowse link
G BEX3 brain expressed X-linked 3 acts_upstream_of_or_within ISO (PMID:10764727) MGI PMID:10764727 NCBI chr  X:92,606,496...92,608,240
Ensembl chr  X:102,985,284...102,986,464 		JBrowse link
G BLOC1S2 biogenesis of lysosomal organelles complex 1 subunit 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:96,878,280...96,887,830
Ensembl chr10:100,358,095...100,368,640 		JBrowse link
G CASP8 caspase 8 acts_upstream_of_or_within ISO (PMID:15322156) MGI PMID:15322156 NCBI chr2B:88,490,611...88,542,132
Ensembl chr2B:206,669,544...206,696,468 		JBrowse link
G CASP8AP2 caspase 8 associated protein 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10235259) TreeGrafter
MGI		 PMID:10235259 GO_REF:0000118 NCBI chr 6:87,707,152...87,754,836
Ensembl chr 6:90,996,127...91,023,757 		JBrowse link
G DAB2IP DAB2 interacting protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:92,696,798...92,912,425
Ensembl chr 9:121,143,457...121,254,336 		JBrowse link
G DAPK1 death associated protein kinase 1 acts_upstream_of_or_within ISO (PMID:15010850)
(PMID:20053891)		 MGI PMID:15010850 PMID:20053891 NCBI chr 9:58,628,872...58,836,205
Ensembl chr 9:86,681,953...86,887,958 		JBrowse link
G DAXX death domain associated protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:32,890,846...32,895,307
Ensembl chr 6:34,004,543...34,008,717 		JBrowse link
G DDX3X DEAD-box helicase 3 X-linked involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:33,780,381...33,796,829
Ensembl chr  X:41,475,116...41,505,837 		JBrowse link
G DDX47 DEAD-box helicase 47 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:12,838,201...12,854,874
Ensembl chr12:13,216,152...13,232,846 		JBrowse link
G DEDD death effector domain containing involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9774341) Ensembl
MGI
TreeGrafter		 PMID:9774341 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:136,533,756...136,545,107
Ensembl chr 1:140,447,011...140,457,876 		JBrowse link
G DEDD2 death effector domain containing 2 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr19:39,086,735...39,108,312
Ensembl chr19:47,678,915...47,700,431 		JBrowse link
G DELE1 DAP3 binding cell death enhancer 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 5:137,283,938...137,302,203
Ensembl chr 5:143,394,554...143,412,532 		JBrowse link
G FADD Fas associated via death domain involved_in ISO (PMID:24025841) UniProt PMID:24025841 NCBI chr11:65,300,889...65,305,020 JBrowse link
G FAS Fas cell surface death receptor involved_in
acts_upstream_of_or_within		 ISO (MGI:5009197|PMID:10950869)
(PMID:10429671)
(PMID:10588860), (PMID:12801066), (PMID:15039234), (PMID:15632112), (PMID:18363966), (PMID:8524870)
(PMID:12431371), (PMID:12801066), (PMID:8524870)		 BHF-UCL
MGI		 PMID:8524870 PMID:10429671 PMID:10588860 PMID:10950869 PMID:12431371 More... MGI:5009197 NCBI chr10:85,707,457...85,741,539
Ensembl chr10:89,217,949...89,243,612 		JBrowse link
G FASLG Fas ligand acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:10588860), (PMID:15039234)
(PMID:26582200)		 RGD
MGI
TreeGrafter
Ensembl		 PMID:10588860 PMID:15039234 PMID:16689665 PMID:26582200 GO_REF:0000107 GO_REF:0000118 RGD:1582444 NCBI chr 1:148,159,826...148,167,785
Ensembl chr 1:151,868,430...151,876,281 		JBrowse link
G GABARAP GABA type A receptor-associated protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:7,270,316...7,272,365
Ensembl chr17:7,257,659...7,260,276 		JBrowse link
G HMGB2 high mobility group box 2 acts_upstream_of ISO (PMID:19139395) MGI PMID:19139395 NCBI chr 4:165,559,848...165,562,625
Ensembl chr 4:177,797,457...177,800,952 		JBrowse link
G IL18 interleukin 18 involved_in ISO (PMID:11429161)
(PMID:11131641)		 UniProt PMID:11131641 PMID:11429161 NCBI chr11:107,024,376...107,045,194
Ensembl chr11:110,867,586...110,888,371 		JBrowse link
G ITPRIP inositol 1,4,5-trisphosphate receptor interacting protein involved_in
acts_upstream_of		 IEA
ISO		 (PMID:20053891) Ensembl
MGI		 PMID:20053891 GO_REF:0000107 NCBI chr10:100,911,715...100,938,543
Ensembl chr10:104,372,767...104,374,410 		JBrowse link
G MOAP1 modulator of apoptosis 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:73,814,859...73,817,607
Ensembl chr14:93,152,551...93,153,606 		JBrowse link
G NF1 neurofibromin 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15039234) Ensembl
MGI		 PMID:15039234 GO_REF:0000107 NCBI chr17:25,425,081...25,703,689
Ensembl chr17:26,160,855...26,439,295 		JBrowse link
G NGF nerve growth factor involved_in ISO (PMID:14985763) BHF-UCL PMID:14985763 NCBI chr 1:87,223,597...87,276,759 JBrowse link
G PIDD1 p53-induced death domain protein 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16183742) Ensembl
MGI		 PMID:16183742 GO_REF:0000107 NCBI chr11:816,629...827,295
Ensembl chr11:860,899...867,436 		JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15039234) Ensembl
MGI		 PMID:15039234 GO_REF:0000107 NCBI chr 5:45,701,219...45,786,652
Ensembl chr 5:47,267,286...47,350,960 		JBrowse link
G RAF1 Raf-1 proto-oncogene, serine/threonine kinase involved_in
acts_upstream_of		 IEA
ISO		 (PMID:16365167) Ensembl
MGI		 PMID:16365167 GO_REF:0000107 NCBI chr 3:12,510,084...12,590,598
Ensembl chr 3:12,853,415...12,932,871 		JBrowse link
G ROCK2 Rho associated coiled-coil containing protein kinase 2 acts_upstream_of_or_within ISO (PMID:16365167) MGI PMID:16365167 NCBI chr2A:11,167,353...11,331,339
Ensembl chr2A:11,318,370...11,478,986 		JBrowse link
G SKIL SKI like proto-oncogene involved_in
acts_upstream_of		 IEA
ISO		 (PMID:10811619) Ensembl
MGI		 PMID:10811619 GO_REF:0000107 NCBI chr 3:167,372,104...167,411,287
Ensembl chr 3:175,562,007...175,600,181 		JBrowse link
G SORT1 sortilin 1 involved_in ISO (PMID:14985763) BHF-UCL PMID:14985763 NCBI chr 1:111,687,119...111,775,339 JBrowse link
G STK3 serine/threonine kinase 3 involved_in
acts_upstream_of		 IEA
ISO		 (PMID:20080598) Ensembl
MGI		 PMID:20080598 GO_REF:0000107 NCBI chr 8:95,098,185...95,465,324
Ensembl chr 8:97,355,173...97,708,437 		JBrowse link
G STK4 serine/threonine kinase 4 involved_in
acts_upstream_of		 IEA
ISO		 (PMID:20080598) Ensembl
MGI		 PMID:20080598 GO_REF:0000107 NCBI chr20:41,297,157...41,410,487
Ensembl chr20:42,389,615...42,503,014 		JBrowse link
G TNF tumor necrosis factor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20080598)
(PMID:12431371)		 Ensembl
MGI
TreeGrafter		 PMID:12431371 PMID:20080598 GO_REF:0000107 GO_REF:0000118 NCBI chr 6:31,236,650...31,239,423
Ensembl chr 6:32,126,618...32,129,381 		JBrowse link
G TNFRSF10A TNF receptor superfamily member 10a ISO RGD PMID:19934367 RGD:4142856 NCBI chr 8:22,440,502...22,476,790
Ensembl chr 8:19,378,547...19,414,724 		JBrowse link
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARHGEF2 Rho/Rac guanine nucleotide exchange factor 2 involved_in ISO (PMID:22711822) BHF-UCL PMID:22711822 NCBI chr 1:131,282,514...131,326,535
Ensembl chr 1:135,112,040...135,159,299 		JBrowse link
G BCL2L1 BCL2 like 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:26582200) MGI
Ensembl		 PMID:26582200 GO_REF:0000107 NCBI chr20:27,955,688...28,015,950
Ensembl chr20:29,088,055...29,146,585 		JBrowse link
G BRCA1 BRCA1 DNA repair associated involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:14,197,946...14,279,064
Ensembl chr17:14,428,526...14,506,815 		JBrowse link
G CAPS calcyphosine acts_upstream_of_or_within ISO (PMID:12466268) MGI PMID:12466268 NCBI chr19:4,925,556...4,936,806
Ensembl chr19:5,855,528...5,861,485 		JBrowse link
G CFLAR CASP8 and FADD like apoptosis regulator acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:26582200) MGI
Ensembl		 PMID:26582200 GO_REF:0000107 NCBI chr2B:88,373,057...88,429,959
Ensembl chr2B:206,528,943...206,577,045 		JBrowse link
G DDX3X DEAD-box helicase 3 X-linked involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:33,780,381...33,796,829
Ensembl chr  X:41,475,116...41,505,837 		JBrowse link
G FAIM Fas apoptotic inhibitory molecule involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10075978) TreeGrafter
MGI		 PMID:10075978 GO_REF:0000118 NCBI chr 3:135,639,242...135,664,449
Ensembl chr 3:143,243,675...143,267,787 		JBrowse link
G FAIM2 Fas apoptotic inhibitory molecule 2 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:26582200) MGI
Ensembl		 PMID:26582200 GO_REF:0000107 NCBI chr12:38,850,588...38,886,614
Ensembl chr12:39,744,700...39,780,702 		JBrowse link
G FGA fibrinogen alpha chain involved_in ISO (PMID:10903502) BHF-UCL PMID:10903502 NCBI chr 4:146,949,680...146,957,291 JBrowse link
G FGB fibrinogen beta chain involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:146,929,561...146,937,665
Ensembl chr 4:158,747,659...158,755,766 		JBrowse link
G FGG fibrinogen gamma chain involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:146,970,671...146,979,348
Ensembl chr 4:158,788,966...158,797,237 		JBrowse link
G FGL1 fibrinogen like 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 8:17,083,524...17,128,152
Ensembl chr 8:14,035,855...14,066,956 		JBrowse link
G GPX1 glutathione peroxidase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:49,280,038...49,281,455
Ensembl chr 3:50,360,947...50,361,826 		JBrowse link
G GSK3B glycogen synthase kinase 3 beta involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:116,943,205...117,215,001
Ensembl chr 3:123,861,379...124,126,771 		JBrowse link
G HGF hepatocyte growth factor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15314156) Ensembl
MGI		 PMID:15314156 GO_REF:0000107 NCBI chr 7:73,667,618...73,738,960
Ensembl chr 7:87,327,798...87,397,811 		JBrowse link
G HMGB2 high mobility group box 2 acts_upstream_of_or_within ISO (PMID:19139395) MGI PMID:19139395 NCBI chr 4:165,559,848...165,562,625
Ensembl chr 4:177,797,457...177,800,952 		JBrowse link
G HMOX1 heme oxygenase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:16,388,368...16,401,289
Ensembl chr22:34,230,825...34,244,063 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:9,821,402...9,837,021
Ensembl chr19:10,484,414...10,500,605 		JBrowse link
G ITPRIP inositol 1,4,5-trisphosphate receptor interacting protein involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20053891) Ensembl
MGI		 PMID:20053891 GO_REF:0000107 NCBI chr10:100,911,715...100,938,543
Ensembl chr10:104,372,767...104,374,410 		JBrowse link
G NOL3 nucleolar protein 3 involved_in ISO PMID:12191471
PMID:15383280		 UniProt PMID:12191471 PMID:15383280 RGD:10047289 RGD:631884 NCBI chr16:47,516,156...47,521,441
Ensembl chr16:66,904,738...66,909,956 		JBrowse link
G PEA15 proliferation and apoptosis adaptor protein 15 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10588860) Ensembl
MGI
TreeGrafter		 PMID:10588860 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:135,559,273...135,569,392
Ensembl chr 1:139,480,394...139,490,503 		JBrowse link
G RAF1 Raf-1 proto-oncogene, serine/threonine kinase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16365167) Ensembl
MGI		 PMID:16365167 GO_REF:0000107 NCBI chr 3:12,510,084...12,590,598
Ensembl chr 3:12,853,415...12,932,871 		JBrowse link
G RFFL ring finger and FYVE like domain containing E3 ubiquitin protein ligase involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr17:21,696,808...21,779,878
Ensembl chr17:22,035,643...22,069,546 		JBrowse link
G RNF34 ring finger protein 34 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr12:118,998,436...119,022,823
Ensembl chr12:122,373,172...122,402,693 		JBrowse link
G SERPINE1 serpin family E member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:93,267,517...93,279,728
Ensembl chr 7:106,510,130...106,518,450 		JBrowse link
G SFRP2 secreted frizzled related protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:146,123,075...146,131,543
Ensembl chr 4:157,944,733...157,953,258 		JBrowse link
G TMBIM1 transmembrane BAX inhibitor motif containing 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:105,533,578...105,551,969
Ensembl chr2B:224,131,478...224,143,170 		JBrowse link
G TNFAIP3 TNF alpha induced protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:135,617,465...135,634,085
Ensembl chr 6:139,705,255...139,720,819 		JBrowse link
G YBX3 Y-box binding protein 3 involved_in ISO (PMID:22711822) BHF-UCL PMID:22711822 NCBI chr12:10,728,049...10,752,267
Ensembl chr12:10,996,380...11,018,172 		JBrowse link
negative regulation of TRAIL-activated apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PARK7 Parkinsonism associated deglycase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:6,722,260...6,745,915
Ensembl chr 1:7,969,280...7,993,271 		JBrowse link
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMPR1B bone morphogenetic protein receptor type 1B involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18363966) Ensembl
MGI		 PMID:18363966 GO_REF:0000107 NCBI chr 4:87,125,911...87,523,084
Ensembl chr 4:98,088,072...98,195,848 		JBrowse link
G FAF1 Fas associated factor 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:8524870) Ensembl
MGI		 PMID:8524870 GO_REF:0000107 NCBI chr 1:49,679,198...50,207,129
Ensembl chr 1:51,188,540...51,606,904 		JBrowse link
G LOC100979315 phorbol-12-myristate-13-acetate-induced protein 1 involved_in ISO (PMID:15705586) BHF-UCL PMID:15705586 NCBI chr18:53,286,590...53,290,913
Ensembl chr18:56,611,098...56,615,449 		JBrowse link
G MAL mal, T cell differentiation protein involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12776198) Ensembl
MGI		 PMID:12776198 GO_REF:0000107 NCBI chr2A:104,355,020...104,382,849
Ensembl chr2A:95,930,315...95,956,573 		JBrowse link
G PEA15 proliferation and apoptosis adaptor protein 15 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10588860) Ensembl
MGI		 PMID:10588860 GO_REF:0000107 NCBI chr 1:135,559,273...135,569,392
Ensembl chr 1:139,480,394...139,490,503 		JBrowse link
G PSEN2 presenilin 2 acts_upstream_of_or_within ISO (PMID:8940094) MGI PMID:8940094 NCBI chr 1:202,328,987...202,354,440
Ensembl chr 1:207,320,937...207,346,295 		JBrowse link
G SFRP1 secreted frizzled related protein 1 involved_in ISO (PMID:9391078) BHF-UCL PMID:9391078 NCBI chr 8:40,507,027...40,555,053 JBrowse link
G SKIL SKI like proto-oncogene involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10811619) Ensembl
MGI		 PMID:10811619 GO_REF:0000107 NCBI chr 3:167,372,104...167,411,287
Ensembl chr 3:175,562,007...175,600,181 		JBrowse link
G STK3 serine/threonine kinase 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20080598) Ensembl
MGI		 PMID:20080598 GO_REF:0000107 NCBI chr 8:95,098,185...95,465,324
Ensembl chr 8:97,355,173...97,708,437 		JBrowse link
G STK4 serine/threonine kinase 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20080598) Ensembl
MGI		 PMID:20080598 GO_REF:0000107 NCBI chr20:41,297,157...41,410,487
Ensembl chr20:42,389,615...42,503,014 		JBrowse link
G THBS1 thrombospondin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:18,521,802...18,538,172
Ensembl chr15:36,776,756...36,793,170 		JBrowse link
G TRPS1 transcriptional repressor GATA binding 1 acts_upstream_of_or_within ISO (PMID:18363966) MGI PMID:18363966 NCBI chr 8:112,079,147...112,339,567 JBrowse link
G ZSWIM2 zinc finger SWIM-type containing 2 acts_upstream_of_or_within ISO (PMID:16522193) MGI PMID:16522193 NCBI chr2B:74,120,669...74,142,560 JBrowse link
positive regulation of TRAIL-activated apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF3 activating transcription factor 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:188,176,728...188,188,842
Ensembl chr 1:193,036,793...193,049,150 		JBrowse link
regulation of extrinsic apoptotic signaling pathway via death domain receptors term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FEM1B fem-1 homolog B involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:47,236,920...47,254,878
Ensembl chr15:66,005,614...66,024,007 		JBrowse link
G LGALS3 galectin 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:35,715,850...35,732,263
Ensembl chr14:53,990,023...54,006,412 		JBrowse link
G MADD MAP kinase activating death domain involved_in ISO (PMID:9115275) UniProt PMID:9115275 NCBI chr11:47,216,006...47,276,422
Ensembl chr11:47,773,733...47,828,360 		JBrowse link
G SP100 SP100 nuclear antigen involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:117,673,152...117,799,911
Ensembl chr2B:236,496,446...236,601,096 		JBrowse link
G STX4 syntaxin 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:23,917,576...23,933,884
Ensembl chr16:31,400,915...31,411,364 		JBrowse link
G TMC8 transmembrane channel like 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:72,204,802...72,218,105
Ensembl chr17:77,759,805...77,771,013 		JBrowse link
TRAIL-activated apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP8 caspase 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:88,490,611...88,542,132
Ensembl chr2B:206,669,544...206,696,468 		JBrowse link
G FADD Fas associated via death domain involved_in ISO (PMID:21785459) ParkinsonsUK-UCL PMID:21785459 NCBI chr11:65,300,889...65,305,020 JBrowse link
G SPI1 Spi-1 proto-oncogene acts_upstream_of_positive_effect
involved_in		 ISO
IEA		 (PMID:28362429) ARUK-UCL
Ensembl		 PMID:28362429 GO_REF:0000107 NCBI chr11:47,301,245...47,326,891
Ensembl chr11:47,853,991...47,880,259 		JBrowse link
G TNFRSF10A TNF receptor superfamily member 10a involved_in IEA UniProt
TreeGrafter
Ensembl		 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 NCBI chr 8:22,440,502...22,476,790
Ensembl chr 8:19,378,547...19,414,724 		JBrowse link
G TNFRSF10B TNF receptor superfamily member 10b involved_in IEA UniProt
TreeGrafter		 GO_REF:0000104 GO_REF:0000118 NCBI chr 8:22,270,325...22,318,841
Ensembl chr 8:19,209,904...19,258,498 		JBrowse link
G TNFRSF10C TNF receptor superfamily member 10c involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 8:22,352,777...22,368,737
Ensembl chr 8:19,292,020...19,307,719 		JBrowse link
G TNFRSF10D TNF receptor superfamily member 10d involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 8:22,385,592...22,414,142
Ensembl chr 8:19,324,232...19,352,766 		JBrowse link
G ZDHHC3 zinc finger DHHC-type palmitoyltransferase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:44,816,359...44,877,318
Ensembl chr 3:45,880,773...45,931,695 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16440
    cellular process 15499
      signal transduction 5440
        apoptotic signaling pathway 644
          extrinsic apoptotic signaling pathway 241
            extrinsic apoptotic signaling pathway via death domain receptors 83
              TRAIL-activated apoptotic signaling pathway + 10
              negative regulation of extrinsic apoptotic signaling pathway via death domain receptors + 30
              positive regulation of extrinsic apoptotic signaling pathway via death domain receptors + 14
              regulation of extrinsic apoptotic signaling pathway via death domain receptors + 49
Path 2
Term Annotations click to browse term
  biological_process 16440
    biological regulation 11453
      regulation of biological process 11104
        regulation of cellular process 10598
          signal transduction 5440
            apoptotic signaling pathway 644
              extrinsic apoptotic signaling pathway 241
                extrinsic apoptotic signaling pathway via death domain receptors 83
                  TRAIL-activated apoptotic signaling pathway + 10
                  negative regulation of extrinsic apoptotic signaling pathway via death domain receptors + 30
                  positive regulation of extrinsic apoptotic signaling pathway via death domain receptors + 14
                  regulation of extrinsic apoptotic signaling pathway via death domain receptors + 49
paths to the root