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ONTOLOGY REPORT - ANNOTATIONS

Term:epsilon DNA polymerase complex
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Accession:GO:0008622 term browser browse the term
Definition:A heterotetrameric DNA polymerase complex that catalyzes processive DNA synthesis in the absence of PCNA, but is further stimulated in the presence of PCNA. The complex contains a large catalytic subunit and three small subunits, and is best characterized in Saccharomyces, in which the subunits are named Pol2p, Dpb2p, Dpb3p, and Dpb4p. Some evidence suggests that DNA polymerase epsilon is the leading strand polymerase; it is also involved in nucleotide-excision repair and mismatch repair.

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epsilon DNA polymerase complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pole DNA polymerase epsilon, catalytic subunit part_of
located_in		 ISO (PMID:10801849), (PMID:22465957) FlyBase
ComplexPortal		 PMID:10801849 PMID:22465957 NCBI chrNW_004955482:373,467...418,000
Ensembl chrNW_004955482:373,555...417,266 		JBrowse link
G Pole2 DNA polymerase epsilon 2, accessory subunit part_of
located_in		 ISO (PMID:10801849), (PMID:22465957) UniProt
ComplexPortal		 PMID:10801849 PMID:22465957 NCBI chrNW_004955409:12,983,488...13,014,669
Ensembl chrNW_004955409:12,983,586...13,014,578 		JBrowse link
G Pole3 DNA polymerase epsilon 3, accessory subunit part_of
located_in		 ISO (PMID:10801849) UniProt
ComplexPortal		 PMID:10801849 NCBI chrNW_004955419:14,086,940...14,089,906
Ensembl chrNW_004955419:14,086,940...14,089,330 		JBrowse link
G Pole4 DNA polymerase epsilon 4, accessory subunit part_of
located_in		 ISO (PMID:10801849) UniProt
ComplexPortal		 PMID:10801849 NCBI chrNW_004955424:10,839,639...10,844,985
Ensembl chrNW_004955424:10,839,639...10,844,985 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 12554
    protein-containing complex 4416
      nuclear protein-containing complex 976
        epsilon DNA polymerase complex 4
Path 2
Term Annotations click to browse term
  cellular_component 12554
    cellular anatomical entity 12397
      intracellular anatomical structure 10515
        intracellular organelle 9421
          intracellular membrane-bounded organelle 8477
            nucleus 5235
              nuclear lumen 3565
                nuclear chromosome 190
                  epsilon DNA polymerase complex 4
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