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ONTOLOGY REPORT - ANNOTATIONS

Term:epsilon DNA polymerase complex
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Accession:GO:0008622 term browser browse the term
Definition:A heterotetrameric DNA polymerase complex that catalyzes processive DNA synthesis in the absence of PCNA, but is further stimulated in the presence of PCNA. The complex contains a large catalytic subunit and three small subunits, and is best characterized in Saccharomyces, in which the subunits are named Pol2p, Dpb2p, Dpb3p, and Dpb4p. Some evidence suggests that DNA polymerase epsilon is the leading strand polymerase; it is also involved in nucleotide-excision repair and mismatch repair.


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epsilon DNA polymerase complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pole DNA polymerase epsilon, catalytic subunit part_of ISO
IBA		 (PMID:10801849), (PMID:22465957)
GO_REF:0000033		 RGD
GO_Central		 PMID:10801849 PMID:22465957 GO_REF:0000033 NCBI chr12:46,345,420...46,393,984
Ensembl chr12:46,345,420...46,393,939 		JBrowse link
G Pole2 DNA polymerase epsilon 2, accessory subunit part_of ISO
IBA		 (PMID:10801849), (PMID:22465957)
GO_REF:0000033		 RGD
GO_Central		 PMID:10801849 PMID:22465957 GO_REF:0000033 NCBI chr 6:87,674,702...87,712,723
Ensembl chr 6:87,674,702...87,699,305 		JBrowse link
G Pole3 DNA polymerase epsilon 3, accessory subunit part_of ISO
ISS
IBA		 (PMID:10801849)
GO_REF:0000024
GO_REF:0000033		 RGD
UniProt
GO_Central		 PMID:10801849 GO_REF:0000024 GO_REF:0000033 NCBI chr 5:75,973,941...75,977,175
Ensembl chr 5:75,974,717...75,977,231
Ensembl chr 7:75,974,717...75,977,231 		JBrowse link
G Pole3-ps2 DNA polymerase epsilon 3, accessory subunit, pseudogene 2 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr17:26,135,927...26,136,417
Ensembl chr17:26,135,927...26,136,235
Ensembl chr17:26,135,927...26,136,235 		JBrowse link
G Pole4 DNA polymerase epsilon 4, accessory subunit part_of ISO
IBA		 (PMID:10801849)
GO_REF:0000033		 RGD
GO_Central		 PMID:10801849 GO_REF:0000033 NCBI chr 4:115,165,285...115,171,097
Ensembl chr 4:115,165,285...115,171,097 		JBrowse link
G Pole4l1 DNA polymerase epsilon 4, accessory subunit like 1 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:67,324,377...67,324,995 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20817
    protein-containing complex 6437
      nuclear protein-containing complex 1305
        epsilon DNA polymerase complex 6
Path 2
Term Annotations click to browse term
  cellular_component 20817
    cellular anatomical entity 20577
      intracellular anatomical structure 15186
        intracellular organelle 13599
          intracellular membrane-bounded organelle 12056
            nucleus 7484
              nuclear lumen 4086
                nuclear chromosome 227
                  epsilon DNA polymerase complex 6
paths to the root