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ONTOLOGY REPORT - ANNOTATIONS


Term:epsilon DNA polymerase complex
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Accession:GO:0008622 term browser browse the term
Definition:A heterotetrameric DNA polymerase complex that catalyzes processive DNA synthesis in the absence of PCNA, but is further stimulated in the presence of PCNA. The complex contains a large catalytic subunit and three small subunits, and is best characterized in Saccharomyces, in which the subunits are named Pol2p, Dpb2p, Dpb3p, and Dpb4p. Some evidence suggests that DNA polymerase epsilon is the leading strand polymerase; it is also involved in nucleotide-excision repair and mismatch repair.



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epsilon DNA polymerase complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07027368.1 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr17:26,135,927...26,136,235 JBrowse link
G AABR07052692.1 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr 3:67,324,510...67,325,566 JBrowse link
G LOC100362333 DNA-directed DNA polymerase epsilon 3 part_of IBA
ISS
PMID:21873635
GO_REF:0000024
UniProt PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 7:109,236,160...109,236,825
Ensembl chr 7:109,236,321...109,236,758
JBrowse link
G Pole DNA polymerase epsilon, catalytic subunit part_of
located_in
ISO
IBA
(PMID:10801849), (PMID:22465957)
PMID:21873635
RGD PMID:10801849 PMID:22465957 PMID:21873635 RGD:13792537 NCBI chr12:46,345,420...46,393,984
Ensembl chr12:46,345,420...46,393,939
JBrowse link
G Pole2 DNA polymerase epsilon 2, accessory subunit part_of
located_in
ISO
IBA
(PMID:10801849), (PMID:22465957)
PMID:21873635
RGD PMID:10801849 PMID:22465957 PMID:21873635 RGD:13792537 NCBI chr 6:87,674,702...87,712,723
Ensembl chr 6:87,674,702...87,699,305
JBrowse link
G Pole3 DNA polymerase epsilon 3, accessory subunit part_of
located_in
IBA
ISO
ISS
PMID:21873635
(PMID:10801849)
GO_REF:0000024
RGD
UniProt
PMID:10801849 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 5:75,973,941...75,977,175
Ensembl chr 5:75,974,717...75,977,231
JBrowse link
G Pole4 DNA polymerase epsilon 4, accessory subunit part_of
located_in
IBA
ISO
PMID:21873635
(PMID:10801849)
RGD PMID:10801849 PMID:21873635 RGD:13792537 NCBI chr 4:115,165,285...115,171,097
Ensembl chr 4:115,165,285...115,171,097
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 19969
    protein-containing complex 6165
      nuclear protein-containing complex 1289
        epsilon DNA polymerase complex 7
Path 2
Term Annotations click to browse term
  cellular_component 19969
    cellular anatomical entity 19676
      intracellular anatomical structure 14364
        intracellular organelle 12730
          intracellular membrane-bounded organelle 11218
            nucleus 7051
              nuclear lumen 3941
                nuclear chromosome 245
                  epsilon DNA polymerase complex 7
paths to the root