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ONTOLOGY REPORT - ANNOTATIONS


Term:attachment of spindle microtubules to kinetochore
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Accession:GO:0008608 term browser browse the term
Definition:The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex.
Comment:This class covers all attachments of spindle microtubules to the kinetochore, including the many incorrect attachments which initially form and are later corrected to stable attachments with the correct orientation for segregation to proceed (sister chromatid biorientation).
Synonyms:exact_synonym: attachment of spindle microtubules to chromosome;   kinetochore-microtubule attachment;   microtubule anchoring at kinetochore;   spindle chromosome attachment;   spindle kinetochore attachment
 narrow_synonym: microtubule capture
 broad_synonym: kinetochore microtubule interaction;   microtubule and chromosome interaction;   spindle-chromosome interaction
 related_synonym: amphotelic attachment;   bipolar attachment;   microtubule and kinetochore interaction
 alt_id: GO:0051313



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attachment of spindle microtubules to kinetochore term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abraxas2 abraxas 2, BRISC complex subunit involved_in ISO (PMID:26195665) UniProt PMID:26195665 NCBI chrNW_004936486:13,038,177...13,064,802 JBrowse link
G Bub3 BUB3 mitotic checkpoint protein involved_in ISO (PMID:18199686) UniProt PMID:18199686 NCBI chrNW_004936486:11,796,066...11,807,826 JBrowse link
G Cenpe centromere protein E involved_in ISO (MGI:2673075|PMID:12925705) UniProt PMID:12925705 MGI:2673075 NCBI chrNW_004936520:188,601...265,904 JBrowse link
G Eml4 EMAP like 4 involved_in ISO (PMID:25789526) UniProt PMID:25789526 NCBI chrNW_004936508:9,303,639...9,447,478 JBrowse link
G Knl1 kinetochore scaffold 1 involved_in ISO (PMID:17981135) UniProt PMID:17981135 NCBI chrNW_004936471:4,079,877...4,110,205 JBrowse link
G Ndc80 NDC80 kinetochore complex component involved_in ISO (PMID:19468067) UniProt PMID:19468067 NCBI chrNW_004936672:1,872,205...1,910,956 JBrowse link
G Sgo1 shugoshin 1 involved_in ISO (PMID:17621308) UniProt PMID:17621308 NCBI chrNW_004936473:12,425,026...12,436,900 JBrowse link
G Tex14 testis expressed 14, intercellular bridge forming factor involved_in ISO (MGI:5318128|PMID:22405274) UniProt PMID:22405274 MGI:5318128 NCBI chrNW_004936490:4,499,825...4,576,952 JBrowse link
G Znf207 zinc finger protein 207 involved_in ISO (PMID:24462186), (PMID:24462187) UniProt PMID:24462186 PMID:24462187 NCBI chrNW_004936538:2,514,772...2,541,198 JBrowse link
attachment of mitotic spindle microtubules to kinetochore term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdt1 chromatin licensing and DNA replication factor 1 involved_in ISO (PMID:22581055) UniProt PMID:22581055 NCBI chrNW_004936641:916,695...925,411 JBrowse link
G Cenpe centromere protein E involved_in ISO (PMID:15843429) UniProt PMID:15843429 NCBI chrNW_004936520:188,601...265,904 JBrowse link
G Champ1 chromosome alignment maintaining phosphoprotein 1 involved_in ISO (PMID:21063390) UniProt PMID:21063390 NCBI chrNW_004937030:268,400...279,341 JBrowse link
G Kif2c kinesin family member 2C involved_in ISO (PMID:23891108) UniProt PMID:23891108 NCBI chrNW_004936474:25,967,095...26,000,678 JBrowse link
G Mis12 MIS12 kinetochore complex component involved_in ISO (PMID:23891108) UniProt PMID:23891108 NCBI chrNW_004936677:2,323,540...2,328,689 JBrowse link
G Ndc80 NDC80 kinetochore complex component involved_in ISO (PMID:23891108), (PMID:25743205) UniProt PMID:23891108 PMID:25743205 NCBI chrNW_004936672:1,872,205...1,910,956 JBrowse link
G Seh1l SEH1 like nucleoporin involved_in ISO (PMID:17363900) UniProt PMID:17363900 NCBI chrNW_004936626:2,538,655...2,562,468 JBrowse link
homologous chromosome orientation involved in meiotic metaphase I plate congression term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brca2 BRCA2 DNA repair associated ISO RGD PMID:16964288 RGD:1599505 NCBI chrNW_004936472:26,945,659...27,017,693 JBrowse link
lateral attachment of mitotic spindle microtubules to kinetochore term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cenpe centromere protein E involved_in ISO (PMID:23891108) UniProt PMID:23891108 NCBI chrNW_004936520:188,601...265,904 JBrowse link
mitotic sister chromatid biorientation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bod1 biorientation of chromosomes in cell division 1 involved_in ISO (PMID:17938248), (PMID:24157919) UniProt PMID:17938248 PMID:24157919 NCBI chrNW_004936609:2,034,271...2,096,274 JBrowse link
positive regulation of attachment of mitotic spindle microtubules to kinetochore term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Becn1 beclin 1 involved_in ISO (PMID:23478334) CACAO PMID:23478334 NCBI chrNW_004936490:17,518,100...17,531,126 JBrowse link
G Hnrnpu heterogeneous nuclear ribonucleoprotein U involved_in ISO (PMID:21242313) UniProt PMID:21242313 NCBI chrNW_004936526:6,014,745...6,022,213 JBrowse link
positive regulation of attachment of spindle microtubules to kinetochore term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccnb1 cyclin B1 involved_in ISO (PMID:18195732) BHF-UCL PMID:18195732 NCBI chrNW_004936480:400,287...407,677 JBrowse link
G Cenpe centromere protein E involved_in ISO (MGI:2447982|PMID:12361599) UniProt PMID:12361599 MGI:2447982 NCBI chrNW_004936520:188,601...265,904 JBrowse link
G Rcc2 regulator of chromosome condensation 2 involved_in ISO (PMID:12919680) UniProt PMID:12919680 NCBI chrNW_004936474:4,265,572...4,307,283 JBrowse link
G Sirt2 sirtuin 2 involved_in ISO (MGI:5567889|PMID:24334550) UniProt PMID:24334550 MGI:5567889 NCBI chrNW_004936661:1,828,868...1,849,892 JBrowse link
positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aurkb aurora kinase B involved_in ISO (PMID:28751710) CACAO PMID:28751710 NCBI chrNW_004936595:1,435,601...1,437,423 JBrowse link
regulation of attachment of spindle microtubules to kinetochore term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apc APC regulator of WNT signaling pathway acts_upstream_of_or_within ISO (MGI:3701148|PMID:17227893)
(PMID:17227893)
MGI PMID:17227893 MGI:3701148 NCBI chrNW_004936531:6,899,580...7,019,016 JBrowse link
G Cdc42 cell division cycle 42 involved_in ISO (PMID:15642749) UniProt PMID:15642749 NCBI chrNW_004936474:7,556,765...7,598,687 JBrowse link
G Ect2 epithelial cell transforming 2 involved_in ISO (PMID:15642749) UniProt PMID:15642749 NCBI chrNW_004936703:5,744...45,636 JBrowse link
G Knstrn kinetochore localized astrin (SPAG5) binding protein involved_in ISO (PMID:21402792) UniProt PMID:21402792 NCBI chrNW_004936471:3,838,507...3,849,521 JBrowse link
G Nek2 NIMA related kinase 2 involved_in ISO (PMID:18297113) UniProt PMID:18297113 NCBI chrNW_004936557:1,683,027...1,695,410 JBrowse link
G Racgap1 Rac GTPase activating protein 1 involved_in ISO (PMID:15642749) UniProt PMID:15642749 NCBI chrNW_004936512:7,665,144...7,696,615 JBrowse link
G Spag5 sperm associated antigen 5 involved_in ISO (PMID:21402792) UniProt PMID:21402792 NCBI chrNW_004936538:4,803,536...4,821,034 JBrowse link
sister chromatid biorientation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Champ1 chromosome alignment maintaining phosphoprotein 1 involved_in ISO (PMID:21063390) UniProt PMID:21063390 NCBI chrNW_004937030:268,400...279,341 JBrowse link
G Rb1 RB transcriptional corepressor 1 involved_in ISO (PMID:20551165) BHF-UCL PMID:20551165 NCBI chrNW_004936565:1,596,227...1,746,706 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12171
    cellular process 11367
      cell cycle process 960
        attachment of spindle microtubules to kinetochore 30
          attachment of mitotic spindle microtubules to kinetochore + 11
          attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation + 1
          negative regulation of attachment of spindle microtubules to kinetochore + 0
          positive regulation of attachment of spindle microtubules to kinetochore + 7
          regulation of attachment of spindle microtubules to kinetochore + 14
          sister chromatid biorientation + 3
Path 2
Term Annotations click to browse term
  biological_process 12171
    cellular process 11367
      cell cycle 1237
        cell cycle process 960
          nuclear chromosome segregation 231
            attachment of spindle microtubules to kinetochore 30
              attachment of mitotic spindle microtubules to kinetochore + 11
              attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation + 1
              negative regulation of attachment of spindle microtubules to kinetochore + 0
              positive regulation of attachment of spindle microtubules to kinetochore + 7
              regulation of attachment of spindle microtubules to kinetochore + 14
              sister chromatid biorientation + 3
paths to the root